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1. Change in Albuminuria and GFR Slope as Joint Surrogate End Points for Kidney Failure: Implications for Phase 2 Clinical Trials in CKD

Author

Heerspink, Hiddo J.L., Inker, Lesley A., Tighiouart, Hocine, Collier, Willem H., Haaland, Benjamin, Luo, Jiyu, Appel, Gerald B., Chan, Tak Mao, Estacio, Raymond O., Fervenza, Fernando, Floege, Jürgen, Imai, Enyu, Jafar, Tazeen H., Lewis, Julia B., Kam-Tao Li, Philip, Locatelli, Francesco, Maes, Bart D., Perna, Annalisa, Perrone, Ronald D., Praga, Manuel, Schena, Francesco P., Wanner, Christoph, Xie, Di, Greene, Tom, Schrier, Robert W., Hanratty, Rebecca, Maschio, Giuseppe, Carlo, Manno, Saddelli, Mauro, Brenner, Barry M., Lewis, Edmund, von Eynatten, Maximilian, de Jong, Paul E., van Essen, GG, Hou, Fan Fan, Chapman, Arlene, Torres, Vicente, Yu, Alan, Brosnahan, Godela, Chow, Kai-Ming, Szeto, Cheuk-Chun, Leung, Chi-Bon, Hunsicker, Lawrence G., Dwyer, Jamie, Pohl, Marc, Raz, Itamar, Del Vecchio, Lucia, Andrulli, Simeone, Pozzi, Claudio, Casartelli, Donatella, Malfait, Thomas, Vanacker, An, Caravaca-Fontán, Fernando, Trujillo, Hernando, Cavero, Teresa, Gutierrez, Eduardo, Beck, Gerald, Kusek, John, Eknoyan, Garabed, Ponticelli, Claudio, Montagnino, Giuseppe, Passerini, Patrizia, Moroni, Gabriella, Kobayashi, Fumiaki, Makino, Hirofumi, Ito, Sadayoshi, Chan, Juliana CN, Tang, Colin, Gaspari, Flavio, Lesti, Maria Domenica, Gherardi, Giulia, Gamba, Sara, Keane, William, Donadio, James, Rauen, Thomas, Seikrit, Claudia, Wied, Stefanie, Dwyer, Jamie, and Becker, Gavin J.

Published
2023
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2. Past Decline Versus Current eGFR and Subsequent Mortality Risk

Author

Naimark, David MJ, Grams, Morgan E, Matsushita, Kunihiro, Black, Corri, Drion, Iefke, Fox, Caroline S, Inker, Lesley A, Ishani, Areef, Jee, Sun Ha, Kitamura, Akihiko, Lea, Janice P, Nally, Joseph, Peralta, Carmen Alicia, Rothenbacher, Dietrich, Ryu, Seungho, Tonelli, Marcello, Yatsuya, Hiroshi, Coresh, Josef, Gansevoort, Ron T, Warnock, David G, Woodward, Mark, and de Jong, Paul E

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Kidney Disease, Clinical Research, Prevention, Renal and urogenital, Good Health and Well Being, Aged, Cause of Death, Female, Glomerular Filtration Rate, Humans, Male, Middle Aged, Proportional Hazards Models, Renal Insufficiency, Chronic, Risk Factors, Time Factors, CKD Prognosis Consortium, chronic kidney disease, epidemiology, glomerular filtration rate, mortality, outcomes, Urology & Nephrology, Clinical sciences
Abstract

A single determination of eGFR associates with subsequent mortality risk. Prior decline in eGFR indicates loss of kidney function, but the relationship to mortality risk is uncertain. We conducted an individual-level meta-analysis of the risk of mortality associated with antecedent eGFR slope, adjusting for established risk factors, including last eGFR, among 1.2 million subjects from 12 CKD and 22 other cohorts within the CKD Prognosis Consortium. Over a 3-year antecedent period, 12% of participants in the CKD cohorts and 11% in the other cohorts had an eGFR slope 5 ml/min per 1.73 m(2) per year, respectively. Compared with a slope of 0 ml/min per 1.73 m(2) per year, a slope of -6 ml/min per 1.73 m(2) per year associated with adjusted hazard ratios for all-cause mortality of 1.25 (95% confidence interval [95% CI], 1.09 to 1.44) among CKD cohorts and 1.15 (95% CI, 1.01 to 1.31) among other cohorts during a follow-up of 3.2 years. A slope of +6 ml/min per 1.73 m(2) per year also associated with higher all-cause mortality risk, with adjusted hazard ratios of 1.58 (95% CI, 1.29 to 1.95) among CKD cohorts and 1.43 (95% CI, 1.11 to 1.84) among other cohorts. Results were similar for cardiovascular and noncardiovascular causes of death and stronger for longer antecedent periods (3 versus

Published
2016

3. A Meta-analysis of the Association of Estimated GFR, Albuminuria, Diabetes Mellitus, and Hypertension With Acute Kidney Injury

Author

James, Matthew T, Grams, Morgan E, Woodward, Mark, Elley, C Raina, Green, Jamie A, Wheeler, David C, de Jong, Paul, Gansevoort, Ron T, Levey, Andrew S, Warnock, David G, Sarnak, Mark J, Tonelli, Marcello, Hemmelgarn, Brenda R, Turin, Tanvir Chowdhury, Coresh, Josef, Matsushita, Kunihiro, Grams, Morgan, Sang, Yingying, Shlipak, Michael, Katz, Ronit, Emberson, Jonathan, Landray, Martin J, Townend, Jonathan N, Green, Jamie, Kirchner, H Les, Perkins, Robert, Chang, Alex R, Romundstad, Solfrid, Aasarød, Knut, Øien, Cecilia M, Hallan, Stein, Smith, David H, Thorp, Micah L, Johnson, Eric S, Chodick, Gabriel, Herzel, Esma, Katz, Rachel, Shalev, Varda, Bakker, Stephan JL, Heerspink, Hiddo J Lambers, van der Harst, Pim, Jee, Sun Ha, Kimm, Heejin, Mok, Yejin, Tangri, Navdeep, Naimark, David, Ärnlöv, Johan, Larsson, Anders, Lannfelt, Lars, Kovesdy, Csaba P, Kalantar-Zadeh, Kamyar, de Jong, Paul E, Iseki, Kunitoshi, Stengel, Benedicte, Warnock, David, and Ballew, Shoshana H

Subjects
Nutrition, Kidney Disease, Clinical Research, Diabetes, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Metabolic and endocrine, Renal and urogenital, Acute Kidney Injury, Adult, Aged, Comorbidity, Diabetes Mellitus, Disease Progression, Female, Glomerular Filtration Rate, Humans, Hypertension, Incidence, Kidney Failure, Chronic, Male, Middle Aged, Prognosis, Renal Insufficiency, Chronic, Estimated glomerular filtration rate, renal function, albuminuria, albumin-creatine ratio, diabetes, hypertension, acute kidney injury, acute renal failure, Chronic Kidney Disease Prognosis Consortium, meta-analysis, CKD Prognosis Consortium, Clinical Sciences, Public Health and Health Services, Urology & Nephrology
Abstract

BackgroundDiabetes mellitus and hypertension are risk factors for acute kidney injury (AKI). Whether estimated glomerular filtration rate (eGFR) and urine albumin-creatinine ratio (ACR) remain risk factors for AKI in the presence and absence of these conditions is uncertain.Study designMeta-analysis of cohort studies.Setting & population8 general-population (1,285,045 participants) and 5 chronic kidney disease (CKD; 79,519 participants) cohorts.Selection criteria for studiesCohorts participating in the CKD Prognosis Consortium.PredictorsDiabetes and hypertension status, eGFR by the 2009 CKD Epidemiology Collaboration creatinine equation, urine ACR, and interactions.OutcomeHospitalization with AKI, using Cox proportional hazards models to estimate HRs of AKI and random-effects meta-analysis to pool results.ResultsDuring a mean follow-up of 4 years, there were 16,480 episodes of AKI in the general-population and 2,087 episodes in the CKD cohorts. Low eGFRs and high ACRs were associated with higher risks of AKI in individuals with or without diabetes and with or without hypertension. When compared to a common reference of eGFR of 80mL/min/1.73m(2) in nondiabetic patients, HRs for AKI were generally higher in diabetic patients at any level of eGFR. The same was true for diabetic patients at all levels of ACR compared with nondiabetic patients. The risk gradient for AKI with lower eGFRs was greater in those without diabetes than with diabetes, but similar with higher ACRs in those without versus with diabetes. Those with hypertension had a higher risk of AKI at eGFRs>60mL/min/1.73m(2) than those without hypertension. However, risk gradients for AKI with both lower eGFRs and higher ACRs were greater for those without than with hypertension.LimitationsAKI identified by diagnostic code.ConclusionsLower eGFRs and higher ACRs are associated with higher risks of AKI among individuals with or without either diabetes or hypertension.

Published
2015

4. A Meta-analysis of the Association of Estimated GFR, Albuminuria, Age, Race, and Sex With Acute Kidney Injury

Author

Grams, Morgan E, Sang, Yingying, Ballew, Shoshana H, Gansevoort, Ron T, Kimm, Heejin, Kovesdy, Csaba P, Naimark, David, Oien, Cecilia, Smith, David H, Coresh, Josef, Sarnak, Mark J, Stengel, Benedicte, Tonelli, Marcello, Hemmelgarn, Brenda R, James, Matthew T, Turin, Tanvir Chowdhury, Matsushita, Kunihiro, Grams, Morgan, Shlipak, Michael, Katz, Ronit, Wheeler, David C, Emberson, Jonathan, Landray, Martin J, Townend, Jonathan N, Green, Jamie, Kirchner, H Les, Perkins, Robert, Chang, Alex R, Romundstad, Solfrid, Aasarød, Knut, Øien, Cecilia M, Hallan, Stein, Thorp, Micah L, Johnson, Eric S, Chodick, Gabriel, Herzel, Esma, Katz, Rachel, Shalev, Varda, Bakker, Stephan JL, Heerspink, Hiddo J Lambers, van der Harst, Pim, Jee, Sun Ha, Mok, Yejin, Tangri, Navdeep, Ärnlöv, Johan, Larsson, Anders, Lannfelt, Lars, Kalantar-Zadeh, Kamyar, de Jong, Paul E, Iseki, Kunitoshi, Levey, Andrew S, Warnock, David, and Woodward, Mark

Subjects
Clinical Research, Prevention, Kidney Disease, Renal and urogenital, Acute Kidney Injury, Adolescent, Adult, African Americans, Age Distribution, Aged, Albuminuria, Female, Glomerular Filtration Rate, Humans, Incidence, Male, Middle Aged, Predictive Value of Tests, Prognosis, Racial Groups, Severity of Illness Index, Sex Distribution, Whites, Young Adult, Estimated glomerular filtration rate, renal function, albuminuria, albumin-creatinine ratio, proteinuria, age, race/ethnicity, sex, acute kidney injury, acute renal failure, Chronic Kidney Disease Prognosis Consortium, meta-analysis, CKD Prognosis Consortium, White People, Black or African American, Clinical Sciences, Public Health and Health Services, Urology & Nephrology
Abstract

BackgroundAcute kidney injury (AKI) is a serious global public health problem. We aimed to quantify the risk of AKI associated with estimated glomerular filtration rate (eGFR), albuminuria (albumin-creatinine ratio [ACR]), age, sex, and race (African American and white).Study designCollaborative meta-analysis.Setting & population8 general-population cohorts (1,285,049 participants) and 5 chronic kidney disease (CKD) cohorts (79,519 participants).Selection criteria for studiesAvailable eGFR, ACR, and 50 or more AKI events.PredictorsAge, sex, race, eGFR, urine ACR, and interactions.OutcomeHospitalized with or for AKI, using Cox proportional hazards models to estimate HRs of AKI and random-effects meta-analysis to pool results.Results16,480 (1.3%) general-population cohort participants had AKI over a mean follow-up of 4 years; 2,087 (2.6%) CKD participants had AKI over a mean follow-up of 1 year. Lower eGFR and higher ACR were strongly associated with AKI. Compared with eGFR of 80mL/min/1.73m(2), the adjusted HR of AKI at eGFR of 45mL/min/1.73m(2) was 3.35 (95% CI, 2.75-4.07). Compared with ACR of 5mg/g, the risk of AKI at ACR of 300mg/g was 2.73 (95% CI, 2.18-3.43). Older age was associated with higher risk of AKI, but this effect was attenuated with lower eGFR or higher ACR. Male sex was associated with higher risk of AKI, with a slight attenuation in lower eGFR but not in higher ACR. African Americans had higher AKI risk at higher levels of eGFR and most levels of ACR.LimitationsOnly 2 general-population cohorts could contribute to analyses by race; AKI identified by diagnostic code.ConclusionsReduced eGFR and increased ACR are consistent strong risk factors for AKI, whereas associations of AKI with age, sex, and race may be weaker in more advanced stages of CKD.

Published
2015

5. Change in albuminuria as a surrogate endpoint for progression of kidney disease: a meta-analysis of treatment effects in randomised clinical trials

Author

Sevillano, Angel, Kamper, Anne-Lise, van Zuilen, Arjan D., Brenner, Barry M., Maes, Bart, Ihle, Benno U., Barret, Brendan, Leung, CB, Szeto, CC, Fitzner, Christina, Wanner, Christoph, Pozzi, Claudio, Montagnino, Claudio Ponticelli, Xie, Di, de Zeeuw, Dick, Lewis, Edmund, Verde, Eduardo, Gutierrez, Eduardo, Imai, Enyu, Hou, Fan Fan, Caravaca, Fernando, Fervenza, Fernando C., Locatelli, Francesco, Schena, Francesco Paolo, Kobayashi, Fumiaki, Moroni, Gabriella, Becker, Gavin J., Beck, Gerald J., Appel, Gerald B., Frisch, Gershon, van Essen, GG, Maschio, Giuseppe, Remuzzi, Giuseppe, Montogrino, Giuseppe, Parving, Hans-Henrik, Heerspink, Hiddo J.L., Makino, Hirofumi, Jehan, Imitiaz, Wetzels, Jack F.M., Donadio, James, Dwyer, Jamie, van den Brand, Jan, Kusek, John, Lachin, John M., Luño, Jose, Lewis, Julia B., Floege, Jürgen, Abebe, Kaleab Z., Chow, KM, Hunsicker, Lawrence G., del Vecchio, Lucia, Carlo, Manno, Praga, Manuel, Goicoechea, Marian, von Eynatten, Maximilian, Poulter, Neil, Chaturvedi, Nish, Passerini, Patrizia, de Jong, Paul E., Blankestijn, Peter J., Li, Philip, Ruggenenti, Piero, Zucchelli, Pietro, Kincaid-Smith, Priscilla S., Hilgers, Ralf-Dieter, Estacio, Raymond O., Rohde, Richard D., Katafuchi, Ritsuko, Toto, Robert D., Schrier, Robert W., Rodby, Roger A., Perrone, Ronald D., Ito, Sadayoshi, Klahr, Saulo, Andrulli, Simeone, Strandgaard, Svend, Chan, Tak Mao, Hannedouche, Thierry P., Rauen, Thomas, Greene, Tom, Verdalles, Ursula, Perkovic, Vlado, Keane, William, Heerspink, Hiddo J L, Tighiouart, Hocine, Gansevoort, Ron T, Coresh, Josef, Simon, Andrew L, Lewis, Julia B, Levey, Andrew S, and Inker, Lesley A

Published
2019
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6. Decline in Estimated Glomerular Filtration Rate and Subsequent Risk of End-Stage Renal Disease and Mortality

Author

Coresh, Josef, Turin, Tanvir Chowdhury, Matsushita, Kunihiro, Sang, Yingying, Ballew, Shoshana H, Appel, Lawrence J, Arima, Hisatomi, Chadban, Steven J, Cirillo, Massimo, Djurdjev, Ognjenka, Green, Jamie A, Heine, Gunnar H, Inker, Lesley A, Irie, Fujiko, Ishani, Areef, Ix, Joachim H, Kovesdy, Csaba P, Marks, Angharad, Ohkubo, Takayoshi, Shalev, Varda, Shankar, Anoop, Wen, Chi Pang, de Jong, Paul E, Iseki, Kunitoshi, Stengel, Benedicte, Gansevoort, Ron T, and Levey, Andrew S

Subjects
Kidney Disease, Clinical Research, Renal and urogenital, Good Health and Well Being, Adult, Aged, Aged, 80 and over, Cohort Studies, Creatinine, Disease Progression, Endpoint Determination, Female, Glomerular Filtration Rate, Humans, Kidney Failure, Chronic, Male, Middle Aged, Reference Values, Risk, Medical and Health Sciences, General & Internal Medicine
Abstract

ImportanceThe established chronic kidney disease (CKD) progression end point of end-stage renal disease (ESRD) or a doubling of serum creatinine concentration (corresponding to a change in estimated glomerular filtration rate [GFR] of −57% or greater) is a late event.ObjectiveTo characterize the association of decline in estimated GFR with subsequent progression to ESRD with implications for using lesser declines in estimated GFR as potential alternative end points for CKD progression. Because most people with CKD die before reaching ESRD, mortality risk also was investigated.Data sources and study selectionIndividual meta-analysis of 1.7 million participants with 12,344 ESRD events and 223,944 deaths from 35 cohorts in the CKD Prognosis Consortium with a repeated measure of serum creatinine concentration over 1 to 3 years and outcome data.Data extraction and synthesisTransfer of individual participant data or standardized analysis of outputs for random-effects meta-analysis conducted between July 2012 and September 2013, with baseline estimated GFR values collected from 1975 through 2012.Main outcomes and measuresEnd-stage renal disease (initiation of dialysis or transplantation) or all-cause mortality risk related to percentage change in estimated GFR over 2 years, adjusted for potential confounders and first estimated GFR.ResultsThe adjusted hazard ratios (HRs) of ESRD and mortality were higher with larger estimated GFR decline. Among participants with baseline estimated GFR of less than 60 mL/min/1.73 m2, the adjusted HRs for ESRD were 32.1 (95% CI, 22.3-46.3) for changes of −57% in estimated GFR and 5.4 (95% CI, 4.5-6.4) for changes of −30%. However, changes of −30% or greater (6.9% [95% CI, 6.4%-7.4%] of the entire consortium) were more common than changes of −57% (0.79% [95% CI, 0.52%-1.06%]). This association was strong and consistent across the length of the baseline period (1 to 3 years), baseline estimated GFR, age, diabetes status, or albuminuria. Average adjusted 10-year risk of ESRD (in patients with a baseline estimated GFR of 35 mL/min/1.73 m2) was 99% (95% CI, 95%-100%) for estimated GFR change of −57%, was 83% (95% CI, 71%-93%) for estimated GFR change of −40%, and was 64% (95% CI, 52%-77%) for estimated GFR change of −30% vs 18% (95% CI, 15%-22%) for estimated GFR change of 0%. Corresponding mortality risks were 77% (95% CI, 71%-82%), 60% (95% CI, 56%-63%), and 50% (95% CI, 47%-52%) vs 32% (95% CI, 31%-33%), showing a similar but weaker pattern.Conclusions and relevanceDeclines in estimated GFR smaller than a doubling of serum creatinine concentration occurred more commonly and were strongly and consistently associated with the risk of ESRD and mortality, supporting consideration of lesser declines in estimated GFR (such as a 30% reduction over 2 years) as an alternative end point for CKD progression.

Published
2014

7. Genome-wide association study identifies eight loci associated with blood pressure

Author

Newton-Cheh, Christopher, Johnson, Toby, Gateva, Vesela, Tobin, Martin D, Bochud, Murielle, Coin, Lachlan, Najjar, Samer S, Zhao, Jing Hua, Heath, Simon C, Eyheramendy, Susana, Papadakis, Konstantinos, Voight, Benjamin F, Scott, Laura J, Zhang, Feng, Farrall, Martin, Tanaka, Toshiko, Wallace, Chris, Chambers, John C, Khaw, Kay-Tee, Nilsson, Peter, van der Harst, Pim, Polidoro, Silvia, Grobbee, Diederick E, Onland-Moret, N Charlotte, Bots, Michiel L, Wain, Louise V, Elliott, Katherine S, Teumer, Alexander, Luan, Jian'an, Lucas, Gavin, Kuusisto, Johanna, Burton, Paul R, Hadley, David, McArdle, Wendy L, Brown, Morris, Dominiczak, Anna, Newhouse, Stephen J, Samani, Nilesh J, Webster, John, Zeggini, Eleftheria, Beckmann, Jacques S, Bergmann, Sven, Lim, Noha, Song, Kijoung, Vollenweider, Peter, Waeber, Gerard, Waterworth, Dawn M, Yuan, Xin, Groop, Leif, Orho-Melander, Marju, Allione, Alessandra, Di Gregorio, Alessandra, Guarrera, Simonetta, Panico, Salvatore, Ricceri, Fulvio, Romanazzi, Valeria, Sacerdote, Carlotta, Vineis, Paolo, Barroso, Inês, Sandhu, Manjinder S, Luben, Robert N, Crawford, Gabriel J, Jousilahti, Pekka, Perola, Markus, Boehnke, Michael, Bonnycastle, Lori L, Collins, Francis S, Jackson, Anne U, Mohlke, Karen L, Stringham, Heather M, Valle, Timo T, Willer, Cristen J, Bergman, Richard N, Morken, Mario A, Döring, Angela, Gieger, Christian, Illig, Thomas, Meitinger, Thomas, Org, Elin, Pfeufer, Arne, Wichmann, H Erich, Kathiresan, Sekar, Marrugat, Jaume, O'Donnell, Christopher J, Schwartz, Stephen M, Siscovick, David S, Subirana, Isaac, Freimer, Nelson B, Hartikainen, Anna-Liisa, McCarthy, Mark I, O'Reilly, Paul F, Peltonen, Leena, Pouta, Anneli, de Jong, Paul E, Snieder, Harold, van Gilst, Wiek H, Clarke, Robert, Goel, Anuj, Hamsten, Anders, and Peden, John F

Subjects
Biological Sciences, Genetics, Hypertension, Cardiovascular, Prevention, Human Genome, Aetiology, 2.1 Biological and endogenous factors, Adaptor Proteins, Signal Transducing, Blood Pressure, Cardiovascular Diseases, Chromosome Mapping, Cytochrome P-450 CYP1A2, DNA-Binding Proteins, Diastole, Europe, Fibroblast Growth Factor 5, Genetic Variation, Genome-Wide Association Study, Humans, India, Intracellular Signaling Peptides and Proteins, Methylenetetrahydrofolate Reductase (NADPH2), Open Reading Frames, Phospholipase C delta, Polymorphism, Single Nucleotide, Proteins, Steroid 17-alpha-Hydroxylase, Systole, White People, Wellcome Trust Case Control Consortium, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N ≤ 71,225 European ancestry, N ≤ 12,889 Indian Asian ancestry) and in silico comparison (CHARGE consortium, N = 29,136). We identified association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 × 10(-24)), CYP1A2 (P = 1 × 10(-23)), FGF5 (P = 1 × 10(-21)), SH2B3 (P = 3 × 10(-18)), MTHFR (P = 2 × 10(-13)), c10orf107 (P = 1 × 10(-9)), ZNF652 (P = 5 × 10(-9)) and PLCD3 (P = 1 × 10(-8)) genes. All variants associated with continuous blood pressure were associated with dichotomous hypertension. These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease.

Published
2009

9. A Meta-analysis of the Association of Estimated GFR, Albuminuria, Diabetes Mellitus, and Hypertension With Acute Kidney Injury

Author

Tonelli, Marcello, Hemmelgarn, Brenda R., James, Matthew T., Turin, Tanvir Chowdhury, Coresh, Josef, Matsushita, Kunihiro, Grams, Morgan, Sang, Yingying, Shlipak, Michael, Sarnak, Mark J., Katz, Ronit, Wheeler, David C., Emberson, Jonathan, Landray, Martin J., Townend, Jonathan N., Green, Jamie, Kirchner, H. Les, Perkins, Robert, Chang, Alex R., Romundstad, Solfrid, Aasarød, Knut, Øien, Cecilia M., Hallan, Stein, Smith, David H., Thorp, Micah L., Johnson, Eric S., Chodick, Gabriel, Herzel, Esma, Katz, Rachel, Shalev, Varda, Gansevoort, Ron T., Bakker, Stephan J.L., Lambers Heerspink, Hiddo J., van der Harst, Pim, Jee, Sun Ha, Kimm, Heejin, Mok, Yejin, Tangri, Navdeep, Naimark, David, Ärnlöv, Johan, Larsson, Anders, Lannfelt, Lars, Kovesdy, Csaba P., Kalantar-Zadeh, Kamyar, de Jong, Paul E., Iseki, Kunitoshi, Levey, Andrew S., Stengel, Benedicte, Warnock, David, Woodward, Mark, Ballew, Shoshana H., Grams, Morgan E., Elley, C. Raina, Green, Jamie A., de Jong, Paul, and Warnock, David G.

Published
2015
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10. A Meta-analysis of the Association of Estimated GFR, Albuminuria, Age, Race, and Sex With Acute Kidney Injury

Author

Tonelli, Marcello, Hemmelgarn, Brenda R., James, Matthew T., Turin, Tanvir Chowdhury, Coresh, Josef, Matsushita, Kunihiro, Grams, Morgan, Sang, Yingying, Shlipak, Michael, Sarnak, Mark J., Katz, Ronit, Wheeler, David C., Emberson, Jonathan, Landray, Martin J., Townend, Jonathan N., Green, Jamie, Kirchner, H. Les, Perkins, Robert, Chang, Alex R., Romundstad, Solfrid, Aasarød, Knut, Øien, Cecilia M., Hallan, Stein, Smith, David H., Thorp, Micah L., Johnson, Eric S., Chodick, Gabriel, Herzel, Esma, Katz, Rachel, Shalev, Varda, Gansevoort, Ron T., Bakker, Stephan J.L., Lambers Heerspink, Hiddo J., van der Harst, Pim, Jee, Sun Ha, Kimm, Heejin, Mok, Yejin, Tangri, Navdeep, Naimark, David, Ärnlöv, Johan, Larsson, Anders, Lannfelt, Lars, Kovesdy, Csaba P., Kalantar-Zadeh, Kamyar, de Jong, Paul E., Iseki, Kunitoshi, Levey, Andrew S., Stengel, Benedicte, Warnock, David, Woodward, Mark, Ballew, Shoshana H., Grams, Morgan E., and Oien, Cecilia

Published
2015
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31. CKD EPIDEMIOLOGY

Author

Turin, Tanvir C, Matsushita, Kunihiro, Coresh, Josef, Arima, Hisatomi, Chadban, Steven J, Cirillo, Massimo, Djurdjev, Ognjenka, Green, Jamie A, Irie, Fujiko, Ix, Joachim H, Kovesdy, Csaba P, Ohkubo, Takayoshi, Shankar, Anoop, Wen, Chi Pang, De Jong, Paul E, Iseki, Kunitoshi, Stengel, Benedicte, and Gansevoort, Ron T

Published
2014

32. ADPKD - CLINICAL OUTCOME STUDIES

Author

Spithoven, Edwin M., Meijer, Esther, Borns, Chris, Boertien, Wendy E., Kappert, Peter, Greuter, Marcel J.W., Van Der Jagt, Eric, De Jong, Paul E., Gaillard, Carlo A.J.M., and Gansevoort, Ron T.

Published
2014

37. Protein intake during hemodialysis maintains a positive whole body protein balance in chronic hemodialysis patients

Author

Veeneman, Jorden M., Kingma, Hermi A., Boer, Theo S., Stellaard, Frans, De Jong, Paul E., Reijngoud, Dirk-Jan, and Huisman, Roel M.

Subjects
Hemodialysis -- Physiological aspects, Malnutrition -- Physiological aspects, Biological sciences
Abstract

Protein energy malnutrition is present in 18 to 56% of hemodialysis patients. Because hemodialysis has been regarded as a catabolic event, we studied whether consumption of a protein- and energy-enriched meal improves the whole body protein balance during dialysis in chronic hemodialysis (CHD) patients. Patients were studied on a single day between dialysis (HD- protocol) in the morning while fasting and in the afternoon while consuming six small test meals. Patients were also studied during two separate dialysis sessions (HD+ protocol). Patients were fasted during one and consumed the meals during the other. Whole body protein metabolism was studied by primed constant infusion of L-[1-[sup.13]C]valine. During HD-, feeding changed the negative whole body protein balance observed during fasting to a positive protein balance. Dialysis deepened the negative balance during fasting, whereas feeding during dialysis induced a positive balance comparable to the HD- protocol while feeding. Plasma valine concentrations during the studies were correlated with whole body protein synthesis and inversely correlated with whole body protein breakdown. We conclude that the consumption of a protein- and energy-enriched meal by CHD patients while dialyzing can strongly improve whole body protein balance, probably because of the increased amino acid concentrations in blood. protein turnover; stable isotope; valine

Published
2003

40. Cost-effectiveness of screening for albuminuria with subsequent fosinopril treatment to prevent cardiovascular events: A pharmacoeconomic analysis linked to the prevention of renal and vascular endstage disease (PREVEND) study and the prevention of renal and vascular endstage disease intervention trial (PREVEND IT)

Author

Atthobari, Jarir, Asselbergs, Folkert W., Boersma, Cornelis, de Vries, Robin, Hillege, Hans L., van Gilst, Wiek H., Gansevoort, Ron T., de Jong, Paul E., de Jong-van den Berg, Lolkje T.W., and Postma, Maarten J.

Published
2006
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