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4. Methods of induction of labor in women with obesity: A secondary analysis of two multicenter randomized controlled trials

Author

MS Verloskunde, Child Health, Arts-assistenten DV&B, Croll, Dorothée M.R., De Vaan, Marieke D.T., Moes, Shinta L., Bloemenkamp, Kitty W.M., Ten Eikelder, Mieke L.G., De Heus, Roel, Jozwiak, Marta, Kooiman, Judith, Mol, Ben Willem, Verhoeven, Corine J.M., De Boer, Marjon A., MS Verloskunde, Child Health, Arts-assistenten DV&B, Croll, Dorothée M.R., De Vaan, Marieke D.T., Moes, Shinta L., Bloemenkamp, Kitty W.M., Ten Eikelder, Mieke L.G., De Heus, Roel, Jozwiak, Marta, Kooiman, Judith, Mol, Ben Willem, Verhoeven, Corine J.M., and De Boer, Marjon A.

Published
2024

5. Placental Pathology Contributes to Impaired Volumetric Brain Development in Neonates With Congenital Heart Disease

Author

Nijman, Maaike, van der Meeren, Lotte E., Nikkels, Peter G.J., Stegeman, Raymond, Breur, Johannes M.P.J., Jansen, Nicolaas J.G., Ter Heide, Henriette, Steenhuis, Trinette J., de Heus, Roel, Bekker, Mireille N., Claessens, Nathalie H.P., Benders, Manon J.N.L., Nijman, Maaike, van der Meeren, Lotte E., Nikkels, Peter G.J., Stegeman, Raymond, Breur, Johannes M.P.J., Jansen, Nicolaas J.G., Ter Heide, Henriette, Steenhuis, Trinette J., de Heus, Roel, Bekker, Mireille N., Claessens, Nathalie H.P., and Benders, Manon J.N.L.

Abstract

BACKGROUND: Neonates with congenital heart disease are at risk for impaired brain development in utero, predisposing children to postnatal brain injury and adverse long-term neurodevelopmental outcomes. Given the vital role of the placenta in fetal growth, we assessed the incidence of placental pathology in fetal congenital heart disease and explored its association with total and regional brain volumes, gyrification, and brain injury after birth. METHODS AND RESULTS: Placentas from 96 term singleton pregnancies with severe fetal congenital heart disease were pro-spectively analyzed for macroscopic and microscopic pathology. We applied a placental pathology severity score to relate placental abnormalities to neurological outcome. Postnatal, presurgical magnetic resonance imaging was used to analyze brain volumes, gyrification, and brain injuries. Placental analyses revealed the following abnormalities: maternal vascular malp-erfusion lesions in 46%, nucleated red blood cells in 37%, chronic inflammatory lesions in 35%, delayed maturation in 30%, and placental weight below the 10th percentile in 28%. Severity of placental pathology was negatively correlated with cortical gray matter, deep gray matter, brainstem, cerebellar, and total brain volumes (r=−0.25 to −0.31, all P<0.05). When correcting for postmenstrual age at magnetic resonance imaging in linear regression, this association remained significant for cortical gray matter, cerebellar, and total brain volume (adjusted R 2=0.25–0.47, all P<0.05). CONCLUSIONS: Placental pathology occurs frequently in neonates with severe congenital heart disease and may contribute to impaired brain development, indicated by the association between placental pathology severity and reductions in postnatal cortical, cerebellar, and total brain volumes.

Published
2024

6. Maternal "mirror" syndrome: Evaluating the benefits of fetal therapy.

Author

Sichitiu, Joanna, Alkazaleh, Fawaz, de Heus, Roel, Abbasi, Nimrah, van Mieghem, Tim, Keunen, Johannes, Windrim, Rory, Seaward, Gareth, Kelly, Edmond N., Lewi, Liesbeth, Deprest, Jan, Ryan, Greg, and Shinar, Shiri

Abstract

Objective: To evaluate maternal and perinatal outcomes following fetal intervention in the context of maternal "mirror" syndrome. Study Design: A multicenter retrospective study of all cases of fetal hydrops complicated by maternal "mirror" syndrome and treated by any form of fetal therapy between 1995 and 2022. Medical records and ultrasound images of all cases were reviewed. "Mirror" syndrome was defined as fetal hydrops and/or placentomegaly associated with the maternal development of pronounced edema, with or without pre‐eclampsia. Fetal hydrops was defined as the presence of abnormal fluid collections in ≥2 body cavities. Results: Twenty‐one pregnancies met the inclusion criteria. Causes of fetal hydrops and/or placentomegaly included fetal lung lesions (n = 9), twin‐twin transfusion syndrome (n = 6), severe fetal anemia (n = 4), and others (n = 2). Mean gestational age at "mirror" presentation was 27.0 ± 3.8 weeks. Maternal "mirror" syndrome was identified following fetal therapeutic intervention in 14 cases (66.6%). "Mirror" symptoms resolved or significantly improved before delivery in 8 (38.1%) cases with a mean interval from fetal intervention to maternal recovery of 13.1 days (range 4–35). Three women needed to be delivered because of worsening "mirror" syndrome. Of the 21 pregnancies treated (27 fetuses), there were 15 (55.5%) livebirths, 7 (25.9%) neonatal deaths and 5 (18.5%) intra‐uterine deaths. Conclusion: Following successful treatment and resolution of fetal hydrops, maternal "mirror" syndrome can improve or sometimes completely resolve before delivery. Furthermore, the recognition that "mirror" syndrome may arise only after fetal intervention necessitates hightened patient maternal surveillance in cases of fetal hydrops. Key points: What's already known about this topic? "Mirror" syndrome, where maternal symptoms reflect fetal hydrops, affects 20%–30% of fetal hydrops cases. Case studies show maternal condition improvement following successful fetal therapy. However, comprehensive research to understand fetal therapy's effect on maternal and fetal outcomes is lacking. What does this study add? This study provides new insights into the efficacy of fetal interventions for "mirror" syndrome and, in particular, underscores the importance of patient counseling, given the significant maternal morbidity involved. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Placental Pathology Contributes to Impaired Volumetric Brain Development in Neonates With Congenital Heart Disease

Author

Nijman, Maaike, primary, van der Meeren, Lotte E., additional, Nikkels, Peter G. J., additional, Stegeman, Raymond, additional, Breur, Johannes M. P. J., additional, Jansen, Nicolaas J. G., additional, ter Heide, Henriette, additional, Steenhuis, Trinette J., additional, de Heus, Roel, additional, Bekker, Mireille N., additional, Claessens, Nathalie H. P., additional, Benders, Manon J. N. L., additional, Nijman, Joppe, additional, Alderliesten, Thomas, additional, Bosch, Rian, additional, Wösten‐van Asperen, Roelie M., additional, Slieker, Martijn G., additional, van Iperen, Gabrielle G., additional, Grotenhuis, Heynric B., additional, van Loon, Kim, additional, Koomen, Erik, additional, van Wijk, Bram, additional, Schoof, Paul H., additional, Talacua, Hanna, additional, van Schooneveld, Monique M. J., additional, Sprong, Maaike C. A., additional, Haak, Monique C., additional, and Snoep, Maartje C., additional

Published
2024
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8. Methods of induction of labor in women with obesity: A secondary analysis of two multicenter randomized controlled trials

Author

Croll, Dorothée M. R., primary, De Vaan, Marieke D. T., additional, Moes, Shinta L., additional, Bloemenkamp, Kitty W. M., additional, Ten Eikelder, Mieke L. G., additional, De Heus, Roel, additional, Jozwiak, Marta, additional, Kooiman, Judith, additional, Mol, Ben Willem, additional, Verhoeven, Corine J. M., additional, and De Boer, Marjon A., additional

Published
2024
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10. The influence of various induction methods on adverse outcomes in small for gestational age neonates:A secondary analysis of the PROBAAT 1 and 2 trials

Author

de Vaan, Marieke D.T., Croll, Dorothée M.R., Verhoeven, Corine J.M., de Boer, Marjon A., Jozwiak, Marta, ten Eikelder, Mieke L.G., Mol, Ben Willem, Bloemenkamp, Kitty W.M., de Heus, Roel, de Vaan, Marieke D.T., Croll, Dorothée M.R., Verhoeven, Corine J.M., de Boer, Marjon A., Jozwiak, Marta, ten Eikelder, Mieke L.G., Mol, Ben Willem, Bloemenkamp, Kitty W.M., and de Heus, Roel

Abstract

Objective: To evaluate the safety aspects of different induction methods in pregnancies with small-for-gestational-age neonates. Study design: This was a secondary analysis of two previously reported multicenter, randomized controlled trials conducted in the Netherlands. In the original trials, women were randomized to either a 30 cc Foley catheter, vaginal prostaglandin E2 (PROBAAT-1) or oral misoprostol (PROBAAT-2). A total of 425 patients with a term, singleton pregnancy in cephalic presentation with an indication for labor induction and a small-for-gestational-age neonate were included in this secondary analysis. Our primary outcome was a composed adverse neonatal outcome of Apgar score < 7 after 5 min and/or a pH in the umbilical artery < 7.05 and/or NICU admission. Secondary outcomes were mode of birth, operative birth for fetal distress and pH < 7.10 in the umbilical artery. For these outcome measures, multivariate as well as bivariate analyses were performed. Results: An adverse neonatal outcome occurred in 4.7 % (10/214) induction with a Foley catheter, versus 12.8 % (19/149) after misoprostol (RR 0.36; 95 % CI 0.17–0.76) and 4.7 % (3/64) after Prostaglandin E2 (RR 0.98; 95 %CI 0.28–3.51). For individual components of the composed outcome of adverse events, a difference was found between a Foley catheter and misoprostol for Apgar score < 7 at 5 min (0.5 % versus 3.4; RR 0.14; 95 %CI 0.02–1.16) and NICU admission (1.9 % versus 6.1 %; RR 0.31; 0.10–0.97). No differences were found for mode of birth. Conclusions: For women who gave birth to a small-for-gestational-age neonate, a Foley catheter is probably a safer induction method compared to oral misoprostol.

Published
2023

11. The influence of various induction methods on adverse outcomes in small for gestational age neonates: A secondary analysis of the PROBAAT 1 and 2 trials

Author

MS Verloskunde, Child Health, de Vaan, Marieke D.T., Croll, Dorothée M.R., Verhoeven, Corine J.M., de Boer, Marjon A., Jozwiak, Marta, ten Eikelder, Mieke L.G., Mol, Ben Willem, Bloemenkamp, Kitty W.M., de Heus, Roel, MS Verloskunde, Child Health, de Vaan, Marieke D.T., Croll, Dorothée M.R., Verhoeven, Corine J.M., de Boer, Marjon A., Jozwiak, Marta, ten Eikelder, Mieke L.G., Mol, Ben Willem, Bloemenkamp, Kitty W.M., and de Heus, Roel

Published
2023

12. Automatic measurements of fetal intracranial volume from 3D ultrasound scans

Author

Caspi, Yaron, de Zwarte, Sonja M. C., Iemenschot, Iris J., Lumbreras, Raquel, de Heus, Roel, Bekker, Mireille N., and Hulshoff Pol, Hilleke

Abstract

Three-dimensional fetal ultrasound is commonly used to study the volumetric development of brain structures. To date, only a limited number of automatic procedures for delineating the intracranial volume exist. Hence, intracranial volume measurements from three-dimensional ultrasound images are predominantly performed manually. Here, we present and validate an automated tool to extract the intracranial volume from three-dimensional fetal ultrasound scans. The procedure is based on the registration of a brain model to a subject brain. The intracranial volume of the subject is measured by applying the inverse of the final transformation to an intracranial mask of the brain model. The automatic measurements showed a high correlation with manual delineation of the same subjects at two gestational ages, namely, around 20 and 30 weeks (linear fitting R2(20 weeks) = 0.88, R2(30 weeks) = 0.77; Intraclass Correlation Coefficients: 20 weeks=0.94, 30 weeks = 0.84). Overall, the automatic intracranial volumes were larger than the manually delineated ones (84 ± 16 vs. 76 ± 15 cm3; and 274 ± 35 vs. 237 ± 28 cm3), probably due to differences in cerebellum delineation. Notably, the automated measurements reproduced both the non-linear pattern of fetal brain growth and the increased inter-subject variability for older fetuses. By contrast, there was some disagreement between the manual and automatic delineation concerning the size of sexual dimorphism differences. The method presented here provides a relatively efficient way to delineate volumes of fetal brain structures like the intracranial volume automatically. It can be used as a research tool to investigate these structures in large cohorts, which will ultimately aid in understanding fetal structural human brain development.

Published
2022
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14. Pregnant women's willingness to participate in a randomized trial comparing induction of labor at 39 weeks versus expectant management: A survey in the Netherlands

Author

MS Verloskunde, Geboortecentrum voorzitterschap, Child Health, Croll, Dorothée M.R., Meuleman, Tessa, de Heus, Roel, de Boer, Marjon A., Verhoeven, Corine J.M., Bloemenkamp, Kitty W.M., van Dillen, Jeroen, MS Verloskunde, Geboortecentrum voorzitterschap, Child Health, Croll, Dorothée M.R., Meuleman, Tessa, de Heus, Roel, de Boer, Marjon A., Verhoeven, Corine J.M., Bloemenkamp, Kitty W.M., and van Dillen, Jeroen

Published
2022

17. Acute tocolysis for intrapartum non-reassuring fetal status: how often does it prevent cesarean delivery? A systematic review and meta-analysis of randomized controlled trials

Author

Xodo, Serena, de Heus, Roel, Berghella, Vincenzo, and Londero, Ambrogio P.

Subjects
acute tocolysis, DDI, Tocolysis, emergency delivery, hexoprenaline, ritodrine, Fetal Distress, systematic review, Pregnancy, cesarean delivery, atosiban, cardiotocography, decision-to-delivery interval, fenoterol, fetal monitoring, labor and delivery, meta-analysis: short-term fetal outcomes, neonatal intensive care unit, nitroglycerin, non-reassuring fetal heart rate tracing, operative delivery, randomized controlled trial, terbutaline, time to the delivery interval, Humans, Randomized Controlled Trials as Topic, Cesarean Section, Infant, Newborn, Obstetrics and Gynecology, Infant, General Medicine, Heart Rate, Fetal, Female
Abstract

This study aimed to evaluate the effectiveness of intrapartum acute tocolysis for nonreassuring fetal heart rate tracing in decreasing the incidence of cesarean delivery. Secondary outcomes included modes of delivery other than cesarean delivery, successful acute tocolysis, time-to-delivery interval, and short-term perinatal outcomes.Searches were performed in MEDLINE/PubMed, Embase, Scopus, the Cochrane Central Register of Controlled Trials and Reviews, ClinicalTrials.gov, and the International Clinical Trials Registry Platform from the inception of each database until February 2022.Selection criteria included randomized controlled trials of laboring patients with singleton gestations randomized to receive intrapartum acute tocolysis for nonreassuring fetal heart rate tracing, as defined by the original trial.All analyses were done using an intention-to-treat approach, evaluating women according to the treatment group to which they were randomly allocated in the original trials. A frequentist network-meta-analysis was performed.Four randomized clinical trials were eligible, including 605 patients with nonreassuring fetal heart rate tracing and singleton gestations at gestational ages32 weeks. The cesarean delivery rate was similar among patients managed with different types of acute tocolysis. Acute tocolysis, compared with emergency delivery, was associated with improved neonatal acid-base status (notably decreasing the prevalence of base deficit12 mmol/L [beta-2 agonists odds ratio, 0.61; 95% confidence interval, 0.37-0.99] and the rate of neonatal intensive care unit admission [beta-2 agonists odds ratio, 0.42; 95% confidence interval, 0.22-0.78]) and with an increase in the time-to-delivery interval (beta-2 agonists mean difference, 17.62 minutes; 95% confidence interval, 15.66-19.58); there was no reduction of cesarean delivery rate, showing an increased rate with atosiban and beta-2 agonists.The cesarean delivery rate was not reduced by acute tocolysis when used for nonreassuring fetal heart rate tracing during labor. Acute tocolysis is associated with improved short-term fetal outcomes and safely increases the time-to-delivery interval.

Published
2022

18. Oral misoprostol tablets (25 µg) for induction of labor: a targeted literature review and cost analysis

Author

Poinas, Anne-Claire, Padgett, Katherine, de Heus, Roel, Perrotin, Franck, and Devlieger, Roland

Subjects
misoprostol, obstetrics, I00, Health Policy, costs, Administration, Oral, oral misoprostol, A10, Pregnancy, Oxytocics, Costs and Cost Analysis, Humans, Female, Labor, Induced, A1, Induction of labor, Misoprostol, Retrospective Studies, Tablets
Abstract

BACKGROUND: Various methods exist for the induction of labor (IOL), and there is limited consensus as to optimal methods. Off-label misoprostol is recommended by the World Health Organization (WHO) for IOL but preparing it into doses suitable for IOL lacks precision, with potential adverse outcomes if dosing is inaccurate. This study explores potential outcomes and costs associated with increased uptake of a low-dose (25 µg) oral misoprostol formulation (Angusta; Norgine BV, Amsterdam) approved for IOL, in France, Belgium, and the Netherlands. METHODS: A literature review was undertaken to derive probabilities of delivery outcomes (vaginal, instrumental, and cesarean sections) for IOL methods, from published meta-analyses. Outcomes for oral misoprostol tablets (25 µg) were unavailable in the meta-analyses, so were estimated using data from two published retrospective cohort studies. A model was developed to predict the frequency of IOL outcomes and associated costs at the national level, across multiple scenarios. Scenarios were tested using a moderate, medium, and high increase in oral misoprostol tablet (25 µg) uptake. Market shares, costs, and induction rates were defined for each country using multiple data sources. RESULTS: Increased uptake of oral misoprostol tablets (25 µg) was estimated to be associated with a slightly increased rate of routine vaginal deliveries, and concurrent decreases in instrumental vaginal deliveries and cesarean sections. Since routine vaginal deliveries are less costly than other delivery outcomes, increased uptake of oral misoprostol tablets (25 µg) within the IOL market has the potential to be cost-saving. These trends were predicted using 25 µg oral misoprostol tablet outcomes informed by both retrospective studies. CONCLUSION: Preliminary outcomes suggest that oral misoprostol tablets at 25 µg per dose may improve outcomes in IOL and be cost-saving. Further study is required to validate these findings and assess the comparative efficacy of IOL methods, including oral misoprostol tablets (25 µg). ispartof: JOURNAL OF MEDICAL ECONOMICS vol:25 issue:1 pages:428-436 ispartof: location:England status: accepted

Published
2022
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20. In Reply

Author

Van Mieghem, Tim, Klaritsch, Philipp, Raio, Luigi, Ranzini, Angela C., Baud, David, Barrett, Jon, De Heus, Roel, and Ryan, Greg

Published
2015
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21. Changes in local protocols on inpatient cervical priming and introduction of outpatient priming: A nationwide survey in the Netherlands

Author

MS Verloskunde, Geboortecentrum voorzitterschap, Child Health, Croll, Dorothée M.R., Hoge, Peter C., Verhoeven, Corine J.M., de Boer, Marjon A., Bloemenkamp, Kitty W.M., de Heus, Roel, MS Verloskunde, Geboortecentrum voorzitterschap, Child Health, Croll, Dorothée M.R., Hoge, Peter C., Verhoeven, Corine J.M., de Boer, Marjon A., Bloemenkamp, Kitty W.M., and de Heus, Roel

Published
2021

23. The YOUth study: Rationale, design, and study procedures

Author

Onland-Moret, N Charlotte, Buizer-Voskamp, Jacobine E, Albers, Maria E W A, Brouwer, Rachel M, Buimer, Elizabeth E L, Hessels, Roy S, de Heus, Roel, Huijding, Jorg, Junge, Caroline M M, Mandl, René C W, Pas, Pascal, Vink, Matthijs, van der Wal, Juliëtte J M, Hulshoff Pol, Hilleke E, Kemner, Chantal, Onland-Moret, N Charlotte, Buizer-Voskamp, Jacobine E, Albers, Maria E W A, Brouwer, Rachel M, Buimer, Elizabeth E L, Hessels, Roy S, de Heus, Roel, Huijding, Jorg, Junge, Caroline M M, Mandl, René C W, Pas, Pascal, Vink, Matthijs, van der Wal, Juliëtte J M, Hulshoff Pol, Hilleke E, and Kemner, Chantal

Abstract

Behavioral development in children shows large inter-individual variation, and is driven by the interplay between biological, psychological, and environmental processes. However, there is still little insight into how these processes interact. The YOUth cohort specifically focuses on two core characteristics of behavioral development: social competence and self-regulation. Social competence refers to the ability to engage in meaningful interactions with others, whereas self-regulation is the ability to control one's emotions, behavior, and impulses, to balance between reactivity and control of the reaction, and to adjust to the prevailing environment. YOUth is an accelerated population-based longitudinal cohort study with repeated measurements, centering on two groups: YOUth Baby & Child and YOUth Child & Adolescent. YOUth Baby & Child aims to include 3,000 pregnant women, their partners and children, wheras YOUth Child & Adolescent aims to include 2,000 children aged between 8 and 10 years old and their parents. All participants will be followed for at least 6 years, and potentially longer. In this paper we describe in detail the design of this study, the population included, the determinants, intermediate neurocognitive measures and outcomes included in the study. Furthermore, we describe in detail the procedures of inclusion, informed consent, and study participation.

Published
2020

24. The YOUth study: Rationale, design, and study procedures

Author

Leerstoel Kemner, Leerstoel Dekovic, Development and Treatment of Psychosocial Problems, Social and personality development: A transactional approach, Experimental Psychology (onderzoeksprogramma PF), Helmholtz Institute, Onland-Moret, N Charlotte, Buizer-Voskamp, Jacobine E, Albers, Maria E W A, Brouwer, Rachel M, Buimer, Elizabeth E L, Hessels, Roy S, de Heus, Roel, Huijding, Jorg, Junge, Caroline M M, Mandl, René C W, Pas, Pascal, Vink, Matthijs, van der Wal, Juliëtte J M, Hulshoff Pol, Hilleke E, Kemner, Chantal, Leerstoel Kemner, Leerstoel Dekovic, Development and Treatment of Psychosocial Problems, Social and personality development: A transactional approach, Experimental Psychology (onderzoeksprogramma PF), Helmholtz Institute, Onland-Moret, N Charlotte, Buizer-Voskamp, Jacobine E, Albers, Maria E W A, Brouwer, Rachel M, Buimer, Elizabeth E L, Hessels, Roy S, de Heus, Roel, Huijding, Jorg, Junge, Caroline M M, Mandl, René C W, Pas, Pascal, Vink, Matthijs, van der Wal, Juliëtte J M, Hulshoff Pol, Hilleke E, and Kemner, Chantal

Published
2020

25. Gastro-intestinal function and quality of life are favorable in adolescent and adult gastroschisis patients

Author

MS Verloskunde, Child Health, Other research (not in main researchprogram), Arts-assistenten DV&B, Zorgeenheid Kinderchirurgie Medisch, Snoep, Maartje C., de Heus, Roel, Manten, Gwendolyn T.R., Lap, Chiara C.M.M., Snoeker, Barbara A.M., Lindeboom, Maud Y.A., MS Verloskunde, Child Health, Other research (not in main researchprogram), Arts-assistenten DV&B, Zorgeenheid Kinderchirurgie Medisch, Snoep, Maartje C., de Heus, Roel, Manten, Gwendolyn T.R., Lap, Chiara C.M.M., Snoeker, Barbara A.M., and Lindeboom, Maud Y.A.

Published
2020

26. The YOUth study: Rationale, design, and study procedures

Author

Onland-Moret, N. Charlotte, primary, Buizer-Voskamp, Jacobine E., additional, Albers, Maria E.W.A., additional, Brouwer, Rachel M., additional, Buimer, Elizabeth E.L., additional, Hessels, Roy S., additional, de Heus, Roel, additional, Huijding, Jorg, additional, Junge, Caroline M.M., additional, Mandl, René C.W., additional, Pas, Pascal, additional, Vink, Matthijs, additional, van der Wal, Juliëtte J.M., additional, Hulshoff Pol, Hilleke E., additional, and Kemner, Chantal, additional

Published
2020
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28. The YOUth study: Rationale, design, and study procedures

Author

Onland-Moret, N Charlotte, Buizer-Voskamp, Jacobine E, Albers, Maria E W A, Brouwer, Rachel M, Buimer, Elizabeth E L, Hessels, Roy S, de Heus, Roel, Huijding, Jorg, Junge, Caroline M M, Mandl, René C W, Pas, Pascal, Vink, Matthijs, van der Wal, Juliëtte J M, Hulshoff Pol, Hilleke E, Kemner, Chantal, Leerstoel Kemner, Leerstoel Dekovic, Development and Treatment of Psychosocial Problems, Social and personality development: A transactional approach, Experimental Psychology (onderzoeksprogramma PF), Helmholtz Institute, Leerstoel Kemner, Leerstoel Dekovic, Development and Treatment of Psychosocial Problems, Social and personality development: A transactional approach, Experimental Psychology (onderzoeksprogramma PF), and Helmholtz Institute

Subjects
self-regulation, Male, Cognitive Neuroscience, Population, Social competence, 050105 experimental psychology, Developmental psychology, Cohort Studies, Social Skills, 03 medical and health sciences, 0302 clinical medicine, Child Development, Informed consent, Pregnancy, Cognitive development, Humans, 0501 psychology and cognitive sciences, Longitudinal Studies, education, Child, Original Research, education.field_of_study, social competence, lcsh:QP351-495, 05 social sciences, Longitudinal cohorts study, Infant, Newborn, Infant, birth cohort, longitudinal cohorts study, Mental health, lcsh:Neurophysiology and neuropsychology, Research Design, Child, Preschool, Cohort, Self-regulation, Female, Psychology, Neurocognitive, Inclusion (education), mental health, 030217 neurology & neurosurgery, Birth cohort, cognitive development
Abstract

Highlights • This article describes the rationale, design, and procedures of the YOUth cohort. • YOUth is set up to investigate what drives the development of social competence and self-regulation in children. • YOUth specifically investigates the role of neurocognitive development in child development. • YOUth has a flexible longitudinal design with repeated measurements throughout childhood, starting prenatally., Behavioral development in children shows large inter-individual variation, and is driven by the interplay between biological, psychological, and environmental processes. However, there is still little insight into how these processes interact. The YOUth cohort specifically focuses on two core characteristics of behavioral development: social competence and self-regulation. Social competence refers to the ability to engage in meaningful interactions with others, whereas self-regulation is the ability to control one’s emotions, behavior, and impulses, to balance between reactivity and control of the reaction, and to adjust to the prevailing environment. YOUth is an accelerated population-based longitudinal cohort study with repeated measurements, centering on two groups: YOUth Baby & Child and YOUth Child & Adolescent. YOUth Baby & Child aims to include 3,000 pregnant women, their partners and children, wheras YOUth Child & Adolescent aims to include 2,000 children aged between 8 and 10 years old and their parents. All participants will be followed for at least 6 years, and potentially longer. In this paper we describe in detail the design of this study, the population included, the determinants, intermediate neurocognitive measures and outcomes included in the study. Furthermore, we describe in detail the procedures of inclusion, informed consent, and study participation.

Published
2019

31. Functional connectome of the fetal brai

Author

Turk, Elise, van den Heuvel, Marion I., Benders, Manon J., de Heus, Roel, Franx, Arie, Manning, Janessa H., Hect, Jasmine L., Hernandez-Andrade, Edgar, Hassan, Sonia S., Romero, Roberto, Kahn, René S., Thomason, Moriah E., van den Heuvel, Martijn P., Turk, Elise, van den Heuvel, Marion I., Benders, Manon J., de Heus, Roel, Franx, Arie, Manning, Janessa H., Hect, Jasmine L., Hernandez-Andrade, Edgar, Hassan, Sonia S., Romero, Roberto, Kahn, René S., Thomason, Moriah E., and van den Heuvel, Martijn P.

Published
2019

32. Functional Connectome of the Fetal Brain

Author

MS Verloskunde, MS Neonatologie, Child Health, Brain, Circulatory Health, Onderzoeksgroep 11, Onderzoeksgroep 6, Turk, Elise, van den Heuvel, Marion I., Benders, Manon J., de Heus, Roel, Franx, Arie, Manning, Janessa H., Hect, Jasmine L., Hernandez-Andrade, Edgar, Hassan, Sonia S., Romero, Roberto, Kahn, René S., Thomason, Moriah E., van den Heuvel, Martijn P., MS Verloskunde, MS Neonatologie, Child Health, Brain, Circulatory Health, Onderzoeksgroep 11, Onderzoeksgroep 6, Turk, Elise, van den Heuvel, Marion I., Benders, Manon J., de Heus, Roel, Franx, Arie, Manning, Janessa H., Hect, Jasmine L., Hernandez-Andrade, Edgar, Hassan, Sonia S., Romero, Roberto, Kahn, René S., Thomason, Moriah E., and van den Heuvel, Martijn P.

Published
2019

35. Functional Connectome of the Fetal Brain

Author

Turk, Elise, primary, van den Heuvel, Marion I., additional, Benders, Manon J., additional, de Heus, Roel, additional, Franx, Arie, additional, Manning, Janessa H., additional, Hect, Jasmine L., additional, Hernandez-Andrade, Edgar, additional, Hassan, Sonia S., additional, Romero, Roberto, additional, Kahn, René S., additional, Thomason, Moriah E., additional, and van den Heuvel, Martijn P., additional

Published
2019
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38. Growth patterns in fetuses with isolated cardiac defects

Author

Haveman, Ilse, Fleurke-Rozema, Johanna H., Mulder, Eduard J.H., Benders, Manon, du Marchie Sarvaas, Gideon, ter Heide, Henriette, de Heus, Roel H., Bilardo, Caterina M., Haveman, Ilse, Fleurke-Rozema, Johanna H., Mulder, Eduard J.H., Benders, Manon, du Marchie Sarvaas, Gideon, ter Heide, Henriette, de Heus, Roel H., and Bilardo, Caterina M.

Published
2018

39. Increased Risk of Pregnancy Complications After Stroke : The FUTURE Study (Follow-Up of Transient Ischemic Attack and Stroke Patients and Unelucidated Risk Factor Evaluation)

Author

Van Alebeek, Mayte E., De Vrijer, Myrthe, Arntz, Renate M., Maaijwee, Noortje A.M.M., Synhaeve, Nathalie E., Schoonderwaldt, Hennie, Van Der Vlugt, Maureen J., Van Dijk, Ewoud J., De Heus, Roel, Rutten-Jacobs, Loes C.A., De Leeuw, Frank Erik, Van Alebeek, Mayte E., De Vrijer, Myrthe, Arntz, Renate M., Maaijwee, Noortje A.M.M., Synhaeve, Nathalie E., Schoonderwaldt, Hennie, Van Der Vlugt, Maureen J., Van Dijk, Ewoud J., De Heus, Roel, Rutten-Jacobs, Loes C.A., and De Leeuw, Frank Erik

Published
2018

41. Accuracy of diagnosis and counseling of fetal brain anomalies prior to 24 weeks of gestational age

Author

Snoek, Rozemarijn, Albers, Marieke E.W.A., Mulder, Eduard J.H., Lichtenbelt, Klaske D., de Vries, Linda S., Nikkels, Peter G.J., Cuppen, Inge, Pistorius, Lourens R., Manten, Gwendolyn T.R., de Heus, Roel, Snoek, Rozemarijn, Albers, Marieke E.W.A., Mulder, Eduard J.H., Lichtenbelt, Klaske D., de Vries, Linda S., Nikkels, Peter G.J., Cuppen, Inge, Pistorius, Lourens R., Manten, Gwendolyn T.R., and de Heus, Roel

Published
2018

42. First-trimester Placental Vascular Development in Multiparous Women differs from that in Nulliparous Women

Author

Arts-assistenten DV&B, CTI Eijkelkamp, DDOD, Child Health, Infection & Immunity, MS Verloskunde, Brain, Ballering, Gea, Leijnse, Janneke, Eijkelkamp, Niels, Peeters, Louis, de Heus, Roel, Arts-assistenten DV&B, CTI Eijkelkamp, DDOD, Child Health, Infection & Immunity, MS Verloskunde, Brain, Ballering, Gea, Leijnse, Janneke, Eijkelkamp, Niels, Peeters, Louis, and de Heus, Roel

Published
2018

43. Accuracy of diagnosis and counseling of fetal brain anomalies prior to 24 weeks of gestational age

Author

Genetica Groep Van Haaften, MS Verloskunde, Brain, Other research (not in main researchprogram), Genetica Klinische Genetica, Child Health, MS Neonatologie, Pathologie Groep Blokx, Pathologie Pathologen staf, Cancer, ZL Kinder Ner en Nec Medisch, Snoek, Rozemarijn, Albers, Marieke E.W.A., Mulder, Eduard J.H., Lichtenbelt, Klaske D., de Vries, Linda S., Nikkels, Peter G.J., Cuppen, Inge, Pistorius, Lourens R., Manten, Gwendolyn T.R., de Heus, Roel, Genetica Groep Van Haaften, MS Verloskunde, Brain, Other research (not in main researchprogram), Genetica Klinische Genetica, Child Health, MS Neonatologie, Pathologie Groep Blokx, Pathologie Pathologen staf, Cancer, ZL Kinder Ner en Nec Medisch, Snoek, Rozemarijn, Albers, Marieke E.W.A., Mulder, Eduard J.H., Lichtenbelt, Klaske D., de Vries, Linda S., Nikkels, Peter G.J., Cuppen, Inge, Pistorius, Lourens R., Manten, Gwendolyn T.R., and de Heus, Roel

Published
2018

44. Intra- and interobserver agreement for fetal cerebral measurements in 3D-ultrasonography

Author

MS Verloskunde, Brain, Onderzoeksgroep 11, DV&B-MT-Medisch, Circulatory Health, Child Health, Cardiovasculaire Epi Team 3, Cancer, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Kanker, Albers, Maria E.W.A., Buisman, Erato T.I.A., Kahn, René S., Franx, Arie, Onland-Moret, N. Charlotte, de Heus, Roel, MS Verloskunde, Brain, Onderzoeksgroep 11, DV&B-MT-Medisch, Circulatory Health, Child Health, Cardiovasculaire Epi Team 3, Cancer, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Kanker, Albers, Maria E.W.A., Buisman, Erato T.I.A., Kahn, René S., Franx, Arie, Onland-Moret, N. Charlotte, and de Heus, Roel

Published
2018

45. Assessing Nephron Hyperplasia in Fetal Congenital Solitary Functioning Kidneys by Measuring Renal Papilla Number

Author

Genetica, Genetica Groep Van Haaften, MS Verloskunde, Child Health, Urologie Medisch Kinderen, Nefrologie, Circulatory Health, Snoek, Rozemarijn, de Heus, Roel, de Mooij, Keetje J., Pistorius, Lou R., Lilien, Marc R., Lely, A. Titia, Bekker, Mireille N., de Jong, Tom P.V.M., Genetica, Genetica Groep Van Haaften, MS Verloskunde, Child Health, Urologie Medisch Kinderen, Nefrologie, Circulatory Health, Snoek, Rozemarijn, de Heus, Roel, de Mooij, Keetje J., Pistorius, Lou R., Lilien, Marc R., Lely, A. Titia, Bekker, Mireille N., and de Jong, Tom P.V.M.

Published
2018

46. First trimester placental vascularization and angiogenetic factors are associated with adverse pregnancy outcome

Author

Arts-assistenten DV&B, MS Verloskunde, Child Health, CTI, Infection & Immunity, Circulatory Health, Brain, CTI Eijkelkamp, Leijnse, Johanna E.W., de Heus, Roel, de Jager, Wilco, Rodenburg, Wendy, Peeters, Louis L.H., Franx, Arie, Eijkelkamp, Niels, Arts-assistenten DV&B, MS Verloskunde, Child Health, CTI, Infection & Immunity, Circulatory Health, Brain, CTI Eijkelkamp, Leijnse, Johanna E.W., de Heus, Roel, de Jager, Wilco, Rodenburg, Wendy, Peeters, Louis L.H., Franx, Arie, and Eijkelkamp, Niels

Published
2018

47. Growth patterns in fetuses with isolated cardiac defects

Author

Other research (not in main researchprogram), MS Verloskunde, MS Neonatologie, Child Health, Brain, Cardiologie patientenzorg, Haveman, Ilse, Fleurke-Rozema, Johanna H., Mulder, Eduard J.H., Benders, Manon, du Marchie Sarvaas, Gideon, ter Heide, Henriette, de Heus, Roel H., Bilardo, Caterina M., Other research (not in main researchprogram), MS Verloskunde, MS Neonatologie, Child Health, Brain, Cardiologie patientenzorg, Haveman, Ilse, Fleurke-Rozema, Johanna H., Mulder, Eduard J.H., Benders, Manon, du Marchie Sarvaas, Gideon, ter Heide, Henriette, de Heus, Roel H., and Bilardo, Caterina M.

Published
2018

48. Increased Risk of Pregnancy Complications After Stroke: The FUTURE Study (Follow-Up of Transient Ischemic Attack and Stroke Patients and Unelucidated Risk Factor Evaluation)

Author

Public Health Practice, Echografie Verloskunde, MS Verloskunde, Child Health, Van Alebeek, Mayte E., De Vrijer, Myrthe, Arntz, Renate M., Maaijwee, Noortje A.M.M., Synhaeve, Nathalie E., Schoonderwaldt, Hennie, Van Der Vlugt, Maureen J., Van Dijk, Ewoud J., De Heus, Roel, Rutten-Jacobs, Loes C.A., De Leeuw, Frank Erik, Public Health Practice, Echografie Verloskunde, MS Verloskunde, Child Health, Van Alebeek, Mayte E., De Vrijer, Myrthe, Arntz, Renate M., Maaijwee, Noortje A.M.M., Synhaeve, Nathalie E., Schoonderwaldt, Hennie, Van Der Vlugt, Maureen J., Van Dijk, Ewoud J., De Heus, Roel, Rutten-Jacobs, Loes C.A., and De Leeuw, Frank Erik

Published
2018

49. Pregnancy and ischemic stroke: A practical guide to management

Author

MS Verloskunde, Child Health, Van Alebeek, Mayte E., De Heus, Roel, Tuladhar, Anil M., De Leeuw, Frank Erik, MS Verloskunde, Child Health, Van Alebeek, Mayte E., De Heus, Roel, Tuladhar, Anil M., and De Leeuw, Frank Erik

Published
2018

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