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3. Differential expression of nuclear genes encoding mitochondrial proteins from urban and rural populations in Morocco

Author

Bickler, Stephen W, Prieto, James M, Cauvi, David M, De Cos, Victor, Nasamran, Chanond, Ameh, Emmanuel, Amin, Said, Nicholson, Sneha, Din, Hena, Mocumbi, Ana Olga, Noormahomed, Emilia Virginia, Tellez-Isaias, Guillermo, Fisch, Kathleen M, and De Maio, Antonio

Subjects
Biological Sciences, Bioinformatics and Computational Biology, Genetics, Biotechnology, Clinical Research, Cell Nucleus, Gene Expression Profiling, Gene Expression Regulation, Geography, Humans, Mitochondrial Proteins, Morocco, Rural Population, Signal Transduction, Urban Population, Urbanization, Noncommunicable diseases, RNA, Mitochondrial, Gene expression, Biochemistry and Cell Biology, Biochemistry & Molecular Biology, Biochemistry and cell biology
Abstract

Urbanization in low-income countries represents an important inflection point in the epidemiology of disease, with rural populations experiencing high rates of chronic and recurrent infections and urban populations displaying a profile of noncommunicable diseases. To investigate if urbanization alters the expression of genes encoding mitochondrial proteins, we queried gene microarray data from rural and urban populations living in Morocco (GSE17065). The R Bioconductor packages edgeR and limma were used to identify genes with different expression. The experimental design was modeled upon location and sex. Nuclear genes encoding mitochondrial proteins were identified from the MitoCarta2.0 database. Of the 1158 genes listed in the MitoCarta2.0 database, 847 genes (73%) were available for analysis in the Moroccan dataset. The urban-rural comparison with the greatest environmental differences showed that 76.5% of the MitoCarta2.0 genes were differentially expressed, with 97% of the genes having an increased expression in the urban area. Enrichment analysis revealed 367 significantly enriched pathways (adjusted p value

Published
2020

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