Search

Your search keyword '"de Greeff, S."' showing total 169 results
Start Over Author "de Greeff, S."
169 results on '"de Greeff, S."'

2. Antimicrobial susceptibility profile of clinically relevant Bacteroides, Phocaeicola, Parabacteroides and Prevotella species, isolated by eight laboratories in the Netherlands

Author

MMB Medische Staf, Infection & Immunity, MMB Research line 2, Boiten, K E, Notermans, D W, Rentenaar, R J, van Prehn, J, Bode, L G M, Maat, I, van der Zwet, W, Jansz, A, Siebers, T J H, Rossen, J W A, de Greeff, S C, Hendrickx, A P A, Kuijper, E J, Veloo, A C M, MMB Medische Staf, Infection & Immunity, MMB Research line 2, Boiten, K E, Notermans, D W, Rentenaar, R J, van Prehn, J, Bode, L G M, Maat, I, van der Zwet, W, Jansz, A, Siebers, T J H, Rossen, J W A, de Greeff, S C, Hendrickx, A P A, Kuijper, E J, and Veloo, A C M

Published
2024

3. Antimicrobial susceptibility profile of clinically relevant Bacteroides, Phocaeicola, Parabacteroides and Prevotella species, isolated by eight laboratories in the Netherlands

Author

Boiten, K. E., Notermans, D. W., Rentenaar, R. J., van Prehn, J., Bode, L. G. M., Maat, I, van der Zwet, W., Jansz, A., Siebers, T. J. H., Rossen, J. W. A., de Greeff, S. C., Hendrickx, A. P. A., Kuijper, E. J., Veloo, A. C. M., Boiten, K. E., Notermans, D. W., Rentenaar, R. J., van Prehn, J., Bode, L. G. M., Maat, I, van der Zwet, W., Jansz, A., Siebers, T. J. H., Rossen, J. W. A., de Greeff, S. C., Hendrickx, A. P. A., Kuijper, E. J., and Veloo, A. C. M.

Abstract

Objectives: Recently, reports on antimicrobial-resistant Bacteroides and Prevotella isolates have increased in the Netherlands. This urged the need for a surveillance study on the antimicrobial susceptibility profile of Bacteroides, Phocaeicola, Parabacteroides and Prevotella isolates consecutively isolated from human clinical specimens at eight different Dutch laboratories. Methods: Each laboratory collected 20–25 Bacteroides (including Phocaeicola and Parabacteroides) and 10–15 Prevotella isolates for 3 months. At the national reference laboratory, the MICs of amoxicillin, amoxicillin/clavulanic acid, piperacillin/tazobactam, meropenem, imipenem, metronidazole, clindamycin, tetracycline and moxifloxacin were determined using agar dilution. Isolates with a high MIC of metronidazole or a carbapenem, or harbouring cfiA, were subjected to WGS. Results: Bacteroides thetaiotaomicron/faecis isolates had the highest MIC 90 values, whereas Bacteroides fragilis had the lowest MIC 90 values for amoxicillin/clavulanic acid, piperacillin/tazobactam, meropenem, imipenem and moxifloxacin. The antimicrobial profiles of the different Prevotella species were similar, except for amoxicillin, for which the MIC 50 ranged from 0.125 to 16 mg/L for Prevotella bivia and Prevotella buccae, respectively. Three isolates with high metronidazole MICs were sequenced, of which one Bacteroides thetaiotaomicron isolate harboured a plasmid-located nimE gene and a Prevotella melaninogenica isolate harboured a nimA gene chromosomally. Five Bacteroides isolates harboured a cfiA gene and three had an IS element upstream, resulting in high MICs of carbapenems. The other two isolates harboured no IS element upstream of the cfiA gene and had low MICs of carbapenems. Conclusions: Variations in resistance between species were observed. To combat emerging resistance in anaerobes, monitoring resistance and conducting surveillance are essential.

Published
2024

8. EPI-Net One Health reporting guideline for antimicrobial consumption and resistance surveillance data: a Delphi approach

Author

Babu Rajendran, N., Arieti, F., Mena-Benitez, C. A., Galia, L., Tebon, M., Alvarez, J., Gladstone, B. P., Collineau, L., De Angelis, Giulia, Duro, R., Gaze, W., Gopel, S., Kanj, S. S., Kasbohrer, A., Limmathurotsakul, D., Lopez de Abechuco, E., Mazzolini, E., Mutters, N. T., Pezzani, M. D., Presterl, E., Renk, H., Rodriguez-Bano, J., Sandulescu, O., Scali, F., Skov, R., Velavan, T. P., Vuong, C., Tacconelli, Evelina, Adegnika, A. A., Avery, L., Bonten, M., Cassini, A., Chauvin, C., Compri, M., Damborg, P., De Greeff, S., Del Toro, M. D., Filter, M., Franklin, A., Gonzalez-Zorn, B., Grave, K., Hocquet, D., Hoelzle, L. E., Kalanxhi, E., Laxminarayan, R., Leibovici, L., Malhotra-Kumar, S., Mendelson, M., Paul, M., Munoz Madero, C., Murri, Rita, Piddock, L. J. V., Ruesen, C., Sanguinetti, Maurizio, Schilling, T., Schrijver, R., Schwaber, M. J., Scudeller, L., Torumkuney, D., Van Boeckel, T., Vanderhaeghen, W., Voss, A., Wozniak, T., De Angelis G. (ORCID:0000-0002-7087-7399), Tacconelli E. (ORCID:0000-0001-8722-5824), Murri R. (ORCID:0000-0003-4263-7854), Sanguinetti M. (ORCID:0000-0002-9780-7059), Babu Rajendran, N., Arieti, F., Mena-Benitez, C. A., Galia, L., Tebon, M., Alvarez, J., Gladstone, B. P., Collineau, L., De Angelis, Giulia, Duro, R., Gaze, W., Gopel, S., Kanj, S. S., Kasbohrer, A., Limmathurotsakul, D., Lopez de Abechuco, E., Mazzolini, E., Mutters, N. T., Pezzani, M. D., Presterl, E., Renk, H., Rodriguez-Bano, J., Sandulescu, O., Scali, F., Skov, R., Velavan, T. P., Vuong, C., Tacconelli, Evelina, Adegnika, A. A., Avery, L., Bonten, M., Cassini, A., Chauvin, C., Compri, M., Damborg, P., De Greeff, S., Del Toro, M. D., Filter, M., Franklin, A., Gonzalez-Zorn, B., Grave, K., Hocquet, D., Hoelzle, L. E., Kalanxhi, E., Laxminarayan, R., Leibovici, L., Malhotra-Kumar, S., Mendelson, M., Paul, M., Munoz Madero, C., Murri, Rita, Piddock, L. J. V., Ruesen, C., Sanguinetti, Maurizio, Schilling, T., Schrijver, R., Schwaber, M. J., Scudeller, L., Torumkuney, D., Van Boeckel, T., Vanderhaeghen, W., Voss, A., Wozniak, T., De Angelis G. (ORCID:0000-0002-7087-7399), Tacconelli E. (ORCID:0000-0001-8722-5824), Murri R. (ORCID:0000-0003-4263-7854), and Sanguinetti M. (ORCID:0000-0002-9780-7059)

Abstract

Strategic and standardised approaches to analysis and reporting of surveillance data are essential to inform antimicrobial resistance (AMR) mitigation measures, including antibiotic policies. Targeted guidance on linking full-scale AMR and antimicrobial consumption (AMC)/antimicrobial residues (AR) surveillance data from the human, animal, and environmental sectors is currently needed. This paper describes the initiative whereby a multidisciplinary panel of experts (56 from 20 countries—52 high income, 4 upper middle or lower income), representing all three sectors, elaborated proposals for structuring and reporting full-scale AMR and AMC/AR surveillance data across the three sectors. An evidence-supported, modified Delphi approach was adopted to reach consensus among the experts for dissemination frequency, language, and overall structure of reporting; core elements and metrics for AMC/AR data; core elements and metrics for AMR data. The recommendations can support multisectoral national and regional plans on antimicrobials policy to reduce resistance rates applying a One Health approach.

Published
2023

9. Increase in invasive group A streptococcal (Streptococcus pyogenes) infections (iGAS) in young children in the Netherlands, 2022

Author

de Gier, Brechje, Marchal, Niek, de Beer-Schuurman, Ilse, te Wierik, Margreet, Hooiveld, Mariëtte, de Melker, Hester E., van Sorge, Nina M., Stuart, J. W. T. Cohen, Melles, D. C., van Dijk, K., Alzubaidy, A., Scholing, M., Kuil, S. D., Blaauw, G. J., Altorf-van der Kuil, W., Bierman, S. M., de Greeff, S. C., Groenendijk, S. R., Hertroys, R., Kuijper, E. J., Marchal, N., Monen, J. C. M., Notermans, D. W., Polman, J., van den Reek, W. J., Schneeberger-van der Linden, C., Schoffelen, A. F., Wielders, C. C. H., de Wit, B. J., Zoetigheid, R. E., van den Bijllaardt, W., Kraan, E. M., Haeseker, M. B., da Silva, J. M., de Jong, E., Maraha, B., van Griethuysen, A. J., Wintermans, B. B., van Trijp, M. J. C. A., Wong, M., Muller, A. E., Ott, A., Lokate, M., Bathoorn, E., Sinnige, J., Silvis, W., Renders, N. H., Bakker, L. J., Dorigo-Zetsma, J. W., Waar, K., van der Beek, M. T., Leversteijn-van Hall, M. A., van Mens, S. P., Schaftenaar, E., Nabuurs-Franssen, M. H., Maat, I., Diederen, B. M. W., Bode, L. G. M., Ong, D. S. Y., van Rijn, M., Dinant, S., Pontesilli, O., van Dam, D. W., de Brauwer, E. I. G. B., Bentvelsen, R. G., Buiting, A. G. M., Vlek, A. L. M., de Graaf, M., Troelstra, A., Jansz, A. R., van Meer, M. P. A., de Vries, J., Dos Santos, C. Oliveira, Rümke, Lidewij W., Vestjens, Stefan M. T., Vlaminckx, Bart J. M., Medical Microbiology and Infection Prevention, AII - Infectious diseases, APH - Global Health, APH - Methodology, APH - Quality of Care, Experimental Immunology, AII - Inflammatory diseases, APH - Aging & Later Life, and APH - Health Behaviors & Chronic Diseases

Subjects
Adult, Chickenpox, Streptococcus pyogenes, Child, Preschool, Streptococcal Infections/diagnosis, COVID-19, Humans, Netherlands/epidemiology, Child, Herpes Zoster, Pandemics
Abstract

In 2022, a sevenfold increase in the number of notifiable invasive Streptococcus pyogenes (iGAS) infections among children aged 0-5 years was observed in the Netherlands compared with pre-COVID-19 pandemic years. Of 42 cases in this age group, seven had preceding or coinciding varicella zoster infections, nine were fatal. This increase is not attributable to a specific emm type. Vigilance for clinical deterioration as iGAS sign is warranted in young children, especially those with varicella zoster infection.

Published
2023

10. Third-generation cephalosporin resistant gram-negative bacteraemia in patients with haematological malignancy; an 11-year multi-centre retrospective study

Author

de la Court, Jara R., Woudt, Sjoukje H. S., Schoffelen, Annelot F., Heijmans, Jarom, de Jonge, Nick A., van der Bruggen, Tjomme, Bomers, Marije K., Lambregts, Merel M. C., Schade, Rogier P., Sigaloff, Kim C. E., Stuart, J. W. T. Cohen, Melles, D. C., van Dijk, K., Alzubaidy, A., Werdmuller, B. F. M., Blaauw, G. J., Diederen, B. M. W., Alblas, H. J., der Kuil, W. Altorf-van, Bierman, S. M., de Greeff, S. C., Groenendijk, S. R., Hertroys, R., Kuijper, E. J., Monen, J. C., Notermans, D. W., van den Reek, W. J., Smilde, A. E., Wielders, C. C. H., Zoetigheid, R. E., van den Bijllaardt, W., Kraan, E. M., Mattsson, E. E., da Silva, J. M., de Jong, E., Maraha, B., van Asselt, G. J., Demeulemeester, A., Wintermans, B. B., van Trijp, M., Ott, A., Sinnige, J., Silvis, W., Bakker, L. J., Dorigo-Zetsma, J. W., Waar, K., Bernards, A. T., Hall, M. A. Leversteijn-van, Schaftenaar, E., Nabuurs-Franssen, M. H., Wertheim, H., Bode, L., van Rijn, M., Dinant, S., Pontesilli, O., de Man, P., Wong, M., Muller, A. E., Renders, N. H., Bentvelsen, R. G., Buiting, A. G. M., Vlek, A. L. M., Stam, A. J., Troelstra, A., Overdevest, I. T. M. A., van Meer, M. P. A., dos Santos, C. Oliveira, Wolfhagen, M. J. H. M., Hematology, Internal medicine, AII - Infectious diseases, Medical Microbiology and Infection Prevention, APH - Quality of Care, Elderly care medicine, APH - Aging & Later Life, Graduate School, General Internal Medicine, CCA - Cancer biology and immunology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, CCA - Cancer Treatment and Quality of Life, Clinical Haematology, Experimental Immunology, and APH - Health Behaviors & Chronic Diseases

Subjects
Third-generation-cephalosporin resistance, Colonization, Microbiology (medical), Febrile neutropenia, Bacteremia, General Medicine, Antimicrobial resistance, Empirical antibiotic therapy, Ceftazidime, Infectious Diseases, Carbapenems, Hematologic Neoplasms, Resistance surveillance, Humans, Prospective Studies, Retrospective Studies
Abstract

Objectives Among patients with haematological malignancy, bacteraemia is a common complication during chemotherapy-induced neutropenia. Resistance of gram-negative bacteria (GNB) to third-generation cephalosporins (3GC) is increasing. In order to explore the value of using surveillance cultures to guide empirical treatment e.g. choosing between carbapenem versus ceftazidime- we aimed to assess the distribution of pathogens causing bacteraemia in patients with haematological malignancy, and the proportion of 3GC-resistant GNB (3GC-R GNB) bacteraemia that was preceded by 3GC-R GNB colonization. Methods Using 11 years of data (2008–2018) from the Dutch national antimicrobial resistance surveillance system, we assessed the prevalence of 3GC-R GNB in episodes of bacteraemia, and the proportion of 3GC-R GNB bacteraemia that was preceded by 3GC-R GNB colonization. Colonization was defined as availability of any GNB surveillance isolate in the year before, independent of the causative micro-organism (time-paired isolates). Results We included 3887 patients, representing 4142 episodes of bacteraemia. GNB were identified in 715/4142 (17.3%), of which 221 (30.9%) were 3GC-R GNB. In 139 of these 221 patients a time-paired surveillance culture was available. In 76.2% (106/139) of patients these surveillance cultures already showed 3GC-R GNB isolates in the year prior to the culture date of the 3GC-R GNB positive blood isolate. Conclusions This multi-centre study shows that in patients with haematological malignancy, the majority of 3GC-R GNB bacteraemia is preceded by 3GC-R GNB colonization. Prospective clinical studies are needed to assess the safety and benefits of the use of surveillance-cultures to guide empirical therapy to restrict the empirical use of carbapenems in this population.

Published
2022
Full Text
View/download PDF

17. Gram-positive cocci in Dutch ICUs with and without selective decontamination of the oropharyngeal and digestive tract: a retrospective database analysis

Author

van der Bij, A. K., Frentz, D., Bonten, M. J. M., Stuart, J. W. T. Cohen, van Hees, B. C., Vijfhuizen, J., Wintermans, R. G. F., der Kuil, W. Altorf-van, Alblas, J., van der Bij, A. K., Frentz, D., van Heereveld, J., Hertroys, R., Leenstra, T., Monen, J. C., Woudt, S. H. S., de Greeff, S. C., van Keulen, P. H. J., Kluytmans, J. A. J. W., Mattsson, E. E., Sebens, F. W., Frenay, H. M. E., Maraha, B., Halaby, T., Versteeg, D., Hendrix, R., Schellekens, J. F. P., Diederen, B. M. W., de Brauwer, E. I. G. B., Stals, F. S., Bakker, L. J., Dorigo-Zetsma, J. W., van Zeijl, J. H., Bernards, A. T., de Jongh, B. M., Vlaminckx, B. J. M., Horrevorts, A., Kuipers, S., Wintermans, R. G. F., Moffie, B., Brimicombe, R. W., Jansen, C. L., Renders, N. H. M., Hendrickx, B. G. A., Buiting, A. G. M., Thijsen, S. F. T., Deege, M. P. D., Frakking, F. N. J., Tjhie, H. T., van Zwet, A. A., Voorn, G. P., Ruijs, G. J. H. M., and Wolfhagen, M. J. H. M.

Published
2016
Full Text
View/download PDF

18. Dragerschap van antibioticaresistente bacteriën bij dierenartsen en dierenartsassistenten. De AREND-studie

Author

Meijs, A, Gijsbers, E, Hengeveld, P, Dierikx, C, de Greeff, S, and van Duijkeren, E

Subjects
RIVM rapport 2021-0029
Abstract

Bepaalde type bacteriën zijn resistent tegen antibiotica, zoals ESBLproducerende bacteriën. ESBL’s komen vaker voor bij dierenartsen en assistenten van dierenartsen dan bij mensen die niet met dieren werken. Het is aannemelijk dat dierenartsen en hun assistenten deze bacteriën bij zich dragen door het contact met dieren tijdens hun werk. Dit blijkt uit onderzoek van het RIVM. Veel deelnemers uit deze zorgsector hadden contact met verschillende soorten dieren, zowel huisdieren als vee. Van hen had 69 procent alleen contact met huisdieren. Het is daardoor niet mogelijk om aan te wijzen welk specifiek dier de bron van de resistente bacterie was. Het RIVM heeft onderzocht of drie soorten (antibioticaresistente) bacteriën in de ontlasting van de dierenartsen en dierenartsassistenten zaten. Dat waren ESBL-producerende bacteriën, bacteriën die resistent zijn tegen het ‘laatste redmiddel’ antibioticum colistine, en Clostridioides difficile (C. diff). Voor deze drie bacteriën zijn er namelijk aanwijzingen dat contact met dieren een kans geeft om ermee besmet te raken. Er deden 482 mensen mee aan het onderzoek. Colistineresistente bacteriën en C. diff kwamen even vaak voor bij dierenartsen en hun assistenten als bij de Nederlandse bevolking. Er zijn daarom geen aanwijzingen dat zij door hun werk een grotere kans hebben om deze twee soort bacteriën bij zich te dragen. Antibioticaresistente bacteriën kunnen in de darmen zitten van gezonde personen of dieren zonder dat zij daar last van hebben. Maar ze kunnen ook infecties veroorzaken. Infecties door deze bacteriën zijn moeilijker te behandelen met antibiotica. De bacteriën worden onder andere via de ontlasting van dieren verspreid. Een goede hygiëne is dan ook belangrijk om besmetting te voorkomen.

Published
2021

20. Selective decontamination of the oropharynx and the digestive tract, and antimicrobial resistance: a 4 year ecological study in 38 intensive care units in the Netherlands

Author

Houben, A. J. M., Oostdijk, E. A. N., van der Voort, P. H. J., Monen, J. C. M., Bonten, M. J. M., van der Bij, A. K., Vlaspolder, F., Stuart, J. W. T. Cohen, van Hees, B. C., Vijfhuizen, J., Wintermans, R. G. F., der Kuil, W. Altorf-van, Alblas, J., van der Bij, A. K., Frentz, D., Leenstra, T., Monen, J. C., Muilwijk, J., Notermans, D. W., de Greeff, S. C., van Keulen, P. H. J., Kluytmans, J. A. J. W., Mattsson, E. E., Sebens, F. W., Frénay, H. M. E., Maraha, B., Heilmann, F. G. C., Halaby, T., Versteeg, D., Hendrix, R., Schellekens, J. F. P., Diederen, B. M. W., de Brauwer, E. I. G. B., Stals, F. S., Bakker, L. J., Dorigo-Zetsma, J. W., van Zeijl, J. H., Bernards, A. T., de Jongh, B. M., Vlaminckx, B. J. M., Horrevorts, A., Kuipers, S., Wintermans, R. G. F., Moffie, B., Brimicombe, R. W., Jansen, C. L., Renders, N. H. M., Hendrickx, B. G. A., Buiting, A. G. M., Kaan, J. A., Thijsen, S. F. T., Deege, M. P. D., Ekkelenkamp, M. B., Tjhie, H. T., van Zwet, A. A., Voorn, G. P., Ruijs, G. J. H. M., and Wolfhagen, M. J. H. M.

Published
2014
Full Text
View/download PDF

22. Community-Onset Infection in Hospitalized Patients in The Netherlands

Author

Crobach, M J T, Notermans, D W, Harmanus, C, Sanders, I M J G, de Greeff, S C, and Kuijper, E J

Subjects
Clostridium difficile infections in humans, genetic structures, Clostridioides difficile, surveillance
Abstract

Clostridioides difficile infection (CDI) is increasingly reported in the community. The aim of this study was to analyze characteristics of hospitalized patients with community-onset CDI (CO-CDI).

Published
2020

23. Exploring determinants of hand hygiene compliance in LTCFs: a qualitative study using Flottorps’ integrated checklist of determinants of practice

Author

Lescure, Dominique, Haenen, A, de Greeff, S, Voss, A, Huis, A, Hulscher, M, Lescure, Dominique, Haenen, A, de Greeff, S, Voss, A, Huis, A, and Hulscher, M

Abstract

Background: Elderly residents in long-term care facilities (LTCFs) are vulnerable to healthcare-associated infections. Although hand hygiene is a leading measure for preventing infection, the compliance of healthcare workers is low. The aim of this study is to identify determinants that influence hand hygiene compliance of nursing staff in LTCFs. This information on determinants can eventually be used to develop a tailored implementation strategy for LTCFs. Methods: This is an explorative, descriptive study using qualitative methods. We performed semi-structured focus group discussions with 31 nurses and nurse assistants from five Dutch LTCFs. Our focus group discussions continued until no new information could be identified from the data. We used Flottorps’ comprehensive checklist for identifying determinants of practice (the TICD checklist) to guide data collection and analysis. The audiotapes were transcribed verbatim and two authors independently analysed the transcripts with Atlas.ti software. Results: LTCFs for the elderly have setting specific determinants that are decisive in explaining hand hygiene compliance. Most of these determinants are related to the residents with whom nurses build close relationships and for whom they want to create a homelike atmosphere. Residents can complicate the provision of care with unpredictable behaviour, being unwilling to receive care or use shared facilities. Our study also discovered setting-transcending determinants related to knowledge, professional interactions, guidelines, and incentives/resources. Conclusions: Nurses in LTCFs are constantly pursuing a balance between working hygienically, responding adequately to acute care needs, and maintaining a homelike environment for their residents. As a result, setting-specific determinants affect hand hygiene compliance, as do the known determinants that are important in other care settings. To improve compliance in LTCFs, interventions should be selected on a theoretica

Published
2021

31. Seasonality in carriage of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae in the general population: a pooled analysis of nationwide cross-sectional studies

Author

Wielders, C. C. H., primary, Van Duijkeren, E., additional, Van Den Bunt, G., additional, Meijs, A. P., additional, Dierikx, C. M., additional, Bonten, M. J. M., additional, Van Pelt, W., additional, Franz, E., additional, and De Greeff, S. C., additional

Published
2020
Full Text
View/download PDF

32. Carbapenemase-producerende enterobacteriën in Nederland : Onopgemerkte versprewiding naar verschillende regio's

Author

Leenstra, T, Bosch, T, Vlek, A L, Bonten, M J M, van der Lubben, I M, and de Greeff, S C

Subjects
polycyclic compounds, biochemical phenomena, metabolism, and nutrition
Abstract

Carbapenemase producing Enterobacteriaceae (CPE), including Klebsiella pneumoniae and Escherichia coli, are only sporadically seen in the Netherlands and then mainly in patients who have been transferred from foreign hospitals.- CPE are resistant to virtually all beta-lactam antibiotics, including carbapenems, e.g., meropenem and imipenem. Several genes, e.g., OXA-48, KPC and NDM-1, code for carbapenemase enzymes that deactivate carbapenems.- Control of CPE focuses on timely identification of patients who are infected or are carriers and the application of preventive measures to prevent spread.- Genotypic analysis of CPE isolates submitted to the national CPE surveillance revealed close relationships between 8 NDM-1 positive K. pneumoniae isolates of patients from different parts of the Netherlands and isolates obtained through contact tracing during a known hospital outbreak.- Based on retrospective epidemiological investigation, no shared exposure could be found.- These findings indicate unnoticed spread of CPE in the Netherlands.

Published
2018

35. Puntprevalentieonderzoek naar antibioticaresistentie in verpleeghuizen

Author

van Kleef, E, Wielders, L, Bijkerk, P, Beishuizen, B, Schouls, L, van der Lubben, M, de Greeff, S, van Kleef, E, Wielders, L, Bijkerk, P, Beishuizen, B, Schouls, L, van der Lubben, M, and de Greeff, S

Abstract

RIVM rapport:In 2018 is in Nederland een landelijk onderzoek gestart naar dragerschap van antibioticaresistente bacteriën onder verpleeghuisbewoners. Als geheel staat de verpleeghuissector er goed voor. Door dit onderzoek is er een completer beeld van antibioticaresistentie in Nederland. Voor dit onderzoek zijn 4420 bewoners in 159 verpleeghuizen onderzocht. Er is naar twee soorten resistente darmbacteriën onderzoek gedaan (ESBL en CPE). Er werd geen CPE aangetroffen. Dat is gunstig, want er zijn nauwelijks antibiotica die infecties met deze bacterie kunnen behandelen. Het aandeel bewoners van verpleeghuizen dat een ESBL-bacterie bij zich droeg komt gemiddeld genomen overeen met het percentage in de Nederlandse bevolking. ESBL's zijn enzymen die veelgebruikte antibiotica zoals penicillines kunnen afbreken waardoor de antibiotica niet meer werken. Bij een derde van de deelnemende verpleeghuizen, kwamen meer ESBL-bacteriën onder bewoners voor dan gemiddeld in Nederland. Bij hen is extra onderzoek gedaan om te bepalen of er sprake was van verspreiding onder de bewoners. Ook kregen ze advies over maatregelen om ervoor te zorgen dat de bacteriën zich niet verder verspreiden. Het onderzoek is onderdeel van de landelijke aanpak van antibioticaresistentie door de Nederlandse overheid. Het doel is om verdere resistentie te voorkomen en de gevolgen ervan zo veel mogelijk te beperken. Tot dit onderzoek werd uitgevoerd was er nog weinig zicht op de situatie in verpleeghuizen. De landelijke aanpak is opgezet omdat bacteriën wereldwijd steeds vaker ongevoelig worden voor antibiotica. Het RIVM coördineerde de studie, die is uitgevoerd door Regionale Zorgnetwerken Antibioticaresistentie (RZN), medisch microbiologische laboratoria, en verpleeghuizen. De RZN zijn opgezet om antibioticaresistentie regionaal te voorkomen en te bestrijden., In 2018, the Dutch Ministry of Health, Welfare and Sport commissioned a nationwide study investigating the presence of antibiotic resistant bacteria among nursing home residents. As a whole, the study revealed that nursing home sector is in good shape. Nonetheless, attention to proper infection prevention and hygiene measures is still needed. This study has improved our understanding of antibiotic resistance in the Netherlands. For the study, 4420 residents of 159 nursing homes were examined, looking for two types of resistant gut bacteria: ESBL and CPE. No CPE was found. This is positive, as there are hardly any antibiotic treatment options for infections caused by this bacterium. The fraction of nursing home residents with ESBL bacteria did not differ from the average percentage of ESBL carriers in the Dutch population. ESBLs are enzymes that can break down commonly used antibiotics such as penicillins, resulting in the antibiotics no longer being effective. In a third of the participating nursing homes, ESBL bacteria occurred more often among residents than on average amongst the general population of the Netherlands. In these nursing homes, extra investigations were carried out to see if the bacteria had spread among the residents. They were also given advice on infection prevention control measures to prevent further spread. The study is part of the Dutch national approach for tackling antibiotic resistance. The aim is to prevent further resistance and to reduce its consequences as much as possible. The situation in nursing homes was rather unclear prior to starting this study. The national approach was set up because bacteria throughout the world are becoming insensitive to antibiotics increasingly often. RIVM, the National Institute for Public Health and the Environment, coordinated the study and carried out the study together with the Regional Care Networks for Antibiotic Resistance (RZN), medical microbiology laboratories and nursing homes. The RZNs have be

Published
2019

36. Prevalence and risk factors for colonization of Clostridium difficile among adults living near livestock farms in the Netherlands

Author

Zomer, T P, VAN Duijkeren, E, Wielders, C C H, Veenman, C, Hengeveld, P, VAN DER Hoek, W, DE Greeff, S C, Smit, L A M, Heederik, D J, Yzermans, C J, Kuijper, E J, and Maassen, C B M

Subjects
Adult, Male, Livestock, Clostridium difficile, Middle Aged, Anti-Bacterial Agents, Young Adult, Cross-Sectional Studies, Residence Characteristics, Risk Factors, Clostridium Infections, Prevalence, Animals, Humans, Female, Animal Husbandry, Aged, Netherlands
Abstract

A cross-sectional study was performed among 2494 adults not living or working on a farm to assess prevalence of Clostridium difficile (CD) colonization and risk factors in a livestock dense area. CD prevalence was 1·2%. Twenty-one persons were colonized with a toxigenic strain and nine with a non-toxigenic strain. CD-positive persons did not live closer to livestock farms than individuals negative for CD. Antibiotic exposure in the preceding 3 months was a risk factor for CD colonization (odds ratio 3·70; 95% confidence interval 1·25-10·95).

Published
2018

37. Prevalence and risk factors for colonization of Clostridium difficile among adults living near livestock farms in the Netherlands

Author

Zomer, Tizza P, van Duijkeren, Eugeline, Wielders, C C H, Veenman, C., Hengeveld, P., {van der Hoek}, W., de Greeff, S C, Smit, L A M, Heederik, D J, Yzermans, C Joris, Kuijper, E J, Maassen, Catharina B M, LS IRAS EEPI GRA (Gezh.risico-analyse), and dIRAS RA-I&I RA

Subjects
livestock, Coronacrisis-Taverne, Clostridium difficile, environment, farms
Abstract

A cross-sectional study was performed among 2494 adults not living or working on a farm to assess prevalence of Clostridium difficile (CD) colonization and risk factors in a livestock dense area. CD prevalence was 1·2%. Twenty-one persons were colonized with a toxigenic strain and nine with a non-toxigenic strain. CD-positive persons did not live closer to livestock farms than individuals negative for CD. Antibiotic exposure in the preceding 3 months was a risk factor for CD colonization (odds ratio 3·70; 95% confidence interval 1·25-10·95).

Published
2017

40. Intestinal carriage of ampicillin- and vancomycin-resistant Enterococcus faecium in humans, dogs and cats in the Netherlands

Author

Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, MMB Research line 1, Epi Infectieziekten, Van den Bunt, G., Top, J., Hordijk, J., De Greeff, S. C., Mughini-Gras, L., Corander, J., van Pelt, W., Bonten, M. J.M., Fluit, A. C., Willems, R. J.L., Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, MMB Research line 1, Epi Infectieziekten, Van den Bunt, G., Top, J., Hordijk, J., De Greeff, S. C., Mughini-Gras, L., Corander, J., van Pelt, W., Bonten, M. J.M., Fluit, A. C., and Willems, R. J.L.

Published
2018

41. Extended-spectrum β-lactamase- and pAmpC-producing Enterobacteriaceae among the general population in a livestock-dense area

Author

Wielders, C C H, van Hoek, A H A M, Hengeveld, P D, Veenman, C, Dierikx, C M, Zomer, T P, Smit, L A M, van der Hoek, W, Heederik, D J, de Greeff, S C, Maassen, C B M, van Duijkeren, E, LS IRAS EEPI GRA (Gezh.risico-analyse), and dIRAS RA-I&I RA

Subjects
β-lactam resistance, Risk factors, Livestock farming, Prevalence, AmpC, Environment, Extended-spectrum β-lactamases, Antimicrobial resistance
Abstract

OBJECTIVES: In the Netherlands there is an ongoing debate regarding environmental health risks of livestock farming for neighbouring residents. This explorative study aims to determine the prevalence of carriage of ESBL/pAmpC-producing Enterobacteriaceae (ESBL/pAmpC-E) in the general population living in a livestock-dense area, and to study associations between determinants, including exposure through contact with animals and the environment, and human carriage of ESBL/pAmpC-E. METHODS: A cross-sectional study was performed among 2,432 adults (aged 20-72 years) in twelve temporary research centres in the south of the Netherlands, consisting of a questionnaire and analysis of a faecal sample to assess carriage of ESBL/pAmpC-E. Risk factors were analysed using logistic regression. RESULTS: The prevalence for carriage of ESBL/pAmpC-E was 4.5% (109/2,432; 95%CI: 3.7-5.4) ranging from 1.4-10.9% among the research centres. ESBL/pAmpC resistance genes were detected in E. coli and K. pneumoniae isolates obtained from these 109 persons and the most common ESBL-resistance genes were blaCTX-M-15, blaCTX-M-14/17, and blaCTX-M-1, originating from 76 participants. Travel in the last twelve months to Africa, Asia or Latin America (OR: 2.82 (95%CI: 1.71-4.63)), having kept cows for a hobby (last five years) (OR: 3.77 (95%CI: 1.22-11.64)), usage of proton-pump inhibitors (OR: 1.84 (95%CI: 1.05-3.23)), and living within 1,000 metres of a mink farm (OR: 2.26 (95%CI: 1.28-3.98)) were identified as risk factors. Exposure to poultry was not identified as a risk factor. CONCLUSIONS: Overall, living in close proximity of livestock animals and farms does not seem to be a risk factor for carriage of ESBL/pAmpC-E.

Published
2017

42. Newly identified risk factors for MRSA carriage in The Netherlands

Author

Lekkerkerk, W. S. N., primary, Haenen, A., additional, van der Sande, M. A. B., additional, Leenstra, T., additional, de Greeff, S., additional, Timen, A., additional, Tjon-a-Tsien, A., additional, Richardus, J. H., additional, van de Sande-Bruinsma, N., additional, and Vos, M. C., additional

Published
2017
Full Text
View/download PDF

43. Prevalence and risk factors for colonization of Clostridium difficile among adults living near livestock farms in the Netherlands

Author

LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-I&I RA, Zomer, Tizza P, van Duijkeren, Eugeline, Wielders, C C H, Veenman, C., Hengeveld, P., {van der Hoek}, W., de Greeff, S C, Smit, L A M, Heederik, D J, Yzermans, C Joris, Kuijper, E J, Maassen, Catharina B M, LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-I&I RA, Zomer, Tizza P, van Duijkeren, Eugeline, Wielders, C C H, Veenman, C., Hengeveld, P., {van der Hoek}, W., de Greeff, S C, Smit, L A M, Heederik, D J, Yzermans, C Joris, Kuijper, E J, and Maassen, Catharina B M

Published
2017

44. Newly identified risk factors for MRSA carriage in The Netherlands

Author

Lekkerkerk, Sybren, Haenen, A, van der Sande, MAB, Leenstra, T, de Greeff, S, Timen, A, Tjon-A-Tsien, A, Richardus, Jan hendrik, van de Sande-Bruinsma, N, Vos, Greet, Lekkerkerk, Sybren, Haenen, A, van der Sande, MAB, Leenstra, T, de Greeff, S, Timen, A, Tjon-A-Tsien, A, Richardus, Jan hendrik, van de Sande-Bruinsma, N, and Vos, Greet

Published
2017

45. Successful control of a hospital-wide outbreak of OXA-48 producing Enterobacteriaceae in the Netherlands, 2009 to 2011

Author

Dautzenberg, M. J., Ossewaarde, J. M., de Kraker, M. E., van der Zee, A., van Burgh, S., de Greeff, S. C., Bijlmer, H. A., Grundmann, H., Stuart, J. W. Cohen, Fluit, A. C., Troelstra, A., Bonten, M. J., and Microbes in Health and Disease (MHD)

Subjects
EMERGENCE, CARBAPENEMASE-PRODUCING ENTEROBACTERIACEAE, RESISTANT KLEBSIELLA-PNEUMONIAE, INTENSIVE-CARE-UNIT, DECONTAMINATION, polycyclic compounds, DIGESTIVE-TRACT, 1ST REPORT, biochemical phenomena, metabolism, and nutrition, SPREAD, MULTIPLEX PCR, BETA-LACTAMASE
Abstract

On 31 May 2011, after notification of Klebsiella pneumoniae(KP)(OXA-48);(CTX-M-15) in two patients, nosocomial transmission was suspected in a Dutch hospital. Hospital-wide infection control measures and an outbreak investigation were initiated. A total of 72,147 patients were categorised into groups based on risk of OXA-48 colonisation or infection, and 7,527 were screened for Enterobacteriaceae(OXA-48) by polymerase chain reaction (PCR). Stored KP isolates (n=408) were retrospectively tested for OXA-48 and CTX-M-1 group extended-spectrum beta-lactamases (ESBL). 285 KP isolates from retrospective and prospective patient screening were genotyped by amplified fragment length polymorphism (AFLP). 41 isolates harbouring different Enterobacteriaceae species were analysed by plasmid multilocus sequence typing (pMLST). No nosocomial transmission of Enterobacteriaceae(OXA-48) was detected after 18 July 2011. Enterobacteriaceae(OXA-48) were found in 118 patients (KP (n=99), Escherichia coli (n=56), >= 1 Enterobacteriaceae(OXA-48) species (n=52)),of whom 21 had clinical infections. 39/41 (95%) of OXA-48 containing plasmids were identical in pMLST. Minimum inhibitory concentrations (MICs) of KPOXA-48 and E. coli(OXA-48) for imipenem and meropenem ranged from = 16 mg/L, and 153/157 (97%) had MIC >0.25mg/L for ertapenem. AFLP identified a cluster of 203 genetically linked isolates (62 KPOXA-48;(CTX-M15); 107 KPCTX-M-15; 34 KPOXA-48). The 'oldest' KPCTX-M-15 and KPOXA-48 clonal types originated from February 2009 and September 2010, respectively. The last presumed outbreak-related KPOXA-48 was detected in April 2012. Uncontrolled transmission of KP (CTX-M-15) evolved into a nosocomial outbreak of KPOXA-48; CTX-M15 with large phenotypical heterogeneity. Although the outbreak was successfully controlled, the contribution of individual containment measures and of the hospital relocating into a new building just before outbreak notification was impossible to quantify.

Published
2014

47. Risk factors for the acquisition of OXA-48-producing Enterobacteriaceae in a hospital outbreak setting: a matched case-control study

Author

Epi Infectieziekten Team 1, MMB Medische Staf, Infection & Immunity, Epi Infectieziekten, JC onderzoeksprogramma Infectieziekten, MMB, Dautzenberg, M J D, Ossewaarde, J M, de Greeff, S C, Troelstra, A, Bonten, M J M, Epi Infectieziekten Team 1, MMB Medische Staf, Infection & Immunity, Epi Infectieziekten, JC onderzoeksprogramma Infectieziekten, MMB, Dautzenberg, M J D, Ossewaarde, J M, de Greeff, S C, Troelstra, A, and Bonten, M J M

Published
2016

50. Bacteraemic and non-bacteraemic/urinary antigen-positive pneumococcal community-acquired pneumonia compared

Author

Immuno/reuma onderzoek 7 (Montfrans), Infection & Immunity, Child Health, Epi Infectieziekten Team 1, Epi Infectieziekten, JC onderzoeksprogramma Infectieziekten, van Mens, S P, van Deursen, A M M, de Greeff, S C, de Melker, H E, Schouls, L M, van der Ende, A, Bonten, M J M, Sanders, E A M, Vlaminckx, B J M, Immuno/reuma onderzoek 7 (Montfrans), Infection & Immunity, Child Health, Epi Infectieziekten Team 1, Epi Infectieziekten, JC onderzoeksprogramma Infectieziekten, van Mens, S P, van Deursen, A M M, de Greeff, S C, de Melker, H E, Schouls, L M, van der Ende, A, Bonten, M J M, Sanders, E A M, and Vlaminckx, B J M

Published
2015

Catalog

Books, media, physical & digital resources
See catalog results