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127 results on '"de Grazia, Ugo"'

2. Safety and efficacy of propranolol for treatment of familial cerebral cavernous malformations (Treat_CCM): a randomised, open-label, blinded-endpoint, phase 2 pilot trial

Author

Abete Fornara, Giorgia, Agnelli, Nicolò M., Albanese, Alessio, Awad, Issam, Bagnati, Renzo, Balconi, Giovanna, Ballabio, Elena, Beghi, Ettore, Bernasconi, Roberto, Bertani, Giulio A., Besana, Silvia, Blanda, Adriana, Bossi, Chiara, Bresolin, Nereo, Buratti, Maria G., Calabrese, Roberta, Carriero, Maria R., Castori, Marco, Ciceri, Elisa F., Ciurleo, Rossella, Comi, Giacomo P., Contarino, Valeria, Conte, Giorgio, D'Agruma, Leonardo, D'Alessandris, Giorgio Q., de Grazia, Ugo, Di Bonaventura, Rina, d'Orio, Piergiorgio, Farago', Giuseppe, Foresta, Andreana, Fusco, Carmela, Gaudino, Chiara, Lampugnani, Maria G., Lanno, Alessia, Lazzaroni, Francesca, Lee, Cornelia, Locatelli, Marco, Maggioni, Aldo P., Magnusson, Peetra, Malinverno, Matteo, Mangiavacchi, Maurizio, Mangraviti, Antonella, Marino, Silvia, Mazzola, Selene, Nicolis, Enrico B., Novelli, Deborah, Ojeda Fernandez, Maria L., Petracca, Antonio, Pignotti, Fabrizio, Pogliani, Simona, Poloni, Marco, Prelle, Alessandro, Raggi, Pamela, Raucci, Franca, Regna-Gladin, Caroline, Ronchi, Dario, Scelzo, Emma, Seyfried, Salim, Simeone, Anna, Sturiale, Carmelo L., Tassi, Laura, Tettamanti, Mauro, Torri, Valter, Tournier-Lasserve, Elisabeth, Treglia, Rita, Triulzi, Fabio M., Ungaro, Celeste, Ursi, Elison, Valcamonica, Gloria, Vasami', Antonella, Zarino, Barbara, Lanfranconi, Silvia, Scola, Elisa, Meessen, Jennifer M T A, Pallini, Roberto, Bertani, Giulio A, Al-Shahi Salman, Rustam, Dejana, Elisabetta, and Latini, Roberto

Published
2023
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4. Laser Synthesized Nanoparticles for Therapeutic Drug Monitoring

Author

Tommasini, Matteo, Zanchi, Chiara, Lucotti, Andrea, Fazio, Enza, Santoro, Marco, Spadaro, Salvatore, Neri, Fortunato, Trusso, Sebastiano, Ciusani, Emilio, de Grazia, Ugo, Casazza, Marina, Ossi, Paolo M., Hull, Robert, Series Editor, Jagadish, Chennupati, Series Editor, Kawazoe, Yoshiyuki, Series Editor, Osgood, Richard M., Series Editor, Parisi, Jürgen, Series Editor, Pohl, Udo W., Series Editor, Seong, Tae-Yeon, Series Editor, Uchida, Shin-ichi, Series Editor, Wang, Zhiming M., Series Editor, Kruzic, Jamie, Series Editor, and Ossi, Paolo M., editor

Published
2018
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5. Modern Green Extraction Techniques

Author

Locatelli, Marcello, primary, Rosato, Enrica, additional, D'Ovidio, Cristian, additional, Bonelli, Martina, additional, Ulusoy, HalilIbrahim, additional, Kabir, Abuzar, additional, Ali, Imran, additional, Savini, Fabio, additional, de Grazia, Ugo, additional, Samanidou, Victoria, additional, and Tartaglia, Angela, additional

Published
2023
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7. Quantitative Analysis of Cenobamate and Concomitant Anti-Seizure Medications in Human Plasma via Ultra-High Performance Liquid Chromatography–Tandem Mass Spectrometry.

Author

Molteni, Linda, Charlier, Bruno, Coglianese, Albino, Izzo, Viviana, Assenza, Giovanni, Menna, Pierantonio, de Grazia, Ugo, and D'Urso, Annachiara

Subjects
LIQUID chromatography-mass spectrometry, ANTICONVULSANTS, SEIZURES (Medicine), DRUG monitoring, MATRIX effect, PEOPLE with epilepsy, MASS transfer coefficients
Abstract

Cenobamate (CNB) is a new anti-seizure medication (ASM) recently introduced in clinical practice after approval by the FDA and EMA for the add-on treatment of focal onset seizures in adult patients. Although its mechanism of action has not been fully understood, CNB showed promising clinical efficacy in patients treated with concomitant ASMs. The accessibility of CNB could pave a way for the treatment of refractory or drug-resistant epilepsies, which still affect at least one-third of the patients under pharmacological treatment. In this context, therapeutic drug monitoring (TDM) offers a massive opportunity for better management of epileptic patients, especially those undergoing combined therapy. Here, we describe the first fully validated ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC–MS/MS) method for the quantification of CNB and concomitant ASMs in human plasma, with samples extracted either manually or by means of a liquid handler. Our method was validated according to the most recent ICH International Guideline M10 for Bioanalytical Method Validation and Study Sample Analysis. The method proved to be selective for CNB and displayed a linear range from 0.8 to 80 mg/L; no matrix effect was found (98.2 ± 4.1%), while intra-day and inter-day accuracy and precision were within the acceptance range. Also, CNB short- and long-term stability in plasma under different conditions was assessed. Leftover human plasma samples were employed as study samples for method validation. Our method proved to be highly sensitive and selective to quantify CNB and concomitant ASMs in human plasma; therefore, this method can be employed for a routinely TDM-based approach to support physicians in the management of an epileptic patient. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Development and Validation of a New LC-MS/MS Bioanalytical Method for the Simultaneous Determination of Levodopa, Levodopa Methyl Ester, and Carbidopa in Human Plasma Samples

Author

Molteni, Linda, primary, Charlier, Bruno, additional, Izzo, Viviana, additional, Coglianese, Albino, additional, Conti, Valeria, additional, Eleopra, Roberto, additional, Cilia, Roberto, additional, Capelli, Chiara, additional, D’Urso, Annachiara, additional, and de Grazia, Ugo, additional

Published
2023
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12. Laser Synthesized Nanoparticles for Therapeutic Drug Monitoring

Author

Tommasini, Matteo, primary, Zanchi, Chiara, additional, Lucotti, Andrea, additional, Fazio, Enza, additional, Santoro, Marco, additional, Spadaro, Salvatore, additional, Neri, Fortunato, additional, Trusso, Sebastiano, additional, Ciusani, Emilio, additional, de Grazia, Ugo, additional, Casazza, Marina, additional, and Ossi, Paolo M., additional

Published
2018
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13. LC-MS/MS Application in Pharmacotoxicological Field: Current State and New Applications

Author

D’Ovidio, Cristian, primary, Locatelli, Marcello, additional, Perrucci, Miryam, additional, Ciriolo, Luigi, additional, Furton, Kenneth G., additional, Gazioglu, Isil, additional, Kabir, Abuzar, additional, Merone, Giuseppe Maria, additional, de Grazia, Ugo, additional, Ali, Imran, additional, Catena, Antonio Maria, additional, Treglia, Michele, additional, Marsella, Luigi T., additional, and Savini, Fabio, additional

Published
2023
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15. Safety and efficacy of propranolol for treatment of familial cerebral cavernous malformations (Treat_CCM): a randomised, open-label, blinded-endpoint, phase 2 pilot trial

Author

Lanfranconi, Silvia, primary, Scola, Elisa, additional, Meessen, Jennifer M T A, additional, Pallini, Roberto, additional, Bertani, Giulio A, additional, Al-Shahi Salman, Rustam, additional, Dejana, Elisabetta, additional, Latini, Roberto, additional, Abete Fornara, Giorgia, additional, Agnelli, Nicolò M., additional, Albanese, Alessio, additional, Awad, Issam, additional, Bagnati, Renzo, additional, Balconi, Giovanna, additional, Ballabio, Elena, additional, Beghi, Ettore, additional, Bernasconi, Roberto, additional, Bertani, Giulio A., additional, Besana, Silvia, additional, Blanda, Adriana, additional, Bossi, Chiara, additional, Bresolin, Nereo, additional, Buratti, Maria G., additional, Calabrese, Roberta, additional, Carriero, Maria R., additional, Castori, Marco, additional, Ciceri, Elisa F., additional, Ciurleo, Rossella, additional, Comi, Giacomo P., additional, Contarino, Valeria, additional, Conte, Giorgio, additional, D'Agruma, Leonardo, additional, D'Alessandris, Giorgio Q., additional, de Grazia, Ugo, additional, Di Bonaventura, Rina, additional, d'Orio, Piergiorgio, additional, Farago', Giuseppe, additional, Foresta, Andreana, additional, Fusco, Carmela, additional, Gaudino, Chiara, additional, Lampugnani, Maria G., additional, Lanno, Alessia, additional, Lazzaroni, Francesca, additional, Lee, Cornelia, additional, Locatelli, Marco, additional, Maggioni, Aldo P., additional, Magnusson, Peetra, additional, Malinverno, Matteo, additional, Mangiavacchi, Maurizio, additional, Mangraviti, Antonella, additional, Marino, Silvia, additional, Mazzola, Selene, additional, Nicolis, Enrico B., additional, Novelli, Deborah, additional, Ojeda Fernandez, Maria L., additional, Petracca, Antonio, additional, Pignotti, Fabrizio, additional, Pogliani, Simona, additional, Poloni, Marco, additional, Prelle, Alessandro, additional, Raggi, Pamela, additional, Raucci, Franca, additional, Regna-Gladin, Caroline, additional, Ronchi, Dario, additional, Scelzo, Emma, additional, Seyfried, Salim, additional, Simeone, Anna, additional, Sturiale, Carmelo L., additional, Tassi, Laura, additional, Tettamanti, Mauro, additional, Torri, Valter, additional, Tournier-Lasserve, Elisabeth, additional, Treglia, Rita, additional, Triulzi, Fabio M., additional, Ungaro, Celeste, additional, Ursi, Elison, additional, Valcamonica, Gloria, additional, Vasami', Antonella, additional, and Zarino, Barbara, additional

Published
2023
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19. Analytical Chemistry: Tasks, Resolutions and Future Standpoints of the Quantitative Analyses of Environmental Complex Sample Matrices

Author

Rosato, Enrica, primary, Merone, Giuseppe Maria, additional, Locatelli, Marcello, additional, D’Ovidio, Cristian, additional, Bonelli, Martina, additional, de Grazia, Ugo, additional, Santavenere, Francesco, additional, Rossi, Sandra, additional, Ali, Imran, additional, Ulusoy, Halil Ibrahim, additional, Kabir, Abuzar, additional, and Savini, Fabio, additional

Published
2022
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20. Indicazioni per l’armonizzazione degli intervalli di riferimento nel monitoraggio terapeutico di farmaci antiepilettici.

Author

de Grazia, Ugo, Menna, Pierantonio, Cantù, Marco, Baldelli, Sara, Goffredo, Bianca Maria, and Deleo, Francesco

Abstract

Therapeutic monitoring (TDM) of antiepileptic drugs (AEDs), or antiseizure medicines (ASMs) represents a pragmatic approach to the management of patients with epilepsy to assess either compliance, efficacy and toxicity. Dose adjustments based on drug concentrations detected in biological fluids allow physicians to optimize and personalize the pharmacologic regimens for the single patient. TDM of AEDs has become increasingly popular since the 1970s because it is difficult to identify the optimal drug dose for each patient and because AEDs concentrations correlate better than dose with clinical effects. This document aims to suggest reference intervals to harmonize the pharmacokinetic activity among Italian Laboratories in the monitoring of AEDs plasma exposures according to recent international literature and guidelines. [ABSTRACT FROM AUTHOR]

Published
2023
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21. LC-MS/MS Application in Pharmacotoxicological Field: Current State and New Applications.

Author

D'Ovidio, Cristian, Locatelli, Marcello, Perrucci, Miryam, Ciriolo, Luigi, Furton, Kenneth G., Gazioglu, Isil, Kabir, Abuzar, Merone, Giuseppe Maria, de Grazia, Ugo, Ali, Imran, Catena, Antonio Maria, Treglia, Michele, Marsella, Luigi T., and Savini, Fabio

Subjects
LIQUID chromatography-mass spectrometry, PREDICATE calculus, DRUG monitoring, DRUGS of abuse, FORENSIC genetics
Abstract

Nowadays, it is vital to have new, complete, and rapid methods to screen and follow pharmacotoxicological and forensic cases. In this context, an important role is undoubtedly played by liquid chromatography-tandem mass spectrometry (LC-MS/MS) thanks to its advanced features. This instrument configuration can offer comprehensive and complete analysis and is a very potent analytical tool in the hands of analysts for the correct identification and quantification of analytes. The present review paper discusses the applications of LC-MS/MS in pharmacotoxicological cases because it is impossible to ignore the importance of this powerful instrument for the rapid development of pharmacological and forensic advanced research in recent years. On one hand, pharmacology is fundamental for drug monitoring and helping people to find the so-called "personal therapy" or "personalized therapy". On the other hand, toxicological and forensic LC-MS/MS represents the most critical instrument configuration applied to the screening and research of drugs and illicit drugs, giving critical support to law enforcement. Often the two areas are stackable, and for this reason, many methods include analytes attributable to both fields of application. In this manuscript, drugs and illicit drugs were divided in separate sections, with particular attention paid in the first section to therapeutic drug monitoring (TDM) and clinical approaches with a focus on central nervous system (CNS). The second section is focused on the methods developed in recent years for the determination of illicit drugs, often in combination with CNS drugs. All references considered herein cover the last 3 years, except for some specific and peculiar applications for which some more dated but still recent articles have been considered. [ABSTRACT FROM AUTHOR]

Published
2023
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22. Novel Applications of Microextraction Techniques Focused on Biological and Forensic Analyses

Author

D’Ovidio, Cristian, primary, Bonelli, Martina, additional, Rosato, Enrica, additional, Tartaglia, Angela, additional, Ulusoy, Halil İbrahim, additional, Samanidou, Victoria, additional, Furton, Kenneth G., additional, Kabir, Abuzar, additional, Ali, Imran, additional, Savini, Fabio, additional, Locatelli, Marcello, additional, and de Grazia, Ugo, additional

Published
2022
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36. Novel MIPs-Parabens based SPE Stationary Phases Characterization and Application

Author

Tartaglia, Angela, primary, Kabir, Abuzar, additional, Ulusoy, Songul, additional, Ulusoy, Halil Ibrahim, additional, Merone, Giuseppe Maria, additional, Savini, Fabio, additional, D’Ovidio, Cristian, additional, de Grazia, Ugo, additional, Gabrielli, Serena, additional, Maroni, Fabio, additional, Bruni, Pantaleone, additional, Croce, Fausto, additional, Melucci, Dora, additional, Furton, Kenneth G., additional, and Locatelli, Marcello, additional

Published
2019
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38. Laser-Synthesized SERS Substrates as Sensors toward Therapeutic Drug Monitoring

Author

Tommasini, Matteo, primary, Zanchi, Chiara, additional, Lucotti, Andrea, additional, Bombelli, Alessandro, additional, Villa, Nicolò S., additional, Casazza, Marina, additional, Ciusani, Emilio, additional, de Grazia, Ugo, additional, Santoro, Marco, additional, Fazio, Enza, additional, Neri, Fortunato, additional, Trusso, Sebastiano, additional, and Ossi, Paolo M., additional

Published
2019
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39. An explanation for the neutral effect of DR2 on IDDM susceptibility in central Italy

Author

Sorrentino, Rosa, De Grazia, Ugo, Buzzetti, Raffaella, Nistico, Lorenza, Iannicola, Carlo, Costanzi, Sandro, and Tosi, Roberto

Subjects
HLA histocompatibility antigens -- Physiological aspects, Italians -- Genetic aspects -- Physiological aspects, Type 1 diabetes -- Genetic aspects, Histocompatibility antigens -- Physiological aspects, Health, Physiological aspects, Genetic aspects
Abstract

Susceptibility to IDDM is strongly associated with HLA. Some HLA allelic combinations (haplotypes) can be found in most patients, whereas other haplotypes are encountered only rarely. It has been proposed [...]

Published
1992

45. Human neural stem cells express extra-neural markers

Author

Parati, Eugenio A, primary, Bez, Alessandra, additional, Ponti, Dario, additional, de Grazia, Ugo, additional, Corsini, Elena, additional, Cova, Lidia, additional, Sala, Simona, additional, Colombo, Augusto, additional, Alessandri, Giulio, additional, and Pagano, Stefano F, additional

Published
2002
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49. Novel Applications of Microextraction Techniques Focused on Biological and Forensic Analyses.

Author

D'Ovidio, Cristian, Bonelli, Martina, Rosato, Enrica, Tartaglia, Angela, Ulusoy, Halil İbrahim, Samanidou, Victoria, Furton, Kenneth G., Kabir, Abuzar, Ali, Imran, Savini, Fabio, Locatelli, Marcello, and de Grazia, Ugo

Subjects
FORENSIC mass spectrometry, SOLID phase extraction, LIQUID-liquid extraction, TOXICOLOGY, FOOD science
Abstract

In recent years, major attention has been focused on microextraction procedures that allow high recovery of target analytes, regardless of the complexity of the sample matrices. The most used techniques included liquid-liquid extraction (LLE), solid-phase extraction (SPE), solid-phase microextraction (SPME), dispersive liquid-liquid microextraction (DLLME), microextraction by packed sorbent (MEPS), and fabric-phase sorptive extraction (FPSE). These techniques manifest a rapid development of sample preparation techniques in different fields, such as biological, environmental, food sciences, natural products, forensic medicine, and toxicology. In the biological and forensic fields, where a wide variety of drugs with different chemical properties are analyzed, the sample preparation is required to make the sample suitable for the instrumental analysis, which often includes gas chromatography (GC) and liquid chromatography (LC) coupled with mass detectors or tandem mass detectors (MS/MS). In this review, we have focused our attention on the biological and forensic application of these innovative procedures, highlighting the major advantages and results that have been accomplished in laboratory and clinical practice. [ABSTRACT FROM AUTHOR]

Published
2022
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50. Therapeutic Drug Monitoring of Antiseizure Medications Using Volumetric Absorptive Microsampling: Where Are We?

Author

D'Urso, Annachiara, Locatelli, Marcello, Tartaglia, Angela, Molteni, Linda, D'Ovidio, Cristian, Savini, Fabio, Rudge, James, and de Grazia, Ugo

Subjects
DRUG monitoring, DRUGS, DRUG interactions, BLOOD sampling, PUBLISHED articles
Abstract

Therapeutic drug monitoring (TDM) of antiseizure medications (ASMs) represents a valuable tool to establish an appropriate patient therapy, to collect important information about drugs' interactions and to evaluate patient's metabolic capabilities. In recent years, a new volumetric absorptive microsampling technique using VAMS® technology and Mitra® devices, consisting of a sampling technique for the collection of fixed-volume capillary blood, was developed. These new devices provide a new home-sampling technique for whole blood that has been spread out to simplify sample collection from finger-pricks. This review is aimed to compare published articles concerning the application of VAMS® in epilepsy and to identify the strengths and improvement points for the TDM of antiseizure medications. VAMS® allowed a minimally invasive blood sampling even in the absence of trained personnel. Good stability data have indicated that storage and delivery can be facilitated only for specific ASMs. Trueness and precision parameters have been evaluated, and the hematocrit (HCT) effect was minimized. [ABSTRACT FROM AUTHOR]

Published
2021
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