26 results on '"de Giorgi, I."'
Search Results
2. Anxiety and Depression (Hospital Anxiety and Depression Scale) in a group of patients affected by myofascial facial pain compared to healthy subjects
- Author
-
Deregibus, Andrea Piero, De Santis, F., De Giorgi, I., Castelli, Lorys, Comba, B., Piancino, M. G., Debernardi, Cesare Lorenzo, and Torta, Riccardo
- Published
- 2012
3. Ansia, depressione e rabbia in pazienti con dolore miofasciale facciale
- Author
-
De Santis, F., Castelli, Lorys, De Giorgi, I., Deregibus, Andrea Piero, Tesio, Valentina, Leombruni, Paolo, Debernardi, Cesare Lorenzo, and Torta, Riccardo
- Published
- 2012
4. Utilisation des laxatifs à l'Hôpital
- Author
-
Dao, Kim, Renard, Delphine, Livio , Françoise, Buclin, Thierry, and De Giorgi , I
- Published
- 2012
5. Evaluation algorithm of the priorities for the planned of the Radiological Equipment
- Author
-
Coppola, V., Molese, V., Alfinito, M., De Giorgi, I., Vallone, G., GATTA, Gianluca, V. Coppola, V. Molese, M. Alfinito, G. Gatta, I. De Giorgi, G. Vallone, Coppola, V., Molese, V., Alfinito, M., Gatta, Gianluca, De Giorgi, I., and Vallone, G.
- Published
- 1997
6. Evaluation of inappropriate prescribing in geriatric psychiatry
- Author
-
Weibel, M.-L., primary, Mall, J.-F., additional, Voirol, P., additional, Pannatier, A., additional, von Gunten, A., additional, Saiah, L., additional, and De Giorgi, I., additional
- Published
- 2014
- Full Text
- View/download PDF
7. Évaluation de l’impact d’un pharmacien clinicien sur la prescription médicamenteuse inappropriée en psychiatrie de l’âge avancé
- Author
-
Hannou, S., primary, Pannatier, A., additional, De Boer, E., additional, von Gunten, A., additional, Voirol, P., additional, Mall, J.-F., additional, and De Giorgi, I., additional
- Published
- 2014
- Full Text
- View/download PDF
8. Could different TMJ disc positions observed in MRI cause different sounds? Analysis on a group of subjects with ADD with reduction: a pilot study
- Author
-
Deregibus, A., primary, Castroflorio, T., additional, De Giorgi, I., additional, Burzio, C., additional, and Debernardi, C., additional
- Published
- 2014
- Full Text
- View/download PDF
9. CP-076 Effects of pharmacist interventions on inappropriate prescribing in a geriatric psychiatry unit
- Author
-
Hannou, S, primary, Pannatier, A, additional, Von Gunten, A, additional, Voirol, P, additional, Mall, JF, additional, De Giorgi, I, additional, and De Boer, E, additional
- Published
- 2014
- Full Text
- View/download PDF
10. Cognitive development in Dravet syndrome: a retrospective, multicenter study of 26 patients
- Author
-
Ragona, F, Granata, T, Dalla Bernardina, B, Offredi, F, Darra, F, Battaglia, Domenica Immacolata, Morbi, Ma, Brazzo, D, Cappelletti, S, Chieffo, Daniela Pia Rosaria, De Giorgi, I, Fontana, E, Freri, E, Marini, C, Toraldo, A, Specchio, N, Veggiotti, P, Vigevano, F, Guerrini, R, Guzzetta, Francesco, Dravet, C., Battaglia, Domenica Immacolata (ORCID:0000-0003-0491-4021), Chieffo, D, Ragona, F, Granata, T, Dalla Bernardina, B, Offredi, F, Darra, F, Battaglia, Domenica Immacolata, Morbi, Ma, Brazzo, D, Cappelletti, S, Chieffo, Daniela Pia Rosaria, De Giorgi, I, Fontana, E, Freri, E, Marini, C, Toraldo, A, Specchio, N, Veggiotti, P, Vigevano, F, Guerrini, R, Guzzetta, Francesco, Dravet, C., Battaglia, Domenica Immacolata (ORCID:0000-0003-0491-4021), and Chieffo, D
- Abstract
To clarify the role of epilepsy and genetic background in determining the cognitive outcome of patients with Dravet syndrome.
- Published
- 2011
11. Diagnostic concordance between MRI and electrovibratography of the temporomandibular joint of subjects with disc displacement disorders
- Author
-
Deregibus, A, primary, Castroflorio, T, additional, De Giorgi, I, additional, Burzio, C, additional, and Debernardi, C, additional
- Published
- 2013
- Full Text
- View/download PDF
12. Risk and pharmacoeconomic analyses of the injectable medication process in the paediatric and neonatal intensive care units
- Author
-
De Giorgi, I., primary, Fonzo-Christe, C., additional, Cingria, L., additional, Caredda, B., additional, Meyer, V., additional, Pfister, R. E., additional, and Bonnabry, P., additional
- Published
- 2010
- Full Text
- View/download PDF
13. Sterility validity period of vials after multiple sampling under vertical laminar airflow hood
- Author
-
De Giorgi, I, primary, Sadeghipour, F, additional, Favet, J, additional, and Bonnabry, P, additional
- Published
- 2005
- Full Text
- View/download PDF
14. Electroclinical features and long-term outcome of cryptogenic epilepsy in children with down syndrome
- Author
-
Caterina Cerminara, Giangennaro Coppola, Pasquale Striano, Salvatore Grosso, Paolo Curatolo, Raffaella Cusmai, Lucio Giordano, Salvatore Savasta, Emilio Franzoni, Antonella Pizzolorusso, Antonino Romeo, Pasquale Parisi, Ilaria De Giorgi, Alberto Spalice, Francesco Nicita, Elisabetta Cesaroni, Piero Pavone, Alberto Verrotti, Tiziana Granata, Maurizio Elia, Nelia Zamponi, Verrotti A, Cusmai R, Nicita F, Pizzolorusso A, Elia M, Zamponi N, Cesaroni E, Granata T, De Giorgi I, Giordano L, Grosso S, Pavone P, Franzoni E, Coppola G, Cerminara C, Curatolo P, Savasta S, Striano P, Parisi P, Romeo A, and Spalice A.
- Subjects
Male ,Pediatrics ,Levetiracetam ,Time Factors ,cryptogenetic epilepsy ,Lennox-Gastaut syndrome ,PS ,CLZ ,FBM ,Clonazepam ,Epilepsy ,ACTH ,AED ,Adrenocorticotropic hormone ,Antiepileptic drug ,CBZ ,Carbamazepine ,EEG ,Electroencephalography ,Felbamate ,GS ,Generalized seizures ,IS ,Infantile spasms ,LEV ,LGS ,NS ,Not significant ,Partial seizures ,VGB ,VPA ,Valproic acid ,Vigabatrin ,Adolescent ,Anticonvulsants ,Child ,Child, Preschool ,Down Syndrome ,Female ,Humans ,Infant ,Retrospective Studies ,Pediatrics, Perinatology and Child Health ,Valproic Acid ,Perinatology and Child Health ,ACTH, AED, Adrenocorticotropic hormone, Antiepileptic drug, CBZ, CLZ, Carbamazepine, Clonazepam, EEG, Electroencephalography, FBM, Felbamate, GS, Generalized seizures ,Anesthesia ,medicine.drug ,acth ,aed ,adrenocorticotropic hormone ,antiepileptic drug ,cbz ,clz ,carbamazepine ,clonazepam ,eeg ,electroencephalography ,fbm ,felbamate ,gs ,generalized seizures ,is ,infantile spasms ,lev ,lgs ,lennox-gastaut syndrome ,levetiracetam ,ns ,not significant ,ps ,partial seizures ,vgb ,vpa ,valproic acid ,vigabatrin ,adolescent ,anticonvulsants ,child ,preschool ,down syndrome ,epilepsy ,female ,humans ,infant ,male ,retrospective studies ,time factors ,pediatrics ,perinatology and child health ,Down syndrome ,medicine.medical_specialty ,electroclinical features ,medicine ,Preschool ,business.industry ,medicine.disease ,business ,Lennox–Gastaut syndrome - Abstract
OBJECTIVE: To describe the electroclinical features and the long-term outcomes of epilepsy in a large cohort of males and females with Down syndrome who developed epilepsy in childhood. STUDY DESIGN: Subjects with Down syndrome and cryptogenic epilepsy with onset in childhood were identified retrospectively from the databases of 16 Italian epilepsy centers over a 40-year period. For each subject, age at onset of seizures, seizure semiology and frequency, electroencephalography characteristics, treatment with antiepileptic drugs, and long-term clinical and electroencephalography outcomes were analyzed. RESULTS: A total of 104 subjects (64 males [61.5%], 40 females [38.5%]) were identified. Seizure onset occurred within 1 year of birth in 54 subjects (51.9%), between 1 and 12 years in 42 subjects (40.4%), and after 12 years in 8 subjects (7.7%). Males had a younger age of seizure onset than females. Of the 104 subjects, 51 (49.0%) had infantile spasms (IS), 35 (33.7%) had partial seizures (PS), and 18 (17.3%) had generalized seizures (GS). Febrile seizures were recorded in 5 (4.8%) subjects. Intractable seizures were observed in 23 (22.1%) subjects, including 5 (9.8%) with IS, 8 (44.4%) with PS, and 10 (31.3%) with GS. CONCLUSION: Cryptogenic epilepsy in Down syndrome may develop during the first year of life in the form of IS or, successively, as PS or GS. Electroclinical features of IS resemble those of idiopathic West syndrome, with a favorable response to treatment with adrenocorticotropic hormone seen. Patients experiencing PS and GS may be resistant to therapy with antiepileptic drugs
- Published
- 2013
15. Borderline personality disorder and aggressive behavior: A study based on the DSM-5 alternative model.
- Author
-
Leucci AC, De Giorgi I, Pelizza L, Bortolotti B, D'Adda F, Gammino L, Gibiino S, Lia L, Magro M, Pellegrini L, and Menchetti M
- Subjects
- Adult, Humans, Aggression, Personality Disorders, Hostility, Anger, Diagnostic and Statistical Manual of Mental Disorders, Personality Inventory, Borderline Personality Disorder psychology
- Abstract
Introduction: Unplanned reactive aggressive acts are a clinical feature of particular interest in patients with borderline personality disorder (BPD). The early identification of personality traits correlated to aggressive behavior is certainly desirable in BDP populations. This study analyzes a clinical sample of 122 adult outpatients with BPD referred to Adult Mental Health Services of the Department of Mental Health of Bologna, in Italy., Methods: The study examines the relationship with personality facets of the DSM-5 alternative model for personality disorders (AMPD), Personality Inventory for DSM (PID-5), with respect to the four main components of aggression measured by the Aggression Questionnaire (AQ): hostility, anger, verbal and physical aggression. Using robust regression models, the relationships between PID-5 facets and domains and the aggression components under consideration were identified., Results: Verbal and physical aggression in our sample of BPD outpatients is mainly associated to PID-5 antagonism domain. Physically aggressive behavior is also related to callousness facet., Conclusions: The traits most consistently associated with aggression were the domain of Antagonism and the facet of Hostility. The study findings highlight the need for clinicians working with individuals with BPD to pay particular attention to traits of hostility, callousness, and hostility to understand aggression., Competing Interests: Declaration of competing interest None., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
16. Does occlusal splint affect posture? A randomized controlled trial.
- Author
-
De Giorgi I DDS, Castroflorio T DDS, PhD, Cugliari G MSc, and Deregibus A MD, DDS, PhD
- Subjects
- Female, Humans, Occlusal Splints, Posture, Lordosis, Temporomandibular Joint Disorders
- Abstract
Objective: The aim of this study was to evaluate the effect of an occlusal splint on body posture of intra-articular temporomandibular joint (TMJ) disorders patients., Methods: The study was performed on 45 women affected by TMJ disorders divided into an occlusal splint group and a control group. Rasterstereographic recordings were performed at baseline and after 1, 3, and 6 months, in order to analyze the following postural parameters: trunk inclination, cervical and lumbar arrows, kyphotic and lordotic angles, trunk imbalance, pelvic tilt and torsion., Results: Regarding the postural parameters in the intragroup analysis, no significant differences were detected. The analysis between the two groups revealed significant differences concerning the cervical arrow, the kyphotic and lordotic angles., Discussion: Even if some differences were found between the control and the occlusal splint group, the low range of statistical significance made these results not significant from a clinical point of view.
- Published
- 2020
- Full Text
- View/download PDF
17. Assessment of acute myocarditis by cardiac magnetic resonance imaging: Comparison of qualitative and quantitative analysis methods.
- Author
-
Imbriaco M, Nappi C, Puglia M, De Giorgi M, Dell'Aversana S, Cuocolo R, Ponsiglione A, De Giorgi I, Polito MV, Klain M, Piscione F, Pace L, and Cuocolo A
- Subjects
- Acute Disease, Adult, Cohort Studies, Coronary Angiography, Female, Humans, Male, Middle Aged, Myocarditis complications, Myocarditis physiopathology, Predictive Value of Tests, ROC Curve, Stroke Volume, Symptom Assessment, Magnetic Resonance Imaging methods, Myocarditis diagnostic imaging
- Abstract
Background: To compare cardiac magnetic resonance (CMR) qualitative and quantitative analysis methods for the noninvasive assessment of myocardial inflammation in patients with suspected acute myocarditis (AM)., Methods: A total of 61 patients with suspected AM underwent coronary angiography and CMR. Qualitative analysis was performed applying Lake-Louise Criteria (LLC), followed by quantitative analysis based on the evaluation of edema ratio (ER) and global relative enhancement (RE). Diagnostic performance was assessed for each method by measuring the area under the curves (AUC) of the receiver operating characteristic analyses. The final diagnosis of AM was based on symptoms and signs suggestive of cardiac disease, evidence of myocardial injury as defined by electrocardiogram changes, elevated troponin I, exclusion of coronary artery disease by coronary angiography, and clinical and echocardiographic follow-up at 3 months after admission to the chest pain unit., Results: In all patients, coronary angiography did not show significant coronary artery stenosis. Troponin I levels and creatine kinase were higher in patients with AM compared to those without (both P < .001). There were no significant differences among LLC, T2-weighted short inversion time inversion recovery (STIR) sequences, early (EGE), and late (LGE) gadolinium-enhancement sequences for diagnosis of AM. The AUC for qualitative (T2-weighted STIR 0.92, EGE 0.87 and LGE 0.88) and quantitative (ER 0.89 and global RE 0.80) analyses were also similar., Conclusions: Qualitative and quantitative CMR analysis methods show similar diagnostic accuracy for the diagnosis of AM. These findings suggest that a simplified approach using a shortened CMR protocol including only T2-weighted STIR sequences might be useful to rule out AM in patients with acute coronary syndrome and normal coronary angiography.
- Published
- 2019
- Full Text
- View/download PDF
18. Postural changes in orthodontic patients treated with clear aligners: A rasterstereographic study.
- Author
-
Parrini S, Comba B, Rossini G, Ravera S, Cugliari G, De Giorgi I, Deregibus A, and Castroflorio T
- Subjects
- Female, Humans, Male, Spinal Curvatures etiology, Spine diagnostic imaging, Young Adult, Malocclusion therapy, Orthodontic Brackets adverse effects, Posture, Spinal Curvatures epidemiology
- Abstract
Background: Correlation between malocclusions and body posture has been discussed in the last decades, but there is still a lack of consensus in existing literature. Rasterstereography allows tridimensional reconstruction of the spine, starting from the back surface analysis. So far studies which tested modifications of rasterstereographic parameters during orthodontic treatment, comparing with those obtained from untreated control group, are not available. Clear aligner treatment produces alteration of vertical height due to the occlusal coverage and, subsequently, a stimulation of periodontal receptors which causes an inhibition of the jaw closing muscles and, hypothetically, changes in mandibular posture., Objectives: Evaluate possible correlations between orthodontic treatment and posture., Materials and Methods: Rasterstereographic values of 15 untreated patients and of 15 patients treated with clear aligners were compared at baseline, after 1, 3 and 6 months. Rasterstereographic parameters considered were the following: the kyphotic angle, the lordotic angle, the upper thoracic inclination, and the pelvic inclination., Results: Correlations between Kyphosis Angle, Upper Toracic Inclination and Pelvic Inclination and body posture were found after 6 months of treatment with clear aligners., Conclusions: Occlusal coverage caused by aligners could influence body posture not only for upper spine sections but also lower spine sections., (Copyright © 2017 Elsevier Ltd. All rights reserved.)
- Published
- 2018
- Full Text
- View/download PDF
19. The use of conventional transcutaneous electrical nerve stimulation in chronic facial myalgia patients.
- Author
-
De Giorgi I, Castroflorio T, Sartoris B, and Deregibus A
- Subjects
- Adult, Female, Humans, Middle Aged, Pain Measurement, Palpation, Treatment Outcome, Chronic Pain therapy, Facial Pain therapy, Myalgia therapy, Transcutaneous Electric Nerve Stimulation
- Abstract
Objectives: The aim of this study was to evaluate the efficacy of conventional TENS in women affected by chronic facial myalgia., Materials and Methods: The study was performed on 49 women affected by chronic facial myalgia randomly allocated in the TENS group (34 women) and the control group (15 women). The subjective level of pain was assessed by the Visual Analogue Scale indicating the mean (VAS MEAN), the maximum (VAS MAX) and the current intensity of pain (VAS NOW). The level of pain at the muscular palpation sites was assessed by the Pericranial Muscle Tenderness Score (PTS) and the Cervical Muscle Tenderness Score (CTS). The TENS therapy lasted for 10 weeks, and data were collected at baseline, after 5, 10, 15 and 25 weeks. The differences between groups before and after treatment were compared with the Mann-Whitney and the Kolmogorov-Smirnov tests. The intra-group differences were compared with the one-way ANOVA test., Results: The results showed that the VAS MEAN, VAS MAX, PTS and CTS were significantly reduced in the TENS group compared to the control group after 10 weeks of TENS (p < 0.05). The intra-group analysis revealed a decreasing tendency of VAS MEAN, VAS MAX, VAS NOW, PTS and CTS in the TENS group in a 25-week period (p < 0.05)., Conclusions: The study demonstrated the efficacy of conventional TENS in patients with chronic facial myalgia and the decrease in both subjective and objective pain., Clinical Relevance: Conventional TENS is a safe, non-invasive, easy-to-administer therapy for chronic facial myalgia.
- Published
- 2017
- Full Text
- View/download PDF
20. Symptomatic and presumed symptomatic focal epilepsies in childhood: An observational, prospective multicentre study.
- Author
-
Vecchi M, Barba C, De Carlo D, Stivala M, Guerrini R, Albamonte E, Ranalli D, Battaglia D, Lunardi G, Boniver C, Piccolo B, Pisani F, Cantalupo G, Nieddu G, Casellato S, Cappanera S, Cesaroni E, Zamponi N, Serino D, Fusco L, Iodice A, Palestra F, Giordano L, Freri E, De Giorgi I, Ragona F, Granata T, Fiocchi I, Bova SM, Mastrangelo M, Verrotti A, Matricardi S, Fontana E, Caputo D, Darra F, Dalla Bernardina B, Beccaria F, Capovilla G, Baglietto MP, Gagliardi A, Vignoli A, Canevini MP, Perissinotto E, and Francione S
- Subjects
- Adolescent, Age Distribution, Child, Child, Preschool, Cognition Disorders diagnosis, Cohort Studies, Electroencephalography, Epilepsies, Partial diagnostic imaging, Female, Humans, Infant, Infant, Newborn, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Prospective Studies, Brain diagnostic imaging, Cognition Disorders etiology, Epilepsies, Partial complications
- Abstract
Objective: To describe the clinical, neuropsychological, and psychopathologic features of a cohort of children with a new diagnosis of symptomatic or presumed symptomatic focal epilepsy at time of recruitment and through the first month. The selected population will be followed for 2-5 years after enrollment to investigate the epilepsy course and identify early predictors of drug resistance., Methods: In this observational, multicenter, nationwide study, children (age 1 month-12.9 years) with a new diagnosis of symptomatic or presumed symptomatic focal epilepsy were consecutively enrolled in 15 Italian tertiary childhood epilepsy centers. Inclusion criteria were as follows: (1) diagnosis of symptomatic focal epilepsy due to acquired and developmental etiologies, and presumed symptomatic focal epilepsy; (2) age at diagnosis older than 1 month and <13 years; and (3) written informed consent. Children were subdivided into three groups: ≤3 years, >3 to 6 years, and >6 years. Clinical, electroencephalography (EEG), neuroimaging, and neuropsychological variables were identified for statistical analyses., Results: Two hundred fifty-nine children were enrolled (116 female and 143 male). Median age: 4.4 years (range 1 month-12.9 years); 46.0% (n = 119) of children were younger than 3 years, 24% (61) from 3 to 6 years of age, and 30% (79) older than 6 years. Neurologic examination findings were normal in 71.8%. Brain magnetic resonance imaging (MRI) was abnormal in 59.9%. Children age ≤3 years experienced the highest seizure frequency in the first month after recruitment (p < 0.0001). Monotherapy in the first month was used in 67.2%. Cognitive tests at baseline revealed abnormal scores in 30%; behavioral problems were present in 21%. At multivariate analysis, higher chances to exhibit more than five seizures in the first month after epilepsy onset was confirmed for younger children and those with temporal lobe epilepsy., Significance: In this prospective cohort study, an extensive characterization of epilepsy onset in children with symptomatic or presumed symptomatic focal epilepsies is reported in relation to the age group and the localization of the epileptogenic zone., (Wiley Periodicals, Inc. © 2016 International League Against Epilepsy.)
- Published
- 2016
- Full Text
- View/download PDF
21. Electroclinical features and long-term outcome of cryptogenic epilepsy in children with Down syndrome.
- Author
-
Verrotti A, Cusmai R, Nicita F, Pizzolorusso A, Elia M, Zamponi N, Cesaroni E, Granata T, De Giorgi I, Giordano L, Grosso S, Pavone P, Franzoni E, Coppola G, Cerminara C, Curatolo P, Savasta S, Striano P, Parisi P, Romeo A, and Spalice A
- Subjects
- Adolescent, Anticonvulsants therapeutic use, Child, Child, Preschool, Electroencephalography, Epilepsy drug therapy, Female, Humans, Infant, Male, Retrospective Studies, Time Factors, Down Syndrome complications, Epilepsy complications, Epilepsy physiopathology
- Abstract
Objective: To describe the electroclinical features and the long-term outcomes of epilepsy in a large cohort of males and females with Down syndrome who developed epilepsy in childhood., Study Design: Subjects with Down syndrome and cryptogenic epilepsy with onset in childhood were identified retrospectively from the databases of 16 Italian epilepsy centers over a 40-year period. For each subject, age at onset of seizures, seizure semiology and frequency, electroencephalography characteristics, treatment with antiepileptic drugs, and long-term clinical and electroencephalography outcomes were analyzed., Results: A total of 104 subjects (64 males [61.5%], 40 females [38.5%]) were identified. Seizure onset occurred within 1 year of birth in 54 subjects (51.9%), between 1 and 12 years in 42 subjects (40.4%), and after 12 years in 8 subjects (7.7%). Males had a younger age of seizure onset than females. Of the 104 subjects, 51 (49.0%) had infantile spasms (IS), 35 (33.7%) had partial seizures (PS), and 18 (17.3%) had generalized seizures (GS). Febrile seizures were recorded in 5 (4.8%) subjects. Intractable seizures were observed in 23 (22.1%) subjects, including 5 (9.8%) with IS, 8 (44.4%) with PS, and 10 (31.3%) with GS., Conclusion: Cryptogenic epilepsy in Down syndrome may develop during the first year of life in the form of IS or, successively, as PS or GS. Electroclinical features of IS resemble those of idiopathic West syndrome, with a favorable response to treatment with adrenocorticotropic hormone seen. Patients experiencing PS and GS may be resistant to therapy with antiepileptic drugs., (Copyright © 2013 Mosby, Inc. All rights reserved.)
- Published
- 2013
- Full Text
- View/download PDF
22. Alexithymia, anger and psychological distress in patients with myofascial pain: a case-control study.
- Author
-
Castelli L, De Santis F, De Giorgi I, Deregibus A, Tesio V, Leombruni P, Granieri A, Debernardi C, and Torta R
- Abstract
Aims: The aim of this study was to investigate psychological distress, anger and alexithymia in a group of patients affected by myofascial pain (MP) in the facial region., Methods: 45 MP patients [mean (SD) age: 38.9 (11.6)] and 45 female healthy controls [mean (SD) age: 37.8 (13.7)] were assessed medically and psychologically. The medically evaluation consisted of muscle palpation of the pericranial and cervical muscles. The psychological evaluation included the assessment of depression (Beck Depression Inventory-short form), anxiety [State-Trait Anxiety Inventory Form Y (STAI-Y)], emotional distress [Distress Thermometer (DT)], anger [State-Trait Anger Expression Inventory-2 (STAXI-2)], and alexithymia [Toronto Alexithymia Scale (TAS)]., Results: the MP patients showed significantly higher scores in the depression, anxiety and emotional distress inventories. With regard to anger, only the Anger Expression-In scale showed a significant difference between the groups, with higher scores for the MP patients. In addition, the MP patients showed significantly higher alexithymic scores, in particular in the Difficulty in identifying feelings (F1) subscale of the TAS-20. Alexithymia was positively correlated with the Anger Expression-In scale. Both anger and alexithymia showed significant positive correlations with anxiety scores, but only anger was positively correlated with depression., Conclusion: A higher prevalence of depressive and anxiety symptoms associated with a higher prevalence of alexithymia and expression-in modality to cope with anger was found in the MP patients. Because the presence of such psychological aspects could contribute to generate or exacerbate the suffering of these patients, our results highlight the need to include accurate investigation of psychological aspects in MP patients in normal clinical practice in order to allow clinicians to carry out more efficacious management and treatment strategies.
- Published
- 2013
- Full Text
- View/download PDF
23. Diagnostic concordance between MRI and electrovibratography of the temporomandibular joint of subjects with disc displacement disorders.
- Author
-
Deregibus A, Castroflorio T, De Giorgi I, Burzio C, and Debernardi C
- Subjects
- Adolescent, Adult, Aged, Electrodiagnosis instrumentation, False Negative Reactions, False Positive Reactions, Female, Humans, Joint Instability diagnosis, Male, Middle Aged, Predictive Value of Tests, Range of Motion, Articular physiology, Sensitivity and Specificity, Sound, Temporomandibular Joint pathology, Transducers, Vibration, Young Adult, Electrodiagnosis methods, Joint Dislocations diagnosis, Magnetic Resonance Imaging methods, Temporomandibular Joint Disc pathology, Temporomandibular Joint Disorders diagnosis
- Abstract
Objectives: The aim of this study is to evaluate the diagnostic concordance of MRI and electrovibratography (EVG) of the temporomandibular joint (TMJ) in the diagnosis of articular disc displacement with reduction (ADDwR) and articular disc displacement without reduction (ADDw/oR)., Methods: 50 patients (12 males, 38 females; mean age 37.46 ± 15.64 years) with a hypothesis of disc displacement were selected. For each patient an MRI of the TMJ was performed. MRIs were evaluated sorting the 100 TMJs by kind of pathology (no pathology, ADDwR, ADDw/oR, and joint hypermobility). Afterwards, the patients had an EVG exam. The EVG exams were performed with vibration transducers over each TMJ, enabling simultaneous, bilateral recording of vibrations emanating from joint sounds during the opening and closing movements. The presence of a sound peak was compared with the MRI diagnosis of ADDwR, while a multipeak aspect was compared with ADDw/oR diagnosis using Cohen's kappa test., Results: The presence of a peak-shaped track has high specificity for ADDwR (90.27%). The Cohen's kappa calculated for the ADDwR was 0.5615 (good-moderate). The presence of a multipeak-shaped track has low specificity (65.22%) and sensitivity (70.42%). The Cohen's kappa calculated for the ADDw/oR was 0.2992 (poor)., Conclusions: The present study recommends the use of EVG to support the clinical diagnosis of a disc displacement with reduction when MRI is not available or when subjects cannot be investigated by MRI.
- Published
- 2013
- Full Text
- View/download PDF
24. Cognitive development in Dravet syndrome: a retrospective, multicenter study of 26 patients.
- Author
-
Ragona F, Granata T, Dalla Bernardina B, Offredi F, Darra F, Battaglia D, Morbi M, Brazzo D, Cappelletti S, Chieffo D, De Giorgi I, Fontana E, Freri E, Marini C, Toraldo A, Specchio N, Veggiotti P, Vigevano F, Guerrini R, Guzzetta F, and Dravet C
- Subjects
- Adolescent, Age of Onset, Child, Child, Preschool, Electroencephalography, Female, Genotype, Heterozygote, Humans, Infant, Italy, Linear Models, Magnetic Resonance Imaging, Male, Mutation physiology, NAV1.1 Voltage-Gated Sodium Channel, Nerve Tissue Proteins genetics, Retrospective Studies, Seizures complications, Seizures genetics, Sodium Channels genetics, Status Epilepticus complications, Status Epilepticus genetics, Child Development physiology, Cognition physiology, Myoclonic Epilepsy, Juvenile genetics, Myoclonic Epilepsy, Juvenile psychology
- Abstract
Purpose: To clarify the role of epilepsy and genetic background in determining the cognitive outcome of patients with Dravet syndrome., Methods: In this retrospective study, we reviewed the clinical history and cognitive development of 26 patients who had been followed with standardized evaluations since seizure onset. The cognitive outcome was quantified as differential general quotient (dGQ) between ages 12 and 60 months. Statistical analysis correlated the dGQ with genotype and epilepsy course., Key Findings: Epilepsy started at the mean age of 5.6 months. All patients experienced prolonged convulsive seizures, whereas absences and myoclonus were reported in 17. Cognitive outcome was poor in almost all patients; the mean dGQ was 33 points, varying from 6-77 points. The analysis of individual cognitive profiles identified seven patients in whom the dGQ was <20 points; the main clinical characteristic in this subset of patients was lack of early absences and myoclonus. The statistical analysis of the whole series failed to reveal significant differences in cognitive outcome with regard to the presence of SCN1A mutations and their type. In particular, mutation-carrier patients with the best cognitive outcome harbored either missense or truncating mutations., Significance: Dravet syndrome encompasses different epileptic and cognitive phenotypes that probably result from both genetic and epigenetic factors. In this series, early appearance of myoclonus and absences was associated with the worst cognitive outcome., (Wiley Periodicals, Inc. © 2011 International League Against Epilepsy.)
- Published
- 2011
- Full Text
- View/download PDF
25. Evaluation of tools to prevent drug incompatibilities in paediatric and neonatal intensive care units.
- Author
-
De Giorgi I, Guignard B, Fonzo-Christe C, and Bonnabry P
- Subjects
- Drug Therapy, Combination, Hospitals, University, Humans, Infusions, Intravenous, Intensive Care Units, Neonatal, Medication Errors prevention & control, Pharmacy Service, Hospital organization & administration, Switzerland, Decision Support Systems, Clinical standards, Drug Incompatibility, Drug Information Services organization & administration, Intensive Care Units, Pediatric
- Abstract
Objective: Intravenous drug administration in neonatal (NICU) and paediatric intensive care units (PICU) is critical because of poor venous access, polymedication, fluid restriction and low infusion rate. Risk is further increased by inadequate information on the physicochemical compatibility of drugs. Eight decision-supporting tools were hence evaluated to improve the detection of drug incompatibilities in paediatric wards., Setting: NICU and PICU, University hospital., Method: Eight tools (Thériaque 2007, Stabilis 3, Perfysi 2 databases; KIK 3.0 software; Neofax 2007 handbook; King 2008 Guide, CHUV 9.0, pH 2007 cross-tables) were assessed by two pharmacists using 40 drug pairs (20 incompatible; 20 compatible) frequently prescribed in PICUs and NICUs. Trissel's 14th Ed. handbook served as the gold standard. Four criteria were evaluated (each with a maximum of 250 points): accuracy (sensitivity, specificity, positive and negative predictive values), completeness (number of drug pairs documented), comprehensiveness (presence of 16 different items), and applicability (by combining the time needed by 7 pharmacists to classify 5 drug pairs, plus an evaluation of their design, usefulness, reliability and ergonomics, using visual analogy scales). The percentage of non-compliant answers (NCA) was calculated for both the performing pharmacists and the tools., Main Outcome Measure: Global score of drug incompatibilities (accuracy + completeness + comprehensiveness + applicability)., Results: Thériaque obtained the best global score (840/1000 points), followed by pH (807), CHUV (803), Perfysi (776), Neofax (678), King Guide (642), Stabilis (584) and KIK (523), respectively. The highest scores were reached by Thériaque for accuracy (234/250); Thériaque and pH for completeness (200/250); Thériaque and Perfysi for comprehensiveness (218/250); and pH for applicability (298/250). The range of pharmacists' NCAs was between 9% (4/45 NCAs) and 33% (15/45), whereas that for drug pairs was between 10% (6/63) and 30% (19/63). The range of NCAs for tools was between 6% (2/35, pH) and 49% (18/35, Perfysi)., Conclusions: Thériaque proved outstanding as a drug-incompatibility tool. However, all resources showed some shortcomings. The large ranges of pharmacists' NCAs shows that such an assessment is subject to different interpretations. Standard operating procedures for drug-incompatibility assessment should be implemented in drug-information centres. Tools with low NCA percentage, such as the pH or CHUV tables, may be useful for nurses in ICUs.
- Published
- 2010
- Full Text
- View/download PDF
26. Dravet syndrome: early clinical manifestations and cognitive outcome in 37 Italian patients.
- Author
-
Ragona F, Brazzo D, De Giorgi I, Morbi M, Freri E, Teutonico F, Gennaro E, Zara F, Binelli S, Veggiotti P, and Granata T
- Subjects
- Adolescent, Brain pathology, Brain physiopathology, Child, Child Behavior Disorders diagnosis, Child Behavior Disorders genetics, Child Behavior Disorders physiopathology, Child, Preschool, Cognition Disorders genetics, Cognition Disorders physiopathology, Diagnosis, Differential, Disease Progression, Epilepsies, Myoclonic genetics, Epilepsies, Myoclonic pathology, Epilepsies, Myoclonic physiopathology, Female, Humans, Infant, Intellectual Disability diagnosis, Intellectual Disability genetics, Intellectual Disability physiopathology, Italy, Male, NAV1.1 Voltage-Gated Sodium Channel, Nerve Tissue Proteins genetics, Seizures diagnosis, Seizures genetics, Seizures physiopathology, Sodium Channels genetics, Syndrome, Young Adult, Cognition Disorders diagnosis, Epilepsies, Myoclonic diagnosis
- Abstract
Aims of our study were to describe the early clinical features of Dravet syndrome (SMEI) and the neurological, cognitive and behavioral outcome. The clinical history of 37 patients with clinical diagnosis of SMEI, associated with a point mutation of SCN1A gene in 84% of cases, were reviewed with particular attention to the symptoms of onset. All the patients received at least one formal cognitive and behavior evaluation. Epilepsy started at a mean age of 5.7 months; the onset was marked by isolated seizure in 25 infants, and by status epilepticus in 12; the first seizure had been triggered by fever, mostly of low degree in 22 infants; the first EEG was normal in all cases. During the second year of life difficult-to-treat seizures recurred, mostly triggered by fever, hot bath, and intermittent lights and delay in psychomotor development became evident. At the last evaluation, performed at a mean age of 16+/-6.9 years, mental retardation was present in 33 patients, associated with behavior disorders in 21. Our data indicate that the most striking features of SMEI are: the early onset of seizures in a previously healthy child, the long duration of the first seizure, the presence of focal ictal symptoms, and sensitivity to low-grade fever. Diagnosis of SMEI may be proposed by the end of the first year of life, and a definite diagnosis can be established during the second year based on the peculiar seizure-favoring factors, EEG photosensitivity and psychomotor slowing. The temporal correlation between high seizure frequency and cognitive impairment support the role of epilepsy in the clinical outcome, even if a role of channelopathy cannot be ruled out., (Copyright 2009 Elsevier B.V. All rights reserved.)
- Published
- 2010
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.