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4. Left Ventricular Diastolic Dysfunction across Levels of Kidney Function: A Cross-Sectional Study Based on Routine Clinical Practice Data.

Author

Porras, Cindy P., Dal Canto, Elisa, van Ommen, Anne-Mar L., Handoko, M. Louis, Haitjema, Saskia, de Groot, Mark C. H., Bots, Michiel L., Verhaar, Marianne C., and Vernooij, Robin W. M.

Subjects
LEFT ventricular dysfunction, KIDNEY physiology, GLOMERULAR filtration rate, CAMPUS visits, ECHOCARDIOGRAPHY
Abstract

Left ventricular diastolic dysfunction (LVDD) commonly coexists with kidney dysfunction. In this study, we investigated the presence of abnormalities in echocardiography parameters indicative of LVDD across stages of kidney function. Methods: We selected patients who visited a university hospital and had a serum creatinine and echocardiography reported in their medical records. Participants were categorized based on their kidney function: normal (estimated glomerular filtration rate [eGFR] ≥ 90 mL/min/1.73 m2), mildly decreased (eGFR: 60–90), moderately decreased (eGFR: 30–60), and severely decreased (eGFR < 30). The relationship between kidney function and echocardiography parameters was examined using logistic and linear regressions. Results: Among 4022 patients (age: 66.5 years [SD: 12.1], 41% women), 26%, 50%, 20%, and 4% had a normal, mildly, moderately, and severely decreased kidney function, respectively. Compared to patients with normal kidney function, patients with mildly decreased kidney function had higher odds for an abnormal E/e′ ratio (OR: 1.51 [95% CI: 1.13, 2.02]). Patients with moderately decreased kidney function presented a higher risk of abnormal E/e′ (OR: 2.90 [95% CI: 2.08, 4.04]), LAVI (OR: 1.62 [95% CI: 1.13, 2.33]), TR velocity (OR: 2.31 [95% CI: 1.49, 3.57]), and LVMI (OR: 1.70 [95% CI: 1.31, 2.20]), while patients with severely decreased kidney function had higher odds for abnormal E/e′ (OR: 2.95 [95% CI: 1.68, 5.17]) and LVMI > 95 g/m2 in women or >115 g/m2 in men (OR: 2.07 [95% CI: 1.27, 3.38]). The linear regression showed a significant inverse association between eGFR and echocardiography parameters, meaning that with worse kidney function, the parameters for LVDD worsened as well. Conclusions: Abnormal echocardiography parameters of LVDD were present even in patients with mildly decreased kidney function. As the kidney function worsened, there was a gradual increase in the risk of abnormal parameters of LVDD. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Rare and low-frequency coding variants alter human adult height

Author

Marouli, Eirini, Graff, Mariaelisa, Medina-Gomez, Carolina, Lo, Ken Sin, Wood, Andrew R, Kjaer, Troels R, Fine, Rebecca S, Lu, Yingchang, Schurmann, Claudia, Highland, Heather M, Rüeger, Sina, Thorleifsson, Gudmar, Justice, Anne E, Lamparter, David, Stirrups, Kathleen E, Turcot, Valérie, Young, Kristin L, Winkler, Thomas W, Esko, Tõnu, Karaderi, Tugce, Locke, Adam E, Masca, Nicholas GD, Ng, Maggie CY, Mudgal, Poorva, Rivas, Manuel A, Vedantam, Sailaja, Mahajan, Anubha, Guo, Xiuqing, Abecasis, Goncalo, Aben, Katja K, Adair, Linda S, Alam, Dewan S, Albrecht, Eva, Allin, Kristine H, Allison, Matthew, Amouyel, Philippe, Appel, Emil V, Arveiler, Dominique, Asselbergs, Folkert W, Auer, Paul L, Balkau, Beverley, Banas, Bernhard, Bang, Lia E, Benn, Marianne, Bergmann, Sven, Bielak, Lawrence F, Blüher, Matthias, Boeing, Heiner, Boerwinkle, Eric, Böger, Carsten A, Bonnycastle, Lori L, Bork-Jensen, Jette, Bots, Michiel L, Bottinger, Erwin P, Bowden, Donald W, Brandslund, Ivan, Breen, Gerome, Brilliant, Murray H, Broer, Linda, Burt, Amber A, Butterworth, Adam S, Carey, David J, Caulfield, Mark J, Chambers, John C, Chasman, Daniel I, Chen, Yii-Der Ida, Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y, Cocca, Massimiliano, Collins, Francis S, Cook, James P, Corley, Janie, Galbany, Jordi Corominas, Cox, Amanda J, Cuellar-Partida, Gabriel, Danesh, John, Davies, Gail, de Bakker, Paul IW, de Borst, Gert J, de Denus, Simon, de Groot, Mark CH, de Mutsert, Renée, Deary, Ian J, Dedoussis, George, Demerath, Ellen W, den Hollander, Anneke I, Dennis, Joe G, Di Angelantonio, Emanuele, Drenos, Fotios, Du, Mengmeng, Dunning, Alison M, Easton, Douglas F, Ebeling, Tapani, Edwards, Todd L, Ellinor, Patrick T, Elliott, Paul, Evangelou, Evangelos, Farmaki, Aliki-Eleni, and Faul, Jessica D

Subjects
Human Genome, Genetics, Aetiology, 2.1 Biological and endogenous factors, ADAMTS Proteins, Adult, Alleles, Body Height, Cell Adhesion Molecules, Female, Gene Frequency, Genetic Variation, Genome, Human, Glycoproteins, Glycosaminoglycans, Hedgehog Proteins, Humans, Intercellular Signaling Peptides and Proteins, Interferon Regulatory Factors, Interleukin-11 Receptor alpha Subunit, Male, Multifactorial Inheritance, NADPH Oxidase 4, NADPH Oxidases, Phenotype, Pregnancy-Associated Plasma Protein-A, Procollagen N-Endopeptidase, Proteoglycans, Proteolysis, Receptors, Androgen, Somatomedins, EPIC-InterAct Consortium, CHD Exome+ Consortium, ExomeBP Consortium, T2D-Genes Consortium, GoT2D Genes Consortium, Global Lipids Genetics Consortium, ReproGen Consortium, MAGIC Investigators, General Science & Technology
Abstract

Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding variants with lower minor-allele frequencies (in the range of 0.1-4.8%) and effects of up to 2 centimetres per allele (such as those in IHH, STC2, AR and CRISPLD2), greater than ten times the average effect of common variants. In functional follow-up studies, rare height-increasing alleles of STC2 (giving an increase of 1-2 centimetres per allele) compromised proteolytic inhibition of PAPP-A and increased cleavage of IGFBP-4 in vitro, resulting in higher bioavailability of insulin-like growth factors. These 83 height-associated variants overlap genes that are mutated in monogenic growth disorders and highlight new biological candidates (such as ADAMTS3, IL11RA and NOX4) and pathways (such as proteoglycan and glycosaminoglycan synthesis) involved in growth. Our results demonstrate that sufficiently large sample sizes can uncover rare and low-frequency variants of moderate-to-large effect associated with polygenic human phenotypes, and that these variants implicate relevant genes and pathways.

Published
2017

7. Relationship of neutrophil-to-lymphocyte ratio, in addition to C-reactive protein, with cardiovascular events in patients with type 2 diabetes

Author

Interne Geneeskunde Vasculaire, CDL Upod, Other research (not in main researchprogram), Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Unit Opleiding Aios, Hoes, Lukas L.F., Riksen, Niels P., Geleijnse, Johanna M., de Groot, Mark C.H., T. van der Schouw, Yvonne, Visseren, Frank L.J., Koopal, Charlotte, Interne Geneeskunde Vasculaire, CDL Upod, Other research (not in main researchprogram), Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Unit Opleiding Aios, Hoes, Lukas L.F., Riksen, Niels P., Geleijnse, Johanna M., de Groot, Mark C.H., T. van der Schouw, Yvonne, Visseren, Frank L.J., and Koopal, Charlotte

Published
2024

8. Improving acute kidney injury alerts in tertiary care by linking primary care data: An observational cohort using routine care data

Author

CDL Arcadia, CDL Cluster Front office & ext. business, MS Nefrologie, CDL Upod, Other research (not in main researchprogram), Centraal Diagnostisch Laboratorium, Circulatory Health, CDL Cluster Speciële Diagnostiek, Joosse, Huibert-Jan, Groenestege, Wouter Tiel, Vernooij, Robin Wm, De Groot, Mark Ch, Hoefer, Imo E, van Solinge, Wouter W, Kok, Maarten B, Haitjema, Saskia, CDL Arcadia, CDL Cluster Front office & ext. business, MS Nefrologie, CDL Upod, Other research (not in main researchprogram), Centraal Diagnostisch Laboratorium, Circulatory Health, CDL Cluster Speciële Diagnostiek, Joosse, Huibert-Jan, Groenestege, Wouter Tiel, Vernooij, Robin Wm, De Groot, Mark Ch, Hoefer, Imo E, van Solinge, Wouter W, Kok, Maarten B, and Haitjema, Saskia

Published
2024

9. Left Ventricular Diastolic Dysfunction across Levels of Kidney Function: A Cross-Sectional Study Based on Routine Clinical Practice Data

Author

Circulatory Health, Experimentele Afd. Cardiologie 1, Experimental Cardiology Laboratory, CDL Poli WKZ, CDL Cluster Speciële Diagnostiek, CDL Upod, Other research (not in main researchprogram), Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovascular Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, MS Nefrologie, Porras, Cindy P., Dal Canto, Elisa, van Ommen, Anne Mar L., Handoko, M. Louis, Haitjema, Saskia, de Groot, Mark C.H., Bots, Michiel L., Verhaar, Marianne C., Vernooij, Robin W.M., Circulatory Health, Experimentele Afd. Cardiologie 1, Experimental Cardiology Laboratory, CDL Poli WKZ, CDL Cluster Speciële Diagnostiek, CDL Upod, Other research (not in main researchprogram), Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovascular Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, MS Nefrologie, Porras, Cindy P., Dal Canto, Elisa, van Ommen, Anne Mar L., Handoko, M. Louis, Haitjema, Saskia, de Groot, Mark C.H., Bots, Michiel L., Verhaar, Marianne C., and Vernooij, Robin W.M.

Published
2024

10. Use of antibiotics in the early COVID-19 pandemic in Poland, the Netherlands and Spain, from erraticism to (more) logic

Author

Apotheek O&O&O, Child Health, Infection & Immunity, Regenerative Medicine and Stem Cells, CDL Upod, Other research (not in main researchprogram), Opalska, Aleksandra, Gardarsdottir, Helga, Kwa, Marcel, Wójkowska-Mach, Jadwiga, Sabate, Monica, Ballarin, Maria Elena, de Groot, Mark, Leufkens, Hubert, Apotheek O&O&O, Child Health, Infection & Immunity, Regenerative Medicine and Stem Cells, CDL Upod, Other research (not in main researchprogram), Opalska, Aleksandra, Gardarsdottir, Helga, Kwa, Marcel, Wójkowska-Mach, Jadwiga, Sabate, Monica, Ballarin, Maria Elena, de Groot, Mark, and Leufkens, Hubert

Published
2024

14. Data mining information from electronic health records produced high yield and accuracy for current smoking status

Author

van Solinge, Wouter, Hoefer, Imo, Haitjema, Saskia, de Groot, Mark, Blasse, Enja, Asselbergs, Folkert W., Nathoe, Hendrik M., de Borst, Gert-Jan, Bots, Michiel L., Geerlings, Mirjam I., Emmelot, Marielle H., de Jong, Pim A., Leiner, Tim, Lely, A. Titia, van der Kaaij, Niels P., Kappelle, L. Jaap, Ruigrok, Ynte M., Verhaar, Marianne C., Visseren, Frank L.J., Westerink, Jan, Groenhof, T. Katrien J., Koers, Laurien R., and Grobbee, Diederick E.

Published
2020
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17. Exploring the role of low-frequency and rare exonic variants in alcohol and tobacco use

Author

Marees, Andries T., Hammerschlag, Anke R., Bastarache, Lisa, de Kluiver, Hilde, Vorspan, Florence, van den Brink, Wim, Smit, Dirk J., Denys, Damiaan, Gamazon, Eric R., Li-Gao, Ruifang, Breetvelt, Elemi J., de Groot, Mark C.H., Galesloot, Tessel E., Vermeulen, Sita H., Poppelaars, Jan L., Souverein, Patrick C., Keeman, Renske, de Mutsert, Renée, Noordam, Raymond, Rosendaal, Frits R., Stringa, Najada, Mook-Kanamori, Dennis O., Vaartjes, Ilonca, Kiemeney, Lambertus A., den Heijer, Martin, van Schoor, Natasja M., Klungel, Olaf H., Maitland-Van der Zee, Anke H., Schmidt, Marjanka K., Polderman, Tinca J.C., van der Leij, Andries R., Posthuma, Danielle, and Derks, Eske M.

Published
2018
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25. A wolf in sheep’s clothing: The re-use of routinely obtained laboratory data in research (Preprint)

Author

Overmars, L. Malin, primary, Niemantsverdriet, Michael S. A., additional, Groenhof, T. Katrien J., additional, De Groot, Mark C. H., additional, Hulsbergen-Veelken, Cornelia A. R., additional, Van Solinge, Wouter W., additional, Musson, Ruben E. A., additional, Ten Berg, Maarten J., additional, Hoefer, Imo E., additional, and Haitjema, Saskia, additional

Published
2022
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26. Data mining to retrieve smoking status from electronic health records in general practice

Author

Epi Infectieziekten Team 1, Infection & Immunity, CDL Upod, Other research (not in main researchprogram), Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, HAG Trombose, Circulatory Health, Cardiovasculaire Epidemiologie, CDL Cluster Speciële Diagnostiek, de Boer, Annemarijn, de Groot, Mark, Groenhof, Katrien, van Doorn, Sander, Vaartjes, Ilonca, Bots, Michael L, Haitjema, Saskia, Epi Infectieziekten Team 1, Infection & Immunity, CDL Upod, Other research (not in main researchprogram), Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, HAG Trombose, Circulatory Health, Cardiovasculaire Epidemiologie, CDL Cluster Speciële Diagnostiek, de Boer, Annemarijn, de Groot, Mark, Groenhof, Katrien, van Doorn, Sander, Vaartjes, Ilonca, Bots, Michael L, and Haitjema, Saskia

Published
2022

27. A Wolf in Sheep's Clothing: Reuse of Routinely Obtained Laboratory Data in Research

Author

CDL Upod, Cardiovasculaire Epi Team 5, Other research (not in main researchprogram), Centraal Diagnostisch Laboratorium, CDL Cluster 24/7 centraal laboratorium, Circulatory Health, CDL Cluster Front office & ext. business, Infection & Immunity, CDL Cluster Speciële Diagnostiek, Overmars, L Malin, Niemantsverdriet, Michael S A, Groenhof, T Katrien J, De Groot, Mark C H, Hulsbergen-Veelken, Cornelia A R, Van Solinge, Wouter W, Musson, Ruben E A, Ten Berg, Maarten J, Hoefer, Imo E, Haitjema, Saskia, CDL Upod, Cardiovasculaire Epi Team 5, Other research (not in main researchprogram), Centraal Diagnostisch Laboratorium, CDL Cluster 24/7 centraal laboratorium, Circulatory Health, CDL Cluster Front office & ext. business, Infection & Immunity, CDL Cluster Speciële Diagnostiek, Overmars, L Malin, Niemantsverdriet, Michael S A, Groenhof, T Katrien J, De Groot, Mark C H, Hulsbergen-Veelken, Cornelia A R, Van Solinge, Wouter W, Musson, Ruben E A, Ten Berg, Maarten J, Hoefer, Imo E, and Haitjema, Saskia

Published
2022

28. Axial light loss of monocytes as a readily available prognostic biomarker in patients with suspected infection at the emergency department

Author

Acute geneeskunde, CDL Chemie en POC, CDL Upod, Other research (not in main researchprogram), Centraal Diagnostisch Laboratorium, Circulatory Health, MS Interne Geneeskunde, Infection & Immunity, CDL Cluster Speciële Diagnostiek, de Hond, Titus A.P., Hamelink, Wout J., de Groot, Mark C.H., Hoefer, Imo E., Oosterheert, Jan Jelrik, Haitjema, Saskia, Kaasjager, Karin A.H., Acute geneeskunde, CDL Chemie en POC, CDL Upod, Other research (not in main researchprogram), Centraal Diagnostisch Laboratorium, Circulatory Health, MS Interne Geneeskunde, Infection & Immunity, CDL Cluster Speciële Diagnostiek, de Hond, Titus A.P., Hamelink, Wout J., de Groot, Mark C.H., Hoefer, Imo E., Oosterheert, Jan Jelrik, Haitjema, Saskia, and Kaasjager, Karin A.H.

Published
2022

29. Preventing unnecessary imaging in patients suspect of coronary artery disease through machine learning of electronic health records

Author

CDL Upod, CDL Onderzoek Pasterkamp, Other research (not in main researchprogram), Centraal Diagnostisch Laboratorium, Circulatory Health, Onderzoek Vrouw Hart & Vaatziekten, CDL Arcadia, Overmars, Malin, van Es, Bram, Groepenhoff, Floor, de Groot, Mark, Pasterkamp, Gerard, den Ruijter, Hester M., van Solinge, W.W., Höfer, IE, Haitjema, Saskia, CDL Upod, CDL Onderzoek Pasterkamp, Other research (not in main researchprogram), Centraal Diagnostisch Laboratorium, Circulatory Health, Onderzoek Vrouw Hart & Vaatziekten, CDL Arcadia, Overmars, Malin, van Es, Bram, Groepenhoff, Floor, de Groot, Mark, Pasterkamp, Gerard, den Ruijter, Hester M., van Solinge, W.W., Höfer, IE, and Haitjema, Saskia

Published
2022

33. Case-only designs for studying the association of antidepressants and hip or femur fracture

Author

de Groot, Mark C. H., Candore, Gianmario, Uddin, Md. Jamal, Souverein, Patrick C., Ali, Sanni M., Belitser, Svetlana V., Huerta, Consuelo, Groenwold, Rolf H. H., Alvarez, Yolanda, Slattery, Jim, Korevaar, Joke, Hoes, Arno W., Roes, Kit C. B., de Boer, Anthonius, Douglas, Ian J., Schlienger, Raymond G., Reynolds, Robert, Klungel, Olaf H., and Gardarsdottir, Helga

Published
2016
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34. Understanding inconsistency in the results from observational pharmacoepidemiological studies: the case of antidepressant use and risk of hip/femur fractures

Author

Souverein, Patrick C., Abbing-Karahagopian, Victoria, Martin, Elisa, Huerta, Consuelo, de Abajo, Francisco, Leufkens, Hubert G. M., Candore, Gianmario, Alvarez, Yolanda, Slattery, Jim, Miret, Montserrat, Requena, Gema, Gil, Miguel J., Groenwold, Rolf H. H., Reynolds, Robert, Schlienger, Raymond G., Logie, John W., de Groot, Mark C. H., Klungel, Olaf H., van Staa, Tjeerd P., Egberts, Toine C. G., De Bruin, Marie L., and Gardarsdottir, Helga

Published
2016
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35. Impact of varying outcomes and definitions of suicidality on the associations of antiepileptic drugs and suicidality: comparisons from UK Clinical Practice Research Datalink (CPRD) and Danish national registries (DNR)†

Author

Schuerch, Markus, Gasse, Christiane, Robinson, Noah Jamie, Alvarez, Yolanda, Walls, Robert, Mors, Ole, Christensen, Jakob, Hesse, Ulrik, de Groot, Mark, Schlienger, Raymond, Reynolds, Robert, Klungel, Olaf, and de Vries, Frank

Published
2016
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37. Exposure to benzodiazepines (anxiolytics, hypnotics and related drugs) in seven European electronic healthcare databases: a cross-national descriptive study from the PROTECT-EU Project

Author

Huerta, Consuelo, Abbing-Karahagopian, Victoria, Requena, Gema, Oliva, Belén, Alvarez, Yolanda, Gardarsdottir, Helga, Miret, Montserrat, Schneider, Cornelia, Gil, Miguel, Souverein, Patrick C., De Bruin, Marie L., Slattery, Jim, De Groot, Mark C. H., Hesse, Ulrik, Rottenkolber, Marietta, Schmiedl, Sven, Montero, Dolores, Bate, Andrew, Ruigomez, Ana, García-Rodríguez, Luis Alberto, Johansson, Saga, de Vries, Frank, Schlienger, Raymond G., Reynolds, Robert F., Klungel, Olaf H., and de Abajo, Francisco José

Published
2016
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38. Hip/femur fractures associated with the use of benzodiazepines (anxiolytics, hypnotics and related drugs): a methodological approach to assess consistencies across databases from the PROTECT-EU project

Author

Requena, Gema, Huerta, Consuelo, Gardarsdottir, Helga, Logie, John, González-González, Rocío, Abbing-Karahagopian, Victoria, Miret, Montserrat, Schneider, Cornelia, Souverein, Patrick C., Webb, Dave, Afonso, Ana, Boudiaf, Nada, Martin, Elisa, Oliva, Belén, Alvarez, Arturo, De Groot, Mark C. H., Bate, Andrew, Johansson, Saga, Schlienger, Raymond, Reynolds, Robert, Klungel, Olaf H., and de Abajo, Francisco J.

Published
2016
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40. Do case-only designs yield consistent results across design and different databases? A case study of hip fractures and benzodiazepines†

Author

Requena, Gema, Logie, John, Martin, Elisa, Boudiaf, Nada, González, Rocío González, Huerta, Consuelo, Alvarez, Arturo, Webb, David, Bate, Andrew, García Rodríguez, Luis A., Reynolds, Robert, Schlienger, Raymond, Gardarsdottir, Helga, de Groot, Mark, Klungel, Olaf H., de Abajo, Fancisco, and Douglas, Ian J.

Published
2016
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42. Prevalence of antibiotic use: a comparison across various European health care data sources

Author

Brauer, Ruth, Ruigómez, Ana, Downey, Gerry, Bate, Andrew, Garcia Rodriguez, Luis Alberto, Huerta, Consuelo, Gil, Miguel, de Abajo, Francisco, Requena, Gema, Alvarez, Yolanda, Slattery, Jim, de Groot, Mark, Souverein, Patrick, Hesse, Ulrik, Rottenkolber, Marietta, Schmiedl, Sven, de Vries, Frank, Tepie, Maurille Feudjo, Schlienger, Raymond, Smeeth, Liam, Douglas, Ian, Reynolds, Robert, and Klungel, Olaf

Published
2016
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43. Switching TNFα inhibitors: Patterns and determinants

Author

Meijboom, Rosanne W., primary, Gardarsdottir, Helga, additional, Becker, Matthijs L., additional, de Groot, Mark C. H., additional, Movig, Kris L. L., additional, Kuijvenhoven, Johan, additional, Egberts, Toine C. G., additional, Leufkens, Hubert G. M., additional, and Giezen, Thijs J., additional

Published
2021
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44. Platelet count and indices as postpartum hemorrhage risk factors: a retrospective cohort study

Author

Poli Van Creveldkliniek Medisch, CDL Arcadia, Circulatory Health, CDL Upod, Other research (not in main researchprogram), CDL Staf Patiëntenzorg KC, MS Verloskunde, Infection & Immunity, Child Health, van Dijk, Wobke E M, Nijdam, Jelle S, Haitjema, Saskia, de Groot, Mark C H, Huisman, Albert, Punt, Marieke C, Evers, Annemiek C C, Schutgens, Roger E G, Lely, A Titia, van Galen, Karin P M, Poli Van Creveldkliniek Medisch, CDL Arcadia, Circulatory Health, CDL Upod, Other research (not in main researchprogram), CDL Staf Patiëntenzorg KC, MS Verloskunde, Infection & Immunity, Child Health, van Dijk, Wobke E M, Nijdam, Jelle S, Haitjema, Saskia, de Groot, Mark C H, Huisman, Albert, Punt, Marieke C, Evers, Annemiek C C, Schutgens, Roger E G, Lely, A Titia, and van Galen, Karin P M

Published
2021

45. Antiepileptic drug use in seven electronic health record databases in Europe: A methodologic comparison

Author

de Groot, Mark C. H., Schuerch, Markus, de Vries, Frank, Hesse, Ulrik, Oliva, Belén, Gil, Miguel, Huerta, Consuelo, Requena, Gema, de Abajo, Francisco, Afonso, Ana S., Souverein, Patrick C., Alvarez, Yolanda, Slattery, Jim, Rottenkolber, Marietta, Schmiedl, Sven, Van Dijk, Liset, Schlienger, Raymond G., Reynolds, Robert, and Klungel, Olaf H.

Published
2014
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47. Persistent inflammation, immunosuppression and catabolism syndrome (PICS) after polytrauma: A rare syndrome with major consequences

Author

Zorgeenheid Traumatologie, Experimentele Afdeling Longziekten, Other research (not in main researchprogram), CDL Arcadia, Infection & Immunity, Hesselink, Lillian, Hoepelman, Ruben J., Spijkerman, Roy, de Groot, Mark C.H., van Wessem, Karlijn J.P., Koenderman, Leo, Leenen, Luke P.H., Hietbrink, Falco, Zorgeenheid Traumatologie, Experimentele Afdeling Longziekten, Other research (not in main researchprogram), CDL Arcadia, Infection & Immunity, Hesselink, Lillian, Hoepelman, Ruben J., Spijkerman, Roy, de Groot, Mark C.H., van Wessem, Karlijn J.P., Koenderman, Leo, Leenen, Luke P.H., and Hietbrink, Falco

Published
2020

48. Intra-Operative Hypotension is a Risk Factor for Post-operative Silent Brain Ischaemia in Patients With Pre-operative Hypertension Undergoing Carotid Endarterectomy

Author

Zorgeenheid Vaatchirurgie Medisch, ZL Cerebrovasculaire Ziekten Medisch, Brain, Circulatory Health, CDL Upod, Other research (not in main researchprogram), CDL Arcadia, Management Vitale Functies, Medische staf Anesthesiologie, Regenerative Medicine and Stem Cells, Rots, Marjolijn L, Fassaert, Leonie M M, Kappelle, L Jaap, de Groot, Mark C H, Haitjema, Saskia, Bonati, Leo H, van Klei, Wilton A, de Borst, Gert J, Zorgeenheid Vaatchirurgie Medisch, ZL Cerebrovasculaire Ziekten Medisch, Brain, Circulatory Health, CDL Upod, Other research (not in main researchprogram), CDL Arcadia, Management Vitale Functies, Medische staf Anesthesiologie, Regenerative Medicine and Stem Cells, Rots, Marjolijn L, Fassaert, Leonie M M, Kappelle, L Jaap, de Groot, Mark C H, Haitjema, Saskia, Bonati, Leo H, van Klei, Wilton A, and de Borst, Gert J

Published
2020

49. A pan-inflammatory microRNA-cluster is associated with orbital non-Hodgkin lymphoma and idiopathic orbital inflammation

Author

Oogheelkunde Onderzoek, Infection & Immunity, MS Oogheelkunde, Other research (not in main researchprogram), Translationele immunologie, Unit Opleiding Reumat./Klin. Immunologie, CDL Arcadia, Laban, Kamil G., Kalmann, Rachel, Bekker, Cornelis P.J., Hiddingh, Sanne, van der Veen, Rob L.P., Eenhorst, Christine A.E., Genders, Stijn W., Mourits, Maarten P., Verhagen, Fleurieke H., Leijten, Emmerik F.A., Haitjema, Saskia, de Groot, Mark C.H., Radstake, Timothy R.D.J., de Boer, Joke H., Kuiper, Jonas J.W., Oogheelkunde Onderzoek, Infection & Immunity, MS Oogheelkunde, Other research (not in main researchprogram), Translationele immunologie, Unit Opleiding Reumat./Klin. Immunologie, CDL Arcadia, Laban, Kamil G., Kalmann, Rachel, Bekker, Cornelis P.J., Hiddingh, Sanne, van der Veen, Rob L.P., Eenhorst, Christine A.E., Genders, Stijn W., Mourits, Maarten P., Verhagen, Fleurieke H., Leijten, Emmerik F.A., Haitjema, Saskia, de Groot, Mark C.H., Radstake, Timothy R.D.J., de Boer, Joke H., and Kuiper, Jonas J.W.

Published
2020

50. Reticulated Platelets as Predictor of Myocardial Injury and 30 Day Mortality After Non-cardiac Surgery

Author

Zorgeenheid Vaatchirurgie Medisch, Medische staf Anesthesiologie, Circulatory Health, Management Vitale Functies, CDL Staf Patiëntenzorg KC, Other research (not in main researchprogram), CDL Arcadia, Centraal Diagnostisch Laboratorium, Regenerative Medicine and Stem Cells, Brain, Meershoek, Armelle J A, Leunissen, Tesse C, van Waes, Judith A R, Klei, Wilton A, Huisman, Albert, de Groot, Mark C H, Hoefer, Imo E, van Solinge, Wouter W, Moll, Frans L, de Borst, Gert J, Zorgeenheid Vaatchirurgie Medisch, Medische staf Anesthesiologie, Circulatory Health, Management Vitale Functies, CDL Staf Patiëntenzorg KC, Other research (not in main researchprogram), CDL Arcadia, Centraal Diagnostisch Laboratorium, Regenerative Medicine and Stem Cells, Brain, Meershoek, Armelle J A, Leunissen, Tesse C, van Waes, Judith A R, Klei, Wilton A, Huisman, Albert, de Groot, Mark C H, Hoefer, Imo E, van Solinge, Wouter W, Moll, Frans L, and de Borst, Gert J

Published
2020

Catalog

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