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6. Quantitative relationship between coronary artery calcium score and hyperemic myocardial blood flow as assessed by hybrid 15O-water PET/CT imaging in patients evaluated for coronary artery disease

Author

Danad, Ibrahim, Raijmakers, Pieter G., Appelman, Yolande E., Harms, Hendrik J., de Haan, Stefan, Marques, Koen M., van Kuijk, Cornelis, Allaart, Cornelis P., Hoekstra, Otto S., Lammertsma, Adriaan A., Lubberink, Mark, van Rossum, Albert C., and Knaapen, Paul

Published
2012
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11. Residual Quantitative Flow Ratio to Estimate Post‐Percutaneous Coronary Intervention Fractional Flow Reserve

Author

van Diemen, Pepijn A., primary, de Winter, Ruben W., additional, Schumacher, Stefan P., additional, Bom, Michiel J., additional, Driessen, Roel S., additional, Everaars, Henk, additional, Jukema, Ruurt A., additional, Somsen, Yvemarie B., additional, Popelkova, Lenka, additional, van de Ven, Peter M., additional, van Rossum, Albert C., additional, van de Hoef, Tim P., additional, de Haan, Stefan, additional, Marques, Koen M., additional, Lemkes, Jorrit S., additional, Appelman, Yolande, additional, Nap, Alexander, additional, Verouden, Niels J., additional, Opolski, Maksymilian P., additional, Danad, Ibrahim, additional, and Knaapen, Paul, additional

Published
2021
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19. Noninvasive Quantification of Myocardial C-11-Meta-Hydroxyephedrine Kinetics

Author

Harms, Hendrik J., Huisman, Marc C., Rijnierse, Mischa T., Greuter, Henri, Hsieh, Yu-Lung, de Haan, Stefan, Schuit, Robert C., Knaapen, Paul, Lubberink, Mark, Lammertsma, Adriaan A., Harms, Hendrik J., Huisman, Marc C., Rijnierse, Mischa T., Greuter, Henri, Hsieh, Yu-Lung, de Haan, Stefan, Schuit, Robert C., Knaapen, Paul, Lubberink, Mark, and Lammertsma, Adriaan A.

Abstract

C-11-meta-hydroxyephedrine (C-11-HED) kinetics in the myocardium can be quantified using a single-tissue-compartment model together with a metabolite-corrected arterial blood sampler input function (BSIF). The need for arterial blood sampling, however, limits clinical applicability. The purpose of this study was to investigate the feasibility of replacing arterial sampling with imaging-derived input function (IDIF) and venous blood samples. Methods: Twenty patients underwent 60-min dynamic C-11-HED PET/CT scans with online arterial blood sampling. Thirteen of these patients also underwent venous blood sampling. Data were reconstructed using both 3 dimensional row-action maximum-likelihood algorithm (3DR) and a time-of-flight (TF) list-mode reconstruction algorithm. For each reconstruction, IDIF results were compared with BSIF results. In addition, IDIF results obtained with venous blood samples and with a transformed venous-to-arterial metabolite correction were compared with results obtained with arterial metabolite corrections. Results: Correlations between IDIF- and BSIF-derived K-1 and V-T were high (r(2) > =0.89 for 3DR and TF). Slopes of the linear fits were significantly different from 1 for K-1, for both 3DR (slope = 0.94) and TF (slope = 1.06). For V-T, the slope of the linear fit was different from 1 for TF (slope = 0.93) but not for 3DR (slope = 0.98). Use of venous blood data introduced a large bias in V-T (r(2) = 0.96, slope = 0.84) and a small bias in K-1 (r(2) = 0.99, slope = 0.98). Use of a second-order polynomial venous-to-arterial transformation was robust and greatly reduced bias in V-T (r(2) = 0.97, slope = 0.99) with no effect on K-1. Conclusion: IDIF yielded precise results for both 3DR and TF. Venous blood samples can be used for absolute quantification of C-11-HED studies, provided a venous-to-arterial transformation is applied. A venous-to-arterial transformation enables noninvasive, absolute quantification of C-11-HED studies.

Published
2016
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22. Use of a Single 11C-Meta-Hydroxyephedrine Scan for Assessing Flow-Innervation Mismatches in Patients with Ischemic Cardiomyopathy

Author

Harms, Hendrik J, Lubberink, Mark, de Haan, Stefan, Knaapen, Paul, Huisman, Marc C, Schuit, Robert C, Windhorst, Albert D, Allaart, Cornelis P, Lammertsma, Adriaan A, Harms, Hendrik J, Lubberink, Mark, de Haan, Stefan, Knaapen, Paul, Huisman, Marc C, Schuit, Robert C, Windhorst, Albert D, Allaart, Cornelis P, and Lammertsma, Adriaan A

Abstract

UNLABELLED: Mismatch between areas of reduced myocardial blood flow (MBF) and reduced myocardial innervation (defect areas) may be used to estimate the risk for ventricular arrhythmias. The presence of a mismatch zone can be derived using a combined protocol consisting of both an MBF scan and an (11)C-meta-hydroxyephedrine ((11)C-HED) scan. The rate of influx from blood to myocardium (K1) of (11)C-HED is proportional to MBF and can potentially be used as an index for defining MBF defects. The aim of this study was to assess whether K1 derived from an (11)C-HED scan can be used as an index of MBF, potentially allowing for an assessment of MBF-innervation mismatch areas from a single (11)C-HED scan. METHODS: Seventeen patients with known ischemic cardiomyopathy underwent dynamic (15)O-water and (11)C-HED scans. Discrete arterial blood samples were taken during (11)C-HED scans for metabolite correction of the image-derived input function. (11)C-HED influx rate was obtained using a single-tissue-compartment model and compared with transmural MBF (MBFT), defined as MBF as measured with (15)O-water multiplied by perfusable tissue fraction. Defect sizes were obtained from parametric K1 and MBFT images, using 50% of a remote control segment as the cutoff value. RESULTS: There was a significant correlation between MBFT and K1 (y = 0.40x + 0.05 mL·g(-1)·min(-1), r = 0.80, P < 0.001), although K1 was significantly lower than MBFT (slope of the regression line significantly different from 1, P < 0.001). Correlation between MBFT and K1 defect sizes was high (y = 0.89x + 1.38%, r = 0.95, P < 0.001), with no significant difference in mean defect size based on K1 or MBFT (20.9% ± 11.3% and 20.1% ± 10.7% for MBFT and K1, respectively, P = 0.41). CONCLUSION: (11)C-HED influx rate K1 can be used as an alternative to a separate MBF scan for assessing mismatch areas between MBF and myocardial innervation.

Published
2015
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26. IMPAIRED HYPEREMIC MYOCARDIAL BLOOD FLOW IS ASSOCIATED WITH INDUCIBILITY OF VENTRICULAR ARRHYTHMIA IN ISCHEMIC CARDIOMYOPATHY

Author

Rijnierse, Mischa, primary, de Haan, Stefan, additional, Harms, Hendrik, additional, Robbers, Lourens, additional, Wu, LiNa, additional, Danad, Ibrahim, additional, Beek, Aernout, additional, Heymans, Martijn, additional, van Rossum, Albert, additional, Lammertsma, Adriaan, additional, Allaart, Cornelis, additional, and Knaapen, Paul, additional

Published
2014
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28. Parametric imaging of myocardial viability using ¹⁵O-labelled water and PET/CT : comparison with late gadolinium-enhanced CMR

Author

de Haan, Stefan, Harms, Hendrik J, Lubberink, Mark, Allaart, Cornelis P, Danad, Ibrahim, Chen, Weena J Y, Diamant, Michaela, van Rossum, Albert C, Iida, Hidehiro, Lammertsma, Adriaan A, Knaapen, Paul, de Haan, Stefan, Harms, Hendrik J, Lubberink, Mark, Allaart, Cornelis P, Danad, Ibrahim, Chen, Weena J Y, Diamant, Michaela, van Rossum, Albert C, Iida, Hidehiro, Lammertsma, Adriaan A, and Knaapen, Paul

Abstract

Purpose The perfusable tissue index (PTI) is a marker of myocardial viability. Recent technological advances have made it possible to generate parametric PTI images from a single [15O]H2O PET/CT scan. The purpose of this study was to validate these parametric PTI images. Methods The study population comprised 46 patients with documented or suspected coronary artery disease who were studied with [15O]H2O PET and late gadolinium-enhanced (LGE) cardiac magnetic resonance imaging (CMR). Results Of the 736 myocardial segments included, 364 showed some degree of LGE. PTI and perfusable tissue fraction (PTF) diminished with increasing LGE. The areas under the curve of the PTI and PTF, used to predict (near) transmural LGE on CMR, were 0.86 and 0.87, respectively. Optimal sensitivity and specificity were 91 % and 73 % for PTI and 69 % and 87 % for PTF, respectively. Conclusion PTI and PTF assessed with a single [15O]H2O scan can be utilized as markers of myocardial viability in patients with coronary artery disease.

Published
2012
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29. Parametric Images of Myocardial Viability Using a Single 15O-H2O PET/CT Scan

Author

Harms, Hendrik J, de Haan, Stefan, Knaapen, Paul, Allaart, Cornelis P, Lammertsma, Adriaan A, Lubberink, Mark, Harms, Hendrik J, de Haan, Stefan, Knaapen, Paul, Allaart, Cornelis P, Lammertsma, Adriaan A, and Lubberink, Mark

Abstract

Perfusable tissue index (PTI) is a marker of myocardial viability and requires acquisition of transmission, 15O-CO, and 15O-H2O scans. The aim of this study was to generate parametric PTI images from a 15O-H2O PET/CT scan without an additional 15O-CO scan. Methods: Data from 20 patients undergoing both 15O-H2O and 15O-CO scans were used, assessing correlation between PTI based on 15O-CO (PTICO) and on fitted blood volume fractions (PTIVb). In addition, parametric PTIVb images of 10 patients undergoing 15O-H2O PET/CT scans were generated using basis-function methods and compared with PTIVb obtained using nonlinear regression. Simulations were performed to study the effects of noise on PTIVb. Results: Correlation between PTICO and PTIVb was high (r2 = 0.73). Parametric PTIVb correlated well with PTIVb obtained using nonlinear regression (r2 = 0.91). Simulations showed low sensitivity to noise (coefficient of variation < 10% at 20% noise). Conclusion: Parametric PTI images can be generated from a single 15O-H2O PET/CT scan.

Published
2011
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30. Impaired Hyperemic Myocardial Blood Flow Is Associated With Inducibility of Ventricular Arrhythmia in Ischemic Cardiomyopathy

Author

Rijnierse, Mischa T., primary, de Haan, Stefan, additional, Harms, Hendrik J., additional, Robbers, Lourens F., additional, Wu, LiNa, additional, Danad, Ibrahim, additional, Beek, Aernout M., additional, Heymans, Martijn W., additional, van Rossum, Albert C., additional, Lammertsma, Adriaan A., additional, Allaart, Cornelis P., additional, and Knaapen, Paul, additional

Published
2014
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32. Hybrid Imaging Using Quantitative H215O PET and CT-Based Coronary Angiography for the Detection of Coronary Artery Disease

Author

Danad, Ibrahim, primary, Raijmakers, Pieter G., additional, Appelman, Yolande E., additional, Harms, Hendrik J., additional, de Haan, Stefan, additional, van den Oever, Mijntje L.P., additional, Heymans, Martijn W., additional, Tulevski, Igor I., additional, van Kuijk, Cornelis, additional, Hoekstra, Otto S., additional, Lammertsma, Adriaan A., additional, Lubberink, Mark, additional, van Rossum, Albert C., additional, and Knaapen, Paul, additional

Published
2012
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33. Quantitative relationship between coronary artery calcium score and hyperemic myocardial blood flow as assessed by hybrid 15O-water PET/CT imaging in patients evaluated for coronary artery disease

Author

Danad, Ibrahim, primary, Raijmakers, Pieter G., additional, Appelman, Yolande E., additional, Harms, Hendrik J., additional, de Haan, Stefan, additional, Marques, Koen M., additional, van Kuijk, Cornelis, additional, Allaart, Cornelis P., additional, Hoekstra, Otto S., additional, Lammertsma, Adriaan A., additional, Lubberink, Mark, additional, van Rossum, Albert C., additional, and Knaapen, Paul, additional

Published
2011
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34. Coronary risk factors and myocardial blood flow in patients evaluated for coronary artery disease: a quantitative [15O]H2O PET/CT study

Author

Danad, Ibrahim, primary, Raijmakers, Pieter G., additional, Appelman, Yolande E., additional, Harms, Hendrik J., additional, de Haan, Stefan, additional, van den Oever, Mijntje L. P., additional, van Kuijk, Cornelis, additional, Allaart, Cornelis P., additional, Hoekstra, Otto S., additional, Lammertsma, Adriaan A., additional, Lubberink, Mark, additional, van Rossum, Albert C., additional, and Knaapen, Paul, additional

Published
2011
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36. QUANTITATIVE RELATIONSHIP BETWEEN CORONARY CALCIUM SCORE AND HYPERAEMIC MYOCARDIAL BLOOD FLOW AS ASSESSED BY HYBRID [15O]PET/CT IMAGING IN PATIENTS EVALUATED FOR CORONARY ARTERY DISEASE

Author

Danad, Ibrahim, primary, Raijmakers, Pieter G., additional, Appelman, Yolande E., additional, Harms, Hans J., additional, de Haan, Stefan, additional, van den Oever, Mijntje L.P., additional, van Kuijk, Cornelis, additional, Allaart, Cornelis P., additional, Hoekstra, Otto S., additional, Lammertsma, Adriaan A., additional, Lubberink, Mark, additional, van Rossum, Albert C., additional, and Knaapen, Paul, additional

Published
2011
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37. DEFINING THE NORMAL LIMITS OF MYOCARDIAL BLOOD FLOW IN PATIENTS EVALUATED FOR CORONARY ARTERY DISEASE BY MEANS OF [15O] POSITRON EMISSION TOMOGRAPHY: IMPACT OF GENDER AND RISK PROFILE

Author

Danad, Ibrahim, primary, Raijmakers, Pieter G., additional, Appelman, Yolande E., additional, Harms, Hans, additional, De Haan, Stefan, additional, van den Oever, Mijntje LP, additional, van Kuijk, Cornelis, additional, Allaart, Cornelis P., additional, Hoekstra, Otto S., additional, Lammertsma, Adriaan A., additional, Lubberink, Mark, additional, van Rossum, Albert C., additional, and Knaapen, Paul, additional

Published
2011
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44. PV SET TO RIDE OUT DOWNTURN INSTALLATIONS SET TO TOP 15 GW IN 2011 AND TO RISE AGAIN IN 2011.

Author

Wicht, Henning, de Haan, Stefan, and Sheppard, Greg

Subjects
PHOTOVOLTAIC power generation, MARKETS, SOLAR energy, PRICE cutting, INSTALLATION of equipment, TARIFF, ECONOMICS
Abstract

The article focuses on the condition of photovoltaic (PV) market in Europe. It reports on the installation growth of PV system from 7.2 gigawatts (GW) in 2009 to 15 GW in 2010. In addition, it cites the factors of the said growth including improved feed-in tariff (FIT), transparent project pipelines, and advanced order books for suppliers. However, it denotes the possible threat of FIT reduction to Germany and Italy. Meanwhile, it notes the attractiveness of the market if there is a price reduction in photovoltaic projects.

Published
2010

48. Estudios fenotípicos y genéticos asociados a la calidad de fritura en Solanum phureja Juz et Buk

Author

Ñústez López, Carlos Eduardo, Cotes Torres, José Miguel, Oliveros Garay, Oscar Arturo, Chaparro Giraldo, Alejandro, De Haan, Stefan, Ligarreto Moreno, Gustavo Adolfo, and Grupo de Investigación en Papa

Subjects
584 - Monocotiledóneas, angiospermas basales, clorantales, magnolias [580 - Plantas], Papas fritas, Procesamiento, Diploid potato, Patatoes - quality, Potato chips, Papas (Tubérculos) - Calidad, Papa diploide, Sweetening, UGPasa, Solanum, Plant breeding, Productos de la papa, Potato products, Endulzamiento, fitomejoramiento
Abstract

ilustraciones, fotografías, gráficas, tablas Se evaluó la colección de Solanum phureja de la Universidad Nacional de Colombia, por color de fritura, gravedad específica, materia seca y rendimiento de tubérculo en nueve ambientes. Nueve genotipos fueron seleccionados por respuestas contrastantes a la fritura y se sembraron bajo el diseño bloques completos al azar en 16 ambientes con tres variedades diploides testigo, para evaluar la estabilidad fenotípica de las variables asociadas con calidad de fritura, rendimiento de tubérculo y la resistencia al endulzamiento de tubérculo inducido por frío (ETIF). A partir de 85 familias de hermanos medios maternos se estimó la heredabilidad en sentido estricto de las variables asociadas con fritura y rendimiento. Finalmente, en cuatro genotipos contrastantes por la respuesta al ETIF y en la variedad Diacol Capiro, se analizaron los polimorfismos de secuencia en fragmentos de ADNc de la invertasa ácida y UGPasa. Los resultados permitieron obtener un modelo de predicción de materia seca en función de la gravedad específica (r2= 0.834), se identificaron los genotipos de la colección con mejor y peor respuesta para cada una de las variables estudiadas, y dos genotipos con resistencia al endulzamiento inducido por frío. La heredabilidad en sentido estricto para fritura, gravedad específica y rendimiento fueron: 0.59 (0.52–0.68); 0.76 (0.71–0.81) y 0.36 (0.24–0.48) respectivamente. En el fragmento amplificado de la UGPasa, se identificaron dos nuevos polimorfismos en la secuencia de aminoácidos, y en las secuencias del fragmento de invertasa ácida los polimorfismos observados no presentaron relación con la respuesta de fritura en los genotipos evaluados. (Texto tomado de la fuente). The Solanum phureja collection from Universidad Nacional de Colombia was evaluated for chip color, specific gravity, dry matter and tuber yield in nine environments. Nine genotypes were selected by contrasting responses to chip color which were grown in a randomized complete block design at 16 environments with three check diploid varieties, to evaluate the phenotypic stability of traits associated to chip quality and tuber yield. In addition, it was evaluated the resistance to cold induced sweetening (CIS). From 85 maternal half-sib families was estimated the narrow-sense heritability of the variables associated to chip quality and tuber yield. Finally, in four contrasting genotypes for CIS (S. phureja) and Diacol Capiro variety (S. tuberosum) were analyzed sequence polymorphisms in cDNA fragments of acid invertase and UGPasa. The results allowed to obtain a predictive model of dry matter depending on the specific gravity (r2= 0.834), genotypes were identified in the collection by the best and worst response for each of the studied variables, and two genotypes with resistance to CIS. The narrow sense heritability for chip color, specific gravity and tuber yield were 0.59 (0.52 - 0.68), 0.76 (0.71 – 0.81) and 0.36 (0.24 – 0.48) respectively. In the amplified fragments of UGPasa were identified two new polymorphisms in amino acid sequences, and in the sequences of acid invertase fragment observed, the polymorphisms showed no relation to the chipping in the evaluated genotypes. Doctorado Doctor en Ciencias Agrarias Mejoramiento genético vegetal Ciencias Agronómicas

Published
2011

49. Sympathetic denervation is associated with microvascular dysfunction in non-infarcted myocardium in patients with cardiomyopathy.

Author

Rijnierse MT, Allaart CP, de Haan S, Harms HJ, Huisman MC, Wu L, Beek AM, Lammertsma AA, van Rossum AC, and Knaapen P

Subjects
Aged, Blood Flow Velocity, Cardiomyopathy, Dilated mortality, Cohort Studies, Coronary Circulation physiology, Female, Humans, Male, Middle Aged, Multimodal Imaging methods, Myocardial Contraction physiology, Myocardial Infarction, Myocardial Ischemia mortality, Myocardial Perfusion Imaging methods, Prospective Studies, Severity of Illness Index, Survival Rate, Cardiomyopathy, Dilated diagnosis, Magnetic Resonance Imaging, Cine methods, Microvessels physiopathology, Myocardial Ischemia diagnosis, Positron-Emission Tomography methods, Sympathectomy methods
Abstract

Aims: Sympathetic denervation typically occurs in the infarcted myocardium and is associated with sudden cardiac death. Impaired innervation was also demonstrated in non-infarcted myocardium in ischaemic and dilated cardiomyopathy (ICMP and DCMP). Factors affecting sympathetic nerve integrity in remote myocardium are unknown. Perfusion abnormalities, even in the absence of epicardial coronary artery disease, may relate to sympathetic dysfunction. This study was aimed to assess the interrelations of myocardial blood flow (MBF), contractile function, and sympathetic innervation in non-infarcted remote myocardium., Methods and Results: Seventy patients with ICMP or DCMP and LVEF ≤35% were included. [(15)O]H2O- and [(11)C]hydroxyephedrine (HED) PET was performed to quantify resting MBF, hyperaemic MBF, and sympathetic innervation. Cardiovascular magnetic resonance (CMR) imaging was performed to assess left ventricular function, mass, wall thickening, and scar size. Wall thickening, [(11)C]HED retention index (RI), and MBF were assessed in remote segments without scar, selected on CMR. [(11)C]HED RI was correlated with resting MBF (r = 0.41, P < 0.001) and hyperaemic MBF (r = 0.55, P < 0.001) in remote myocardium in both ICMP and DCMP. In addition, LV volumes (r = -0.40, P = 0.001), LV mass (r = -0.31, P = 0.008), and wall thickening (r = 0.45, P < 0.001) correlated with remote [(11)C]HED RI. Multivariable analysis revealed that hyperaemic MBF (B = 0.79, P < 0.001), wall thickening (B = 0.01, P = 0.03), and LVEDV (B = -0.03, P = 0.02) were independent predictors for remote [(11)C]HED RI., Conclusion: Hyperaemic MBF is independently associated with sympathetic innervation in non-infarcted remote myocardium in patients with ICMP and DCMP. This suggests that microvascular dysfunction might be an important factor related to sympathetic nerve integrity. Whether impaired hyperaemic MBF is the primary cause of this relation remains unclear., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015. For permissions please email: journals.permissions@oup.com.)

Published
2015
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50. Hybrid imaging using quantitative H215O PET and CT-based coronary angiography for the detection of coronary artery disease.

Author

Danad I, Raijmakers PG, Appelman YE, Harms HJ, de Haan S, van den Oever ML, Heymans MW, Tulevski II, van Kuijk C, Hoekstra OS, Lammertsma AA, Lubberink M, van Rossum AC, and Knaapen P

Subjects
Cohort Studies, Coronary Artery Disease physiopathology, Coronary Circulation, Female, Humans, Male, Middle Aged, Oxygen Radioisotopes, Regional Blood Flow, Retrospective Studies, Sensitivity and Specificity, Coronary Angiography, Coronary Artery Disease diagnostic imaging, Positron-Emission Tomography, Tomography, X-Ray Computed, Water
Abstract

Unlabelled: Hybrid imaging using PET in conjunction with CT-based coronary angiography (PET/CTCA) enables near-simultaneous quantification of myocardial blood flow (MBF) and anatomical evaluation of coronary arteries. CTCA is an excellent imaging modality to rule out obstructive coronary artery disease (CAD), but functional assessment is warranted in the presence of a CTCA-observed stenosis because the specificity of CTCA is relatively low. Quantitative H(2)(15)O PET/CTCA may yield complementary information and enhance diagnostic accuracy. The purpose of this study was to evaluate the diagnostic accuracy of quantitative H(2)(15)O PET/CTCA in a clinical cohort of patients with suspected CAD who underwent both cardiac H(2)(15)O PET/CTCA and invasive coronary angiography (ICA). In addition, this study aimed to evaluate and compare the accuracy of hyperemic MBF versus coronary flow reserve (CFR)., Methods: Patients (n = 120; mean age ± SD, 61 ± 10 y; 77 men and 43 women) with a predominantly intermediate pretest likelihood for CAD underwent both quantitative H(2)(15)O PET/CTCA and ICA. A ≥50% stenosis at ICA or a fractional flow reserve ≤ 0.80 was considered significant., Results: Obstructive CAD was diagnosed in 49 of 120 patients (41%). The diagnostic accuracy of hyperemic MBF was significantly higher than CFR (80% vs. 68%, respectively, P = 0.02), with optimal cutoff values of 1.86 mL/min/g and 2.30, respectively. On a per-patient basis, the sensitivity, specificity, negative predictive value, and positive predictive value of CTCA were 100%, 34%, 100%, and 51%, respectively, as compared with 76%, 83%, 83%, and 76%, respectively, for quantitative hyperemic MBF PET. Quantitative H(2)(15)O PET/CTCA reduced the number of false-positive CTCA studies from 47 to 6, although 12 of 49 true-positive CTCAs were incorrectly reclassified as false-negative hybrid scans on the basis of (presumably) sufficient hyperemic MBF. Compared with CTCA (61%) or H(2)(15)O PET (80%) alone (both P < 0.05), the hybrid approach significantly improved diagnostic accuracy (85%)., Conclusion: The diagnostic accuracy of quantitative H(2)(15)O PET/CTCA is superior to either H(2)(15)O PET or CTCA alone for the detection of clinically significant CAD. Hyperemic MBF was more accurate than CFR, implying that a single measurement of MBF in diagnostic protocols may suffice.

Published
2013
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