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25 results on '"de Haan, Laura H.J."'

16. The Regulatory Framework Across International Jurisdictions for Risks Associated with Consumption of Botanical Food Supplements

Author

Low, Teng Yong, Wong, Kwok Onn, Yap, Adelene L.L., De Haan, Laura H.J., and Rietjens, Ivonne M.C.M.

Subjects
BU Authenticiteit & Bioassays, BU Authenticity & Bioassays, botanical food supplements, botanicals, regulatory challenges, risk assessment, regulatory framework, Toxicology, Toxicologie, VLAG
Abstract

Dietary supplements, including those containing botanical ingredients and botanical-derived compounds, have been marketed to consumers globally for many decades. However, the legislative framework for such products remains inconsistent across jurisdictions internationally. This study aims to compare the regulatory framework of botanical food supplements in the EU, USA, Canada, Australia, New Zealand, India, Japan, and China. The study also aims to investigate and describe safety assessment criteria for botanical food supplements where they are present in the above said jurisdictions, and attempts to analyze whether these criteria are suitable for addressing the toxicological risks associated with the use of botanical food supplement products, based on the evaluation of reported adverse effects related to botanical food supplement use as examples. Finally, this study discusses some future issues that need further attention, such as the consideration of less than lifetime exposures, potential for misidentification, and adulteration of botanical supplements by pharmacologically active substances. It is concluded that the regulatory approaches towards botanical food supplements differ significantly across jurisdictions. In addition, national authorities are increasingly considering having more regulatory oversight for such products. Further consideration of the actual impact of adverse events arising from botanical food supplement usage will be helpful in guiding such decisions.

Published
2017

17. Integrating in vitro data and physiologically based kinetic (PBK) modelling to assess the in vivo potential developmental toxicity of a series of phenols

Author

Strikwold, Marije, Spenkelink, Bert, de Haan, Laura H.J., Woutersen, Ruud A., Punt, Ans, Rietjens, Ivonne M.C.M., Strikwold, Marije, Spenkelink, Bert, de Haan, Laura H.J., Woutersen, Ruud A., Punt, Ans, and Rietjens, Ivonne M.C.M.

Abstract

Toxicity outcomes derived in vitro do not always reflect in vivo toxicity values, which was previously observed for a series of phenols tested in the embryonic stem cell test (EST). Translation of in vitro data to the in vivo situation is therefore an important, but still limiting step for the use of in vitro toxicity outcomes in the safety assessment of chemicals. The aim of the present study was to translate in vitro embryotoxicity data for a series of phenols to in vivo developmental toxic potency values for the rat by physiologically based kinetic (PBK) modelling-based reverse dosimetry. To this purpose, PBK models were developed for each of the phenols. The models were parameterised with in vitro-derived values defining metabolism and transport of the compounds across the intestinal and placental barrier and with in silico predictions and data from the literature. Using PBK-based reverse dosimetry, in vitro concentration–response curves from the EST were translated into in vivo dose–response curves from which points of departure (PoDs) were derived. The predicted PoDs differed less than 3.6-fold from PoDs derived from in vivo toxicity data for the phenols available in the literature. Moreover, the in vitro PBK-based reverse dosimetry approach could overcome the large disparity that was observed previously between the in vitro and the in vivo relative potency of the series of phenols. In conclusion, this study shows another proof-of-principle that the in vitro PBK approach is a promising strategy for non-animal-based safety assessment of chemicals.

Published
2017

25. Ethnomedicine and ethnobotany of Maerua subcordata(Gilg) DeWolf

Author

Hiben, Mebrahtom Gebrelibanos, Louisse, Jochem, de Haan, Laura H.J., and Rietjens, Ivonne M. C. M.

Abstract

Background: Wild edible plants are valuable resources for improving food and nutritional security. Besides, they may provide important health benefits since the health-promoting components of plant-based foods usually exist at higher levels in wild plants. As a result, they are being sought as under-exploited potential sources of a health-promoting diet or a possible strategy to develop novel foods. In such exploration, ethnobotanical and ethnomedicinal data offer a fundamental step. The present study provides ethnomedicinal data on Maerua subcordata(Gilg) DeWolf (Capparidaceae). Methods: The ethnomedicinal data was collected from the Kunama ethnics of northern Ethiopia via focus group discussion and oral interview. Supporting ethnobotanical data from relevant literature was also compiled and systematically reviewed. Results: The results show that M. subcordatatuber is used by the Kunamas to manage malaria, malaria symptoms (fever, pain, gastrointestinal disorders), and seasonal cough while leaves are used for wound healing. In east Africa, its triple potential use as water purifying agent, food item, and herbal medicine was specified. As a herbal medicine, the tuber is used to manage a wide range of disorders including pain, infections, wounds, diabetes, blood pressure, and loss of appetite. Its use as laxative and abortifacient was also indicated. Leaves are used to treat wounds and ophthalmic and respiratory problems. As a food item, fruits are eaten during times of both food scarcity and food abundance while the tuber is used as a famine food. Conclusion: In East Africa, M. subcordatarepresents a wild food and medicinal plant, which may be developed into a functional food.

Published
2019
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