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351 results on '"de Camargo, Zoilo Pires"'

7. Clinical and epidemiological aspects of feline sporotrichosis caused by Sporothrix brasiliensis and in vitro antifungal susceptibility

Author

Maschio-Lima, Taiza, Marques, Mariela Domiciano Ribeiro, Lemes, Thiago Henrique, Brizzotti-Mazuchi, Natália Seron, Caetano, Maicon Henrique, de Almeida, Bianca Gottardo, Bianco, Letícia Monteiro, Monteiro, Ruan Campos, Rodrigues, Anderson Messias, de Camargo, Zoilo Pires, Siqueira, João Paulo Zen, and de Almeida, Margarete Teresa Gottardo

Published
2021
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10. Effect of proton pump inhibitors on susceptibility and melanogenesis of Sporothrix species

Author

Nobre, Augusto Feynman Dias, de Sousa, Alanna Mayara Soares, da Cunha Costa, Anderson, Fernandes, Mirele Rodrigues, Kumar, Rajender, Ponne, Saravanaraman, Rocha, Maria Gleiciane, Rodrigues, Anderson Messias, de Camargo, Zoilo Pires, Brilhante, Raimunda Sâmia Nogueira, Nobre, Augusto Feynman Dias, de Sousa, Alanna Mayara Soares, da Cunha Costa, Anderson, Fernandes, Mirele Rodrigues, Kumar, Rajender, Ponne, Saravanaraman, Rocha, Maria Gleiciane, Rodrigues, Anderson Messias, de Camargo, Zoilo Pires, and Brilhante, Raimunda Sâmia Nogueira

Abstract

Introduction. Sporotrichosis is a subcutaneous infection caused by dimorphic Sporothrix species embedded in the clinical clade. Fungi have virulence factors, such as biofilm and melanin production, which contribute to their survival and are related to the increase in the number of cases of therapeutic failure, making it necessary to search for new options.Gap statement. Proton pump inhibitors (PPIs) have already been shown to inhibit the growth and melanogenesis of other fungi.Aim. Therefore, this study aimed to evaluate the effect of the PPIs omeprazole (OMP), rabeprazole (RBP), esomeprazole, pantoprazole and lansoprazole on the susceptibility and melanogenesis of Sporothrix species, and their interactions with itraconazole, terbinafine and amphotericin B.Methodology. The antifungal activity of PPIs was evaluated using the microdilution method, and the combination of PPIs with itraconazole, terbinafine and amphotericin B was assessed using the checkerboard method. The assessment of melanogenesis inhibition was assessed using grey scale.Results. The OMP and RBP showed significant MIC results ranging from 32 to 256 µg ml-1 and 32 to 128 µg ml-1, respectively. Biofilms were sensitive, with a significant reduction (P<0.05) in metabolic activity of 52% for OMP and 50% for RBP at a concentration of 512 µg ml-1 and of biomass by 53% for OMP and 51% for RBP at concentrations of 512 µg ml-1. As for the inhibition of melanogenesis, only OMP showed inhibition, with a 54% reduction.Conclusion. It concludes that the PPIs OMP and RBP have antifungal activity in vitro against planktonic cells and biofilms of Sporothrix species and that, in addition, OMP can inhibit the melanization process in Sporothrix species., QC 20240830

Published
2024
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11. Clinical response to prednisone in a severe case of infant-juvenile paracoccidioidomycosis

Author

Guevara, Armando, Siqueira, Nathan Pereira, de Sousa, Ronaldo Pereira, Dos Santos, Thiago Braga, Assis, Sandra Breder, de Camargo, Zoilo Pires, Rodrigues, Anderson Messias, Hagen, Ferry, Hahn, Rosane Christine, Guevara, Armando, Siqueira, Nathan Pereira, de Sousa, Ronaldo Pereira, Dos Santos, Thiago Braga, Assis, Sandra Breder, de Camargo, Zoilo Pires, Rodrigues, Anderson Messias, Hagen, Ferry, and Hahn, Rosane Christine

Abstract

BACKGROUND: Paracoccidioidomycosis is a neglected tropical disease caused by fungi of the genus Paracoccidioides. A wide range of symptoms is related to the disease; however, lungs and skin are the sites predominantly affected. The disease is mostly seen in people living in rural areas in Latin America.CASE REPORT: We present a pediatric case of severe disseminated paracoccidioidomycosis that slowly responded to the antifungal treatment. Within three months, symptoms evolved into hepatosplenomegaly, necrotic cervical and abdominal lymph nodes, and splenic abscess. Clinical response to amphotericin B deoxycholate and itraconazole was slow, resulting in pleural and peritoneal cavity effusions, heart failure and shock. Amphotericin B deoxycholate was replaced by the liposomal formulation, with no response. Subsequently, prednisone was added to the treatment, which led to improvement in the clinical response. Serological Paracoccidioides antibody titers were atypical, with very low titers in the critical phase and significant increase during the convalescence phase. The infection was finally cleared up with amphotericin B deoxycholate, liposomal amphotericin B and the use of corticosteroids. Paracoccidioidomycosis serology was non-reactive two years post-discharge.CONCLUSIONS: Due to the intense inflammatory response triggered by Paracoccidioides cells, giving low-dose prednisone for a short period of time modulated the inflammatory response and supported antifungal treatment.

Published
2024

14. Feline Sporotrichosis

Author

Rodrigues, Anderson Messias, de Hoog, G. Sybren, de Camargo, Zoilo Pires, Seyedmousavi, Seyedmojtaba, editor, de Hoog, G. Sybren, editor, Guillot, Jacques, editor, and Verweij, Paul E., editor

Published
2018
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15. Sporotrichosis

Author

Rodrigues, Anderson Messias, Fernandes, Geisa Ferreira, de Camargo, Zoilo Pires, and Bayry, Jagadeesh, editor

Published
2017
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18. Sporothrix spp.

Author

Rodrigues, Anderson Messias, primary, Orofino-Costa, Rosane, additional, and de Camargo, Zoilo Pires, additional

Published
2019
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20. High-Throughput Microsatellite Markers Development for Genetic Characterization of Emerging Sporothrix Species

Author

Losada, Luiza Chaves de Miranda Leonhardt, primary, Monteiro, Ruan Campos, additional, de Carvalho, Jamile Ambrósio, additional, Hagen, Ferry, additional, Fisher, Matthew C., additional, Spruijtenburg, Bram, additional, Meis, Jacques F., additional, de Groot, Theun, additional, Gonçalves, Sarah Santos, additional, Negroni, Ricardo, additional, Kano, Rui, additional, Bonifaz, Alexandro, additional, de Camargo, Zoilo Pires, additional, and Rodrigues, Anderson Messias, additional

Published
2023
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21. Paracoccidioides and Paracoccidioidomycosis in the 21st Century

Author

MMB, MMB Medische Staf, Rodrigues, Anderson Messias, Hagen, Ferry, Puccia, Rosana, Hahn, Rosane Christine, de Camargo, Zoilo Pires, MMB, MMB Medische Staf, Rodrigues, Anderson Messias, Hagen, Ferry, Puccia, Rosana, Hahn, Rosane Christine, and de Camargo, Zoilo Pires

Published
2023

23. Paracoccidioidomycosis: Current Status and Future Trends

Author

Hahn, Rosane Christine, primary, Hagen, Ferry, additional, Mendes, Rinaldo Poncio, additional, Burger, Eva, additional, Nery, Andreia Ferreira, additional, Siqueira, Nathan Pereira, additional, Guevara, Armando, additional, Rodrigues, Anderson Messias, additional, and de Camargo, Zoilo Pires, additional

Published
2022
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24. Molecular epidemiology and clinical‐laboratory aspects of chromoblastomycosis in Mato Grosso, Brazil

Author

Guevara, Armando, primary, Nery, Andréia Ferreira, additional, de Souza Carvalho Melhem, Márcia, additional, Bonfietti, Lucas, additional, Rodrigues, Anderson Messias, additional, Hagen, Ferry, additional, de Carvalho, Jamile Ambrósio, additional, de Camargo, Zoilo Pires, additional, de Souza Lima, Bruna Jacomel F., additional, Vicente, Vânia Aparecida, additional, and Hahn, Rosane Christine, additional

Published
2022
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25. FEMALE PRESENTING WITH PARACOCCIDIOIDOMYCOSIS

Author

De Souza Santos Dias, Elisângela, primary, Miyazawa, Marta, additional, Pôssa, Ana Paula, additional, De Camargo, Zoilo Pires, additional, De Sá Magalhães, Evandro Monteiro, additional, Pereira, Alessandro Antônio Costa, additional, and Hanemann, João Adolfo Costa, additional

Published
2022
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27. Antiretroviral drugs saquinavir and ritonavir reduce inhibitory concentration values of itraconazole against Histoplasma capsulatum strains in vitro

Author

Brilhante, Raimunda Samia Nogueira, Caetano, Erica Pacheco, Riello, Giovanna Barbosa, de Melo Guedes, Glaucia Morgana, de Souza Collares Maia Castelo-Branco, Debora, Fechine, Maria Auxiliadora Bezerra, de Oliveira, Jonathas Sales, de Camargo, Zoilo Pires, de Mesquita, Jaco Ricarte Lima, Monteiro, Andre Jalles, de Aguiar Cordeiro, Rossana, Rocha, Marcos Fabio Gadelha, and Sidrim, Jose Julio Costa

Published
2016
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29. Paracoccidioidomycosis: Current Status and Future Trends

Author

Hahn, Rosane Christine, Hagen, Ferry, Mendes, Rinaldo Poncio, Burger, Eva, Nery, Andreia Ferreira, Siqueira, Nathan Pereira, Guevara, Armando, Rodrigues, Anderson Messias, de Camargo, Zoilo Pires, Hahn, Rosane Christine, Hagen, Ferry, Mendes, Rinaldo Poncio, Burger, Eva, Nery, Andreia Ferreira, Siqueira, Nathan Pereira, Guevara, Armando, Rodrigues, Anderson Messias, and de Camargo, Zoilo Pires

Abstract

Paracoccidioidomycosis (PCM), initially reported in 1908 in the city of São Paulo, Brazil, by Adolpho Lutz, is primarily a systemic and neglected tropical mycosis that may affect individuals with certain risk factors around Latin America, especially Brazil. Paracoccidioides brasiliensis sensu stricto, a classical thermodimorphic fungus associated with PCM, was long considered to represent a monotypic taxon. However, advances in molecular taxonomy revealed several cryptic species, including Paracoccidioides americana, P. restrepiensis, P. venezuelensis, and P. lutzii, that show a preference for skin and mucous membranes, lymph nodes, and respiratory organs but can also affect many other organs. The classical diagnosis of PCM benefits from direct microscopy culture-based, biochemical, and immunological assays in a general microbiology laboratory practice providing a generic identification of the agents. However, molecular assays should be employed to identify Paracoccidioides isolates to the species level, data that would be complemented by epidemiological investigations. From a clinical perspective, all probable and confirmed cases should be treated. The choice of treatment and its duration must be considered, along with the affected organs, process severity, history of previous treatment failure, possibility of administering oral medication, associated diseases, pregnancy, and patient compliance with the proposed treatment regimen. Nevertheless, even after appropriate treatment, there may be relapses, which generally occur 5 years after the apparent cure following treatment, and also, the mycosis may be confused with other diseases. This review provides a comprehensive and critical overview of the immunopathology, laboratory diagnosis, clinical aspects, and current treatment of PCM, highlighting current issues in the identification, treatment, and patient follow-up in light of recent Paracoccidioides species taxonomic developments.

Published
2022

30. Paracoccidioidomycosis: Current Status and Future Trends

Author

MMB Medische Staf, Hahn, Rosane Christine, Hagen, Ferry, Mendes, Rinaldo Poncio, Burger, Eva, Nery, Andreia Ferreira, Siqueira, Nathan Pereira, Guevara, Armando, Rodrigues, Anderson Messias, de Camargo, Zoilo Pires, MMB Medische Staf, Hahn, Rosane Christine, Hagen, Ferry, Mendes, Rinaldo Poncio, Burger, Eva, Nery, Andreia Ferreira, Siqueira, Nathan Pereira, Guevara, Armando, Rodrigues, Anderson Messias, and de Camargo, Zoilo Pires

Published
2022

39. Biofilm formation on cat claws by Sporothrix species: An ex vivo model

Author

Brilhante, Raimunda Sâmia Nogueira, Fernandes, Mirele Rodrigues, Pereira, Vandbergue Santos, Costa, Anderson da Cunha, Oliveira, Jonathas Sales de, de Aguiar, Lara, Rodrigues, Anderson Messias, de Camargo, Zoilo Pires, Pereira-Neto, Waldemiro Aquino, Sidrim, José Júlio Costa, and Rocha, Marcos Fábio Gadelha

Published
2021
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43. Antigens of Coccidioides posadasii as an Important Tool for the Immunodiagnosis of Coccidioidomycosis

Author

de Aguiar Cordeiro, Rossana, Patoilo, Kharla Rabelo Nobre, Praciano, Silviane Bandeira, Medrano, Delia Jessica Astete, de Farias Marques, Francisca Jakelyne, Martins, Liline Maria Soares, Eulalio, Kelsen Dantas, de Deus Filho, Antônio, Cavalvanti, Maria do Amparo Salmito, Fechine, Maria Auxiliadora Bezerra, Brilhante, Raimunda Samia Nogueira, de Camargo, Zoilo Pires, Rocha, Marcos Fábio Gadelha, and Sidrim, José Júlio Costa

Published
2013
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44. Paracoccidioidomycosis due to P. lutzii: the importance of neutrophil/lymphocyte ratio in the symptomatic and asymptomatic phases in severe cases

Author

Nery, Andreia Ferreira, de Camargo, Zoilo Pires, Rodrigues, Anderson Messias, Portela, Tiago Ferreira, Hoffmann-Santos, Hugo Dias, Dambros, Pedro Vitor Krüger, de Souza, Jânio Felipe Ribeiro, Garcia, Alexandre Carvalho, Santos, Carolina Araújo Damasio, Hagen, Ferry, Hahn, Rosane Christine, Nery, Andreia Ferreira, de Camargo, Zoilo Pires, Rodrigues, Anderson Messias, Portela, Tiago Ferreira, Hoffmann-Santos, Hugo Dias, Dambros, Pedro Vitor Krüger, de Souza, Jânio Felipe Ribeiro, Garcia, Alexandre Carvalho, Santos, Carolina Araújo Damasio, Hagen, Ferry, and Hahn, Rosane Christine

Abstract

BACKGROUND: PCM is a neglected systemic mycosis endemic in Brazil. The middle-west region of Brazil has shown the highest number of PCM by P. lutzii cases. Differentiating cases of severe PCM from non-severe ones should be a concern at the bedside. Diagnosis of severe PCM by P. lutzii is based on the subjectivity of clinical manifestations, which can result in a delay in starting its treatment and, consequently evolution to severe sequelae. There isn't laboratory biomarker available to support the early diagnosis of severe PCM that is feasible for all the realities that coexist in Brazil.OBJECTIVES: The aim of this study was to investigate the usefulness of laboratory biomarkers as erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and neutrophil/lymphocyte ratio (NLR) in the diagnosis of severe PCM.PATIENTS/METHODS: ESR, CRP, and NLR were analyzed for 44 patients with PCM by P.lutzii and a Receiver Operation Characteristic (ROC) curve were generated to identify the NLR cut-off point and point out the presence of severe PCM.RESULTS: Sixteen (36.4%) had severe PCM and 28 (63.6%) had non-severe PCM. The mean NLR was higher and statistically significant among patients with severe PCM than among those with non-severe PCM. The area under the ROC curve was 0.859 for the diagnosis of severe PCM. The cut-off point for NLR for the diagnosis of severe PCM was 3.318 (sensitivity of 100%, specificity of 77%).CONCLUSIONS: According to results, it is plausible to conclude that NLR represents a potential biomarker for the diagnosis of severe PCM.

Published
2021

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