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409 results on '"de Kleuver, Marinus"'

5. Lumbar spine segmentation in MR images: a dataset and a public benchmark

Author

van der Graaf, Jasper W., van Hooff, Miranda L., Buckens, Constantinus F. M., Rutten, Matthieu, van Susante, Job L. C., Kroeze, Robert Jan, de Kleuver, Marinus, van Ginneken, Bram, and Lessmann, Nikolas

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition
Abstract

This paper presents a large publicly available multi-center lumbar spine magnetic resonance imaging (MRI) dataset with reference segmentations of vertebrae, intervertebral discs (IVDs), and spinal canal. The dataset includes 447 sagittal T1 and T2 MRI series from 218 patients with a history of low back pain and was collected from four different hospitals. An iterative data annotation approach was used by training a segmentation algorithm on a small part of the dataset, enabling semi-automatic segmentation of the remaining images. The algorithm provided an initial segmentation, which was subsequently reviewed, manually corrected, and added to the training data. We provide reference performance values for this baseline algorithm and nnU-Net, which performed comparably. Performance values were computed on a sequestered set of 39 studies with 97 series, which were additionally used to set up a continuous segmentation challenge that allows for a fair comparison of different segmentation algorithms. This study may encourage wider collaboration in the field of spine segmentation and improve the diagnostic value of lumbar spine MRI., Comment: Published in Scientific Data

Published
2023
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11. The Influence of Multilevel Spinal Deformity Surgery on the EuroQol 5 Dimensions' (EQ-5D) Questionnaire and Residential Status in the Elderly: A Prospective, Observational, Multicenter Study.

Author

Jentzsch, Thorsten, Lewis, Stephen J., Oitment, Colby, Rienmüller, Anna, Martin, Allan R., Nielsen, Christopher J., Shear-Yashuv, Hananel, de Kleuver, Marinus, Qiu, Yong, Matsuyama, Yukihiro, Lenke, Lawrence G., Alanay, Ahmet, Pellisé-Urquiza, Ferran, Cheung, Kenneth M. C., Spruit, Maarten, Polly, David W., Sembrano, Jonathan N., Shaffrey, Christopher I., Smith, Justin S., and Kelly, Michael P.

Subjects
SPINE abnormalities, OLDER patients, TREATMENT effectiveness, MEDICAL care, SCOLIOSIS, SPINAL surgery
Abstract

Study Design: Multicenter, international prospective study. Objective: This study investigated the clinical outcome up to 2 years after multi-level spinal deformity surgery in the elderly by reporting the minimal clinically important difference (MCID) of EuroQol 5-dimensions (EQ-5D), EQ-VAS, and residential status. Methods: As an ancillary study of 219 patients ≥60 years with spinal deformity undergoing primary instrumented fusion surgery of ≥5 levels, this study focuses on EQ-5D (3-L) as the primary outcome and EQ-VAS and residential status as secondary outcomes. Data on EQ-5D were compared between pre-operatively and postoperatively at 10 weeks, 12 months, and 24 months. An anchor-based approach was used to calculate the MCID. Results: The EQ-5D index and EQ-VAS, respectively, improved significantly at each time point compared to pre-operatively (from.53 (SD.21) and 55.6 (SD 23.0) pre-operatively to.64 (SD.18) and 65.8 (SD 18.7) at 10 weeks,.74 (SD.18) and 72.7 (SD 18.1) at 12 months, and.73 (SD.20) and 70.4 (SD 20.4) at 24 months). 217 (99.1%) patients lived at home pre-operatively, while 186 (88.6%), 184 (98.4%), and 172 (100%) did so at 10 weeks, 12 months, and 24 months, respectively. Our calculated MCID for the EQ-5D index at 1 year was.22 (95% CI.15-.29). Conclusions: The EQ-5D index significantly increased at each time point over 24 months after ≥5 level spinal deformity surgery in elderly patients. The MCID of the EQ-5D-3 L was.22. Patients living at home pre-operatively can expect to be able to live at home 2 years postoperatively. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Stratifying outcome based on the Oswestry Disability Index for operative treatment of adult spinal deformity on patients 60 years of age or older: a multicenter, multi-continental study on Prospective Evaluation of Elderly Deformity Surgery (PEEDS)

Author

Nielsen, Christopher J., Lewis, Stephen J., Oitment, Colby, Martin, Allan R., Lenke, Lawrence G., Qiu, Yong, Cheung, Kenneth MC, de Kleuver, Marinus, Polly, David W., Shaffrey, Christopher I., Smith, Justin S., Spruit, Maarten, Alanay, Ahmet, Matsuyama, Yukihiro, Jentzsch, Thorsten, Rienmuller, Anna, Shear-Yashuv, Hananel, Pellisé, Ferran, Kelly, Michael P., Sembrano, Jonathan N., Dahl, Benny T., Berven, Sigurd H., and Forum Deformity, AO Spine Knowledge

Published
2021
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14. The Dutch version of the Spinal Appearance Questionnaire for adolescents with idiopathic scoliosis:patient-based cross-cultural adaptation and measurement properties evaluation

Author

van de Fliert, Dineke G., Schlösser, Tom P.C., Kempen, Diederik H.R., Rutges, Joost P.H.J., Bisseling, Pepijn, de Kleuver, Marinus, van Hooff, Miranda L., van de Fliert, Dineke G., Schlösser, Tom P.C., Kempen, Diederik H.R., Rutges, Joost P.H.J., Bisseling, Pepijn, de Kleuver, Marinus, and van Hooff, Miranda L.

Abstract

Purpose: Adolescent idiopathic scoliosis (AIS) affects the appearance of spine and trunk. The Spinal Appearance Questionnaire (SAQ) assesses the perception of appearance in AIS patients. The aim of this study is to translate and culturally adapt the recommended short version of the SAQ into Dutch and to test its measurement properties. Methods: A Dutch SAQ (14-item; appearance and expectations domains) was developed following guidelines for translation and cross-cultural adaptation. The COSMIN Study Design checklist was used for measurement properties evaluation. In this multicenter study, the Dutch SAQ, SRS-22R and NPRS (back pain) were administered to 113 AIS patients (aged 15.4 years [SD 2.2], 21.2% male). Floor and ceiling effects were evaluated for content analysis. For reliability, internal consistency (Cronbach’s alpha) and test–retest reliability (ICC; n = 34) were evaluated. Predefined hypotheses of relationships with other questionnaires and between subgroups based on scoliosis severity (radiological and clinical) were tested for construct validity. Exploratory factor analysis (EFA) was performed to investigate the validity of the underlying structure of this 14-item questionnaire. Results: No floor and ceiling effects were found for domains and total scores. Cronbach’s alpha ranged from 0.84 to 0.89. ICCs varied from 0.76 to 0.77. For construct validity, 89% (8/9) of the predefined hypotheses were confirmed. Significant higher scores for the appearance domain were found for subgroups based on radiological (Cobb angle; > 25.0°) and clinical outcomes. (Angle of Trunk Rotation; > 9.0°). A two-factor structure was found (EV 5.13; 36.63% explained variance). Conclusion: The Dutch SAQ is an adequate, valid and reliable instrument to evaluate patients’ perception of appearance in AIS. Level of evidence: Level I—diagnostic studies.

Published
2024

28. The Influence of Multilevel Spinal Deformity Surgery on the EuroQol 5 Dimensions' (EQ-5D) Questionnaire and Residential Status in the Elderly: A Prospective, Observational, Multicenter Study

Author

Jentzsch, Thorsten; https://orcid.org/0000-0002-6133-3314, Lewis, Stephen J; https://orcid.org/0000-0002-9173-8443, Oitment, Colby; https://orcid.org/0000-0003-1351-9410, Rienmüller, Anna, Martin, Allan R, Nielsen, Christopher J, Shear-Yashuv, Hananel, de Kleuver, Marinus, Qiu, Yong; https://orcid.org/0000-0003-4202-6092, Matsuyama, Yukihiro, Lenke, Lawrence G, Alanay, Ahmet, Pellisé-Urquiza, Ferran, Cheung, Kenneth M C; https://orcid.org/0000-0001-8304-0419, Spruit, Maarten, Polly, David W, Sembrano, Jonathan N, Shaffrey, Christopher I, Smith, Justin S, Kelly, Michael P; https://orcid.org/0000-0001-6221-7406, Dahl, Benny, Berven, Sigurd H, Jentzsch, Thorsten; https://orcid.org/0000-0002-6133-3314, Lewis, Stephen J; https://orcid.org/0000-0002-9173-8443, Oitment, Colby; https://orcid.org/0000-0003-1351-9410, Rienmüller, Anna, Martin, Allan R, Nielsen, Christopher J, Shear-Yashuv, Hananel, de Kleuver, Marinus, Qiu, Yong; https://orcid.org/0000-0003-4202-6092, Matsuyama, Yukihiro, Lenke, Lawrence G, Alanay, Ahmet, Pellisé-Urquiza, Ferran, Cheung, Kenneth M C; https://orcid.org/0000-0001-8304-0419, Spruit, Maarten, Polly, David W, Sembrano, Jonathan N, Shaffrey, Christopher I, Smith, Justin S, Kelly, Michael P; https://orcid.org/0000-0001-6221-7406, Dahl, Benny, and Berven, Sigurd H

Abstract

STUDY DESIGN: Multicenter, international prospective study. OBJECTIVE: This study investigated the clinical outcome up to 2 years after multi-level spinal deformity surgery in the elderly by reporting the minimal clinically important difference (MCID) of EuroQol 5-dimensions (EQ-5D), EQ-VAS, and residential status. METHODS: As an ancillary study of 219 patients ≥60 years with spinal deformity undergoing primary instrumented fusion surgery of ≥5 levels, this study focuses on EQ-5D (3-L) as the primary outcome and EQ-VAS and residential status as secondary outcomes. Data on EQ-5D were compared between pre-operatively and postoperatively at 10 weeks, 12 months, and 24 months. An anchor-based approach was used to calculate the MCID. RESULTS: The EQ-5D index and EQ-VAS, respectively, improved significantly at each time point compared to pre-operatively (from .53 (SD .21) and 55.6 (SD 23.0) pre-operatively to .64 (SD .18) and 65.8 (SD 18.7) at 10 weeks, .74 (SD .18) and 72.7 (SD 18.1) at 12 months, and .73 (SD .20) and 70.4 (SD 20.4) at 24 months). 217 (99.1%) patients lived at home pre-operatively, while 186 (88.6%), 184 (98.4%), and 172 (100%) did so at 10 weeks, 12 months, and 24 months, respectively. Our calculated MCID for the EQ-5D index at 1 year was .22 (95% CI .15-.29). CONCLUSIONS: The EQ-5D index significantly increased at each time point over 24 months after ≥5 level spinal deformity surgery in elderly patients. The MCID of the EQ-5D-3 L was .22. Patients living at home pre-operatively can expect to be able to live at home 2 years postoperatively.

Published
2023

33. Supplemental Material - The Influence of Multilevel Spinal Deformity Surgery on the EuroQol 5 Dimensions’ (EQ-5D) Questionnaire and Residential Status in the Elderly: A Prospective, Observational, Multicenter Study

Author

Jentzsch, Thorsten, Lewis, Stephen J., Oitment, Colby, Rienmüller, Anna, Martin, Allan R., Nielsen, Christopher J., Shear-Yashuv, Hananel, de Kleuver, Marinus, Qiu, Yong, Matsuyama, Yukihiro, Lenke, Lawrence G., Alanay, Ahmet, Pellisé-Urquiza, Ferran, Cheung, Kenneth M. C., Spruit, Maarten, Polly, David W., Sembrano, Jonathan N., Shaffrey, Christopher I., Smith, Justin S., Kelly, Michael P., Dahl, Benny, and Berven, Sigurd H.

Subjects
FOS: Clinical medicine, 110323 Surgery, 110604 Sports Medicine, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases, 110314 Orthopaedics
Abstract

Supplemental Material for The Influence of Multilevel Spinal Deformity Surgery on the EuroQol 5 Dimensions’ (EQ-5D) Questionnaire and Residential Status in the Elderly: A Prospective, Observational, Multicenter Study by Thorsten Jentzsch, Stephen J. Lewis, Colby Oitment, Anna Rienmüller, Allan R. Martin, Christopher J. Nielsen, Hananel Shear-Yashuv, Marinus de Kleuver, Yong Qiu, Yukihiro Matsuyama, Lawrence G. Lenke, Ahmet alanay, Ferran Pellisé-Urquiza, Kenneth M. C. Cheung, Maarten Spruit, David W. Polly, Jonathan N. Sembrano, Christopher I. Shaffrey, Justin S. Smith, Michael P. Kelly, Benny Dahl, Sigurd H. Berven, and AO Spine Knowledge Forum D in Global Spine Journal

Published
2023
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38. Toward the Development of a Comprehensive Clinically Oriented Patient Profile: A Systematic Review of the Purpose, Characteristic, and Methodological Quality of Classification Systems of Adult Spinal Deformity

Author

Kwan, Kenny Yat Hong, Naresh-Babu, J., Jacobs, Wilco, de Kleuver, Marinus, Polly, David W., Yilgor, Caglar, Wu, Yabin, Park, Jong-Beom, Ito, Manabu, van Hooff, Miranda L., Deformity, A.O. Spine Knowledge Forum, and Acibadem University Dspace

Subjects
Adult, Male, medicine.medical_specialty, media_common.quotation_subject, MEDLINE, Adult spinal deformity, Scoliosis, CINAHL, Spinal Curvatures, 03 medical and health sciences, 0302 clinical medicine, medicine, Patient profile, Humans, Quality (business), Medical physics, 030212 general & internal medicine, Methodological quality, media_common, business.industry, Reproducibility of Results, medicine.disease, Classification, Spine, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], Radiography, Treatment Outcome, Characteristics, Purpose, Radiological weapon, Practice Guidelines as Topic, Spinal deformity, Systematic review, Surgery, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

Contains fulltext : 245123.pdf (Publisher’s version ) (Open Access) BACKGROUND: Existing adult spinal deformity (ASD) classification systems are based on radiological parameters but management of ASD patients requires a holistic approach. A comprehensive clinically oriented patient profile and classification of ASD that can guide decision-making and correlate with patient outcomes is lacking. OBJECTIVE: To perform a systematic review to determine the purpose, characteristic, and methodological quality of classification systems currently used in ASD. METHODS: A systematic literature search was conducted in MEDLINE, EMBASE, CINAHL, and Web of Science for literature published between January 2000 and October 2018. From the included studies, list of classification systems, their methodological measurement properties, and correlation with treatment outcomes were analyzed. RESULTS: Out of 4470 screened references, 163 were included, and 54 different classification systems for ASD were identified. The most commonly used was the Scoliosis Research Society-Schwab classification system. A total of 35 classifications were based on radiological parameters, and no correlation was found between any classification system levels with patient-related outcomes. Limited evidence of limited quality was available on methodological quality of the classification systems. For studies that reported the data, intraobserver and interobserver reliability were good (kappa = 0.8). CONCLUSION: This systematic literature search revealed that current classification systems in clinical use neither include a comprehensive set of dimensions relevant to decision-making nor did they correlate with outcomes. A classification system comprising a core set of patient-related, radiological, and etiological characteristics relevant to the management of ASD is needed.

Published
2021

43. 215. Assessing key functional outcomes after multilevel fusion for adult spinal deformity in patients over 60 years of age: A prospective, observational, multicenter study with two-year follow-up

Author

Yashuv, Hananel Shear, primary, Lewis, Stephen J., additional, Jentzsch, Thorsten, additional, Martin, Allan R., additional, Oitment, Colby T., additional, Rienmueller, Anna C., additional, Nielsen, Christopher, additional, de Kleuver, Marinus, additional, Qiu, Yong, additional, Matsuyama, Yukihiro, additional, Lenke, Lawrence G., additional, Alanay, Ahmet, additional, Pellise, Ferran, additional, Cheung, Kenneth M., additional, Spruit, Maarten, additional, Polly, David W., additional, Sembrano, Jonathan N., additional, Shaffrey, Christopher I., additional, Dahl, Benny, additional, and Berven, Sigurd H., additional

Published
2021
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46. Stratifying outcome based on the Oswestry Disability Index for operative treatment of adult spinal deformity on patients 60 years of age or older:a multicenter, multi-continental study on Prospective Evaluation of Elderly Deformity Surgery (PEEDS)

Author

Nielsen, Christopher J., Lewis, Stephen J., Oitment, Colby, Martin, Allan R., Lenke, Lawrence G., Qiu, Yong, Cheung, Kenneth MC, de Kleuver, Marinus, Polly, David W., Shaffrey, Christopher I., Smith, Justin S., Spruit, Maarten, Alanay, Ahmet, Matsuyama, Yukihiro, Jentzsch, Thorsten, Rienmuller, Anna, Shear-Yashuv, Hananel, Pellisé, Ferran, Kelly, Michael P., Sembrano, Jonathan N., Dahl, Benny T., Berven, Sigurd H., Forum Deformity, AO Spine Knowledge, Nielsen, Christopher J., Lewis, Stephen J., Oitment, Colby, Martin, Allan R., Lenke, Lawrence G., Qiu, Yong, Cheung, Kenneth MC, de Kleuver, Marinus, Polly, David W., Shaffrey, Christopher I., Smith, Justin S., Spruit, Maarten, Alanay, Ahmet, Matsuyama, Yukihiro, Jentzsch, Thorsten, Rienmuller, Anna, Shear-Yashuv, Hananel, Pellisé, Ferran, Kelly, Michael P., Sembrano, Jonathan N., Dahl, Benny T., Berven, Sigurd H., and Forum Deformity, AO Spine Knowledge

Abstract

BACKGROUND CONTEXT: Patients with adult spinal deformity suffer from disease related disability as measured by the Oswestry Disability Index (ODI) for which surgery can result in significant improvements. PURPOSE: The purpose of this study was to show the change in overall and individual components of the ODI in patients aged 60 years or older following multi-level spinal deformity surgery. STUDY DESIGN: Prospective, multicenter, multi-continental, observational longitudinal cohort study PATIENT SAMPLE: Patients ≥60 years undergoing primary spinal fusion surgery of ≥5 levels for coronal, sagittal or combined deformity. OUTCOME MEASURES: Oswestry Disability Index (ODI) METHODS: : Patients completed the ODI pre-operatively for baseline, then at 10 weeks, 12 months and 24 months post-operatively. ODI scores were grouped into deciles, and change was calculated with numerical score and improvement or worsening was further categorized from baseline as substantial (≥20%), marginal (≥10–<20%) or no change (within 10%). RESULTS: Two-hundred nineteen patients met inclusion criteria for the study. The median number of spinal levels fused was 9 [Q1=5.0, Q3=12.0]. Two-year mean (95% CI) ODI improvement was 19.3% (16.7%; 21.9%; p<.001) for all age groups, with mean scores improved from a baseline of 46.3% (44.1%; 48.4%) to 41.1% (38.5%; 43.6%) at 10 weeks (p<.001), 28.1% (25.6%; 30.6%) at 12 months (p<.001), and 27.0% (24.4%; 29.5%) at 24 months (p<.001). At 2 years, 45.5% of patients showed 20% or greater improvement in ODI, 23.7% improved between 10% and 20%, 26.3% reported no change (defined as±10% from baseline), 4.5% of patients reported a worsening between 10% to 20%, and none reported worsening greater than 20%. 59.0% of patients were severely disabled (ODI >40%) pre-operatively, which decreased to 20.2% at 2 years. Significant improvement was observed across all 10 ODI items at 12 and 24 months. The largest improvements were seen in pain, walking, sta

Published
2021

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