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5. Co-sensitization between legumes is frequently seen, but variable and not always clinically relevant

Author

Smits, Mark, Verhoeckx, Kitty, Knulst, André, Welsing, Paco, de Jong, Aard, Gaspari, Marco, Ehlers, Anna, Verhoeff, Paulien, Houben, Geert, Le, Thuy My, Smits, Mark, Verhoeckx, Kitty, Knulst, André, Welsing, Paco, de Jong, Aard, Gaspari, Marco, Ehlers, Anna, Verhoeff, Paulien, Houben, Geert, and Le, Thuy My

Abstract

Background: Food allergy to peanut and soybean, both legumes, is highly prevalent. The consumption of other legumes and legume protein isolates, some of which may be considered novel foods, is increasing. This may lead to an increase in sensitization and allergy and may pose a risk for legume-allergic (e.g. peanut and soybean) patients due to cross-reactivity. Objective: This study investigated the frequency of co-sensitization and co-allergy between legumes and the role of different protein families. Methods: Six legume-allergic patient groups were included: peanut (n = 30), soybean (n = 30), lupine (n = 30), green pea (n = 30), lentil (n = 17), bean (n = 9). IgE binding to total extracts, protein fractions (7S/11S globulin, 2S albumin, albumin), and 16 individual proteins from 10 legumes (black lentil, blue lupine, chickpea, faba bean, green lentil, pea, peanut, soybean, white bean, and white lupine) was measured by line blot Results: Co-sensitization varied from 36.7% to 100%. Mono-sensitization was only found in soybean (16.7%), peanut (10%), and green pea-allergic (3.3%) patients. A high frequency of co-sensitization between the 7S/11S globulin fractions of all 10 legumes and individual 7S and 11S globulins was observed. In peanut and soybean-allergic patients, co-allergies for other legumes were uncommon (≤16,7%), while in green pea, lupine, lentil, and bean-allergic patients co-allergy for peanut (64.7%–77.8%) or soybean (50%–64.7%) was frequently seen. Conclusion: Co-sensitization between legumes was high, but generally not clinically relevant. Co-allergy to other legumes was not often seen in peanut- and soybean allergic patients. The 7S and 11S globulins were likely responsible for the observed co-sensitization.

Published
2023

6. Co-sensitization between legumes is frequently seen, but variable and not always clinically relevant

Author

CTI Eijkelkamp, Infection & Immunity, MS Dermatologie/Allergologie, Lab Dermatologie/Allergologie, MS Reumatologie/Immunologie/Infectie, Regenerative Medicine and Stem Cells, JC onderzoeksprogramma Methodologie, Lab Reumatologie/Klinische Immunologie, CTI Research, Smits, Mark, Verhoeckx, Kitty, Knulst, André, Welsing, Paco, de Jong, Aard, Gaspari, Marco, Ehlers, Anna, Verhoeff, Paulien, Houben, Geert, Le, Thuy My, CTI Eijkelkamp, Infection & Immunity, MS Dermatologie/Allergologie, Lab Dermatologie/Allergologie, MS Reumatologie/Immunologie/Infectie, Regenerative Medicine and Stem Cells, JC onderzoeksprogramma Methodologie, Lab Reumatologie/Klinische Immunologie, CTI Research, Smits, Mark, Verhoeckx, Kitty, Knulst, André, Welsing, Paco, de Jong, Aard, Gaspari, Marco, Ehlers, Anna, Verhoeff, Paulien, Houben, Geert, and Le, Thuy My

Published
2023

9. Additional file 2 of Predicting the allergenicity of legume proteins using a PBMC gene expression assay

Author

Smits, Mark, Meijerink, Marjolein, Thuy-My Le, Knulst, André, De Jong, Aard, Caspers, Martinus Petrus Maria, Everton Souto Lima, Babé, Lilia, Ladics, Gregory, McClain, Scott, Houben, Geert, and Verhoeckx, Kitty

Abstract

Additional file 2: Table 2. Source and protein family of proteins examined in the study. Overview table which includes the legumes from which the individual proteins were purified. In addition, the protein family is indicated and the classification if the protein is either a weakly or strongly allergenic protein is indicated.

Published
2021
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10. Additional file 1 of Predicting the allergenicity of legume proteins using a PBMC gene expression assay

Author

Smits, Mark, Meijerink, Marjolein, Thuy-My Le, Knulst, André, De Jong, Aard, Caspers, Martinus Petrus Maria, Everton Souto Lima, Babé, Lilia, Ladics, Gregory, McClain, Scott, Houben, Geert, and Verhoeckx, Kitty

Subjects
immune system diseases
Abstract

Additional file 1: Table 1. 64 DEGs shared by the two comparisons of weakly and strongly allergenic 2S albumins and 7S globulins. 64 genes that were differently expressed when PBMCs were incubated with a pair of weakly and strongly allergenic proteins from the 2S albumin protein family compared to a protein pair of weakly and strongly allergenic proteins from the 7S globulin protein family.

Published
2021
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11. Additional file 4 of Predicting the allergenicity of legume proteins using a PBMC gene expression assay

Author

Smits, Mark, Meijerink, Marjolein, Thuy-My Le, Knulst, André, De Jong, Aard, Caspers, Martinus Petrus Maria, Everton Souto Lima, Babé, Lilia, Ladics, Gregory, McClain, Scott, Houben, Geert, and Verhoeckx, Kitty

Abstract

Additional file 4: Table 4. Multiplex gene set 2. Table containing the sequences of the primers and probes of CCL7 and RASD2 designed with primer express software (Applied Biosystems).

Published
2021
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12. Additional file 5 of Predicting the allergenicity of legume proteins using a PBMC gene expression assay

Author

Smits, Mark, Meijerink, Marjolein, Thuy-My Le, Knulst, André, De Jong, Aard, Caspers, Martinus Petrus Maria, Everton Souto Lima, Babé, Lilia, Ladics, Gregory, McClain, Scott, Houben, Geert, and Verhoeckx, Kitty

Subjects
endocrine system
Abstract

Additional file 5: Figure 1. The immunological roles of CCL2, CCL7 and RASD2 in mast cell activation and food allergy. Figure explaining the immunological roles of CCL2, CCL7 and RASD2 in mast cell activation and food allergy.

Published
2021
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13. Additional file 3 of Predicting the allergenicity of legume proteins using a PBMC gene expression assay

Author

Smits, Mark, Meijerink, Marjolein, Thuy-My Le, Knulst, André, De Jong, Aard, Caspers, Martinus Petrus Maria, Everton Souto Lima, Babé, Lilia, Ladics, Gregory, McClain, Scott, Houben, Geert, and Verhoeckx, Kitty

Abstract

Additional file 3: Table 3. Multiplex gene set 1. Table containing the sequences of the primers and probes of CCL2 and IL-24 designed with primer express software (Applied Biosystems).

Published
2021
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16. Ranking of 10 legumes according to the prevalence of sensitization as a parameter to characterize allergenic proteins

Author

MS Dermatologie/Allergologie, Infection & Immunity, Lab Dermatologie/Allergologie, Lab Reumatologie/Klinische Immunologie, Regenerative Medicine and Stem Cells, JC onderzoeksprogramma Methodologie, CTI Research, Smits, Mark, Verhoeckx, Kitty, Knulst, André, Welsing, Paco, de Jong, Aard, Houben, Geert, Le, Thuy My, MS Dermatologie/Allergologie, Infection & Immunity, Lab Dermatologie/Allergologie, Lab Reumatologie/Klinische Immunologie, Regenerative Medicine and Stem Cells, JC onderzoeksprogramma Methodologie, CTI Research, Smits, Mark, Verhoeckx, Kitty, Knulst, André, Welsing, Paco, de Jong, Aard, Houben, Geert, and Le, Thuy My

Published
2021

17. Predicting the allergenicity of legume proteins using a PBMC gene expression assay

Author

Infection & Immunity, MS Dermatologie/Allergologie, CTI Research, Lab Dermatologie/Allergologie, Smits, Mark, Meijerink, Marjolein, Le, Thuy My, Knulst, André, de Jong, Aard, Caspers, Martinus Petrus Maria, Lima, Everton Souto, Babé, Lilia, Ladics, Gregory, McClain, Scott, Houben, Geert, Verhoeckx, Kitty, Infection & Immunity, MS Dermatologie/Allergologie, CTI Research, Lab Dermatologie/Allergologie, Smits, Mark, Meijerink, Marjolein, Le, Thuy My, Knulst, André, de Jong, Aard, Caspers, Martinus Petrus Maria, Lima, Everton Souto, Babé, Lilia, Ladics, Gregory, McClain, Scott, Houben, Geert, and Verhoeckx, Kitty

Published
2021

18. Digestion and Transport across the Intestinal Epithelium Affects the Allergenicity of Ara h 1 and 3 but Not of Ara h 2 and 6

Author

MS Dermatologie/Allergologie, Infection & Immunity, CTI Research, Lab Dermatologie/Allergologie, Smits, Mark, Nooijen, Irene, Redegeld, Frank, de Jong, Aard, Le, Thuy-My, Knulst, André, Houben, Geert, Verhoeckx, Kitty, MS Dermatologie/Allergologie, Infection & Immunity, CTI Research, Lab Dermatologie/Allergologie, Smits, Mark, Nooijen, Irene, Redegeld, Frank, de Jong, Aard, Le, Thuy-My, Knulst, André, Houben, Geert, and Verhoeckx, Kitty

Published
2021

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