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4MOST is a wide-field, high-multiplex spectroscopic survey facility under development for the VISTA telescope of the European Southern Observatory (ESO). Its main science drivers are in the areas of galactic archeology, high-energy physics, galaxy evolution and cosmology. 4MOST will in particular provide the spectroscopic complements to the large area surveys coming from space missions like Gaia, eROSITA, Euclid, and PLATO. 4MOST will have an unique operations concept in which 5-years public surveys from both the consortium and the ESO community will be combined and observed in parallel during each exposure, resulting in more than 25 million spectra of targets spread over a large fraction of the southern sky. As a dedicated spectroscopic survey facility with a large field-of-view, a high multiplex that can be reconfigured quickly, and with a broad wavelength coverage, 4MOST is particularly well suited to complement the upcoming asteroseismology space missions like TESS and PLATO. Here we show that, by dedicating the observing time during twilight and poor observing conditions to bright stars, 4MOST will obtain resolution R > 18000 spectra of nearly all stars brighter than 12th magnitude at Dec <30° every 2 years. 4MOST is also expected to spectroscopically complement any fainter asteroseismology target tobe observed with PLATO. These observations will provide a chemical characterization of nearly all stars tobe observed with the TESS and PLATO missions and place any planets found in a full chemo-dynamical context of the star formation history of the Galaxy, yield very accurate ages and masses for all stars that can be characterized with asteroseismology, and allow removal of contaminants from target samples (e.g., spectroscopic binaries). [ABSTRACT FROM AUTHOR]

Context. With its origin coming from several sources (Big Bang, stars, cosmic rays) and given its strong depletion during its stellar lifetime, the lithium element is of great interest as its chemical evolution in the Milky Way is not well understood at present. To help constrain stellar and galactic chemical evolution models, numerous and precise lithium abundances are necessary for a large range of evolutionary stages, metallicities, and Galactic volume. Aims. In the age of stellar parametrization on industrial scales, spectroscopic surveys such as APOGEE, GALAH, RAVE, and LAMOST have used data-driven methods to rapidly and precisely infer stellar labels (atmospheric parameters and abundances). To prepare the ground for future spectroscopic surveys such as 4MOST and WEAVE, we aim to apply machine learning techniques to lithium measurements and analyses. Methods. We trained a convolution neural network (CNN), coupling Gaia-ESO Survey iDR6 stellar labels (Teff, log(g), [Fe/H], and A(Li)) and GIRAFFE HR15N spectra, to infer the atmospheric parameters and lithium abundances for ∼40 000 stars. The CNN architecture and accompanying notebooks are available online via GitHub. Results. We show that the CNN properly learns the physics of the stellar labels, from relevant spectral features through a broad range of evolutionary stages and stellar parameters. The lithium feature at 6707.8 Å is successfully singled out by our CNN, among the thousands of lines in the GIRAFFE HR15N setup. Rare objects such as lithium-rich giants are found in our sample. This level of performance is achieved thanks to a meticulously built, high-quality, and homogeneous training sample. Conclusions. The CNN approach is very well adapted for the next generations of spectroscopic surveys aimed at studying (among other elements) lithium, such as the 4MIDABLE-LR/HR (4MOST Milky Way disk and bulge low- and high-resolution) surveys. In this context, the caveats of machine-learning applications should be appropriately investigated, along with the realistic label uncertainties and upper limits for abundances. [ABSTRACT FROM AUTHOR]

Context. The determination of stellar mctallicity and its gradient in external galaxies is a difficult task, but crucial for the understanding of galaxy formation and evolution. Alms. The color of the Red Giant Branch (RGB) can be used to determine metallicities of stellar populations that have only shallow photometry. We will quantify the relation between mctallicity and color in the widely used HST/ACS filters F606W and F8I4W. Methods. We use a sample of globular clusters from the ACS Globular Cluster Survey and measure their RGB color at given absolute magnitudes to derive the color-metal I icily relation. We especially investigate the scatter and the uncertainties in this relation and show Results. There is a clear relation between mctallicity and RGB color. A comparison with isochrones shows reasonably good agreement with BaSTl models, a small offset to Dartmouth models, and a larger offset to Padua models. Conclusions. Even for the best globular cluster data available, the mctallicity of a simple stellar population can be determined from the RGB alone only with an accuracy of 0.3dex for [M/H] ≳ -1, and 0.15dcx for [M/H] ≳ -1. For mixed populations, as they are observed in external galaxies, the uncertainties will be even larger due to uncertainties in extinction, age. etc. Therefore caution is necessary when interpreting photometric metallicities. [ABSTRACT FROM AUTHOR]

ABSTRACT The stellar haloes of galaxies can currently be studied either through observations of resolved halo stars or through surface photometry. Curiously, the two methods appear to give conflicting results, as a number of surface photometry measurements have revealed integrated colours that are too red to be reconciled with the halo properties inferred from the study of resolved stars. Several explanations for this anomaly have been proposed - including dust photoluminescence, extinction of extragalactic background light and a bottom-heavy stellar initial mass function. A decisive test is, however, still lacking. Here, we explain how observations of the halo of a nearby galaxy, involving a combination of both surface photometry and bright star counts, can be used to distinguish between the proposed explanations. We derive the observational requirements for this endeavour and find that star counts in filters VI and surface photometry in filters VIJ appear to be the optimal strategy. Since the required halo star counts are already available for many nearby galaxies, the most challenging part of this test is likely to be the optical surface photometry, which requires several nights of exposure time on a 4-8 m telescope, and the near-infrared surface photometry, which is most readily carried out using the upcoming James Webb Space Telescope. [ABSTRACT FROM AUTHOR]

The breaks and truncations in the luminosity profile of face-on spiral galaxies offer valuable insights in their formation history. The traditional method of deriving the surface photometry profile for face-on galaxies is to use elliptical averaging. In this paper, we explore the question whether elliptical averaging is the best way to do this. We apply two additional surface photometry methods, one new: principal axis summation, and one old that has become seldom used: equivalent profiles. These are compared to elliptically averaged profiles using a set of 29 face-on galaxies. We find that the equivalent profiles match extremely well with elliptically averaged profiles, confirming the validity of using elliptical averaging. The principal axis summation offers a better comparison to edge-on galaxies. [ABSTRACT FROM AUTHOR]

The breaks and truncations in the luminosity profile of face-on spiral galaxies offer valuable insights in their formation history. The traditional method of deriving the surface photometry profile for face-on galaxies is to use elliptical averaging. In this paper, we explore the question whether elliptical averaging is the best way to do this. We apply two additional surface photometry methods, one new: principal axis summation, and one old that has become seldom used: equivalent profiles. These are compared to elliptically averaged profiles using a set of 29 face-on galaxies. We find that the equivalent profiles match extremely well with elliptically averaged profiles, confirming the validity of using elliptical averaging. The principal axis summation offers a better comparison to edge-on galaxies. [ABSTRACT FROM AUTHOR]

We study the late-time evolution of the central regions of two Milky Way (MW)-like simulations of galaxies formed in a cosmological context, one hosting a fast bar and the other a slow one. We find that bar length, R b, measurements fluctuate on a dynamical time-scale by up to 100 per cent, depending on the spiral structure strength and measurement threshold. The bar amplitude oscillates by about 15 per cent, correlating with R b. The Tremaine–Weinberg method estimates of the bars' instantaneous pattern speeds show variations around the mean of up to |$\sim \!20{{\ \rm per\ cent}}$|⁠ , typically anticorrelating with the bar length and strength. Through power spectrum analyses, we establish that these bar pulsations, with a period in the range ∼60–200 Myr, result from its interaction with multiple spiral modes, which are coupled with the bar. Because of the presence of odd spiral modes, the two bar halves typically do not connect at exactly the same time to a spiral arm, and their individual lengths can be significantly offset. We estimated that in about 50 per cent of bar measurements in MW-mass external galaxies, the bar lengths of SBab-type galaxies are overestimated by |$\sim \!15{{\ \rm per\ cent}}$| and those of SBbc types by |$\sim \!55{{\ \rm per\ cent}}$|⁠. Consequently, bars longer than their corotation radius reported in the literature, dubbed 'ultrafast bars', may simply correspond to the largest biases. Given that the Scutum–Centaurus arm is likely connected to the near half of the MW bar, recent direct measurements may be overestimating its length by 1–1.5 kpc, while its present pattern speed may be 5–10  |$\rm km\ s^{-1}\ kpc^{-1}$| smaller than its time-averaged value. [ABSTRACT FROM AUTHOR]

Context. It is generally agreed upon that stars form in open clusters (OCs) and stellar associations, but little is known about structures in the Galactic OC population; whether OCs and stellar associations are born isolated or if they prefer to form in groups, for example. Answering this question provides new insight into star and cluster formation, along with a better understanding of Galactic structures. Aims. In the past decade, studies of OC groupings have either been based solely on spatial criteria or have also included tangential velocities for identifications. In contrast to previous approaches, we assumed that real OC groupings occupy a well defined area in the sky and show similar velocity vectors. For the first time, we have used 6D phase-space information, including radial velocities from the RAdial Velocity Experiment (RAVE) and other catalogues, for the detection of OC groupings. We also checked the age spread of potential candidates to distinguish between genuine groupings and chance alignments. Methods. We explored the Catalogue of Open Cluster Data (COCD) and determined 6D phase-space information for 432 out of 650 listed OCs and compact associations. The group identification was performed using an adapted version of the Friends-of-Friends algorithm, as used in cosmology, with linking lengths of 100 pc and 10-20 km s-1. For the verification of the identified structures, we applied Monte Carlo simulations with randomised samples. Results. For the linking lengths 100 pc and 10 km s-1, we detected 19 groupings, including 14 pairs, 4 groups with 3-5 members, and 1 complex with 15 members. The Monte Carlo simulations revealed that, in particular, the complex is most likely genuine, whereas pairs are more likely chance alignments. A closer look at the age spread of the complex and the comparison between spatial distributions of young and old cluster populations suggested that OC groupings likely originated from a common molecular cloud. [ABSTRACT FROM AUTHOR]

The past decade and a half has seen the design and execution of several ground-based spectroscopic surveys, both Galactic and Extragalactic. Additionally, new surveys are being designed that extend the boundaries of current surveys. In this context, many important considerations must be done when designing a spectrograph for the future. Among these is the determination of the optimum wavelength coverage. In this work, we present a new code for determining the wavelength ranges that provide the optimal amount of information to achieve the required science goals for a given survey. In its first mode, it utilizes a user-defined list of spectral features to compute a figure-of-merit for different spectral configurations. The second mode utilizes a set of flux-calibrated spectra, determining the spectral regions that show the largest differences among the spectra. Our algorithm is easily adaptable for any set of science requirements and any spectrograph design. We apply the algorithm to several examples, including 4MOST, showing the method yields important design constraints to the wavelength regions. [ABSTRACT FROM AUTHOR]

From stellar spectra, a variety of physical properties of stars can be derived. In particular, the chemical composition of stellar atmospheres can be inferred from absorption line analyses. These provide key information on large scales, such as the formation of our Galaxy, down to the small-scale nucleosynthesis processes that take place in stars and supernovae. By extending the observed wavelength range toward bluer wavelengths, we optimize such studies to also include critical absorption lines in metal-poor stars, and allow for studies of heavy elements ( Z ≥ 38) whose formation processes remain poorly constrained. In this context, spectrographs optimized for observing blue wavelength ranges are essential, since many absorption lines at redder wavelengths are too weak to be detected in metal-poor stars. This means that some elements cannot be studied in the visual-redder regions, and important scientific tracers and science cases are lost. The present era of large public surveys will target millions of stars. It is therefore important that the next generation of spectrographs are designed such that they cover a wide wavelength range and can observe a large number of stars simultaneously. Only then, we can gain the full information from stellar spectra, from both metal-poor to metal-rich ones, that will allow us to understand the aforementioned formation scenarios in greater detail. Here we describe the requirements driving the design of the forthcoming survey instrument 4MOST, a multi-object spectrograph commissioned for the ESO VISTA 4 m-telescope. While 4MOST is also intended for studies of active galactic nuclei, baryonic acoustic oscillations, weak lensing, cosmological constants, supernovae and other transients, we focus here on high-density, wide-area survey of stars and the science that can be achieved with high-resolution stellar spectroscopy. Scientific and technical requirements that governed the design are described along with a thorough line blending analysis. For the high-resolution spectrograph, we find that a sampling of ≥2.5 (pixels per resolving element), spectral resolution of 18000 or higher, and a wavelength range covering 393-436 nm, is the most well-balanced solution for the instrument. A spectrograph with these characteristics will enable accurate abundance analysis (±0.1 dex) in the blue and allow us to confront the outlined scientific questions. (© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [ABSTRACT FROM AUTHOR]

We made new estimates of the Galactic escape speed at various Galactocentric radii using the latest data release of the RAdial Velocity Experiment (RAVE DR4). Compared to previous studies we have a database that is larger by a factor of 10, as well as reliable distance estimates for almost all stars. Our analysis is based on statistical analysis of a rigorously selected sample of 90 highvelocity halo stars from RAVE and a previously published data set. We calibrated and extensively tested our method using a suite of cosmological simulations of the formation of Milky Way-sized galaxies. Our best estimate of the local Galactic escape speed, which we define as the minimum speed required to reach three virial radii R340, is 533+54 -41 km s-1 (90% confidence), with an additional 4% systematic uncertainty, where R340 is the Galactocentric radius encompassing a mean overdensity of 340 times the critical density for closure in the Universe. From the escape speed we further derived estimates of the mass of the Galaxy using a simple mass model with two options for the mass profile of the dark matter halo: an unaltered and an adiabatically contracted Navarro, Frenk & White (NFW) sphere. If we fix the local circular velocity, the latter profile yields a significantly higher mass than the uncontracted halo, but if we instead use the statistics for halo concentration parameters in large cosmological simulations as a constraint, we find very similar masses for both models. Our best estimate for M340, the mass interior to R340 (dark matter and baryons), is 1.3+0.4 -0.3 × 1012 M☉ (corresponds to M200 = 1.6+0.5 -0.4 × 1012 M☉). This estimate is in good agreement with recently published, independent mass estimates based on the kinematics of more distant halo stars and the satellite galaxy Leo I. [ABSTRACT FROM AUTHOR]

Context. Galactic open clusters (OCs) mainly belong to the young stellar population in the Milky Way disk, but are there groups and complexes of OCs that possibly define an additional level in hierarchical star formation? Current compilations are too incomplete to address this question, especially regarding radial velocities (RVs) and metallicities ([M/H]). Aims. Here we provide and discuss newly obtained RV and [M/H] data, which will enable us to reinvestigate potential groupings of open clusters and associations. Methods. We extracted additional RVs and [M/H] from the RAdial Velocity Experiment (RAVE) via a cross-match with the Catalogue of Stars in Open Cluster Areas (CSOCA). For the identified OCs in RAVE we derived RV and [M/H] from a cleaned working sample and compared the results with previous findings. Results. Although our RAVE sample does not show the same accuracy as the entire survey, we were able to derive reliable RV for 110 Galactic open clusters. For 37 OCs we publish RV for the first time. Moreover, we determined [M/H] for 81 open clusters, extending the number of OCs with [M/H] by 69. [ABSTRACT FROM AUTHOR]

We present Herschel/SPIRE images at 250, 350, and 500 μm of NGC 4244, a typical low-mass, disk-only and edge-on spiral galaxy. The dust disk is clumpy and shows signs of truncation at the break radius of the stellar disk. This disk coincides with the densest part of the Hi disk. We compare the spectral energy distribution (SED), including the new SPIRE fluxes, to 3D radiative transfer models; a smooth model disk and a clumpy model with embedded heating. Each model requires a very high value for the dust scale-length (hd = 2-5 h"), higher dust masses than previous models of NGC 4244 (Md = 0.47-1.39 ×107 M☉) and a face-on optical depth of τf.o.V = 0.4-1.12, in agreement with previous disk opacity studies. The vertical scales of stars and dust are similar. The clumpy model much better mimics the general morphology in the sub-mm images and the general SED. The inferred gas-to-dust mass ratio is compatible with those of similar low-mass disks. The relatively large radial scale-length of the dust disk points to radial mixing of the dusty ISM within the stellar disk. The large vertical dust scale and the clumpy dust distribution of our SED model are both consistent with a scenario in which the vertical structure of the ISM is dictated by the balance of turbulence and self-gravity. [ABSTRACT FROM AUTHOR]

Background: The Tamoxifen and Exemestane Adjuvant Multinational (TEAM) trial investigates the efficacy and safety of adjuvant exemestane alone and in sequence after tamoxifen in postmenopausal women with hormone-sensitive early breast cancer. As there was a nationwide participation in The Netherlands, we studied the variations in patterns of care in the Comprehensive Cancer Centre Regions (CCCRs) and compliance with national guidelines. [ABSTRACT FROM PUBLISHER]

Advanced adenocarcinoma of the pancreas has a very poor prognosis. The aim of this study was to assess the efficacy and tolerability of a combination of the chemotherapeutic agents gemcitabine and raltitrexed. Chemonaive patients with advanced adenocarcinoma of the pancreas were treated with a combination of raltitrexed (3.5 mg m(-2) on day 1 of a 21-day treatment cycle) and gemcitabine (800 mg m(-2) intravenously (i.v.) on days 1 and 8 of a 21-day cycle). Between April 2000 and February 2003, 27 patients were enrolled onto the study. The mean duration of treatment was 11 weeks. Four of 27 patients experienced at least one episode of grade 3 or 4 neutropenia. One patient with grade 4 neutropenia died due to sepsis. Four of 27 patients experienced grade 4 diarrhoea. There was one partial remission (4%) and 12 patients experienced disease stabilisation (44%). The 6-month and 1-year survival rates were 37 and 11%, respectively. Symptomatic benefit occurred in seven (26%) patients. We conclude that a combination of raltitrexed and gemcitabine, using the schedule and doses in this study, cannot be recommended for patients with advanced pancreatic cancer. [ABSTRACT FROM AUTHOR]

The presence of a well-defined and narrow dust lane in an edge-on spiral galaxy is the observational signature of a thin and dense molecular disk, in which gravitational collapse has overcome turbulence. Using a sample of galaxies out to z ∼ 1 extracted from the COSMOS survey, we identify the fraction of massive (L*V) disks that display a dust lane. Our goal is to explore the evolution in the stability of the molecular interstellar medium (ISM) disks in spiral galaxies over a cosmic timescale. We check the reliability of our morphological classifications against changes in rest-frame wavelength, resolution, and cosmic dimming with (artificially redshifted) images of local galaxies from the Sloan Digital Sky Survey. We find that the fraction of L*V disks with dust lanes in COSMOS is consistent with the local fraction (≈80%) out to z ∼ 0.7. At z = 0.8, the dust lane fraction is only slightly lower. A somewhat lower dust lane fraction in starbursting galaxies tentatively supports the notion that a high specific star formation rate can efficiently destroy or inhibit a dense molecular disk. A small subsample of higher redshift COSMOS galaxies display low internal reddening (E[B – V]), as well as a low incidence of dust lanes. These may be disks in which the growth of the dusty ISM disk lags behind that of the stellar disk. We note that at z = 0.8, the most massive galaxies display a lower dust lane fraction than lower mass galaxies. A small contribution of recent mergers or starbursts to this most massive population may be responsible. The fact that the fraction of galaxies with dust lanes in COSMOS is consistent with little or no evolution implies that models to explain the spectral energy distribution or the host galaxy dust extinction of supernovae based on local galaxies are still applicable to higher redshift spirals. It also suggests that dust lanes are long-lived phenomena or can be reformed over very short timescales. [ABSTRACT FROM AUTHOR]