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3. BCG vaccination in infancy does not protect against COVID-19. Evidence from a natural experiment in Sweden

Author

de Chaisemartin, Clément and de Chaisemartin, Luc

Subjects
Quantitative Biology - Populations and Evolution
Abstract

The Bacille Calmette-Gu\'erin (BCG) tuberculosis vaccine has immunity benefits against respiratory infections. Accordingly, it has been hypothesized that it may have a protective effect against COVID-19. Recent research found that countries with universal Bacillus Calmette-Gu\'erin (BCG) childhood vaccination policies tend to be less affected by the COVID-19 pandemic. However, such ecological studies are biased by numerous confounders. Instead, this paper takes advantage of a rare nationwide natural experiment that took place in Sweden in 1975, where discontinuation of newborns BCG vaccination led to a dramatic fall of the BCG coverage rate from 92% to 2% , thus allowing us to estimate the BCG's effect without all the biases associated with cross-country comparisons. Numbers of COVID-19 cases and hospitalizations were recorded for birth cohorts born just before and just after that change, representing 1,026,304 and 1,018,544 individuals, respectively. We used regression discontinuity to assess the effect of BCG vaccination on Covid-19 related outcomes. This method used on such a large population allows for a high precision that would be hard to achieve using a classical randomized controlled trial. The odds ratio for Covid-19 cases and Covid-19 related hospitalizations were 0.9997 (CI95: [0.8002-1.1992]) and 1.1931 (CI95: [0.7558-1.6304]), respectively. We can thus reject with 95\% confidence that universal BCG vaccination reduces the number of cases by more than 20% and the number of hospitalizations by more than 24%. While the effect of a recent vaccination must be evaluated, we provide strong evidence that receiving the BCG vaccine at birth does not have a protective effect against COVID-19.

Published
2020

4. BCG vaccination in infancy does not protect against COVID-19. Evidence from a natural experiment in Sweden

Author

de Chaisemartin, Clément and de Chaisemartin, Luc

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Immunization, Rare Diseases, Clinical Research, Vaccine Related, Prevention of disease and conditions, and promotion of well-being, 3.4 Vaccines, Infection, Good Health and Well Being, BCG Vaccine, COVID-19, Cohort Studies, Humans, Infant, Infant, Newborn, Middle Aged, Pandemics, SARS-CoV-2, Sweden, Vaccination, BCG, regression discontinuity, Biological Sciences, Medical and Health Sciences, Microbiology, Clinical sciences
Abstract

BackgroundThe bacille Calmette-Guérin (BCG) tuberculosis vaccine has immunity benefits against respiratory infections. Accordingly, it has been hypothesized to have a protective effect against coronavirus disease 2019 (COVID-19). Recent research found that countries with universal BCG childhood vaccination policies tend to be less affected by the COVID-19 pandemic. However, such ecological studies are biased by numerous confounders. Instead, this paper reports on a rare nationwide natural experiment that occurred in Sweden in 1975, where discontinuation of newborns' BCG vaccination led to a dramatic decrease in BCG coverage rate, thus allowing us to estimate BCG's effect without the biases associated with cross-country comparisons.MethodsNumbers of COVID-19 cases and hospitalizations were recorded for birth cohorts born just before and just after 1975, representing 1 026 304 and 1 018 544 individuals, respectively. We used regression discontinuity to assess the effect of BCG vaccination on COVID-19-related outcomes. On such a large population, this method allows for a precision that would be hard to achieve using a randomized controlled trial.ResultsThe odds ratios (95% CI) for COVID-19 cases and COVID-19-related hospitalizations were 1.0005 (.8130-1.1881) and 1.2046 (.7532-1.6560), allowing us to reject fairly modest effects of universal BCG vaccination. We can reject with 95% confidence that universal BCG vaccination reduces the number of cases by 19% and the number of hospitalizations by 25%.ConclusionsWhile the effect of a recent vaccination must be evaluated, we provide strong evidence that receiving the BCG vaccine at birth does not have a protective effect against COVID-19 among middle-aged individuals.

Published
2021

5. Bacille Calmette-Guérin Vaccination in Infancy Does Not Protect Against Coronavirus Disease 2019 (COVID-19): Evidence From a Natural Experiment in Sweden.

Author

de Chaisemartin, Clément and de Chaisemartin, Luc

Subjects
Humans, BCG Vaccine, Vaccination, Cohort Studies, Middle Aged, Infant, Infant, Newborn, Sweden, Pandemics, COVID-19, SARS-CoV-2, BCG, regression discontinuity, Covid-19, Regression discontinuity, Microbiology, Biological Sciences, Medical and Health Sciences
Abstract

BackgroundThe bacille Calmette-Guérin (BCG) tuberculosis vaccine has immunity benefits against respiratory infections. Accordingly, it has been hypothesized to have a protective effect against coronavirus disease 2019 (COVID-19). Recent research found that countries with universal BCG childhood vaccination policies tend to be less affected by the COVID-19 pandemic. However, such ecological studies are biased by numerous confounders. Instead, this paper reports on a rare nationwide natural experiment that occurred in Sweden in 1975, where discontinuation of newborns' BCG vaccination led to a dramatic decrease in BCG coverage rate, thus allowing us to estimate BCG's effect without the biases associated with cross-country comparisons.MethodsNumbers of COVID-19 cases and hospitalizations were recorded for birth cohorts born just before and just after 1975, representing 1 026 304 and 1 018 544 individuals, respectively. We used regression discontinuity to assess the effect of BCG vaccination on COVID-19-related outcomes. On such a large population, this method allows for a precision that would be hard to achieve using a randomized controlled trial.ResultsThe odds ratios (95% CI) for COVID-19 cases and COVID-19-related hospitalizations were 1.0005 (.8130-1.1881) and 1.2046 (.7532-1.6560), allowing us to reject fairly modest effects of universal BCG vaccination. We can reject with 95% confidence that universal BCG vaccination reduces the number of cases by 19% and the number of hospitalizations by 25%.ConclusionsWhile the effect of a recent vaccination must be evaluated, we provide strong evidence that receiving the BCG vaccine at birth does not have a protective effect against COVID-19 among middle-aged individuals.

Published
2021

12. Is telomere length a predictor of long-term survival in patients with COVID-19 pneumonia?

Author

Bernardinello, Nicol, primary, Crestani, Bruno, additional, Spagnolo, Paolo, additional, Ghanem, Mada, additional, Homps-Legrand, Méline, additional, Morer, Lise, additional, Goletto, Tiphaine, additional, Frija-Masson, Justine, additional, Bancal, Catherine, additional, Hurtado-Nedelec, Margarita, additional, de Chaisemartin, Luc, additional, Debray, Marie Pierre, additional, Neukirch, Catherine, additional, Taillé, Camille, additional, Ba, Ibrahima, additional, Kannengiesser, Caroline, additional, Lainey, Elodie, additional, Abels, Anne, additional, Vankann, Lucia, additional, Beier, Fabian, additional, and Borie, Raphaël, additional

Published
2023
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15. Circulating microbiome analysis in patients with perioperative anaphylaxis.

Author

de Chaisemartin, Luc, Ciocan, Dragos, Gouel-Chéron, Aurélie, Granger, Vanessa, Longrois, Dan, Montravers, Philippe, Cassard, Anne-Marie, and Chollet-Martin, Sylvie

Subjects
ANAPHYLAXIS, NEUROMUSCULAR blocking agents, DRUG side effects, MAST cells, IMMUNOGLOBULIN E
Abstract

Background: Perioperative anaphylaxis is a rare and acute systemic manifestation of drug-induced hypersensitivity reactions that occurs following anesthesia induction; the two main classes of drugs responsible for these reactions being neuromuscular blocking agents (NMBA) and antibiotics. The sensitization mechanisms to the drugs are not precisely known, and few risk factors have been described. A growing body of evidence underlines a link between occurrence of allergy and microbiota composition. However, no data exist on microbiota in perioperative anaphylaxis. The aim of this study was to compare circulating microbiota richness and composition between perioperative anaphylaxis patients and matched controls. Methods: Circulating 16s rDNA was quantified and sequenced in serum samples from 20 individuals with fully characterized IgE-mediated NMBA-related anaphylaxis and 20 controls matched on sex, age, NMBA received, type of surgery and infectious status. Microbiota composition was analyzed with a published bioinformatic pipeline and links with patients clinical and biological data investigated. Results: Analysis of microbiota diversity showed that anaphylaxis patients seem to have a richer circulating microbiota than controls, but no major differences of composition could be detected with global diversity indexes. Pairwise comparison showed a difference in relative abundance between patients and controls for Saprospiraceae, Enterobacteriaceae, Veillonellaceae, Escherichia-Shigella, Pseudarcicella, Rhodoferax, and Lewinella. Some taxa were associated with concentrations of mast cell tryptase and specific IgE. Conclusion: We did not find a global difference in terms of microbiota composition between anaphylaxis patient and controls. However, several taxa were associated with anaphylaxis patients and with their biological data. These findings must be further confirmed in different settings to broaden our understanding of drug anaphylaxis pathophysiology and identify predisposition markers. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Basal serum tryptase: A critical reconsideration of reference values.

Author

Francois, Fabien, Mauff, Brigitte Le, Waeckel, Louis, de Chaisemartin, Luc, Tabary, Thierry, Dumontet, Erwan, Lecron, Jean Claude, Delamare, Benoit, Boumediene, Ahmed, Chauvineau‐Grenier, Angélique, Pescarmona, Remi, Garnier, Lorna, and Lambert, Claude

Subjects
TRYPTASE, REFERENCE values, MAST cells
Abstract

This article discusses the reference values for basal serum tryptase (BST), which is released by mast cells and is used as a diagnostic marker for certain conditions. The current reference value for BST is controversial, with studies showing that most people have BST values lower than the defined threshold. The article presents data from multiple laboratories, showing that the distribution of BST in healthy donors is not Gaussian and can be explained by two populations: "low-producers" with BST values below 8 μg/L and "high-producers" with values above 8 μg/L. The study also suggests that a small minority of healthy donors may have a defect in basal tryptase production that needs further investigation. [Extracted from the article]

Published
2023
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18. Supplementary Table 5 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

Author

Goc, Jérémy, primary, Germain, Claire, primary, Vo-Bourgais, Thi Kim Duy, primary, Lupo, Audrey, primary, Klein, Christophe, primary, Knockaert, Samantha, primary, de Chaisemartin, Luc, primary, Ouakrim, Hanane, primary, Becht, Etienne, primary, Alifano, Marco, primary, Validire, Pierre, primary, Remark, Romain, primary, Hammond, Scott A., primary, Cremer, Isabelle, primary, Damotte, Diane, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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19. Supplementary Table 7 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

Author

Goc, Jérémy, primary, Germain, Claire, primary, Vo-Bourgais, Thi Kim Duy, primary, Lupo, Audrey, primary, Klein, Christophe, primary, Knockaert, Samantha, primary, de Chaisemartin, Luc, primary, Ouakrim, Hanane, primary, Becht, Etienne, primary, Alifano, Marco, primary, Validire, Pierre, primary, Remark, Romain, primary, Hammond, Scott A., primary, Cremer, Isabelle, primary, Damotte, Diane, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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20. Data from Characterization of Chemokines and Adhesion Molecules Associated with T cell Presence in Tertiary Lymphoid Structures in Human Lung Cancer

Author

de Chaisemartin, Luc, primary, Goc, Jérémy, primary, Damotte, Diane, primary, Validire, Pierre, primary, Magdeleinat, Pierre, primary, Alifano, Marco, primary, Cremer, Isabelle, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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21. Supplementary Figure 5 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

Author

Goc, Jérémy, primary, Germain, Claire, primary, Vo-Bourgais, Thi Kim Duy, primary, Lupo, Audrey, primary, Klein, Christophe, primary, Knockaert, Samantha, primary, de Chaisemartin, Luc, primary, Ouakrim, Hanane, primary, Becht, Etienne, primary, Alifano, Marco, primary, Validire, Pierre, primary, Remark, Romain, primary, Hammond, Scott A., primary, Cremer, Isabelle, primary, Damotte, Diane, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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22. Supplementary Figure 8 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

Author

Goc, Jérémy, primary, Germain, Claire, primary, Vo-Bourgais, Thi Kim Duy, primary, Lupo, Audrey, primary, Klein, Christophe, primary, Knockaert, Samantha, primary, de Chaisemartin, Luc, primary, Ouakrim, Hanane, primary, Becht, Etienne, primary, Alifano, Marco, primary, Validire, Pierre, primary, Remark, Romain, primary, Hammond, Scott A., primary, Cremer, Isabelle, primary, Damotte, Diane, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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23. Supplementary Figure 2 from Characterization of Chemokines and Adhesion Molecules Associated with T cell Presence in Tertiary Lymphoid Structures in Human Lung Cancer

Author

de Chaisemartin, Luc, primary, Goc, Jérémy, primary, Damotte, Diane, primary, Validire, Pierre, primary, Magdeleinat, Pierre, primary, Alifano, Marco, primary, Cremer, Isabelle, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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24. Supplementary Table 2 from Characterization of Chemokines and Adhesion Molecules Associated with T cell Presence in Tertiary Lymphoid Structures in Human Lung Cancer

Author

de Chaisemartin, Luc, primary, Goc, Jérémy, primary, Damotte, Diane, primary, Validire, Pierre, primary, Magdeleinat, Pierre, primary, Alifano, Marco, primary, Cremer, Isabelle, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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25. Supplementary Figure 1 from Characterization of Chemokines and Adhesion Molecules Associated with T cell Presence in Tertiary Lymphoid Structures in Human Lung Cancer

Author

de Chaisemartin, Luc, primary, Goc, Jérémy, primary, Damotte, Diane, primary, Validire, Pierre, primary, Magdeleinat, Pierre, primary, Alifano, Marco, primary, Cremer, Isabelle, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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26. Supplementary Figure 4 from Characterization of Chemokines and Adhesion Molecules Associated with T cell Presence in Tertiary Lymphoid Structures in Human Lung Cancer

Author

de Chaisemartin, Luc, primary, Goc, Jérémy, primary, Damotte, Diane, primary, Validire, Pierre, primary, Magdeleinat, Pierre, primary, Alifano, Marco, primary, Cremer, Isabelle, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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27. Supplementary Figure 7 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

Author

Goc, Jérémy, primary, Germain, Claire, primary, Vo-Bourgais, Thi Kim Duy, primary, Lupo, Audrey, primary, Klein, Christophe, primary, Knockaert, Samantha, primary, de Chaisemartin, Luc, primary, Ouakrim, Hanane, primary, Becht, Etienne, primary, Alifano, Marco, primary, Validire, Pierre, primary, Remark, Romain, primary, Hammond, Scott A., primary, Cremer, Isabelle, primary, Damotte, Diane, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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28. Supplementary Table 4 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

Author

Goc, Jérémy, primary, Germain, Claire, primary, Vo-Bourgais, Thi Kim Duy, primary, Lupo, Audrey, primary, Klein, Christophe, primary, Knockaert, Samantha, primary, de Chaisemartin, Luc, primary, Ouakrim, Hanane, primary, Becht, Etienne, primary, Alifano, Marco, primary, Validire, Pierre, primary, Remark, Romain, primary, Hammond, Scott A., primary, Cremer, Isabelle, primary, Damotte, Diane, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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29. Supplementary Table 3 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

Author

Goc, Jérémy, primary, Germain, Claire, primary, Vo-Bourgais, Thi Kim Duy, primary, Lupo, Audrey, primary, Klein, Christophe, primary, Knockaert, Samantha, primary, de Chaisemartin, Luc, primary, Ouakrim, Hanane, primary, Becht, Etienne, primary, Alifano, Marco, primary, Validire, Pierre, primary, Remark, Romain, primary, Hammond, Scott A., primary, Cremer, Isabelle, primary, Damotte, Diane, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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30. Supplementary Figure Legend from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

Author

Goc, Jérémy, primary, Germain, Claire, primary, Vo-Bourgais, Thi Kim Duy, primary, Lupo, Audrey, primary, Klein, Christophe, primary, Knockaert, Samantha, primary, de Chaisemartin, Luc, primary, Ouakrim, Hanane, primary, Becht, Etienne, primary, Alifano, Marco, primary, Validire, Pierre, primary, Remark, Romain, primary, Hammond, Scott A., primary, Cremer, Isabelle, primary, Damotte, Diane, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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31. Supplementary Figure 3 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

Author

Goc, Jérémy, primary, Germain, Claire, primary, Vo-Bourgais, Thi Kim Duy, primary, Lupo, Audrey, primary, Klein, Christophe, primary, Knockaert, Samantha, primary, de Chaisemartin, Luc, primary, Ouakrim, Hanane, primary, Becht, Etienne, primary, Alifano, Marco, primary, Validire, Pierre, primary, Remark, Romain, primary, Hammond, Scott A., primary, Cremer, Isabelle, primary, Damotte, Diane, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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32. Supplementary Figure 6 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

Author

Goc, Jérémy, primary, Germain, Claire, primary, Vo-Bourgais, Thi Kim Duy, primary, Lupo, Audrey, primary, Klein, Christophe, primary, Knockaert, Samantha, primary, de Chaisemartin, Luc, primary, Ouakrim, Hanane, primary, Becht, Etienne, primary, Alifano, Marco, primary, Validire, Pierre, primary, Remark, Romain, primary, Hammond, Scott A., primary, Cremer, Isabelle, primary, Damotte, Diane, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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33. Supplementary Table 2 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

Author

Goc, Jérémy, primary, Germain, Claire, primary, Vo-Bourgais, Thi Kim Duy, primary, Lupo, Audrey, primary, Klein, Christophe, primary, Knockaert, Samantha, primary, de Chaisemartin, Luc, primary, Ouakrim, Hanane, primary, Becht, Etienne, primary, Alifano, Marco, primary, Validire, Pierre, primary, Remark, Romain, primary, Hammond, Scott A., primary, Cremer, Isabelle, primary, Damotte, Diane, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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34. Supplementary Figure 3 from Characterization of Chemokines and Adhesion Molecules Associated with T cell Presence in Tertiary Lymphoid Structures in Human Lung Cancer

Author

de Chaisemartin, Luc, primary, Goc, Jérémy, primary, Damotte, Diane, primary, Validire, Pierre, primary, Magdeleinat, Pierre, primary, Alifano, Marco, primary, Cremer, Isabelle, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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35. Supplementary Table 1 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

Author

Goc, Jérémy, primary, Germain, Claire, primary, Vo-Bourgais, Thi Kim Duy, primary, Lupo, Audrey, primary, Klein, Christophe, primary, Knockaert, Samantha, primary, de Chaisemartin, Luc, primary, Ouakrim, Hanane, primary, Becht, Etienne, primary, Alifano, Marco, primary, Validire, Pierre, primary, Remark, Romain, primary, Hammond, Scott A., primary, Cremer, Isabelle, primary, Damotte, Diane, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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36. Supplementary Figure 4 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

Author

Goc, Jérémy, primary, Germain, Claire, primary, Vo-Bourgais, Thi Kim Duy, primary, Lupo, Audrey, primary, Klein, Christophe, primary, Knockaert, Samantha, primary, de Chaisemartin, Luc, primary, Ouakrim, Hanane, primary, Becht, Etienne, primary, Alifano, Marco, primary, Validire, Pierre, primary, Remark, Romain, primary, Hammond, Scott A., primary, Cremer, Isabelle, primary, Damotte, Diane, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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37. Supplementary Table 1 from Characterization of Chemokines and Adhesion Molecules Associated with T cell Presence in Tertiary Lymphoid Structures in Human Lung Cancer

Author

de Chaisemartin, Luc, primary, Goc, Jérémy, primary, Damotte, Diane, primary, Validire, Pierre, primary, Magdeleinat, Pierre, primary, Alifano, Marco, primary, Cremer, Isabelle, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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38. Supplementary Figure 2 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

Author

Goc, Jérémy, primary, Germain, Claire, primary, Vo-Bourgais, Thi Kim Duy, primary, Lupo, Audrey, primary, Klein, Christophe, primary, Knockaert, Samantha, primary, de Chaisemartin, Luc, primary, Ouakrim, Hanane, primary, Becht, Etienne, primary, Alifano, Marco, primary, Validire, Pierre, primary, Remark, Romain, primary, Hammond, Scott A., primary, Cremer, Isabelle, primary, Damotte, Diane, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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39. Supplementary Table 6 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

Author

Goc, Jérémy, primary, Germain, Claire, primary, Vo-Bourgais, Thi Kim Duy, primary, Lupo, Audrey, primary, Klein, Christophe, primary, Knockaert, Samantha, primary, de Chaisemartin, Luc, primary, Ouakrim, Hanane, primary, Becht, Etienne, primary, Alifano, Marco, primary, Validire, Pierre, primary, Remark, Romain, primary, Hammond, Scott A., primary, Cremer, Isabelle, primary, Damotte, Diane, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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40. Supplementary Figure 1 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

Author

Goc, Jérémy, primary, Germain, Claire, primary, Vo-Bourgais, Thi Kim Duy, primary, Lupo, Audrey, primary, Klein, Christophe, primary, Knockaert, Samantha, primary, de Chaisemartin, Luc, primary, Ouakrim, Hanane, primary, Becht, Etienne, primary, Alifano, Marco, primary, Validire, Pierre, primary, Remark, Romain, primary, Hammond, Scott A., primary, Cremer, Isabelle, primary, Damotte, Diane, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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41. Genome-wide association study of a semicontinuous trait: illustration of the impact of the modeling strategy through the study of Neutrophil Extracellular Traps levels

Author

Munsch, Gaëlle, primary, Proust, Carole, additional, Labrouche-Colomer, Sylvie, additional, Aïssi, Dylan, additional, Boland, Anne, additional, Morange, Pierre-Emmanuel, additional, Roche, Anne, additional, de Chaisemartin, Luc, additional, Harroche, Annie, additional, Olaso, Robert, additional, Deleuze, Jean-François, additional, James, Chloé, additional, Emmerich, Joseph, additional, Smadja, David M, additional, Jacqmin-Gadda, Hélène, additional, and Trégouët, David-Alexandre, additional

Published
2023
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42. Risk stratification through extensive allergy work‐up in COVID‐19‐mRNA vaccine allergic reactions

Author

Soria, Angèle, primary, Labella, Marina, additional, Doña, Inmaculada, additional, Nicaise‐Roland, Pascale, additional, Chollet‐Martin, Sylvie, additional, Autegarden, Jean‐Eric, additional, Castagna, Julie, additional, Le Thai, Claire, additional, de Chaisemartin, Luc, additional, Torres, Maria José, additional, and Barbaud, Annick, additional

Published
2023
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43. Blood fibrocytes are associated with severity and prognosis in COVID-19 pneumonia

Author

Ghanem, Mada, Homps-Legrand, Méline, Garnier, Marc, Morer, Lise, Goletto, Tiphaine, Frija-Masson, Justine, Wicky, Paul-Henri, Jaquet, Pierre, Bancal, Catherine, Hurtado-Nedelec, Margarita, de Chaisemartin, Luc, Jaillet, Madeleine, Mailleux, Arnaud, Quesnel, Christophe, Poté, Nicolas, Debray, Marie-Pierre, de Montmollin, Etienne, Neukirch, Catherine, Borie, Raphael, Taillé, Camille, Crestani, Bruno, Covid Cohort Study Group, French, Andréjak, Claire, Physiopathologie et Epidémiologie des Maladies Respiratoires (PHERE (UMR_S_1152 / U1152)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d'Anesthésie réanimation [CHU Tenon], CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut Pasteur [Paris] (IP), Agents infectieux, résistance et chimiothérapie - UR UPJV 4294 (AGIR ), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, CHU Amiens-Picardie, French COVID cohort study group, ANR-21-CO12-0007,FIBROCO,Implication des fibrocytes circulants dans la physiopathogénie et le pronostic de la pneumopathie sévère au cours du COVID-19(2021), HAL-SU, Gestionnaire, and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
Male, Physiology, CD34, Severity of Illness Index, Gastroenterology, law.invention, 0302 clinical medicine, law, Fibrocyte, Aged, 80 and over, 0303 health sciences, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, medicine.diagnostic_test, Middle Aged, Intensive care unit, 3. Good health, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Cytokines, Female, Research Article, Adult, Pulmonary and Respiratory Medicine, medicine.medical_specialty, CCL2, 03 medical and health sciences, Antigens, CD, Physiology (medical), Internal medicine, Severity of illness, medicine, Humans, COVID-19 pneumonia, Aged, 030304 developmental biology, Serum Amyloid A Protein, Blood Cells, Lung, SARS-CoV-2, business.industry, COVID-19, Cell Biology, medicine.disease, Blood Cell Count, Pneumonia, Bronchoalveolar lavage, fibrocyte, prognosis, Tomography, X-Ray Computed, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Increased blood fibrocytes are associated with a poor prognosis in fibrotic lung diseases. We aimed to determine whether the percentage of circulating fibrocytes could be predictive of severity and prognosis during coronavirus disease 2019 (COVID-19) pneumonia. Blood fibrocytes were quantified by flow cytometry as CD45+/CD15−/CD34+/collagen-1+ cells in patients hospitalized for COVID-19 pneumonia. In a subgroup of patients admitted in an intensive care unit (ICU), fibrocytes were quantified in blood and bronchoalveolar lavage (BAL). Serum amyloid P (SAP), transforming growth factor-β1 (TGF-β1), CXCL12, CCL2, and FGF2 concentrations were measured. We included 57 patients in the hospitalized group (median age = 59 yr [23–87]) and 16 individuals as healthy controls. The median percentage of circulating fibrocytes was higher in the patients compared with the controls (3.6% [0.2–9.2] vs. 2.1% [0.9–5.1], P = 0.04). Blood fibrocyte count was lower in the six patients who died compared with the survivors (1.6% [0.2–4.4] vs. 3.7% [0.6–9.2], P = 0.02). Initial fibrocyte count was higher in patients showing a complete lung computed tomography (CT) resolution at 3 mo. Circulating fibrocyte count was decreased in the ICU group (0.8% [0.1–2.0]), whereas BAL fibrocyte count was 6.7% (2.2–15.4). Serum SAP and TGF-β1 concentrations were increased in hospitalized patients. SAP was also increased in ICU patients. CXCL12 and CCL2 were increased in ICU patients and negatively correlated with circulating fibrocyte count. We conclude that circulating fibrocytes were increased in patients hospitalized for COVID-19 pneumonia, and a lower fibrocyte count was associated with an increased risk of death and a slower resolution of lung CT opacities.

Published
2021
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44. Differential activation of human neutrophils by SARS-CoV-2 variants of concern

Author

Lebourgeois, Samuel, primary, David, Ambroise, additional, Chenane, Houssem Redha, additional, Granger, Vanessa, additional, Menidjel, Reyene, additional, Fidouh, Nadhira, additional, Noël, Benoît, additional, Delelis, Olivier, additional, Richetta, Clémence, additional, Charpentier, Charlotte, additional, Chollet-Martin, Sylvie, additional, Descamps, Diane, additional, Visseaux, Benoit, additional, and de Chaisemartin, Luc, additional

Published
2022
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46. Cytosolic PCNA interacts with S100A8 and controls an inflammatory subset of neutrophils in COVID-19

Author

de Oliveira Formiga, Rodrigo, primary, Pesenti, Lucie, additional, Ladjemi, Maha Zohra, additional, Frachet, Philippe, additional, Andrieu, Muriel, additional, Many, Souganya, additional, Karunanithy, Vaarany, additional, Bailly, Karine, additional, Dhôte, Théo, additional, Castel, Manon, additional, Rousseau, Christophe, additional, Starick, Marick, additional, da Rocha, Edroaldo Lummertz, additional, Lombardi, Emilia Puig, additional, Granger, Vanessa, additional, Chollet-Martin, Sylvie, additional, De Chaisemartin, Luc, additional, Mouthon, Luc, additional, Spiller, Fernando, additional, Hosmalin, Anne, additional, Hurtado-Nedelec, Margarita, additional, Martin, Clémence, additional, Pène, Frédéric, additional, Burgel, Pierre-Regis, additional, Tourneur, Léa, additional, and Witko-Sarsat, Véronique, additional

Published
2022
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50. Genome-wide association study of a semicontinuous trait: Illustration of the impact of the modeling strategy through the study of Neutrophil Extracellular Traps levels

Author

Munsch, Gaëlle, primary, Proust, Carole, additional, Labrouche-Colomer, Sylvie, additional, Aïssi, Dylan, additional, Boland, Anne, additional, Morange, Pierre-Emmanuel, additional, Roche, Anne, additional, de Chaisemartin, Luc, additional, Harroche, Annie, additional, Olaso, Robert, additional, Deleuze, Jean-François, additional, James, Chloé, additional, Emmerich, Joseph, additional, Smadja, David M, additional, Jacqmin-Gadda, Hélène, additional, and Trégouët, David-Alexandre, additional

Published
2022
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