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1. Concurrent evaluation of cytokines improves the accuracy of antibodies against Mycobacterium tuberculosis antigens in the diagnosis of active tuberculosis

Author

Walzl, Gerhard, Chegou, Novel N., Kriel, Magdalena, van der Spuy, Gian, Loxton, Andre G., Stanley, Kim, Malherbe, Stephanus T., Kriel, Belinda, Sutherland, Jayne S., Owolabi, Olumuyiwa, Sillah, Abdou, Mendy, Joseph, Gindeh, Awa, Donkor, Simon, Togun, Toyin, Ota, Martin, Crampin, Amelia C., Simukonda, Felanji, Amberbir, Alemayehu, Chilongo, Femia, Houben, Rein, Kassa, Desta, Gebrezgeabher, Atsbeha, Mesfin, Getnet, Belay, Yohannes, Gebremichael, Gebremedhin, Alemayehu, Yodit, van der Vyver, Marieta, Amutenya, Faustina N., Nelongo, Josefina N., Monye, Lidia, Sheehama, Jacob A., Iipinge, Scholastica, Mayanja-Kizza, Harriet, Namuganga, Anna Ritah, Muzanye, Grace, Nsereko, Mary, Peters, Pierre, Howe, Rawleigh, Mihret, Adane, Bekele, Yonas, Tessema, Bamlak, Yamuah, Lawrence, Ottenhoff, Tom H.M., Geluk, Annemieke, Franken, Kees, van der Ploeg-van Schip, Jolien J., Corstjens, Paul L.A.M., Tjon Kon Fat, Elisa M., de Dood, Claudia J., Rosenkrands, Ida, Aagaard, Claus, Kaufmann, Stefan H.E., Esterhuyse, Maria M., Cliff, Jacqueline M., Dockrell, Hazel M., Jacobs, Ruschca, Awoniyi, Dolapo O., Baumann, Ralf, McAnda, Shirley, Kaempfer, Susanne, and Singh, Mahavir

Published
2022
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2. Potential of antibody test using Schistosoma mansoni recombinant serpin and RP26 to detect light-intensity infections in endemic areas

Author

Tanaka, Mio, Kildemoes, Anna O., Chadeka, Evans Asena, Cheruiyot, Benard Ngetich, Sassa, Miho, Moriyasu, Taeko, Nakamura, Risa, Kikuchi, Mihoko, Fujii, Yoshito, de Dood, Claudia J., Corstjens, Paul L.A.M., Kaneko, Satoshi, Maruyama, Haruhiko, Njenga, Sammy M., de Vrueh, Remco, Hokke, Cornelis H., and Hamano, Shinjiro

Published
2021
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3. Cervicovaginal bacterial communities in reproductive-aged Tanzanian women with Schistosoma mansoni, Schistosoma haematobium, or without schistosome infection

Author

Bullington, Brooke W., Lee, Myung Hee, Mlingi, Jane, Paul, Ndalloh, Aristide, Christine, Fontana, Emily, Littmann, Eric R., Mukerebe, Crispin, Shigella, Peter, Kashangaki, Philibert, Kalluvya, Samuel E., de Dood, Claudia J., van Dam, Govert J., Corstjens, Paul L.A.M., Fitzgerald, Daniel W., Pamer, Eric G., and Downs, Jennifer A.

Published
2021
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4. Rhesus macaques self-curing from a schistosome infection can display complete immunity to challenge

Author

Amaral, Murilo Sena, Santos, Daisy Woellner, Pereira, Adriana S. A., Tahira, Ana Carolina, Malvezzi, João V. M., Miyasato, Patrícia Aoki, Freitas, Rafaela de Paula, Kalil, Jorge, Tjon Kon Fat, Elisa M., de Dood, Claudia J., Corstjens, Paul L. A. M., van Dam, Govert J., Nakano, Eliana, Castro, Simone de Oliveira, Mattaraia, Vânia Gomes de Moura, Augusto, Ronaldo de Carvalho, Grunau, Christoph, Wilson, R. Alan, and Verjovski-Almeida, Sergio

Published
2021
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5. A controlled human Schistosoma mansoni infection model to advance novel drugs, vaccines and diagnostics

Author

Langenberg, Marijke C. C., Hoogerwerf, Marie-Astrid, Koopman, Jan Pieter R., Janse, Jacqueline J., Kos-van Oosterhoud, Janneke, Feijt, Carola, Jochems, Simon P., de Dood, Claudia J., van Schuijlenburg, Roos, Ozir-Fazalalikhan, Arifa, Manurung, Mikhael D., Sartono, Erliyani, van der Beek, Martha T., Winkel, Béatrice M. F., Verbeek-Menken, Petra H., Stam, Koen A., van Leeuwen, Fijs W. B., Meij, Pauline, van Diepen, Angela, van Lieshout, Lisette, van Dam, Govert J., Corstjens, Paul L. A. M., Hokke, Cornelis H., Yazdanbakhsh, Maria, Visser, Leo G., and Roestenberg, Meta

Published
2020
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6. Schistosoma mansoni infection alters the host pre-vaccination environment resulting in blunted Hepatitis B vaccination immune responses

Author

Muir, Roshell, primary, Metcalf, Talibah, additional, Fourati, Slim, additional, Bartsch, Yannic, additional, Kyosiimire-Lugemwa, Jacqueline, additional, Canderan, Glenda, additional, Alter, Galit, additional, Muyanja, Enoch, additional, Okech, Brenda, additional, Namatovu, Teddy, additional, Namara, Irene, additional, Namuniina, Annemarie, additional, Ssetaala, Ali, additional, Mpendo, Juliet, additional, Nanvubya, Annet, additional, Kitandwe, Paul Kato, additional, Bagaya, Bernard S., additional, Kiwanuka, Noah, additional, Nassuna, Jacent, additional, Biribawa, Victoria Menya, additional, Elliott, Alison M., additional, de Dood, Claudia J., additional, Senyonga, William, additional, Balungi, Priscilla, additional, Kaleebu, Pontiano, additional, Mayanja, Yunia, additional, Odongo, Matthew, additional, Connors, Jennifer, additional, Fast, Pat, additional, Price, Matt A., additional, Corstjens, Paul L. A. M., additional, van Dam, Govert J., additional, Kamali, Anatoli, additional, Sekaly, Rafick Pierre, additional, and Haddad, Elias K., additional

Published
2023
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7. Sensitivity and specificity of human point-of-care circulating cathodic antigen (POC-CCA) test in African livestock for rapid diagnosis of schistosomiasis: A Bayesian latent class analysis

Author

Calvo-Urbano, Beatriz, primary, Léger, Elsa, additional, Gabain, Isobel, additional, De Dood, Claudia J., additional, Diouf, Nicolas D., additional, Borlase, Anna, additional, Rudge, James W., additional, Corstjens, Paul L. A. M., additional, Sène, Mariama, additional, Van Dam, Govert J., additional, Walker, Martin, additional, and Webster, Joanne P., additional

Published
2023
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8. Schistosoma mansoniinfection alters the host pre-vaccination environment resulting in blunted Hepatitis B vaccination immune responses

Author

Muir, Roshell, primary, Metcalf, Talibah, additional, Fourati, Slim, additional, Bartsch, Yannic, additional, Lugemwa, Jacqueline Kyosiimire, additional, Canderan, Glenda, additional, Alter, Galit, additional, Muyanja, Enoch, additional, Okech, Brenda, additional, Namatovu, Teddy, additional, Namara, Irene, additional, Namuniina, Annemarie, additional, Ssetaala, Ali, additional, Mpendo, Juliet, additional, Nanvubya, Annet, additional, Kitandwe, Paul Kato, additional, Bagaya, Bernard S., additional, Kiwanuka, Noah, additional, Nassuna, Jacent, additional, Biribawa, Victoria Menya, additional, Elliott, Alison M., additional, de Dood, Claudia J., additional, Senyonga, William, additional, Balungi, Priscilla, additional, Kaleebu, Pontiano, additional, Mayanja, Yunia, additional, Odongo, Mathew, additional, Fast, Pat, additional, Price, Matt A., additional, Corstjens, Paul L.A.M., additional, van Dam, Govert J., additional, Kamali, Anatoli, additional, Sekaly, Rafick Pierre, additional, and Haddad, Elias K, additional

Published
2023
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9. Association of schistosome infection with adiposity in Tanzania

Author

Pham, Khanh, primary, PrayGod, George, additional, Faurholt-Jepsen, Daniel, additional, Olsen, Mette F., additional, Kavishe, Bazil, additional, Kitilya, Brenda, additional, Corstjens, Paul L. A. M., additional, de Dood, Claudia J., additional, Friis, Henrik, additional, Filteau, Suzanne, additional, Downs, Jennifer A., additional, and Peck, Robert N., additional

Published
2023
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10. Multi-center evaluation of a user-friendly lateral flow assay to determine IP-10 and CCL4 levels in blood of TB and non-TB cases in Africa

Author

Corstjens, Paul L.A.M., Tjon Kon Fat, Elisa M., de Dood, Claudia J., van der Ploeg-van Schip, Jolien J., Franken, Kees L.M.C., Chegou, Novel N., Sutherland, Jayne S., Howe, Rawleigh, Mihret, Adane, Kassa, Desta, van der Vyver, Marieta, Sheehama, Jacob, Simukonda, Felanji, Mayanja-Kizza, Harriet, Ottenhoff, Tom H.M., Walzl, Gerhard, and Geluk, Annemieke

Published
2016
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13. Sensitivity and specificity of human point-of-care circulating cathodic antigen (POC-CCA) test in African livestock for rapid diagnosis of schistosomiasis: a Bayesian latent class analysis

Author

Calvo-Urbano, Beatriz, primary, Léger, Elsa, additional, Gabain, Isobel, additional, De Dood, Claudia J., additional, Diouf, Nicolas D., additional, Borlase, Anna, additional, Rudge, James W., additional, Corstjens, Paul L. A. M., additional, Sène, Mariama, additional, Van Dam, Govert J., additional, Walker, Martin, additional, and Webster, Joanne P., additional

Published
2022
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15. Sensitive Diagnosis and Post-Treatment Follow-Up of Schistosoma mansoni Infections in Asymptomatic Eritrean Refugees by Circulating Anodic Antigen Detection and Polymerase Chain Reaction

Author

Hoekstra, Pytsje T., primary, Chernet, Afona, additional, de Dood, Claudia J., additional, Brienen, Eric A. T., additional, Corstjens, Paul L. A. M., additional, Labhardt, Niklaus D., additional, Nickel, Beatrice, additional, Wammes, Linda J., additional, van Dam, Govert J., additional, Neumayr, Andreas, additional, and van Lieshout, Lisette, additional

Published
2022
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16. Concurrent evaluation of cytokines improves the accuracy of antibodies against Mycobacterium tuberculosis antigens in the diagnosis of active tuberculosis

Author

Jacobs, Ruschca, primary, Awoniyi, Dolapo O., additional, Baumann, Ralf, additional, Stanley, Kim, additional, McAnda, Shirley, additional, Kaempfer, Susanne, additional, Malherbe, Stephanus T., additional, Singh, Mahavir, additional, Walzl, Gerhard, additional, Chegou, Novel N., additional, Kriel, Magdalena, additional, van der Spuy, Gian, additional, Loxton, Andre G., additional, Kriel, Belinda, additional, Sutherland, Jayne S., additional, Owolabi, Olumuyiwa, additional, Sillah, Abdou, additional, Mendy, Joseph, additional, Gindeh, Awa, additional, Donkor, Simon, additional, Togun, Toyin, additional, Ota, Martin, additional, Crampin, Amelia C., additional, Simukonda, Felanji, additional, Amberbir, Alemayehu, additional, Chilongo, Femia, additional, Houben, Rein, additional, Kassa, Desta, additional, Gebrezgeabher, Atsbeha, additional, Mesfin, Getnet, additional, Belay, Yohannes, additional, Gebremichael, Gebremedhin, additional, Alemayehu, Yodit, additional, van der Vyver, Marieta, additional, Amutenya, Faustina N., additional, Nelongo, Josefina N., additional, Monye, Lidia, additional, Sheehama, Jacob A., additional, Iipinge, Scholastica, additional, Mayanja-Kizza, Harriet, additional, Namuganga, Anna Ritah, additional, Muzanye, Grace, additional, Nsereko, Mary, additional, Peters, Pierre, additional, Howe, Rawleigh, additional, Mihret, Adane, additional, Bekele, Yonas, additional, Tessema, Bamlak, additional, Yamuah, Lawrence, additional, Ottenhoff, Tom H.M., additional, Geluk, Annemieke, additional, Franken, Kees, additional, van der Ploeg-van Schip, Jolien J., additional, Corstjens, Paul L.A.M., additional, Tjon Kon Fat, Elisa M., additional, de Dood, Claudia J., additional, Rosenkrands, Ida, additional, Aagaard, Claus, additional, Kaufmann, Stefan H.E., additional, Esterhuyse, Maria M., additional, Cliff, Jacqueline M., additional, and Dockrell, Hazel M., additional

Published
2022
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17. Excretion patterns of Schistosoma mansoni antigens CCA and CAA by adult male and female worms, using a mouse model and ex vivo parasite cultures

Author

Casacuberta-Partal, Miriam, primary, van Lieshout, Lisette, additional, van Diepen, Angela, additional, Sijtsma, Jeroen, additional, Ozir-Fazalalikhan, Arifa, additional, Koopman, Jan Pieter R., additional, de Dood, Claudia J., additional, Corstjens, Paul L.A.M., additional, van Dam, Govert J., additional, Hokke, Cornelis H., additional, and Roestenberg, Meta, additional

Published
2021
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18. Sensitive diagnosis and post-treatment follow-up of Schistosoma mansoni infections in asymptomatic Eritrean refugees by Circulating Anodic Antigen (CAA) detection and PCR

Author

Hoekstra, Pytsje T., Chernet, Afona, de Dood, Claudia J., Brienen, Eric A. T., Corstjens, Paul L. A. M., Labhardt, Niklaus D., Nickel, Beatrice, Wammes, Linda, van Dam, Govert J., Neumayr, Andreas, and van Lieshout, Lisette

Abstract

The increasing number of refugees coming from or passing through Schistosoma-endemic areas and arriving in Europe highlights the importance of screening for schistosomiasis on arrival, and focuses attention on the choice of diagnostic test. We evaluate the diagnostic performance of circulating anodic antigen (CAA) detection in 92 asymptomatic refugees from Eritrea. Results were compared with already-available stool microscopy, serology, and urine point-of-care circulating cathodic antigen (POC-CCA) data. For a full diagnostic comparison, real-time polymerase chain reaction (PCR) and the POC-CCA were included. All outcomes were compared against a composite reference standard. Urine and serum samples were subjected to the ultra-sensitive and highly specific up-converting particle lateral flow CAA test, Schistosoma spp. real-time PCR was performed on urine and stool, and the POC-CCA was used on urine using the G-score method. CAA was detected in 43% of urine and in 40% of serum samples. Urine PCR was negative in all 92 individuals, whereas 25% showed Schistosoma DNA in stool. POC-CCA was positive in 30% of individuals. The CAA test confirmed all microscopy positives, except for two cases that were also negative by all other diagnostic procedures. Post-treatment, a significant reduction in the number of positives and infection intensity was observed, in particular regarding CAA levels. Our findings confirm that microscopy, serology, and POC-CCA lack the sensitivity to detect all active Schistosoma infections. Accuracy of stool PCR was similar to microscopy, indicating that this method also lacks sensitivity. The CAA test appeared to be the most accurate method for screening active Schistosoma infections and for monitoring treatment efficacy.

Published
2021

19. High prevalence of Schistosoma mansoni infection and stunting among school age children in communities along the Albert-Nile, Northern Uganda: A cross sectional study.

Author

Mulindwa, Julius, Namulondo, Joyce, Kitibwa, Anna, Nassuuna, Jacent, Nyangiri, Oscar Asanya, Kimuda, Magambo Phillip, Boobo, Alex, Nerima, Barbara, Busingye, Fred, Candia, Rowel, Namukuta, Annet, Ssenyonga, Ronald, Ukumu, Noah, Ajal, Paul, Adriko, Moses, Noyes, Harry, de Dood, Claudia J., Corstjens, Paul L. A. M., van Dam, Govert J., and Elliott, Alison M.

Subjects
STUNTED growth, SCHOOL children, SCHISTOSOMA mansoni, SHORELINES, CHILD nutrition, FRESH water, GIRLS
Abstract

Background: Knowing the prevalence of schistosomiasis is key to informing programmes to control and eliminate the disease as a public health problem. It is also important to understand the impact of infection on child growth and development in order to allocate appropriate resources and effort to the control of the disease. Methods: We conducted a survey to estimate the prevalence of schistosomiasis among school aged children in villages along the Albert-Nile shore line in the district of Pakwach, North Western Uganda. A total of 914 children aged between 10–15 years were screened for Schistosoma mansoni using the POC-CCA and Kato Katz (KK) techniques. The infection intensities were assessed by POC-CCA and KK as well as CAA tests. The KK intensities were also correlated with POC-CCA and with CAA intensity. Anthropometric measurements were also taken and multivariate analysis was carried out to investigate their association with infection status. Results: The prevalence of schistosomiasis using the POC-CCA diagnostic test was estimated at 85% (95% CI: 83–87), being highest amongst children living closer to the Albert-Nile shoreline. Visual scoring of the POC-CCA results was more sensitive than the Kato Katz test and was positively correlated with the quantified infection intensities by the CAA test. The majority of the children were underweight (BMI<18.5), and most notably, boys had significantly lower height for age (stunting) than girls in the same age range (p < 0.0001), but this was not directly associated with S. mansoni infection. Conclusion: High prevalence of S. mansoni infection in the region calls for more frequent mass drug administration with praziquantel. We observed high levels of stunting which was not associated with schistosomiasis. There is a need for improved nutrition among the children in the area. Author summary: Schistosomiasis is a neglected but frequent disease that is caused by schistosomes, with over 290 million people worldwide at risk of infection. The major mode of transmission is through contact with fresh water sources infested with infected snails (the intermediate host). In this study, using the point of care test (POC-CCA), we screened 914 school aged children (10–15 years) living in the rural communities along the Lake Albert- River Nile shores of Pakwach district in Northern Uganda. We observed a very high prevalence of S. mansoni infections (over 80%) although the prevalence dropped to 40% in communities that were further from the lake shores. This high prevalence was also coupled with Kato Katz light schistosome infection intensities as categorised by WHO guidelines. We further compared the POC-CCA and Kato Katz tests to the more sensitive CAA assay and this revealed that even though both tests gave good probability of positive prediction, the POC-CCA had higher sensitivity in screening for S. mansoni infections than Kato Katz assay. The study also revealed high levels of stunting within the children, more so amongst boys. Frequent screening and mass treatment of these communities with praziquantel will reduce on the infection rates. But in addition, improved hygiene and sanitation will be required for a sustainable reduction in the prevalence and morbidity of schistosomiasis in the Albert-Nile communities along with dietary intervention for optimal child health. [ABSTRACT FROM AUTHOR]

Published
2022
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21. Early diagnosis and follow-up of acute schistosomiasis in a cluster of infected Belgian travellers by detection of antibodies and circulating anodic antigen (CAA): A diagnostic evaluation study

Author

Hoekstra, Pytsje T., primary, van Esbroeck, Marjan, additional, de Dood, Claudia J., additional, Corstjens, Paul LAM., additional, Cnops, Lieselotte, additional, van Zeijl-van der Ham, Christel JG., additional, Wammes, Linda J., additional, van Dam, Govert J., additional, Clerinx, Jan, additional, and van Lieshout, Lisette, additional

Published
2021
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22. Specificity of the Point-of-Care Urine Strip Test for Schistosoma Circulating Cathodic Antigen (POC-CCA) Tested in Non-Endemic Pregnant Women and Young Children

Author

Casacuberta-Partal, Miriam, primary, Beenakker, Margreet, additional, de Dood, Claudia J., additional, Hoekstra, Pytsje T., additional, Kroon, Lisa, additional, Kornelis, Dieuwke, additional, Corstjens, Paul, additional, Hokke, Cornelis H., additional, van Dam, Govert J., additional, Roestenberg, Meta, additional, and van Lieshout, Lisette, additional

Published
2021
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23. Circulating Anodic Antigen (CAA): A Highly Sensitive Diagnostic Biomarker to Detect Active Schistosoma Infections—Improvement and Use during SCORE

Author

Corstjens, Paul L. A. M., primary, de Dood, Claudia J., additional, Knopp, Stefanie, additional, Clements, Michelle N., additional, Ortu, Giuseppina, additional, Umulisa, Irenee, additional, Ruberanziza, Eugene, additional, Wittmann, Udo, additional, Kariuki, Thomas, additional, LoVerde, Philip, additional, Secor, William Evan, additional, Atkins, Lydia, additional, Kinung’hi, Safari, additional, Binder, Sue, additional, Campbell, Carl H., additional, Colley, Daniel G., additional, and van Dam, Govert J., additional

Published
2020
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24. Insufficiency of annual praziquantel treatment to control Schistosoma mansoni infections in adult women: A longitudinal cohort study in rural Tanzania

Author

Mishra, Pallavi, primary, Colombe, Soledad, additional, Paul, Ndalloh, additional, Mlingi, Jane, additional, Tosiri, Inobena, additional, Aristide, Christine, additional, Gao, Joanna, additional, Kashangaki, Philibert, additional, Nagai, Honest, additional, Kalluvya, Samuel E., additional, de Dood, Claudia J., additional, Corstjens, Paul L., additional, Mngara, Julius, additional, van Dam, Govert J., additional, and Downs, Jennifer A., additional

Published
2019
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26. Excretion patterns of Schistosoma mansoni antigens CCA and CAA by adult male and female worms, using a mouse model and ex vivo parasite cultures.

Author

Casacuberta-Partal, Miriam, van Lieshout, Lisette, van Diepen, Angela, Sijtsma, Jeroen C., Ozir-Fazalalikhan, Arifa, Koopman, Jan Pieter R., de Dood, Claudia J., Corstjens, Paul L.A.M., van Dam, Govert J., Hokke, Cornelis H., and Roestenberg, Meta

Subjects
SCHISTOSOMA mansoni, LABORATORY mice, EXCRETION, ANIMAL disease models, WORMS
Abstract

Assays which enable the detection of schistosome gut-associated circulating anodic (CAA) and cathodic (CCA) antigen in serum or urine are increasingly used as a diagnostic tool for schistosome infection. However, little is known about the production and clearance of these circulating antigens in relation to the sex and reproductive maturity of the parasite. Here we describe CAA and CCA excretion patterns by exploring a mouse model after exposure to 36 male-only, female-only and mixed (male/female) Schistosoma mansoni cercariae. We found that serum and urine CAA levels, analysed at 3 weeks intervals, peaked at 6 weeks post-infection. Worms recovered after perfusion at 14 weeks were cultured ex vivo. Male parasites excreted more circulating antigens than females, in the mouse model as well as ex vivo. In mixed infections (supporting egg production), serum CAA levels correlated to the number of recovered worms, whereas faecal egg counts or Schistosoma DNA in stool did not. No viable eggs and no inflammation were seen in the livers from mice infected with female worms only. Ex vivo, CAA levels were higher than CCA levels. Our study confirms that CAA levels reflect worm burden and allows detection of low-level single-sex infections. [ABSTRACT FROM AUTHOR]

Published
2022
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27. Performance of an Ultra-Sensitive Assay Targeting the Circulating Anodic Antigen (CAA) for Detection of Schistosoma mansoni Infection in a Low Endemic Area in Brazil

Author

Sousa, Mariana Silva, primary, van Dam, Govert J., additional, Pinheiro, Marta Cristhiany Cunha, additional, de Dood, Claudia J., additional, Peralta, Jose Mauro, additional, Peralta, Regina Helena Saramago, additional, Daher, Elizabeth de Francesco, additional, Corstjens, Paul L. A. M., additional, and Bezerra, Fernando Schemelzer Moraes, additional

Published
2019
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28. Gene Expression Differences in Host Response to Schistosoma haematobium Infection

Author

Dupnik, Kathryn M., primary, Reust, Mary Juliet, additional, Vick, Kaitlin M., additional, Yao, Benjamin, additional, Miyaye, Donald, additional, Lyimo, Eric, additional, Mukerebe, Crispin, additional, Mngara, Julius, additional, Kalluvya, Samuel E., additional, de Dood, Claudia J., additional, Corstjens, Paul L. A. M., additional, van Dam, Govert J., additional, Zhang, Tuo, additional, Xiang, Jenny, additional, Lee, Myung Hee, additional, and Downs, Jennifer A., additional

Published
2019
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29. Altered Cervical Mucosal Gene Expression and Lower Interleukin 15 Levels in Women With Schistosoma haematobium Infection but Not in Women With Schistosoma mansoni Infection

Author

Dupnik, Kathryn M, primary, Lee, Myung Hee, additional, Mishra, Pallavi, additional, Reust, Mary Juliet, additional, Colombe, Soledad, additional, Haider, Syeda Razia, additional, Yao, Benjamin, additional, Vick, Kaitlin, additional, Zhang, Tuo, additional, Xiang, Jenny, additional, Miyaye, Donald, additional, Magawa, Ruth, additional, Lyimo, Eric, additional, Mukerebe, Crispin, additional, Mngara, Julius, additional, Kalluvya, Samuel E, additional, de Dood, Claudia J, additional, van Dam, Govert J, additional, Corstjens, Paul L A M, additional, and Downs, Jennifer A, additional

Published
2018
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30. Effect of schistosomiasis on the outcome of patients infected with HIV-1 starting antiretroviral therapy in rural Tanzania

Author

Stete, Katarina, primary, Glass, Tracy R., additional, van Dam, Govert J., additional, Ntamatungiro, Alex, additional, Letang, Emilio, additional, de Dood, Claudia J., additional, Corstjens, Paul L. A. M., additional, Ndege, Robert, additional, Mapesi, Herry, additional, Kern, Winfried V., additional, Hatz, Christoph, additional, Weisser, Maja, additional, Utzinger, Jürg, additional, and Müller, Matthias C., additional

Published
2018
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31. HIV-1 Viral Loads Are Not Elevated in Individuals Co-infected With Schistosoma spp. After Adjustment for Duration of HIV-1 Infection

Author

Colombe, Soledad, primary, Corstjens, Paul L. A. M., additional, de Dood, Claudia J., additional, Miyaye, Donald, additional, Magawa, Ruth G., additional, Mngara, Julius, additional, Kalluvya, Samuel E., additional, van Lieshout, Lisette, additional, van Dam, Govert J., additional, and Downs, Jennifer A., additional

Published
2018
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32. Impact of schistosome infection on long-term HIV/AIDS outcomes

Author

Colombe, Soledad, primary, Machemba, Richard, additional, Mtenga, Baltazar, additional, Lutonja, Peter, additional, Kalluvya, Samuel E., additional, de Dood, Claudia J., additional, Hoekstra, Pytsje T., additional, van Dam, Govert J., additional, Corstjens, Paul L. A. M., additional, Urassa, Mark, additional, Changalucha, John M., additional, Todd, Jim, additional, and Downs, Jennifer A., additional

Published
2018
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34. Rapid clearance of Schistosoma mansoni circulating cathodic antigen after treatment shown by urine strip tests in a Ugandan fishing community – Relevance for monitoring treatment efficacy and re-infection

Author

Kildemoes, Anna O., primary, Vennervald, Birgitte J., additional, Tukahebwa, Edridah M., additional, Kabatereine, Narcis B., additional, Magnussen, Pascal, additional, de Dood, Claudia J., additional, Deelder, André M., additional, Wilson, Shona, additional, and van Dam, Govert J., additional

Published
2017
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36. Effects of schistosomiasis on susceptibility to HIV-1 infection and HIV-1 viral load at HIV-1 seroconversion: A nested case-control study

Author

Downs, Jennifer A., primary, Dupnik, Kathryn M., additional, van Dam, Govert J., additional, Urassa, Mark, additional, Lutonja, Peter, additional, Kornelis, Dieuwke, additional, de Dood, Claudia J., additional, Hoekstra, Pytsje, additional, Kanjala, Chifundo, additional, Isingo, Raphael, additional, Peck, Robert N., additional, Lee, Myung Hee, additional, Corstjens, Paul L. A. M., additional, Todd, Jim, additional, Changalucha, John M., additional, Johnson, Warren D., additional, and Fitzgerald, Daniel W., additional

Published
2017
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37. Selecting accurate post-elimination monitoring tools to prevent reemergence of urogenital schistosomiasis in Morocco: a pilot study

Author

Balahbib, Abdelaali, primary, Amarir, Fatima, additional, Corstjens, Paul L.A.M., additional, de Dood, Claudia J., additional, van Dam, Govert J., additional, Hajli, Amina, additional, Belhaddad, Meryem, additional, El Mansouri, Bouchra, additional, Sadak, Abderrahim, additional, Rhajaoui, Mohamed, additional, and Adlaoui, El Bachir, additional

Published
2017
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38. Schistosomiasis and Human Immunodeficiency Virus in Men in Tanzania

Author

Downs, Jennifer A., primary, de Dood, Claudia J., additional, Dee, Hannah E., additional, McGeehan, Megan, additional, Khan, Hijab, additional, Marenga, Abena, additional, Adel, Patrick E., additional, Faustine, Edward, additional, Issarow, Benson, additional, Kisanga, Emmanuel F., additional, Kisigo, Godfrey Alfred, additional, Ngahyolerwa, Salvius, additional, Zahoro, Frank, additional, Miyaye, Donald, additional, Magawa, Ruth Gideon, additional, Mngara, Julius, additional, Lee, Myung Hee, additional, Corstjens, Paul L. A. M., additional, van Dam, Govert J., additional, and Fitzgerald, Daniel W., additional

Published
2017
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39. A controlled human Schistosoma mansoniinfection model to advance novel drugs, vaccines and diagnostics

Author

Langenberg, Marijke C. C., Hoogerwerf, Marie-Astrid, Koopman, Jan Pieter R., Janse, Jacqueline J., Kos-van Oosterhoud, Janneke, Feijt, Carola, Jochems, Simon P., de Dood, Claudia J., van Schuijlenburg, Roos, Ozir-Fazalalikhan, Arifa, Manurung, Mikhael D., Sartono, Erliyani, van der Beek, Martha T., Winkel, Béatrice M. F., Verbeek-Menken, Petra H., Stam, Koen A., van Leeuwen, Fijs W. B., Meij, Pauline, van Diepen, Angela, van Lieshout, Lisette, van Dam, Govert J., Corstjens, Paul L. A. M., Hokke, Cornelis H., Yazdanbakhsh, Maria, Visser, Leo G., and Roestenberg, Meta

Abstract

Schistosomiasis treatment relies on the use of a single drug, praziquantel, which is insufficient to control transmission in highly endemic areas1. Novel medicines and vaccines are urgently needed2,3. An experimental human model for schistosomiasis could accelerate the development of these products. We performed a dose-escalating clinical safety trial in 17 volunteers with male Schistosoma mansonicercariae, which do not produce eggs (clinicaltrials.gov NCT02755324), at the Leiden University Medical Center, the Netherlands. The primary endpoints were adverse events and infectivity. We found a dose-related increase in adverse events related to acute schistosomiasis syndrome, which occurred in 9 of 17 volunteers. Overall, 5 volunteers (all 3 of the high dose group and 2 of 11 of the medium dose group) reported severe adverse events. Worm-derived circulating anodic antigen, the biomarker of the primary infection endpoint, peaked in 82% of volunteers at 3–10 weeks following exposure. All volunteers showed IgM and IgG1 seroconversion and worm-specific cytokine production by CD4+T cells. All volunteers were cured with praziquantel provided at 12 weeks after exposure. Infection with 20 Schistosoma mansonicercariae led to severe adverse events in 18% of volunteers and high infection rates. This infection model paves the way for fast-track product development for treatment and prevention of schistosomiasis.

Published
2020
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40. Quantitative lateral flow strip assays as User-Friendly Tools To Detect Biomarker Profiles For Leprosy

Author

van Hooij, Anouk, primary, Tjon Kon Fat, Elisa M., additional, Richardus, Renate, additional, van den Eeden, Susan J. F., additional, Wilson, Louis, additional, de Dood, Claudia J., additional, Faber, Roel, additional, Alam, Korshed, additional, Richardus, Jan Hendrik, additional, Corstjens, Paul L. A. M., additional, and Geluk, Annemieke, additional

Published
2016
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41. Evaluation of cytokine responses against novel Mtb antigens as diagnostic markers for TB disease

Author

Awoniyi, Dolapo O., primary, Teuchert, Andrea, additional, Sutherland, Jayne S., additional, Mayanja-Kizza, Harriet, additional, Howe, Rawleigh, additional, Mihret, Adane, additional, Loxton, Andre G., additional, Sheehama, Jacob, additional, Kassa, Desta, additional, Crampin, Amelia C., additional, Dockrell, Hazel M., additional, Kidd, Martin, additional, Rosenkrands, Ida, additional, Geluk, Annemieke, additional, Ottenhoff, Tom H.M., additional, Corstjens, P.L.A.M., additional, Chegou, Novel N., additional, Walzl, Gerhard, additional, Kriel, Magdalena, additional, van der Spuy, Gian, additional, Stanley, Kim, additional, Malherbe, Stephanus, additional, Mcanda, Shirley, additional, Kriel, Belinda, additional, Phalane, Khutso G., additional, Essone, Paulin, additional, Owolabi, Olumuyiwa, additional, Sillah, Abdou, additional, Mendy, Joseph, additional, Gindeh, Awa, additional, Donkor, Simon, additional, Togun, Toyin, additional, Ota, Martin, additional, Simukonda, Felanji, additional, Amberbir, Alemayehu, additional, Chilongo, Femia, additional, Houben, Rein, additional, Gebrezgeabher, Atsbeha, additional, Mesfin, Getnet, additional, Belay, Yohannes, additional, Gebremichael, Gebremedhin, additional, Alemayehu, Yodit, additional, van der Vyver, Marieta, additional, Amutenya, Faustina N., additional, Nelongo, Josefina N., additional, Monye, Lidia, additional, Sheehama, Jacob A., additional, Iipinge, Scholastica, additional, Namuganga, Ann Ritah, additional, Muzanye, Grace, additional, Nsereko, Mary, additional, Peters, Pierre, additional, Bekele, Yonas, additional, Tessema, Bamlak, additional, Yamuah, Lawrence, additional, Franken, Kees, additional, Corstjens, Paul L.A.M., additional, Tjon Kon Fat, Elisa M., additional, de Dood, Claudia J., additional, van der Ploeg-van Schip, Jolien J., additional, Aagaard, Claus, additional, Kaufmann, Stefan H.E., additional, Esterhuyse, Maria M., additional, and Cliff, Jacqueline M., additional

Published
2016
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42. Sensitivity and Specificity of a Urine Circulating Anodic Antigen Test for the Diagnosis of Schistosoma haematobium in Low Endemic Settings

Author

Knopp, Stefanie, primary, Corstjens, Paul L. A. M., additional, Koukounari, Artemis, additional, Cercamondi, Colin I., additional, Ame, Shaali M., additional, Ali, Said M., additional, de Dood, Claudia J., additional, Mohammed, Khalfan A., additional, Utzinger, Jürg, additional, Rollinson, David, additional, and van Dam, Govert J., additional

Published
2015
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44. Evaluation of banked urine samples for the detection of circulating anodic and cathodic antigens in Schistosoma mekongi and S. japonicum infections: A proof-of-concept study

Author

van Dam, Govert J., primary, Odermatt, Peter, additional, Acosta, Luz, additional, Bergquist, Robert, additional, de Dood, Claudia J., additional, Kornelis, Dieuwke, additional, Muth, Sinuon, additional, Utzinger, Jürg, additional, and Corstjens, Paul L.A.M., additional

Published
2015
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45. An ultra-sensitive assay targeting the circulating anodic antigen for the diagnosis of Schistosoma japonicum in a low-endemic area, People's Republic of China

Author

van Dam, Govert J., primary, Xu, Jing, additional, Bergquist, Robert, additional, de Dood, Claudia J., additional, Utzinger, Jürg, additional, Qin, Zhi-Qiang, additional, Guan, Wei, additional, Feng, Ting, additional, Yu, Xin-Ling, additional, Zhou, Jie, additional, Zheng, Ma, additional, Zhou, Xiao-Nong, additional, and Corstjens, Paul L.A.M., additional

Published
2015
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46. Effects of schistosomiasis on susceptibility to HIV-1 infection and HIV-1 viral load at HIV-1 seroconversion: A nested case-control study.

Author

Dupnik, Kathryn M., Lee, Myung Hee, Jr.Johnson, Warren D., Fitzgerald, Daniel W., Downs, Jennifer A., Peck, Robert N., van Dam, Govert J., Kornelis, Dieuwke, Hoekstra, Pytsje, Urassa, Mark, Lutonja, Peter, Kanjala, Chifundo, Isingo, Raphael, Changalucha, John M., de Dood, Claudia J., Corstjens, Paul L. A. M., and Todd, Jim

Subjects
SCHISTOSOMIASIS, HIV-positive persons, IMMUNOREGULATION, SURVEYS, PATIENTS, DISEASE risk factors
Abstract

Background: Schistosomiasis affects 218 million people worldwide, with most infections in Africa. Prevalence studies suggest that people with chronic schistosomiasis may have higher risk of HIV-1 acquisition and impaired ability to control HIV-1 replication once infected. We hypothesized that: (1) pre-existing schistosome infection may increase the odds of HIV-1 acquisition and that the effects may differ between men and women, and (2) individuals with active schistosome infection at the time of HIV-1 acquisition may have impaired immune control of HIV-1, resulting in higher HIV-1 viral loads at HIV-1 seroconversion. Methology/Principal findings: We conducted a nested case-control study within a large population-based survey of HIV-1 transmission in Tanzania. A population of adults from seven villages was tested for HIV in 2007, 2010, and 2013 and dried blood spots were archived for future studies with participants’ consent. Approximately 40% of this population has Schistosoma mansoni infection, and 2% has S. haematobium. We tested for schistosome antigens in the pre- and post-HIV-1-seroconversion blood spots of people who acquired HIV-1. We also tested blood spots of matched controls who did not acquire HIV-1 and calculated the odds that a person with schistosomiasis would become HIV-1-infected compared to these matched controls. Analysis was stratified by gender. We compared 73 HIV-1 seroconverters with 265 controls. Women with schistosome infections had a higher odds of HIV-1 acquisition than those without (adjusted OR = 2.8 [1.2–6.6], p = 0.019). Schistosome-infected men did not have an increased odds of HIV-1 acquisition (adjusted OR = 0.7 [0.3–1.8], p = 0.42). We additionally compared HIV-1 RNA levels in the post-seroconversion blood spots in HIV-1 seroconverters with schistosomiasis versus those without who became HIV-infected in 2010, before antiretroviral therapy was widely available in the region. The median whole blood HIV-1 RNA level in the 15 HIV-1 seroconverters with schistosome infection was significantly higher than in the 22 without schistosomiasis: 4.4 [3.9–4.6] log10 copies/mL versus 3.7 [3.2–4.3], p = 0.017. Conclusions/Significance: We confirm, in an area with endemic S. mansoni, that pre-existing schistosome infection increases odds of HIV-1 acquisition in women and raises HIV-1 viral load at the time of HIV-1 seroconversion. This is the first study to demonstrate the effect of schistosome infection on HIV-1 susceptibility and viral control, and to differentiate effects by gender. Validation studies will be needed at additional sites. [ABSTRACT FROM AUTHOR]

Published
2017
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47. Tools for diagnosis, monitoring and screening ofSchistosomainfections utilizing lateral-flow based assays and upconverting phosphor labels

Author

CORSTJENS, PAUL L. A. M., primary, DE DOOD, CLAUDIA J., additional, KORNELIS, DIEUWKE, additional, TJON KON FAT, ELISA M., additional, WILSON, R. ALAN, additional, KARIUKI, THOMAS M., additional, NYAKUNDI, RUTH K., additional, LOVERDE, PHILIP T., additional, ABRAMS, WILLIAM R., additional, TANKE, HANS J., additional, VAN LIESHOUT, LISETTE, additional, DEELDER, ANDRÉ M., additional, and VAN DAM, GOVERT J., additional

Published
2014
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48. Field-Evaluation of a New Lateral Flow Assay for Detection of Cellular and Humoral Immunity against Mycobacterium leprae

Author

Bobosha, Kidist, primary, Tjon Kon Fat, Elisa M., additional, van den Eeden, Susan J. F., additional, Bekele, Yonas, additional, van der Ploeg-van Schip, Jolien J., additional, de Dood, Claudia J., additional, Dijkman, Karin, additional, Franken, Kees L. M. C., additional, Wilson, Louis, additional, Aseffa, Abraham, additional, Spencer, John S., additional, Ottenhoff, Tom H. M., additional, Corstjens, Paul L. A. M., additional, and Geluk, Annemieke, additional

Published
2014
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