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4. Diabetes Overtreatment and Hypoglycemia in Older Patients With Type 2 Diabetes on Insulin Therapy: Insights From the HYPOAGE Cohort Study.

Author

Christiaens, Antoine, Boureau, Anne-Sophie, Guyomarch, Béatrice, de Decker, Laure, Boland, Benoit, Hadjadj, Samy, Cariou, Bertrand, Morcel, Pierre, Wargny, Matthieu, Chapelet, Guillaume, Anweiller, Cédric, Allix, Ingrid, Briet, Claire, Gourdy, Pierre, Guyonnet, Sophie, Paccalin, Marc, Saulnier, Pierre-Jean, Delabrière, Isabelle, Litke, Rachel, and Cervantes, Nathalie

Subjects
TYPE 2 diabetes, OLDER patients, OLDER people, INSULIN therapy, HYPOGLYCEMIA
Abstract

OBJECTIVE: To assess the accuracy of "diabetes overtreatment" proxy definitions in predicting hypoglycemia in older adults with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: Inclusion of patients from HYPOAGE cohort with insulin-treated T2D, aged ≥75 years, and using a continuous glycemic monitoring (CGM) device for 28 days. "Diabetes overtreatment" was defined as HbA1c <7.0% (fixed proxy definition) or as HbA1c <7.0%, 7.5%, and 8.0% according to patient's health status (individualized proxy definition). The primary outcome was time below range (TBR) ≥1%. RESULTS: Of the 134 patients included (81.6 ± 5.4 years, 59% male), 25 (19%) and 53 (40%) were overtreated, based on fixed and individualized proxy definitions, respectively. CGM data showed TBR >1% in nearly all patients regardless of overtreatment status. Both proxy definitions had low sensitivity (20% [14; 29] and 41% [32; 50]) and accuracy (27% [20; 35] and 44% [35; 53]) in predicting hypoglycemia. CONCLUSIONS: A revised definition of diabetes overtreatment is needed to better manage older insulin-treated patients and protect them from hypoglycemia. [ABSTRACT FROM AUTHOR]

Published
2025
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11. Alterations in comprehensive geriatric assessment decrease survival of elderly patients with cancer

Author

Jeannin, Gaelle, Patrick, Merle, Nehme, Hélène, Leroy, Virginie, De Mones Del Pujol, Erwan, Ravaud, Alain, Maget, Brigitte, Jovenin, Nicolas, Feugier, Pierre, Bologna, Serge, Comte, Brigitte, Falandry, Claire, Mailliez, Audrey, Villers, Arnauld, Rose, Christian, Bonnal, Jean-Louis, Minard, Aurélien, Gisselbrecht, Mathilde, Ladoire, Sylvain, Quipourt, Valérie, Lavau-Denes, Sandrine, Le Brun-Ly, Valérie, Thiberville, Luc, Rigal, Olivier, Lagrange, Jean Léon, Caillet, Philippe, Rousseau, Frédérique, De Decker, Laure, Bourbouloux, Emmanuelle, Carola, Elisabeth, Woerth, Florence, Brain, Etienne, Ribiere, Ludmilla, Stefani, Laeticia, Debray, Matthieu, Thieblemont, Catherine, Gisselbrecht, Christian, Balardy, Laurent, Mourey, Loic, Chaibi, Pascal, Frasca, M., Soubeyran, P., Bellera, C., Rainfray, M., Leffondre, K., and Mathoulin-Pélissier, S.

Published
2018
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12. Rethinking care management for older adults with cancer: Proposals from the “PRIORITES AGE CANCER” French group

Author

Galvin, Angéline, primary, Bertrand, Nicolas, additional, Boulahssass, Rabia, additional, De Decker, Laure, additional, Dorval, Etienne, additional, Clairaz, Béatrice, additional, Castaignède, Monique, additional, Mourey, Loic, additional, Baldini, Capucine, additional, Bauvin, Eric, additional, Jacques, Béatrice, additional, Mallon, Isabelle, additional, Durand-Zaleski, Isabelle, additional, Guérin, Olivier, additional, Krouri, Sadek, additional, and Soubeyran, Pierre, additional

Published
2023
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19. Nocturnal hypoglycemia is underdiagnosed in older people with insulin‐treated type 2 diabetes: The HYPOAGE observational study

Author

Boureau, Anne‐Sophie, primary, Guyomarch, Béatrice, additional, Gourdy, Pierre, additional, Allix, Ingrid, additional, Annweiler, Cédric, additional, Cervantes, Nathalie, additional, Chapelet, Guillaume, additional, Delabrière, Isabelle, additional, Guyonnet, Sophie, additional, Litke, Rachel, additional, Paccalin, Marc, additional, Penfornis, Alfred, additional, Saulnier, Pierre‐Jean, additional, Wargny, Matthieu, additional, Hadjadj, Samy, additional, de Decker, Laure, additional, and Cariou, Bertrand, additional

Published
2023
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25. Effectiveness of Geriatric Assessment-Driven Interventions on Survival and Functional and Nutritional Status in Older Patients with Head and Neck Cancer: A Randomized Controlled Trial (EGeSOR)

Author

Paillaud, Elena, primary, Brugel, Lydia, additional, Bertolus, Chloe, additional, Baron, Melany, additional, Bequignon, Emilie, additional, Caillet, Philippe, additional, Schouman, Thomas, additional, Lacau Saint Guily, Jean, additional, Périé, Sophie, additional, Bouvard, Eric, additional, Laurent, Marie, additional, Salvan, Didier, additional, Chaumette, Laurence, additional, de Decker, Laure, additional, Piot, Benoit, additional, Barry, Beatrix, additional, Raynaud-Simon, Agathe, additional, Sauvaget, Elisabeth, additional, Bach, Christine, additional, Bizard, Antoine, additional, Bounar, Abderrahmane, additional, Minard, Aurelien, additional, Aziz, Bechara, additional, Chevalier, Eric, additional, Chevalier, Dominique, additional, Gaxatte, Cedric, additional, Malard, Olivier, additional, Liuu, Evelyne, additional, Lacour, Sandrine, additional, Gregoire, Laetitia, additional, Lafont, Charlotte, additional, and Canouï-Poitrine, Florence, additional

Published
2022
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26. Additional file 1 of Functional decline, long term symptoms and course of frailty at 3-months follow-up in COVID-19 older survivors, a prospective observational cohort study

Author

Prampart, Simon, Le Gentil, Sylvain, Bureau, Marie Laure, Macchi, Claire, Leroux, Caroline, Chapelet, Guillaume, de Decker, Laure, Rouaud, Agnes, and Boureau, Anne Sophie

Abstract

Additional file 1: Table 1S. Univariable analysis of factors associated with functional decline. Table 2S. Overall COVID-19 survivors and dead patients’ characteristics.

Published
2022
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27. Artificial Neural Networks Help to Better Understand the Interplay Between Cognition, Mediterranean Diet, and Physical Performance: Clues from TRELONG Study

Author

Berrut, Gilles, de Decker, Laure, Aquino, Jean-Pierre, Ahmine, Sabiha, Amalberti, Nathalie, Arlaud, Cyprien, Aubry, Astrid, Beau, Philippe, Behara, Harold, Bernard, Fanny, Bloch, Frederic, Bonin-Guillaume, Sylvie, Boureau, Anne-Sophie, Chaffringeon, Astrid, Chaudier, Bernard, Collins, Claire, Courau, Axelle, Cudennec, Tristan, Debray, Matthieu, Fougère, Bertrand, Gaudeau, Déborah, Huvent-Grelle, Dominique, Laurent, Marie, Mizzi, Barbara, Maley, Karin, Mecheri, Hassan, Merlhès, Camille, Merouani, Braham, Nicolini, Marc, Pautas, Eric, Pellerano, Bruno, Piet, Emilie, Rascle, Catherine, Rouaud, Agnes, Somme, Dominique, Gavazzi, Gaetan, Salles, Nathalie, Guérin, Olivier, Gallucci, Maurizio, Pallucca, Claudia, Di Battista, Maria Elena, Grossi, Enzo, Motricité, interactions, performance EA 4334 / Movement - Interactions - Performance (MIP), Le Mans Université (UM)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université de Nantes - UFR des Sciences et Techniques des Activités Physiques et Sportives (UFR STAPS), Université de Nantes (UN)-Université de Nantes (UN), Médecine Aiguë Gériatrique [Nantes], Université de Nantes (UN), Société Francophone d’OncoGériatrie [Saint-Herblain] (SoFOG), Centre hospitalier universitaire de Nantes (CHU Nantes), Fondation Médéric Alzheimer, Department of Internal Medicine and Geriatrics, Assistance Publique - Hôpitaux de Marseille (APHM), Aix Marseille Université (AMU), Unité de recherche de l'institut du thorax (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Hôpital d'Instruction des Armées Laveran, Service de Santé des Armées, Irish College of General Practitioners [Dublin, Irlande] (ICGP), Service de médecine gériatrique, CHU Bordeaux [Bordeaux]-Groupe Hospitalier Sud-Hôpital Xavier Arnozan, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Éducation Éthique Santé EA 7505 (EES), and Université de Tours (UT)

Subjects
Male, 0301 basic medicine, Gerontology, Mediterranean diet, Institutionalisation, Neuropsychological Tests, Diet, Mediterranean, [SHS]Humanities and Social Sciences, Healthy Aging, 03 medical and health sciences, Cognition, 0302 clinical medicine, medicine, Humans, Association (psychology), Geriatric Assessment, Physical Examination, ComputingMilieux_MISCELLANEOUS, Aged, Aged, 80 and over, Mini–Mental State Examination, Successful aging, Artificial neural network, medicine.diagnostic_test, General Neuroscience, General Medicine, Physical Functional Performance, Psychiatry and Mental health, Clinical Psychology, 030104 developmental biology, Italy, Physical performance, Female, Neural Networks, Computer, Geriatrics and Gerontology, Psychology, Risk Reduction Behavior, 030217 neurology & neurosurgery
Abstract

BACKGROUND Nutrition plays an important role in the aging process. Adherence to the Mediterranean diet (MedDiet) has been shown to be associated with lower rates of diseases. Cognitive status seems to be strongly interrelated with physical well-being, so that one influences the other. Physical performance measures are not only associated with clinical and subclinical age-related modifications, but are also able to predict disability, institutionalization, and mortality. OBJECTIVE To evaluate prospectively the associations between Mediterranean-Style Dietary Pattern Score (MSDPS), clinical characteristics, and cognition of the population sample of The TREVISO LONGEVA (TRELONG) Study, in Treviso, Italy. METHODS Global cognition, physical performance measures, MSDPS, and other clinical features were detected in 2010 in 82 men and 108 women. These characteristics were evaluated in relation to the physical performance measures identified 3.8 years later in 2013 in the same subjects, using a semantic connectivity map, through Auto-CM system, to grasp further and non-linear associations between variables which might remain, otherwise, undetected. RESULTS The Auto-CM system's map showed a close association between better levels of global cognition and MSDPS in 2010 and higher physical performance in 2013. On the other hand, worse levels of global cognition and MSDPS in 2010 were associated with lower physical performance in 2013. CONCLUSION The prevention models for successful aging may benefit from integrated programs that include cognitive, physical, and dietary interventions, since these aspects are mutually interrelated.

Published
2019
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30. Individual and Environmental Risk Factors for COVID- 19 Mortality in Elderly

Author

Bourdrel, Thomas, primary, Zabrocki, Leo, additional, Compte, Nathalie, additional, Bravenboer, Bert, additional, Decours, Romain, additional, Pelerin, Hélène, additional, De decker, Laure, additional, Kergaradec, Laurence Le Jumeau, additional, Lilamand, Matthieu, additional, Baudron, Claire Roubaud, additional, Fougère, Bertrand, additional, Mahmoudi, Rachid, additional, Schorr, Benoit, additional, Kaltenbach, Georges, additional, Vogel, Thomas, additional, Puech, Vincent-Henri, additional, Blanc, Fréderic, additional, and Bind, Marie-Abèle, additional

Published
2021
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32. Prevalence and prognostic impact of cachexia among older patients with cancer: a nationwide cross‐sectional survey (NutriAgeCancer)

Author

Poisson, Johanne, primary, Martinez‐Tapia, Claudia, additional, Heitz, Damien, additional, Geiss, Romain, additional, Albrand, Gilles, additional, Falandry, Claire, additional, Gisselbrecht, Mathilde, additional, Couderc, Anne‐Laure, additional, Boulahssass, Rabia, additional, Liuu, Evelyne, additional, Boudou‐Rouquette, Pascaline, additional, Chah Wakilian, Anne, additional, Gaxatte, Cedric, additional, Pamoukdjian, Fréderic, additional, de Decker, Laure, additional, Antoine, Valery, additional, Cattenoz, Catherine, additional, Solem‐Laviec, Heidi, additional, Guillem, Olivier, additional, Medjenah, Hayat, additional, Natella, Pierre André, additional, Canouï‐Poitrine, Florence, additional, Laurent, Marie, additional, and Paillaud, Elena, additional

Published
2021
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40. Empagliflozin in the elderly

Author

Berrut, Gilles, additional, Boureau, Anne Sophie, additional, Trochu, Jean Noel, additional, Genet, Bastien, additional, de Decker, Laure, additional, and Hanon, Olivier, additional

Published
2021
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42. Length of Stay in Older Patients Undergoing Transcatheter Aortic Valve Replacement: Value of a Geriatric Approach.

Author

Bobet, Anne Sophie, Brouessard, Céline, Le Tourneau, Thierry, Manigold, Thibaut, de Decker, Laure, and Boureau, Anne-Sophie

Abstract

Background: For patients with transcatheter aortic valve replacement (TAVR), increased length of stay (LOS) is associated with increased long-term mortality. The main objective of our study was to analyze the association between geriatrics factors and the hospital LOS for older patients undergoing TAVR for severe aortic stenosis. Methods: This retrospective single-center study included all patients aged ≥75 who underwent TAVR between January 2018 and January 2019. Hospital LOS and postoperative complications were analyzed regarding the geriatric factors recorded during a systematic preoperative, comprehensive geriatric assessment (CGA). The individualized-care plans established after the preoperative CGA were also analyzed. Results: median LOS of the 196 patients included was 6 days (interquartile range: 4–8), and 29% of patients had prolonged LOS. In a multivariable analysis, the preoperative factors associated with a prolonged hospital LOS were EuroSCORE I (p value = 0.02), prior major neurocognitive disorders (p value = 0.01), femoral access (p value <0.001), all complications (p value <0.001), and discharge in a rehabilitation center (p value <0.001). One-fourth (27%) of the patients had at least 1 geriatric complication. After CGA, 69 patients did not need any geriatric recommendation, whereas for the 127 other patients, an individualized-care plan was established but only 46 (36%) of them were followed up. Conclusion: Our results favor the preoperative screening for major neurocognitive disorders in order to reduce LOS. Furthermore, the proposed individual-care plans after CGA were poorly followed. Practitioners may perceive the preoperative CGA as a screening tool, but its primary objective is to develop an individualized-care plan as a prehabilitation plan in order to optimize the physical, functional, and social issues. [ABSTRACT FROM AUTHOR]

Published
2022
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43. Impact of Severe Sarcopenia on Rehospitalization and Survival One Year After a TAVR Procedure in Patients Aged 75 and Older

Author

Brouessard,Céline, Bobet,Anne Sophie, Mathieu,Marie, Manigold,Thibaut, Arrigoni,Pierre Paul, Le Tourneau,Thierry, De Decker,Laure, Boureau,Anne-Sophie, Brouessard,Céline, Bobet,Anne Sophie, Mathieu,Marie, Manigold,Thibaut, Arrigoni,Pierre Paul, Le Tourneau,Thierry, De Decker,Laure, and Boureau,Anne-Sophie

Abstract

Céline Brouessard,1 Anne Sophie Bobet,1 Marie Mathieu,1 Thibaut Manigold,2 Pierre Paul Arrigoni,3 Thierry Le Tourneau,4 Laure De Decker,1 Anne-Sophie Boureau1,4 1Department of Geriatrics, University Hospital, Nantes, France; 2Department of Cardiology, Institut du Thorax, University Hospital, Nantes, France; 3Department of Radiology, University Hospital, Nantes, France; 4Université de Nantes, CHU Nantes, CNRS, INSERM, Institut du Thorax, Nantes, F-44000, FranceCorrespondence: Anne-Sophie BoureauDepartment of Geriatrics, University Hospital, Nantes, 44093, FranceTel +33 2 40165046Email annesophie.boureau@chu-nantes.frBackground: Transcatheter aortic-valve replacement (TAVR) reduces mortality and improves quality of life in patients with severe aortic valve stenosis. One third of patients have no benefit one year after TAVR. Sarcopenia, an age-related loss of skeletal muscle mass, is associated with increased physical disability and mortality. The main purpose was to evaluate the impact of severe sarcopenia on rehospitalization one year after TAVR in older patients.Methods: All patients aged ≥ 75 referred for a TAVR in 2018 were included. Severe sarcopenia was defined by a loss of skeletal muscle mass defined on CT-scan measurement associated with a gait speed ≤ 0.8m/s. The main outcome was rehospitalization one year after TAVR.Results: Median age of the 182 included patients was 84, and 35% had an unplanned hospitalization at one year. Severe sarcopenia was diagnosed in 9 patients (4.9%). Univariable analysis showed that gait speed was a factor associated with readmission [HR=0.32, 95% CI (0.10– 0.97), p=0.04] but not severe sarcopenia. In multivariable analysis, only diabetes was significantly associated with rehospitalization [HR=2.06, 95% CI (1.11– 3.84), p=0.02]. Prevalence of severe sarcopenia varied according to different thresholds of skeletal muscle mass on CT-scan.Conclusion: Even though severe sarcopenia was not correlated with rehospitalization an

Published
2021

48. La méthode Snoezelen : une alternative thérapeutique chez les patients ayant des troubles cognitifs ?

Author

Barbier, Chloé, Nizard, Julien, Blanchet, Alain, Suissa, Véronique, Guérin, Serge, Derkinderen, Pascal, de Decker, Laure, Berrut, Gilles, and Chapelet, Guillaume

Subjects
SNOEZELEN, NEUROBEHAVIORAL disorders, COGNITION disorders, ACTIVITIES of daily living, TREATMENT effectiveness
Abstract

Résumé: La prise en soin des symptômes neuropsychiatriques de patients ayant des troubles neurocognitifs est basée sur des traitements non médicamenteux. Certains auteurs suggèrent que la méthode Snoezelen pourrait être une alternative thérapeutique. L'objectif de cette revue de littérature était de faire une recherche systématique des essais contrôlés et randomisés ayant analysé l'effet de la méthode Snoezelen sur les patients âgés ayant des troubles cognitifs. Le processus de sélection a permis d'inclure 18 études, ayant des méthodologies hétérogènes. Dans plusieurs études, la méthode Snoezelen pourrait avoir un effet bénéfique, à court terme, sur les troubles du comportement, sur l'humeur, la cognition, ou les capacités fonctionnelles. Cependant, la méthode Snoezelen ne semblait pas être supérieure à d'autres interventions non médicamenteuses et certaines études montraient des résultats discordants. Finalement, le niveau de preuve d'efficacité de la méthode Snoezelen reste faible et des études mixtes (quantitatives et qualitatives) seraient intéressantes à mener pour évaluer l'intérêt de la méthode Snoezelen sur des profils spécifiques de patients ayant des troubles neurocognitifs. Neuropsychiatric disorders are one of the frequent complications of neurocognitive disease, and have an impact on the quality of life of patients and caregivers. Non-phamacologic interventions are recommended as first-line treatment. The Snoezelen method is a multisensory stimulation method based on the assumption that acting on sensoriality can improve neuropsychiatric symptoms and thus quality of life, but its level of evidence is controversial. To explore this, we performed a systematic literature review of randomized controlled articles focusing on the use of the Snoezelen method in patients with cognitive disorders. Eighteen studies were included. The clinical outcomes studied were multiple (behavior, mood, cognition, functional capacities and biomedical parameters). When the Snoezelen method was compared to the "standard activities" group, it appears to be effective on short-term behavior. This was more negligible when the method was compared to others non-pharmacological interventions. Although the Snoezelen method could be effective on mood, cognition, and functional abilities, its level of evidence remains low. Furthers mixed studies (quantitative and qualitative) would be an interesting approach to delve into this topic in the most holistic way by integrating the patients, the caregivers and the cost of the method. [ABSTRACT FROM AUTHOR]

Published
2022
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