6 results on '"de Klerk, Jabke J"'
Search Results
2. Erratum to 'Contribution of acute infarcts to cerebral small vessel disease progression'
- Author
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Telgte, Annemieke ter, Wiegertjes, Kim, Klijn, 3 Catharina J. M., Dichgans, Martin, Tuladhar, Anil M., Duering, Marco, Leeuw, Frank-Erik de, Gesierich, Benno, Marques, José P., Huebner, Mathias, de Klerk, Jabke J., Schreuder, Floris H. B. M., Araque Caballero, Miguel Angel, Kuijf, Hugo J., and Norris, David G.
- Subjects
ddc:610 - Abstract
Cerebral small vessel disease (SVD) constitutes the mainvascular cause of cognitive impairment and dementia,and accounts for about one-fifth of all strokes.1,2 SVD is further associated with gait impairment, mood disturbances, andlate-life disability.3 Conventional magnetic resonance imaging (MRI) markers of SVD include white matter hyperintensities(WMH), lacunes, and cerebral microbleeds, with WMHbeing the most widely studied.2 Traditionally, WMH havebeen attributed to chronic cerebral hypoperfusion. However,evidence for this hypothesis remains inconclusive.4,5
- Published
- 2019
3. The contribution of acute infarcts to cerebral small vessel disease progression
- Author
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Ter Telgte, Annemieke, Wiegertjes, Kim, Gesierich, Benno, Marques, José P, Huebner, Mathias, de Klerk, Jabke J, Schreuder, Floris H B M, Araque Caballero, Miguel A, Kuijf, Hugo J, Norris, David G, Klijn, Catharina J M, Dichgans, Martin, Tuladhar, Anil M, Duering, Marco, de Leeuw, Frank-Erik, Ter Telgte, Annemieke, Wiegertjes, Kim, Gesierich, Benno, Marques, José P, Huebner, Mathias, de Klerk, Jabke J, Schreuder, Floris H B M, Araque Caballero, Miguel A, Kuijf, Hugo J, Norris, David G, Klijn, Catharina J M, Dichgans, Martin, Tuladhar, Anil M, Duering, Marco, and de Leeuw, Frank-Erik
- Published
- 2019
4. The contribution of acute infarcts to cerebral small vessel disease progression
- Author
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Beeldverwerking ISI, Brain, Ter Telgte, Annemieke, Wiegertjes, Kim, Gesierich, Benno, Marques, José P, Huebner, Mathias, de Klerk, Jabke J, Schreuder, Floris H B M, Araque Caballero, Miguel A, Kuijf, Hugo J, Norris, David G, Klijn, Catharina J M, Dichgans, Martin, Tuladhar, Anil M, Duering, Marco, de Leeuw, Frank-Erik, Beeldverwerking ISI, Brain, Ter Telgte, Annemieke, Wiegertjes, Kim, Gesierich, Benno, Marques, José P, Huebner, Mathias, de Klerk, Jabke J, Schreuder, Floris H B M, Araque Caballero, Miguel A, Kuijf, Hugo J, Norris, David G, Klijn, Catharina J M, Dichgans, Martin, Tuladhar, Anil M, Duering, Marco, and de Leeuw, Frank-Erik
- Published
- 2019
5. Contribution of acute infarcts to cerebral small vessel disease progression.
- Author
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Telgte, Annemieke, Wiegertjes, Kim, Gesierich, Benno, Marques, José P., Huebner, Mathias, Klerk, Jabke J., Schreuder, Floris H. B. M., Araque Caballero, Miguel A., Kuijf, Hugo J., Norris, David G., Klijn, Catharina J. M., Dichgans, Martin, Tuladhar, Anil M., Duering, Marco, Leeuw, Frank‐Erik, Ter Telgte, Annemieke, de Klerk, Jabke J, and de Leeuw, Frank-Erik
- Subjects
CEREBRAL small vessel diseases ,DISEASE progression ,DIFFUSION magnetic resonance imaging ,MAGNETIC resonance imaging ,BRAIN ,CEREBRAL hemorrhage ,COMPARATIVE studies ,INFARCTION ,RESEARCH methodology ,MEDICAL cooperation ,NEURORADIOLOGY ,RESEARCH ,EVALUATION research ,DISEASE incidence ,LACUNAR stroke ,DISEASE complications - Abstract
Objective: To determine the contribution of acute infarcts, evidenced by diffusion-weighted imaging positive (DWI+) lesions, to progression of white matter hyperintensities (WMH) and other cerebral small vessel disease (SVD) markers.Methods: We performed monthly 3T magnetic resonance imaging (MRI) for 10 consecutive months in 54 elderly individuals with SVD. MRI included high-resolution multishell DWI, and 3-dimensional fluid-attenuated inversion recovery, T1, and susceptibility-weighted imaging. We determined DWI+ lesion evolution, WMH progression rate (ml/mo), and number of incident lacunes and microbleeds, and calculated for each marker the proportion of progression explained by DWI+ lesions.Results: We identified 39 DWI+ lesions on 21 of 472 DWI scans in 9 of 54 subjects. Of the 36 DWI+ lesions with follow-up MRI, 2 evolved into WMH, 4 evolved into a lacune (3 with cavity <3mm), 3 evolved into a microbleed, and 27 were not detectable on follow-up. WMH volume increased at a median rate of 0.027 ml/mo (interquartile range = 0.005-0.073), but was not significantly higher in subjects with DWI+ lesions compared to those without (p = 0.195). Of the 2 DWI+ lesions evolving into WMH on follow-up, one explained 23% of the total WMH volume increase in one subject, whereas the WMH regressed in the other subject. DWI+ lesions preceded 4 of 5 incident lacunes and 3 of 10 incident microbleeds.Interpretation: DWI+ lesions explain only a small proportion of the total WMH progression. Hence, WMH progression seems to be mostly driven by factors other than acute infarcts. DWI+ lesions explain the majority of incident lacunes and small cavities, and almost one-third of incident microbleeds, confirming that WMH, lacunes, and microbleeds, although heterogeneous on MRI, can have a common initial appearance on MRI. ANN NEUROL 2019;86:582-592. [ABSTRACT FROM AUTHOR]- Published
- 2019
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6. Contribution of acute infarcts to cerebral small vessel disease progression.
- Author
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Ter Telgte A, Wiegertjes K, Gesierich B, Marques JP, Huebner M, de Klerk JJ, Schreuder FHBM, Araque Caballero MA, Kuijf HJ, Norris DG, Klijn CJM, Dichgans M, Tuladhar AM, Duering M, and de Leeuw FE
- Subjects
- Aged, Aged, 80 and over, Brain Infarction complications, Cerebral Small Vessel Diseases complications, Diffusion Magnetic Resonance Imaging, Disease Progression, Female, Humans, Incidence, Intracranial Hemorrhages complications, Intracranial Hemorrhages pathology, Male, Neuroimaging, Stroke, Lacunar complications, Stroke, Lacunar pathology, White Matter blood supply, White Matter pathology, Brain Infarction pathology, Cerebral Small Vessel Diseases pathology
- Abstract
Objective: To determine the contribution of acute infarcts, evidenced by diffusion-weighted imaging positive (DWI+) lesions, to progression of white matter hyperintensities (WMH) and other cerebral small vessel disease (SVD) markers., Methods: We performed monthly 3T magnetic resonance imaging (MRI) for 10 consecutive months in 54 elderly individuals with SVD. MRI included high-resolution multishell DWI, and 3-dimensional fluid-attenuated inversion recovery, T1, and susceptibility-weighted imaging. We determined DWI+ lesion evolution, WMH progression rate (ml/mo), and number of incident lacunes and microbleeds, and calculated for each marker the proportion of progression explained by DWI+ lesions., Results: We identified 39 DWI+ lesions on 21 of 472 DWI scans in 9 of 54 subjects. Of the 36 DWI+ lesions with follow-up MRI, 2 evolved into WMH, 4 evolved into a lacune (3 with cavity <3mm), 3 evolved into a microbleed, and 27 were not detectable on follow-up. WMH volume increased at a median rate of 0.027 ml/mo (interquartile range = 0.005-0.073), but was not significantly higher in subjects with DWI+ lesions compared to those without (p = 0.195). Of the 2 DWI+ lesions evolving into WMH on follow-up, one explained 23% of the total WMH volume increase in one subject, whereas the WMH regressed in the other subject. DWI+ lesions preceded 4 of 5 incident lacunes and 3 of 10 incident microbleeds., Interpretation: DWI+ lesions explain only a small proportion of the total WMH progression. Hence, WMH progression seems to be mostly driven by factors other than acute infarcts. DWI+ lesions explain the majority of incident lacunes and small cavities, and almost one-third of incident microbleeds, confirming that WMH, lacunes, and microbleeds, although heterogeneous on MRI, can have a common initial appearance on MRI. ANN NEUROL 2019;86:582-592., (© 2019 The Authors. Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association.)
- Published
- 2019
- Full Text
- View/download PDF
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