13 results on '"de Fays, K"'
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2. Vorapaxar in the secondary prevention of atherothrombotic events
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Braunwald E, Morrow DA, Scirica BM, Bonaca MP, McCabe CH, Morin S, Fish P, Lamp J, Gershman E, Murphy S, Deenadayalu N, Skene A, Hill K, Bennett L, Strony J, Plat F, Berman G, Lipka L, Kilian A, He W, Liu X, Fox KA, Aylward P, Bassand JP, Betriu A, Bounameaux H, Corbalan R, Creager M, Dalby A, De Ferrari G, Dellborg M, Diehm CH, Dietz R, Goto S, Grande P, Gurbel P, Hankey G, Isaza D, Jensen P, Kiss R, Lewis B, Merlini P, Moliterno D, Morais J, Nicolau JC, Nieminen M, Nilsen D, Olin J, Ophuis TO, Paolasso E, Pichler M, Shinohara Y, Spinar J, Teal P, Tendera M, Theroux P, Thomassen L, Van de Werf F, White H, Wilcox R, Alberts M, Ameriso S, Diener H, Mohr J, Welch M, Wiviott SD, Awtry E, Berger C, Desai A, Gelfand E, Ho C, Leeman D, Link M, Norden A, Pande A, Rost N, Ruberg R, Silverman S, Singhal A, Vita J, Frye RL, Bailey KR, Easton J, Hochman J, Steg PG, Verheught F, Lee K, Mauro DO, Centurion A, Carlevaro O, Cardozo E, Cartasegna L, Soccini N, Farras HA, Molina Aguirre E, Duronto E, Arrechavala L, Rey R, Stilman A, Fernández H, Marinsalta G, Tartaglione J, Chekherdemian M, Povedano G, Casares E, Kantor P, Reges P, Cuneo C, Martinez G, MacKinnon I, Bagnato B, Fernandez A, Funosas C, Lozada A, Barilati P, Ferrari J, Ferrari N, Llanos J, Casaccia G, Giannaula R, García Méndez C, Cirio J, García Dávila C, Estol C, Chiezzo D, Ramirez J, Garrido S, López M, Hominal M, Bianchini MV, Ramos M, Verdini E, Herrera G, Monne H, Ioli P, Samudio MA, Rotta Escalante R, Tarulla A, Reich E, Perez G, Milesi R, Berli M, Marino J, Funes I, Prado A, Bezi M, Fernandez R, Rojas M, Cimbaro Canella JP, Galarza Salazan M, Chew D, Horsfall L, Claxton A, French J, O'Brien K, Nelson G, Loxton A, McCann A, Downey C, Aroney C, Cleave P, Worthley S, Roach A, Amerena J, Long A, Thompson P, Ferguson L, Fitzpatrick M, Mackenzie M, Youssef G, Goldsmith H, Jayasinghe R, Quinlan S, Arstall M, Rose J, Counsell J, Martin M, Crimmins D, Slattery A, Anderson C, Paraskevaidis T, Davis S, Silver G, Gerraty RP, Gapper J, Donnan G, Petrolo S, Whelan A, Tulloch G, Singh B, Campo Ma, Dick R, Savage C, Hill A, Conway B, Waites J, Keays P, Kopp K, Hainzer D, Podczeck Schweighofer A, Priesnitz T, Drexel H, Hagspiel V, Foeger B, Hilbe C, Trinka E, Sinadinoska D, Pilger E, Brodmann M, Stöllberger C, Jungbauer LV, Koppensteiner R, Hoke M, Grisold W, Berger O, Gaul GB, Fazekas N, Wandaller C, Stockenhuber F, Rek A, Willeit J, Zangerle A, Kiechl S, Sturm W, Theurl M, Gruber F, Schacherl S, Auer J, Primus C, Eber B, Ammer M, Hofer JF, Mayr H, Moser S, Hoellmueller I, Van der Werf F, Motte S, Jorion M, Schroë H, Zwinnen W, Vermassen F, Geenens M, De Wolf L, Briké C, De Deyn P, Ongena P, De Klippel N, Meeuwissen K, Desfontaines P, Tincani G, Vandermeeren Y, de Fays K, Pandolfo M, Alaerts N, Peeters A, Findik A, Tack P, deGrande E, Thijs V, Marcelis E, Van Landegem W, Vanhagendoren S, Vanhooren G, Schotte V, Celen H, Bes N, De Letter J, Holvoet G, Claerbout B, Verhamme P, Debaveye B, Bourgeois P, Debrabandere K, Stalpaert S, Dhondt E, De Maeseneire S, De Bleecker J, de Koning K, Vincent M, Tahon S, Monté C, Maes J, Vossaert R, Vandenhoven C, Roosen J, Vissers C, Sinnaeve P, de Velder L, Thoeng J, Cauwenberghs J, Deceuninck F, Nicolau J, Ardito WR, Queirantes C, de Araujo Filho JD, Queirantes CS, Ribeiro JP, Guizzardi SP, Chaves ML, Titton NF, Pereira AH, Webber I, da Silva DG Jr, Uehara RM, Brasileiro J, Maia LN, Souza A, Bodanese LC, Homem R, Friedrich MA, Macagnan AP, Dutra OP, Brum AB, Rossi PR, Herek L, Feitosa GS, Bernardes Ade S, Braga J, Rodrigues D, Guimarães A, Teixeira AB, Marin Neto JA, Tonani M, Piegas LS, Amato V, Leães P, Osorio RL, Ganem F, Vieira AP, Leao P, Kanashiro V, Franken RA, Martins EP, Gagliardi RJ, Silva L, Caffaro RA, Novaes GS, Carvalho A, Laet VL, Miranda F. Jr, Crippa BA, Saraiva JF, Ormundo CT, Speciali JG, Guandolini G, de Albuquerque DC, Silva V, Abrantes JA, Pinheiro L, Teixeira MS, Guanaes DF, Resende ES, Andrade SF, Alves ÁR Jr, Oliveira OM, Tauil CB, Araujo E, de Souza J, de Freitas GR, Horokosky AP, Barbosa EC, Muniz P, de Moraes JB Jr, Cabral M, Faria Neto JR, Belemer A, Paiva MS, Brito A, Hernandes ME, Amorim R, Pittella FJ, Brito HH, Kouz S, Roy M, Gosselin G, David M, Huynh T, Boudreault C, Heath J, Scott L, Bhargava R, Stafford C, Klinke WP, Martin L, Chan YK, Zaniol D, Rebane T, Abramovich M, Vizel S, Fox B, Kornder J, Breakwell L, Constance C, Gauthier M, Cleveland D, Valley S, Dion D, Morissette A, Vertes G, Ross B, Pandey AS, Byrne M, Abramson B, Sodhi N, Ervin F, Thiessen S, Halperin F, Stedham V, Pesant Y, Sardin V, Saw J, Tarry L, Pouliot J, Marquette S, Belisle P, Gagne D, Ducas J, Munoz A, Sussex B, Newman S, Madan M, Hsu E, Bata I, Cossett J, Glanz A, Vilag C, Paddock V, Collings E, Sabbah E, Chausse I, Fortin C, Lepage C, Chehayeb R, Viau C, Ma P, Seib M, Lamy A, Rizzo A, Rajakumar AR, Eikel L, Nigro F, Stoger S, Welsh R, Lindholm L, Parker JD, Webber S, Winkler L, Hannah G, Gupta M, Kubiak A, Mukherjee A, Bozek B, Nguyen M, Dufort L, Haichin R, Toyota V, Bujold S, Syan G, Chinnasane S, Houde G, Rousseau S, Poirier P, Lariviere M, Dupuis R, Ouimet F, Audet J, Darveau C, Labonte R, Rice T, Nawaz S, Cantor W, Robbins K, Boucher P. Jr, Roberge J, Zadra R, McPherson C, Prieto JC, Noriega V, Cereño C, Mestas M, Yovaniniz P, Ferrada W, Pincetti C, Torres G, Perez L, Villan C, Escobar E, Martin R, Padilla I, Ramirez M, Hormazabal R, Pedemonte O, Suazo E, Hasbun S, Mejias M, Cardenas F, Donoso L, Godoy I, Henriquez P, Mariné L, Vergara T, Juri C, Vergara E, Muñoz M, Solano E, Toro J, Cardenas S, Mendoza F, Martinez S, Saaibi JF, Castillo KM, Ruiz NP, Castillo T, Orozco A, Muñoz C, Martínez J, Lopez D, Ochoa J, Andrade J, Jaramillo C, Garces GP, Botero R, Cáceres A, Jaramillo M, Mejia C, Schlesinger A, Munevar V, Rodriguez J, Granados LM, Jaramillo N, Aristizabal C, Cano N, Salazar JC, Urina M, Manco T, Valenzuela C, Hernandez HJ, Delgado PS, Vagner B, Castaño LA, Ucros P, Tellez M, Delgado JA, Piedrahita CA, Crump J, Fernandez V, Quintero CA, Moreno M, Hernandez Triana E, Cuentas I, Accini JL, Accini M, Manzur F, Rivera E, Reynales H, Huertas D, Hovorka J, Filipovsky J, Hirmerova J, Peska S, Jura R, Kanovsky P, Herzig R, Jansky P, Fiala R, Kalita Z, Gatkova A, Bauer J, Fiksa J, Sedlacek J, Monhart Z, Bren J, Linhart A, Skalicka L, Vitovec J, Hlinomaz O, Parenica J, Soucek M, Rihacek I, Branny M, Sknouril L, Klimsa Z, Holub M, Línkova H, Rektor I, Mikulik R, Mayer O. Sr, Novakova B, Bar M, Brodova P, Polasek R, Sabl P, Kos P, Lorenc Z, Macel I, Graversen KH, Galatius S, Soderberg LH, Sillesen H, Madelung S, Overgård K, Stan V, Rasmussen LH, Mortensen B, Iversen HK, Back C, Olesen C, Christensen H, Pedersen A, Nielsen T, Hasain M, Tanggaard L, Husted S, Christensen LL, Haas L, Mickley H, Hosbond S, Rosenlund I, Jepsen J, Kaspersen BB, Bronnum Schou J, Hempel H, Nyvad O, Feldthaus B, Jensen BS, Jensen MK, Andersen G, Thomsen RB, Rokkedal J, Joergensen A, Bülow M, Jeppesen J, Lederballe O, Scheibel I, Sjol A, Larsen J, Graner M, Svahn T, Melin J, Kaakkomäki A, Airaksinen J, Vasankari T, Tatlisumak T, Metso M, Remes A, Näppä M, Jäkälä P, Sivenius J, Kalinen M, Roine RO, Ketola R, Bassand J, Pales D, Coisne D, Berger N, Galinier M, Rosolin N, Elbaz M, Lacassagne L, Montalescot G, Vignolles N, Gully C, Lepage I, Roynard J, Hamon M, Brucato S, Macquin Mavier I, Beitar T, Berthezene P, Medkour T, Amarenco P, Gueblaoui N, Timsit S, Riou D, Mahagne M, Suissa L, Quere I, Clouzot S, Emmerich J, Martinez I, Moulin T, Cole M, Hosseini H, Monod V, Cottin Y, Bichat F, Galley D, Beltra C, Samson Y, Pires R, Bura Riviere A, Pelvet B, Giroud M, Lecheneaut C, Ohlmann P, Ait m. bark Z, Farah B, Petit F, Caussin C, Braun C, Diehm C, Mehrhof F, Inkrot S, Darius H, Heinze H, Radke P, Kulikowsky C, Ferrari M, Utschig S, Strasser R, Haacke K, Felix SB, Bruder M, Nienaber C, Pfaff H, Sohn H, Baylacher M, Mudra H, Setzer P, Konstantinides S, Hallmann A, Kreuzer J, Tsoy I, Schneider P, Appel KF, Habermeier A, Zeiher AM, Kretschmer T, Mitrovic V, Lehinant S, Bohlscheid V, Palme B, Heuer H, Espinola Klein C, Savvidis S, Kleinertz K, Hänel J, Schmidt E, Schmidt A, Ringleb PA, Ludwig I, Dietzold M, Schaffranka A, Ranft J, Cegla C, Berrouschot J, Stoll A, Tanislav C, Brandtner MA, Rosenkranz M, Otto D, Görtler M, Barleben M, Haberl R, Miedl S, Maschke M, Schröder K, Aral Becher B, Herzog Hauff S, Guenther A, Herzau C, Hoffmann U, Roth Zetzsche S, Grond M, Becker M, Hamann G, Simon K, Köhrmann M, Glahn J, Wuttig H, Nabavi DG, Seraphin D, Schellong S, Frommhold R, Dichgans M, Doerr A, Blessing E, Buss I, Butter C, Bettin D, Grosch B, Blank E, Wong L, Liu R, Lee S, Kong S, Yu C, So E, Jakal Á, Masszi G, Czuriga I, Kapocsi J, Soós E, Csiba L, Fekete K, Valikovics A, Dioszeghy P, Muskóczki E, Csányi A, Matoltsy A, Yuval R, Bornstein N, Elimelech R, Chajek Shaul T, Bursztyn M, Hayek T, Hazbon K, Gavish D, Anat N, Wexler D, Azar P, Mosseri M, Tsirulnikov E, Rozenman Y, Logvinenko S, Tanne D, Don A, Gross B, Feldman Y, Klainman E, Genin Dmitrishin I, Eldar M, Eizenberg N, Atar S, Lasri E, Hammerman H, Aharoni G, Zimlichman R, Zuker S, Telman G, Afanasiev S, Katz A, Biton A, Goldhaber A, Goldhaber M, Elian D, Linor A, Meyuhas S, Tsalihin D, Kissos D, Lampl Y, Israelson M, Gottlieb S, Dotan L, Elis A, Karny M, Hussein O, Shestatski K, Brenner H, Segal E, Baldini U, Gavazzi A, Poloni M, Censori B, Aiazzi L, Maraglino C, Marenzi G, Specchia G, Tritto I, Golino P, CIANFLONE , DOMENICO, Martignoni A, Tamburino C, Rubartelli P, Ardissino D, Tadonio I, Stramba Badiale M, Cernuschi P, Nardulli R, Sommariva L, Giordano A, Berni A, Cavallini C, Fiscella A, Azzarelli S, Esposito G, Cassese S, Danzi G, Fattore L, Barbieri E, De Caterina R, Odero A, Puttini M, Corrada E, Monzini N, Vadalà A, Pistarini C, Scrutinio D, Ferratini M, Marcheselli S, Moretti L, Partemi L, Pupilella T, Lazzari A, Ledda A, Geraci G, Rasura M, Beccia M, Cassadonte F, Vatrano M, Bongiorni D, Mos L, Marcuzzi G, Murena E, Uguccioni L, Ferretti C, Piti ATerrosu P, Perrone PF, Marconi R, Grasso L, Severi S, Evola R, Russo N, Agnelli G, Paci C, Carugo S, Silvestri O, Testa R, Novo S., Braunwald, E, Morrow, Da, Scirica, Bm, Bonaca, Mp, Mccabe, Ch, Morin, S, Fish, P, Lamp, J, Gershman, E, Murphy, S, Deenadayalu, N, Skene, A, Hill, K, Bennett, L, Strony, J, Plat, F, Berman, G, Lipka, L, Kilian, A, He, W, Liu, X, Fox, Ka, Aylward, P, Bassand, Jp, Betriu, A, Bounameaux, H, Corbalan, R, Creager, M, Dalby, A, De Ferrari, G, Dellborg, M, Diehm, Ch, Dietz, R, Goto, S, Grande, P, Gurbel, P, Hankey, G, Isaza, D, Jensen, P, Kiss, R, Lewis, B, Merlini, P, Moliterno, D, Morais, J, Nicolau, Jc, Nieminen, M, Nilsen, D, Olin, J, Ophuis, To, Paolasso, E, Pichler, M, Shinohara, Y, Spinar, J, Teal, P, Tendera, M, Theroux, P, Thomassen, L, Van de Werf, F, White, H, Wilcox, R, Alberts, M, Ameriso, S, Diener, H, Mohr, J, Welch, M, Wiviott, Sd, Awtry, E, Berger, C, Desai, A, Gelfand, E, Ho, C, Leeman, D, Link, M, Norden, A, Pande, A, Rost, N, Ruberg, R, Silverman, S, Singhal, A, Vita, J, Frye, Rl, Bailey, Kr, Easton, J, Hochman, J, Steg, Pg, Verheught, F, Lee, K, Mauro, Do, Centurion, A, Carlevaro, O, Cardozo, E, Cartasegna, L, Soccini, N, Farras, Ha, Molina Aguirre, E, Duronto, E, Arrechavala, L, Rey, R, Stilman, A, Fernández, H, Marinsalta, G, Tartaglione, J, Chekherdemian, M, Povedano, G, Casares, E, Kantor, P, Reges, P, Cuneo, C, Martinez, G, Mackinnon, I, Bagnato, B, Fernandez, A, Funosas, C, Lozada, A, Barilati, P, Ferrari, J, Ferrari, N, Llanos, J, Casaccia, G, Giannaula, R, García Méndez, C, Cirio, J, García Dávila, C, Estol, C, Chiezzo, D, Ramirez, J, Garrido, S, López, M, Hominal, M, Bianchini, Mv, Ramos, M, Verdini, E, Herrera, G, Monne, H, Ioli, P, Samudio, Ma, Rotta Escalante, R, Tarulla, A, Reich, E, Perez, G, Milesi, R, Berli, M, Marino, J, Funes, I, Prado, A, Bezi, M, Fernandez, R, Rojas, M, Cimbaro Canella, Jp, Galarza Salazan, M, Chew, D, Horsfall, L, Claxton, A, French, J, O'Brien, K, Nelson, G, Loxton, A, Mccann, A, Downey, C, Aroney, C, Cleave, P, Worthley, S, Roach, A, Amerena, J, Long, A, Thompson, P, Ferguson, L, Fitzpatrick, M, Mackenzie, M, Youssef, G, Goldsmith, H, Jayasinghe, R, Quinlan, S, Arstall, M, Rose, J, Counsell, J, Martin, M, Crimmins, D, Slattery, A, Anderson, C, Paraskevaidis, T, Davis, S, Silver, G, Gerraty, Rp, Gapper, J, Donnan, G, Petrolo, S, Whelan, A, Tulloch, G, Singh, B, Campo, Ma, Dick, R, Savage, C, Hill, A, Conway, B, Waites, J, Keays, P, Kopp, K, Hainzer, D, Podczeck Schweighofer, A, Priesnitz, T, Drexel, H, Hagspiel, V, Foeger, B, Hilbe, C, Trinka, E, Sinadinoska, D, Pilger, E, Brodmann, M, Stöllberger, C, Jungbauer, Lv, Koppensteiner, R, Hoke, M, Grisold, W, Berger, O, Gaul, Gb, Fazekas, N, Wandaller, C, Stockenhuber, F, Rek, A, Willeit, J, Zangerle, A, Kiechl, S, Sturm, W, Theurl, M, Gruber, F, Schacherl, S, Auer, J, Primus, C, Eber, B, Ammer, M, Hofer, Jf, Mayr, H, Moser, S, Hoellmueller, I, Van der Werf, F, Motte, S, Jorion, M, Schroë, H, Zwinnen, W, Vermassen, F, Geenens, M, De Wolf, L, Briké, C, De Deyn, P, Ongena, P, De Klippel, N, Meeuwissen, K, Desfontaines, P, Tincani, G, Vandermeeren, Y, de Fays, K, Pandolfo, M, Alaerts, N, Peeters, A, Findik, A, Tack, P, Degrande, E, Thijs, V, Marcelis, E, Van Landegem, W, Vanhagendoren, S, Vanhooren, G, Schotte, V, Celen, H, Bes, N, De Letter, J, Holvoet, G, Claerbout, B, Verhamme, P, Debaveye, B, Bourgeois, P, Debrabandere, K, Stalpaert, S, Dhondt, E, De Maeseneire, S, De Bleecker, J, de Koning, K, Vincent, M, Tahon, S, Monté, C, Maes, J, Vossaert, R, Vandenhoven, C, Roosen, J, Vissers, C, Sinnaeve, P, de Velder, L, Thoeng, J, Cauwenberghs, J, Deceuninck, F, Nicolau, J, Ardito, Wr, Queirantes, C, de Araujo Filho, Jd, Ribeiro, Jp, Guizzardi, Sp, Chaves, Ml, Titton, Nf, Pereira, Ah, Webber, I, da Silva DG, Jr, Uehara, Rm, Brasileiro, J, Maia, Ln, Souza, A, Bodanese, Lc, Homem, R, Friedrich, Ma, Macagnan, Ap, Dutra, Op, Brum, Ab, Rossi, Pr, Herek, L, Feitosa, G, Bernardes Ade, S, Braga, J, Rodrigues, D, Guimarães, A, Teixeira, Ab, Marin Neto, Ja, Tonani, M, Piegas, L, Amato, V, Leães, P, Osorio, Rl, Ganem, F, Vieira, Ap, Leao, P, Kanashiro, V, Franken, Ra, Martins, Ep, Gagliardi, Rj, Silva, L, Caffaro, Ra, Novaes, G, Carvalho, A, Laet, Vl, Miranda F., Jr, Crippa, Ba, Saraiva, Jf, Ormundo, Ct, Speciali, Jg, Guandolini, G, de Albuquerque, Dc, Silva, V, Abrantes, Ja, Pinheiro, L, Teixeira, M, Guanaes, Df, Resende, E, Andrade, Sf, Alves ÁR, Jr, Oliveira, Om, Tauil, Cb, Araujo, E, de Souza, J, de Freitas, Gr, Horokosky, Ap, Barbosa, Ec, Muniz, P, de Moraes JB, Jr, Cabral, M, Faria Neto, Jr, Belemer, A, Paiva, M, Brito, A, Hernandes, Me, Amorim, R, Pittella, Fj, Brito, Hh, Kouz, S, Roy, M, Gosselin, G, David, M, Huynh, T, Boudreault, C, Heath, J, Scott, L, Bhargava, R, Stafford, C, Klinke, Wp, Martin, L, Chan, Yk, Zaniol, D, Rebane, T, Abramovich, M, Vizel, S, Fox, B, Kornder, J, Breakwell, L, Constance, C, Gauthier, M, Cleveland, D, Valley, S, Dion, D, Morissette, A, Vertes, G, Ross, B, Pandey, A, Byrne, M, Abramson, B, Sodhi, N, Ervin, F, Thiessen, S, Halperin, F, Stedham, V, Pesant, Y, Sardin, V, Saw, J, Tarry, L, Pouliot, J, Marquette, S, Belisle, P, Gagne, D, Ducas, J, Munoz, A, Sussex, B, Newman, S, Madan, M, Hsu, E, Bata, I, Cossett, J, Glanz, A, Vilag, C, Paddock, V, Collings, E, Sabbah, E, Chausse, I, Fortin, C, Lepage, C, Chehayeb, R, Viau, C, Ma, P, Seib, M, Lamy, A, Rizzo, A, Rajakumar, Ar, Eikel, L, Nigro, F, Stoger, S, Welsh, R, Lindholm, L, Parker, Jd, Webber, S, Winkler, L, Hannah, G, Gupta, M, Kubiak, A, Mukherjee, A, Bozek, B, Nguyen, M, Dufort, L, Haichin, R, Toyota, V, Bujold, S, Syan, G, Chinnasane, S, Houde, G, Rousseau, S, Poirier, P, Lariviere, M, Dupuis, R, Ouimet, F, Audet, J, Darveau, C, Labonte, R, Rice, T, Nawaz, S, Cantor, W, Robbins, K, Boucher P., Jr, Roberge, J, Zadra, R, Mcpherson, C, Prieto, Jc, Noriega, V, Cereño, C, Mestas, M, Yovaniniz, P, Ferrada, W, Pincetti, C, Torres, G, Perez, L, Villan, C, Escobar, E, Martin, R, Padilla, I, Ramirez, M, Hormazabal, R, Pedemonte, O, Suazo, E, Hasbun, S, Mejias, M, Cardenas, F, Donoso, L, Godoy, I, Henriquez, P, Mariné, L, Vergara, T, Juri, C, Vergara, E, Muñoz, M, Solano, E, Toro, J, Cardenas, S, Mendoza, F, Martinez, S, Saaibi, Jf, Castillo, Km, Ruiz, Np, Castillo, T, Orozco, A, Muñoz, C, Martínez, J, Lopez, D, Ochoa, J, Andrade, J, Jaramillo, C, Garces, Gp, Botero, R, Cáceres, A, Jaramillo, M, Mejia, C, Schlesinger, A, Munevar, V, Rodriguez, J, Granados, Lm, Jaramillo, N, Aristizabal, C, Cano, N, Salazar, Jc, Urina, M, Manco, T, Valenzuela, C, Hernandez, Hj, Delgado, P, Vagner, B, Castaño, La, Ucros, P, Tellez, M, Delgado, Ja, Piedrahita, Ca, Crump, J, Fernandez, V, Quintero, Ca, Moreno, M, Hernandez Triana, E, Cuentas, I, Accini, Jl, Accini, M, Manzur, F, Rivera, E, Reynales, H, Huertas, D, Hovorka, J, Filipovsky, J, Hirmerova, J, Peska, S, Jura, R, Kanovsky, P, Herzig, R, Jansky, P, Fiala, R, Kalita, Z, Gatkova, A, Bauer, J, Fiksa, J, Sedlacek, J, Monhart, Z, Bren, J, Linhart, A, Skalicka, L, Vitovec, J, Hlinomaz, O, Parenica, J, Soucek, M, Rihacek, I, Branny, M, Sknouril, L, Klimsa, Z, Holub, M, Línkova, H, Rektor, I, Mikulik, R, Mayer O., Sr, Novakova, B, Bar, M, Brodova, P, Polasek, R, Sabl, P, Kos, P, Lorenc, Z, Macel, I, Graversen, Kh, Galatius, S, Soderberg, Lh, Sillesen, H, Madelung, S, Overgård, K, Stan, V, Rasmussen, Lh, Mortensen, B, Iversen, Hk, Back, C, Olesen, C, Christensen, H, Pedersen, A, Nielsen, T, Hasain, M, Tanggaard, L, Husted, S, Christensen, Ll, Haas, L, Mickley, H, Hosbond, S, Rosenlund, I, Jepsen, J, Kaspersen, Bb, Bronnum Schou, J, Hempel, H, Nyvad, O, Feldthaus, B, Jensen, B, Jensen, Mk, Andersen, G, Thomsen, Rb, Rokkedal, J, Joergensen, A, Bülow, M, Jeppesen, J, Lederballe, O, Scheibel, I, Sjol, A, Larsen, J, Graner, M, Svahn, T, Melin, J, Kaakkomäki, A, Airaksinen, J, Vasankari, T, Tatlisumak, T, Metso, M, Remes, A, Näppä, M, Jäkälä, P, Sivenius, J, Kalinen, M, Roine, Ro, Ketola, R, Bassand, J, Pales, D, Coisne, D, Berger, N, Galinier, M, Rosolin, N, Elbaz, M, Lacassagne, L, Montalescot, G, Vignolles, N, Gully, C, Lepage, I, Roynard, J, Hamon, M, Brucato, S, Macquin Mavier, I, Beitar, T, Berthezene, P, Medkour, T, Amarenco, P, Gueblaoui, N, Timsit, S, Riou, D, Mahagne, M, Suissa, L, Quere, I, Clouzot, S, Emmerich, J, Martinez, I, Moulin, T, Cole, M, Hosseini, H, Monod, V, Cottin, Y, Bichat, F, Galley, D, Beltra, C, Samson, Y, Pires, R, Bura Riviere, A, Pelvet, B, Giroud, M, Lecheneaut, C, Ohlmann, P, Ait m., bark Z, Farah, B, Petit, F, Caussin, C, Braun, C, Diehm, C, Mehrhof, F, Inkrot, S, Darius, H, Heinze, H, Radke, P, Kulikowsky, C, Ferrari, M, Utschig, S, Strasser, R, Haacke, K, Felix, Sb, Bruder, M, Nienaber, C, Pfaff, H, Sohn, H, Baylacher, M, Mudra, H, Setzer, P, Konstantinides, S, Hallmann, A, Kreuzer, J, Tsoy, I, Schneider, P, Appel, Kf, Habermeier, A, Zeiher, Am, Kretschmer, T, Mitrovic, V, Lehinant, S, Bohlscheid, V, Palme, B, Heuer, H, Espinola Klein, C, Savvidis, S, Kleinertz, K, Hänel, J, Schmidt, E, Schmidt, A, Ringleb, Pa, Ludwig, I, Dietzold, M, Schaffranka, A, Ranft, J, Cegla, C, Berrouschot, J, Stoll, A, Tanislav, C, Brandtner, Ma, Rosenkranz, M, Otto, D, Görtler, M, Barleben, M, Haberl, R, Miedl, S, Maschke, M, Schröder, K, Aral Becher, B, Herzog Hauff, S, Guenther, A, Herzau, C, Hoffmann, U, Roth Zetzsche, S, Grond, M, Becker, M, Hamann, G, Simon, K, Köhrmann, M, Glahn, J, Wuttig, H, Nabavi, Dg, Seraphin, D, Schellong, S, Frommhold, R, Dichgans, M, Doerr, A, Blessing, E, Buss, I, Butter, C, Bettin, D, Grosch, B, Blank, E, Wong, L, Liu, R, Lee, S, Kong, S, Yu, C, So, E, Jakal, Á, Masszi, G, Czuriga, I, Kapocsi, J, Soós, E, Csiba, L, Fekete, K, Valikovics, A, Dioszeghy, P, Muskóczki, E, Csányi, A, Matoltsy, A, Yuval, R, Bornstein, N, Elimelech, R, Chajek Shaul, T, Bursztyn, M, Hayek, T, Hazbon, K, Gavish, D, Anat, N, Wexler, D, Azar, P, Mosseri, M, Tsirulnikov, E, Rozenman, Y, Logvinenko, S, Tanne, D, Don, A, Gross, B, Feldman, Y, Klainman, E, Genin Dmitrishin, I, Eldar, M, Eizenberg, N, Atar, S, Lasri, E, Hammerman, H, Aharoni, G, Zimlichman, R, Zuker, S, Telman, G, Afanasiev, S, Katz, A, Biton, A, Goldhaber, A, Goldhaber, M, Elian, D, Linor, A, Meyuhas, S, Tsalihin, D, Kissos, D, Lampl, Y, Israelson, M, Gottlieb, S, Dotan, L, Elis, A, Karny, M, Hussein, O, Shestatski, K, Brenner, H, Segal, E, Baldini, U, Gavazzi, A, Poloni, M, Censori, B, Aiazzi, L, Maraglino, C, Marenzi, G, Specchia, G, Tritto, I, Golino, P, Cianflone, Domenico, Martignoni, A, Tamburino, C, Rubartelli, P, Ardissino, D, Tadonio, I, Stramba Badiale, M, Cernuschi, P, Nardulli, R, Sommariva, L, Giordano, A, Berni, A, Cavallini, C, Fiscella, A, Azzarelli, S, Esposito, G, Cassese, S, Danzi, G, Fattore, L, Barbieri, E, De Caterina, R, Odero, A, Puttini, M, Corrada, E, Monzini, N, Vadalà, A, Pistarini, C, Scrutinio, D, Ferratini, M, Marcheselli, S, Moretti, L, Partemi, L, Pupilella, T, Lazzari, A, Ledda, A, Geraci, G, Rasura, M, Beccia, M, Cassadonte, F, Vatrano, M, Bongiorni, D, Mos, L, Marcuzzi, G, Murena, E, Uguccioni, L, Ferretti, C, Piti ATerrosu, P, Perrone, Pf, Marconi, R, Grasso, L, Severi, S, Evola, R, Russo, N, Agnelli, G, Paci, C, Carugo, S, Silvestri, O, Testa, R, and Novo, S.
- Abstract
BACKGROUND:Thrombin potently activates platelets through the protease-activated receptor PAR-1. Vorapaxar is a novel antiplatelet agent that selectively inhibits the cellular actions of thrombin through antagonism of PAR-1.METHODS:We randomly assigned 26,449 patients who had a history of myocardial infarction, ischemic stroke, or peripheral arterial disease to receive vorapaxar (2.5 mg daily) or matching placebo and followed them for a median of 30 months. The primary efficacy end point was the composite of death from cardiovascular causes, myocardial infarction, or stroke. After 2 years, the data and safety monitoring board recommended discontinuation of the study treatment in patients with a history of stroke owing to the risk of intracranial hemorrhage.RESULTS:At 3 years, the primary end point had occurred in 1028 patients (9.3%) in the vorapaxar group and in 1176 patients (10.5%) in the placebo group (hazard ratio for the vorapaxar group, 0.87; 95% confidence interval [CI], 0.80 to 0.94; P
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- 2012
3. The Bovine Herpesvirus 4 Bo10 Gene Encodes a Nonessential Viral Envelope Protein That Regulates Viral Tropism through both Positive and Negative Effects
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Machiels, B., primary, Lete, C., additional, de Fays, K., additional, Mast, J., additional, Dewals, B., additional, Stevenson, P. G., additional, Vanderplasschen, A., additional, and Gillet, L., additional
- Published
- 2010
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4. Ixodes ticks belonging to the Ixodes ricinus complex encode a family of anticomplement proteins
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Daix, V., primary, Schroeder, H., additional, Praet, N., additional, Georgin, J.-P., additional, Chiappino, I., additional, Gillet, L., additional, de Fays, K., additional, Decrem, Y., additional, Leboulle, G., additional, Godfroid, E., additional, Bollen, A., additional, Pastoret, P.-P., additional, Gern, L., additional, Sharp, P. M., additional, and Vanderplasschen, A., additional
- Published
- 2007
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5. Structure and function prediction of the Brucella abortus P39 protein by comparative modeling with marginal sequence similarities
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de Fays, K., primary, Tibor, A., additional, Lambert, C., additional, Vinals, C., additional, Denoël, P., additional, De Bolle, X., additional, Wouters, J., additional, Letesson, J.-J., additional, and Depiereux, E., additional
- Published
- 1999
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6. Effect of a single dose of retigabine in cortical excitability parameters: A cross-over, double-blind placebo-controlled TMS study.
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Ossemann M, de Fays K, Bihin B, and Vandermeeren Y
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- Adult, Analysis of Variance, Cross-Over Studies, Double-Blind Method, Electromyography, Female, Humans, Male, Movement drug effects, Movement physiology, Muscle, Skeletal physiology, Rest, Anticonvulsants pharmacology, Carbamates pharmacology, Motor Cortex drug effects, Motor Cortex physiology, Phenylenediamines pharmacology, Transcranial Magnetic Stimulation
- Abstract
Background: Antiepileptic drugs (AEDs) decrease the occurrence of epileptic seizures and modulate cortical excitability through several mechanisms that likely interact. The modulation of brain excitability by AEDs is believed to reflect their antiepileptic action(s) and could be used as a surrogate marker of their efficacy. Transcranial magnetic stimulation (TMS) is one of the best noninvasive methods to study cortical excitability in human subjects. Specific TMS parameters can be used to quantify the various mechanisms of action of AEDs. A new AED called retigabine increases potassium efflux by changing the conformation of KCNQ 2-5 potassium channels, which leads to neuronal hyperpolarisation and a decrease in excitability., Hypothesis: The purpose of this study is to investigate the effect of retigabine on cortical excitability. Based on the known mechanisms of action of retigabine, we hypothesized that the oral intake of retigabine would increase the resting motor threshold (RMT)., Methods: Fifteen healthy individuals participated in a placebo-controlled, double-blind, randomised, clinical trial (RCT). The primary outcome measure was the RMT quantified before and after oral intake of retigabine. Several secondary TMS outcome measures were acquired., Results: The mean RMT, active motor threshold (AMT) and intensity to obtain a 1mV peak-to-peak amplitude potential (SI1mV) were significantly increased after retigabine intake compared to placebo (RMT: P=0.039; AMT: P=0.014; SI1mV: P=0.019). No significant differences were found for short-interval intracortical inhibition/intracortical facilitation (SICI/ICF), long-interval intracortical inhibition (LICI) or short-interval intracortical facilitation (SICF)., Conclusion: A single dose of retigabine increased the RMT, AMT and S1mV in healthy individuals. No modulating intracortical facilitation or inhibition was observed. This study provides the first in vivo demonstration of the modulating effects of retigabine on the excitability of the human brain, and the results are consistent with the data showing that retigabine hyperpolarizes neurons mainly by increasing potassium conductance., (Copyright © 2016 Elsevier B.V. All rights reserved.)
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- 2016
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7. Postoperative analgesic effect of transcranial direct current stimulation in lumbar spine surgery: a randomized control trial.
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Dubois PE, Ossemann M, de Fays K, De Bue P, Gourdin M, Jamart J, and Vandermeeren Y
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Analgesia, Patient-Controlled, Double-Blind Method, Female, Humans, Lumbosacral Region surgery, Male, Middle Aged, Outcome Assessment, Health Care, Pain Measurement, Young Adult, Analgesics, Opioid therapeutic use, Electric Stimulation Therapy methods, Morphine therapeutic use, Pain, Postoperative therapy
- Abstract
Background: Ultimately, the experience of pain derives from changes in brain excitability. Therefore, modulating the excitability of cortical areas involved in pain processing may become an attractive option in the context of multimodal analgesia during the postoperative period. Repetitive transcranial magnetic stimulation (rTMS) can reduce morphine consumption during the postoperative period after gastric bypass surgery. We tested the potential of another method of noninvasive brain stimulation, transcranial direct current stimulation (tDCS), to reduce morphine consumption or pain perception during the postoperative period., Methods: Fifty-nine ASA I to II patients undergoing lumbar spine surgery were randomized to receive anodal (n=20), cathodal (n=20), or sham (n=19) tDCS in the recovery room in a double-blind manner. Morphine consumption administrated through patient-controlled analgesia (PCA) was the primary outcome; pain perception as measured by visual analog scale was the secondary outcome., Results: There were no statistically significant differences between the 3 groups of patients, either for PCA morphine consumption or for pain scores., Conclusions: Several factors may explain the observed lack of impact of tDCS on PCA morphine consumption and pain perception: the method of brain stimulation (tDCS/rTMS), potential interactions with anesthetic drugs, differences in patients population (gastric bypass surgery/lumbar spine surgery), and the previous experience of pain and chronic consumption of analgesic drugs. Further studies with tDCS should be performed before concluding that tDCS is inefficient for postoperative pain control, because noninvasive brain stimulation methods, such as rTMS and tDCS, may become attractive in the setting of multimodal analgesia.
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- 2013
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8. Short- and long-lasting tinnitus relief induced by transcranial direct current stimulation.
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Garin P, Gilain C, Van Damme JP, de Fays K, Jamart J, Ossemann M, and Vandermeeren Y
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- Adult, Aged, Chronic Disease, Double-Blind Method, Electrodes, Female, Humans, Male, Middle Aged, Young Adult, Tinnitus therapy, Transcranial Magnetic Stimulation methods
- Abstract
A significant proportion of the population suffers from tinnitus, a bothersome auditory phantom perception that can severely alter the quality of life. Numerous experimental studies suggests that a maladaptive plasticity of the auditory and limbic cortical areas may underlie tinnitus. Accordingly, repetitive transcranial magnetic stimulation (rTMS) has been repeatedly used with success to reduce tinnitus intensity. The potential of transcranial direct current stimulation (tDCS), another promising method of noninvasive brain stimulation, to relieve tinnitus has not been explored systematically. In a double-blind, placebo-controlled and balanced order design, 20 patients suffering from chronic untreatable tinnitus were submitted to 20 minutes of 1 mA anodal, cathodal and sham tDCS targeting the left temporoparietal area. The primary outcome measure was a change in tinnitus intensity or discomfort assessed with a Visual Analogic Scale (VAS) change-scale immediately after tDCS and 1 hour later. Compared to sham tDCS, anodal tDCS significantly reduced tinnitus intensity immediately after stimulation; whereas cathodal tDCS failed to do so. The variances of the tinnitus intensity and discomfort VAS change-scales increased dramatically after anodal and cathodal tDCS, whereas they remained virtually unchanged after sham tDCS. Moreover, several patients unexpectedly reported longer-lasting effects (at least several days) such as tinnitus improvement, worsening, or changes in tinnitus features, more frequently after real than sham tDCS. Anodal tDCS is a promising therapeutic tool for modulating tinnitus perception. Moreover, both anodal and cathodal tDCS seem able to alter tinnitus perception and could, thus, be used to trigger plastic changes.
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- 2011
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9. The bovine herpesvirus 4 Bo10 gene encodes a nonessential viral envelope protein that regulates viral tropism through both positive and negative effects.
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Machiels B, Lété C, de Fays K, Mast J, Dewals B, Stevenson PG, Vanderplasschen A, and Gillet L
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- Animals, Cattle, Cell Line, Epithelial Cells virology, Gene Deletion, Molecular Weight, Proteome analysis, Viral Envelope Proteins chemistry, Viral Envelope Proteins genetics, Virion chemistry, Virus Attachment, Herpesvirus 4, Bovine physiology, Viral Envelope Proteins isolation & purification, Viral Envelope Proteins physiology, Viral Tropism
- Abstract
All gammaherpesviruses encode a glycoprotein positionally homologous to the Epstein-Barr virus gp350 and the Kaposi's sarcoma-associated herpesvirus (KSHV) K8.1. In this study, we characterized the positional homologous glycoprotein of bovine herpesvirus 4 (BoHV-4), encoded by the Bo10 gene. We identified a 180-kDa gene product, gp180, that was incorporated into the virion envelope. A Bo10 deletion virus was viable but showed a growth deficit associated with reduced binding to epithelial cells. This seemed to reflect an interaction of gp180 with glycosaminoglycans (GAGs), since compared to the wild-type virus, the Bo10 mutant virus was both less infectious for GAG-positive (GAG(+)) cells and more infectious for GAG-negative (GAG(-)) cells. However, we could not identify a direct interaction between gp180 and GAGs, implying that any direct interaction must be of low affinity. This function of gp180 was very similar to that previously identified for the murid herpesvirus 4 gp150 and also to that of the Epstein-Barr virus gp350 that promotes CD21(+) cell infection and inhibits CD21(-) cell infection. We propose that such proteins generally regulate virion attachment both by binding to cells and by covering another receptor-binding protein until they are displaced. Thus, they regulate viral tropism both positively and negatively depending upon the presence or absence of their receptor.
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- 2011
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10. Evolution of Bovine herpesvirus 4: recombination and transmission between African buffalo and cattle.
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Dewals B, Thirion M, Markine-Goriaynoff N, Gillet L, de Fays K, Minner F, Daix V, Sharp PM, and Vanderplasschen A
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- Animals, Cattle, DNA, Viral analysis, Genetic Variation, Herpesviridae Infections transmission, Herpesviridae Infections veterinary, Herpesviridae Infections virology, Herpesvirus 4, Bovine isolation & purification, Molecular Sequence Data, Phylogeny, Sequence Analysis, DNA, Tumor Virus Infections transmission, Tumor Virus Infections veterinary, Tumor Virus Infections virology, Buffaloes virology, Cattle Diseases transmission, Cattle Diseases virology, Evolution, Molecular, Herpesvirus 4, Bovine genetics, Recombination, Genetic
- Abstract
Bovine herpesvirus 4 (BoHV-4) has been isolated from cattle throughout the world, but virological and serological studies have suggested that the African buffalo is also a natural host for this virus. It has previously been found that the Bo17 gene of BoHV-4 was acquired from an ancestor of the African buffalo, probably around 1.5 million years ago. Analysis of the variation of the Bo17 gene sequence among BoHV-4 strains suggested a relatively ancient transmission of BoHV-4 from the buffalo to the Bos primigenius lineage, followed by a host-dependent split between zebu and taurine BoHV-4 strains. In the present study, the evolutionary history of BoHV-4 was investigated by analysis of five gene sequences from each of nine strains representative of the viral species: three isolated from African buffalo in Kenya and six from cattle from Europe, North America and India. No two gene sequences had the same evolutionary tree, indicating that recombination has occurred between divergent lineages; six recombination events were delineated for these sequences. Nevertheless, exchange has been infrequent enough that a clonal evolutionary history of the strains could be discerned, upon which the recombination events were superimposed. The dates of divergence among BoHV-4 lineages were estimated from synonymous nucleotide-substitution rates. The inferred evolutionary history suggests that African buffalo were the original natural reservoir of BoHV-4 and that there have been at least three independent transmissions from buffalo to cattle, probably via intermediate hosts and--at least in the case of North American strains--within the last 500 years.
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- 2006
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11. Biological characterization of bovine herpesvirus 1 recombinants possessing the vaccine glycoprotein E negative phenotype.
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Muylkens B, Meurens F, Schynts F, de Fays K, Pourchet A, Thiry J, Vanderplasschen A, Antoine N, and Thiry E
- Subjects
- Animals, Cattle, Cattle Diseases immunology, Cattle Diseases prevention & control, Cattle Diseases virology, Cells, Cultured, Fluorescent Antibody Technique veterinary, Herpesviridae Infections immunology, Herpesviridae Infections prevention & control, Herpesviridae Infections virology, Herpesvirus 1, Bovine genetics, Herpesvirus 1, Bovine growth & development, Kinetics, Mutation, Polymerase Chain Reaction veterinary, Sequence Deletion, Vaccines, Marker, Viral Plaque Assay veterinary, Viral Proteins, Virulence, Herpesviridae Infections veterinary, Herpesvirus 1, Bovine immunology, Herpesvirus Vaccines immunology, Recombination, Genetic, Viral Envelope Proteins genetics, Viral Envelope Proteins immunology
- Abstract
Intramolecular recombination is a frequent event during the replication cycle of bovine herpesvirus 1 (BoHV-1). Recombinant viruses frequently arise and survive in cattle after concomitant nasal infections with two BoHV-1 mutants. The consequences of this process, related to herpesvirus evolution, have to be assessed in the context of large use of live marker vaccines based on glycoprotein E (gE) gene deletion. In natural conditions, double nasal infections by vaccine and wild-type strains are likely to occur. This situation might generate virulent recombinant viruses inducing a serological response indistinguishable from the vaccine one. This question was addressed by generating in vitro BoHV-1 recombinants deleted in the gE gene from seven wild-type BoHV-1 strains and one mutant strain deleted in the genes encoding gC and gE. In vitro growth properties were assessed by virus production, one step growth kinetics and plaque size assay. Heterogeneity in the biological properties was shown among the investigated recombinant viruses. The results demonstrated that some recombinants, in spite of their gE minus phenotype, have biological characteristics close to wild-type BoHV-1.
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- 2006
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12. Characterization of caprine herpesvirus 1 glycoprotein D gene and its translation product.
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Keuser V, Detry B, Thiry J, de Fays K, Schynts F, Pastoret PP, Vanderplasschen A, and Thiry E
- Subjects
- Alphaherpesvirinae chemistry, Alphaherpesvirinae genetics, Amino Acid Sequence, Animals, Cattle, Cell Line, Conserved Sequence, Cysteine genetics, DNA, Viral chemistry, DNA, Viral genetics, Gene Expression Regulation, Viral, Glycoproteins chemistry, Molecular Sequence Data, Molecular Weight, Oligosaccharides analysis, Oligosaccharides chemistry, Sequence Analysis, DNA, Sequence Homology, Amino Acid, Glycoproteins genetics, Varicellovirus chemistry, Varicellovirus genetics, Viral Envelope Proteins chemistry, Viral Envelope Proteins genetics
- Abstract
Caprine herpesvirus 1 (CpHV-1) is responsible of systemic infection in neonatal kids as well as abortion and fertility disorders in adult goats. This virus is closely related to bovine herpesvirus 1 (BoHV-1) which causes infectious bovine rhinotracheitis. Glycoprotein D (gD) mediates important functions in alphaherpesviruses and is also a main immunogen. The sequence of CpHV-1 gD gene and the biochemical properties of its translation product were analyzed and compared to those of BoHV-1 and other alphaherpesviruses. A relatively high homology was found between CpHV-1 and BoHV-1 glycoproteins D amino acid sequences (similarity of 68.8%). Moreover, six cysteine residues are conserved by CpHV-1 gD and the other studied alphaherpesviruses. CpHV-1 gD has a molecular mass similar to BoHV-1 gD and contains complex N-linked oligosaccharides. In contrast to the BoHV-1 gD, CpHV-1 gD is expressed as a late protein. In spite of the observed differences which could influence its biological functions, CpHV-1 gD shares most characteristics with other alphaherpesviruses and especially BoHV-1.
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- 2006
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13. Glycol chitosan improves the efficacy of intranasally administrated replication defective human adenovirus type 5 expressing glycoprotein D of bovine herpesvirus 1.
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Gogev S, de Fays K, Versali MF, Gautier S, and Thiry E
- Subjects
- Administration, Intranasal, Animals, Cattle, Cell Line, Herpesvirus 1, Bovine genetics, Herpesvirus Vaccines administration & dosage, Humans, Nasal Mucosa immunology, Nasal Mucosa virology, Neutralization Tests, Viral Envelope Proteins biosynthesis, Adenoviridae immunology, Chitin analogs & derivatives, Chitin pharmacology, Chitosan, Herpesvirus 1, Bovine immunology, Herpesvirus Vaccines immunology, Viral Envelope Proteins immunology
- Abstract
The ability of two soluble formulations, namely chitosan and glycol chitosan, when used as an intranasal adjuvant, to improve the immunogenicity of an intranasal human adenovirus type 5 replication defective expressing bovine herpesvirus 1 (BoHV-1) glycoprotein D based vaccine, was investigated in cattle. Their adjuvant effects on immune response by increasing clinical and especially virological protection against an intranasal BoHV-1 challenge were then evaluated. The best virological protection was obtained in calves immunized with the vaccine vector adjuvanted with glycol chitosan which decreased the challenge BoHV-1 virus excretion titres by 0.5-1.5 log when compared to those obtained in calves immunized with the vaccine vector alone or adjuvanted with chitosan. A slight difference in clinical scores was observed in calves immunized with the adjuvanted vaccine vector compared to calves immunized with the vaccine vector alone. The obtained data suggest that the tested soluble formulation of glycol chitosan has promising potential use as an intranasal adjuvant for recombinant viral vector vaccines in cattle.
- Published
- 2004
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