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This study analyses and quantifies the effects of vertical wind shear (VWS) on the properties of shallow cumulus cloud fields over Central Amazonia. We perform idealised simulations with high resolution (50 m horizontally and 20 m vertically) using the Dutch Atmospheric Large-Eddy Simulation (DALES) model, changing the initial conditions and large-scale forcing of VWS. The resulting cloud field is analysed by applying a cloud tracking algorithm to generate Lagrangian datasets of the life cycle of individual clouds as well as their time-varying core and margin dimensions. The reference run has no wind speed or directional shear and represents a typical day in the local dry season. Numerical experiments with moderate and high wind speed shear are simulated by adding linear increases in the wind speed of 1.2 and 2.4 m s−1 km−1, respectively. Three additional runs are made by adding 90∘ of wind rotation between the surface and the top of the domain (5 km) on top of the three wind speed shear conditions. We find that clouds developing in a sheared environment have horizontal equivalent diameter increased by up to 100 m on average, but the cloud depth is reduced. Our quantification shows that VWS tends to increase the size of the cloud cores but reduces their relative area, volume, and mass fractions compared to the overall cloud dimensions. The addition of 2.4 m s−1 km−1 of VWS decreases the relative core area by about 0.03 (about 10 % of the overall average) and its volume and mass ratios by about 0.05 (10 %–25 % in relative terms). Relevant for the cloud transport properties is that the updraught speed and the liquid water content are lower within the cores, and consequently so is the upward mass flux. All quantifications of mean cloud properties point to the inhibition of convective strength by VWS, therefore hampering the shallow-to-deep transition. However, open questions still remain given that the individually deepest clouds were simulated under high environmental shear, even though they occur in small numbers. This could indicate other indirect effects of VWS that have opposite effects on cloud development if found to be significant in the future.

Large-eddy simulation (LES) models are an excellent tool to improve our understanding of aerosol–cloud interactions (ACI). We introduce a prognostic aerosol scheme with multiple aerosol species in the Dutch Atmospheric Large-Eddy Simulation model (DALES), especially focused on simulating the impact of cloud microphysical processes on the aerosol population. The numerical treatment of aerosol activation is a crucial element for simulating both cloud and aerosol characteristics. Two methods are implemented and discussed: an explicit activation scheme based on κ-Köhler theory and a more classic approach using updraught strength. Sample model simulations are based on the Rain in Shallow Cumulus over the Ocean (RICO) campaign, characterized by rapidly precipitating warm-phase shallow cumulus clouds. We find that in this pristine ocean environment virtually all aerosol mass in cloud droplets is the result of the activation process, while in-cloud scavenging is relatively inefficient. Despite the rapid formation of precipitation, most of the in-cloud aerosol mass is returned to the atmosphere by cloud evaporation. The strength of aerosol processing through subsequent cloud cycles is found to be particularly sensitive to the activation scheme and resulting cloud characteristics. However, the precipitation processes are considerably less sensitive. Scavenging by precipitation is the dominant source for in-rain aerosol mass. About half of the in-rain aerosol reaches the surface, while the rest is released by evaporation of falling precipitation. The effect of cloud microphysics on the average aerosol size depends on the balance between the evaporation of clouds and rain and ultimate removal by precipitation. Analysis of typical aerosol size associated with the different microphysical processes shows that aerosols resuspended by cloud evaporation have a radius that is only 5 % to 10 % larger than the originally activated aerosols. In contrast, aerosols released by evaporating precipitation are an order of magnitude larger.

This paper presents the first results of an age-of-air (AoA) inter-comparison of six global transport models. Following a protocol, three global circulation models and three chemistry transport models simulated five tracers with boundary conditions that grow linearly in time. This allows for an evaluation of the AoA and transport times associated with inter-hemispheric transport, vertical mixing in the troposphere, transport to and in the stratosphere, and transport of air masses between land and ocean. Since AoA is not a directly measurable quantity in the atmosphere, simulations of 222Rn and SF6 were also performed. We focus this first analysis on averages over the period 2000–2010, taken from longer simulations covering the period 1988–2014. We find that two models, NIES and TOMCAT, show substantially slower vertical mixing in the troposphere compared to other models (LMDZ, TM5, EMAC, and ACTM). However, while the TOMCAT model, as used here, has slow transport between the hemispheres and between the atmosphere over land and ocean, the NIES model shows efficient horizontal mixing and a smaller latitudinal gradient in SF6 compared to the other models and observations. We find consistent differences between models concerning vertical mixing of the troposphere, expressed as AoA differences and modelled 222Rn gradients between 950 and 500 hPa. All models agree, however, on an interesting asymmetry in inter-hemispheric mixing, with faster transport from the Northern Hemisphere surface to the Southern Hemisphere than vice versa. This is attributed to a rectifier effect caused by a stronger seasonal cycle in boundary layer venting over Northern Hemispheric land masses, and possibly to a related asymmetric position of the intertropical convergence zone. The calculated AoA in the mid–upper stratosphere varies considerably among the models (4–7 years). Finally, we find that the inter-model differences are generally larger than differences in AoA that result from using the same model with a different resolution or convective parameterisation. Taken together, the AoA model inter-comparison provides a useful addition to traditional approaches to evaluate transport timescales. Results highlight that inter-model differences associated with resolved transport (advection, reanalysis data, nudging) and parameterised transport (convection, boundary layer mixing) are still large and require further analysis. For this purpose, all model output and analysis software are available.

The representation of aerosol–cloud interaction in global climate models (GCMs) remains a large source of uncertainty in climate projections. Due to its complexity, precipitation evaporation is either ignored or taken into account in a simplified manner in GCMs. This research explores various ways to treat aerosol resuspension and determines the possible impact of precipitation evaporation and subsequent aerosol resuspension on global aerosol burdens and distribution. The representation of aerosol wet deposition by large-scale precipitation in the EC-Earth model has been improved by utilising additional precipitation-related 3-D fields from the dynamical core, the Integrated Forecasting System (IFS) general circulation model, in the chemistry and aerosol module Tracer Model, version 5 (TM5). A simple approach of scaling aerosol release with evaporated precipitation fraction leads to an increase in the global aerosol burden (+7.8 to +15 % for different aerosol species). However, when taking into account the different sizes and evaporation rate of raindrops following Gong et al. (2006), the release of aerosols is strongly reduced, and the total aerosol burden decreases by −3.0 to −8.5 %. Moreover, inclusion of cloud processing based on observations by Mitra et al. (1992) transforms scavenged small aerosol to coarse particles, which enhances removal by sedimentation and hence leads to a −10 to −11 % lower aerosol burden. Finally, when these two effects are combined, the global aerosol burden decreases by −11 to −19 %. Compared to the Moderate Resolution Imaging Spectroradiometer (MODIS) satellite observations, aerosol optical depth (AOD) is generally underestimated in most parts of the world in all configurations of the TM5 model and although the representation is now physically more realistic, global AOD shows no large improvements in spatial patterns. Similarly, the agreement of the vertical profile with Cloud-Aerosol Lidar with Orthogonal Polarization (CALIOP) satellite measurements does not improve significantly. We show, however, that aerosol resuspension has a considerable impact on the modelled aerosol distribution and needs to be taken into account.

The height of the atmospheric boundary layer or mixing layer is an important parameter for understanding the dynamics of the atmosphere and the dispersion of trace gases and air pollution. The height of the mixing layer (MLH) can be retrieved, among other methods, from lidar or ceilometer backscatter data. These instruments use the vertical backscatter lidar signal to infer MLHL, which is feasible because the main sources of aerosols are situated at the surface and vertical gradients are expected to go from the aerosol loaded mixing layer close to the ground to the cleaner free atmosphere above. Various lidar/ceilometer algorithms are currently applied, but accounting for MLH temporal development is not always well taken care of. As a result, MLHL retrievals may jump between different atmospheric layers, rather than reliably track true MLH development over time. This hampers the usefulness of MLHL time series, e.g. for process studies, model validation/verification and climatology. Here, we introduce a new method pathfinder, which applies graph theory to simultaneously evaluate time frames that are consistent with scales of MLH dynamics, leading to coherent tracking of MLH. Starting from a grid of gradients in the backscatter profiles, MLH development is followed using Dijkstra's shortest path algorithm (Dijkstra, 1959). Locations of strong gradients are connected under the condition that subsequent points on the path are limited to a restricted vertical range. The search is further guided by rules based on the presence of clouds and residual layers. After being applied to backscatter lidar data from Cabauw, excellent agreement is found with wind profiler retrievals for a 12-day period in 2008 (R2 = 0.90) and visual judgment of lidar data during a full year in 2010 (R2 = 0.96). These values compare favourably to other MLHL methods applied to the same lidar data set and corroborate more consistent MLH tracking by pathfinder.

The distribution of methane (CH4) in the stratosphere can be a major driver of spatial variability in the dry-air column-averaged CH4 mixing ratio (XCH4), which is being measured increasingly for the assessment of CH4 surface emissions. Chemistry-transport models (CTMs) therefore need to simulate the tropospheric and stratospheric fractional columns of XCH4 accurately for estimating surface emissions from XCH4. Simulations from three CTMs are tested against XCH4 observations from the Total Carbon Column Network (TCCON). We analyze how the model–TCCON agreement in XCH4 depends on the model representation of stratospheric CH4 distributions. Model equivalents of TCCON XCH4 are computed with stratospheric CH4 fields from both the model simulations and from satellite-based CH4 distributions from MIPAS (Michelson Interferometer for Passive Atmospheric Sounding) and MIPAS CH4 fields adjusted to ACE-FTS (Atmospheric Chemistry Experiment Fourier Transform Spectrometer) observations. Using MIPAS-based stratospheric CH4 fields in place of model simulations improves the model–TCCON XCH4 agreement for all models. For the Atmospheric Chemistry Transport Model (ACTM) the average XCH4 bias is significantly reduced from 38.1 to 13.7 ppb, whereas small improvements are found for the models TM5 (Transport Model, version 5; from 8.7 to 4.3 ppb) and LMDz (Laboratoire de Météorologie Dynamique model with zooming capability; from 6.8 to 4.3 ppb). Replacing model simulations with MIPAS stratospheric CH4 fields adjusted to ACE-FTS reduces the average XCH4 bias for ACTM (3.3 ppb), but increases the average XCH4 bias for TM5 (10.8 ppb) and LMDz (20.0 ppb). These findings imply that model errors in simulating stratospheric CH4 contribute to model biases. Current satellite instruments cannot definitively measure stratospheric CH4 to sufficient accuracy to eliminate these biases. Applying transport diagnostics to the models indicates that model-to-model differences in the simulation of stratospheric transport, notably the age of stratospheric air, can largely explain the inter-model spread in stratospheric CH4 and, hence, its contribution to XCH4. Therefore, it would be worthwhile to analyze how individual model components (e.g., physical parameterization, meteorological data sets, model horizontal/vertical resolution) impact the simulation of stratospheric CH4 and XCH4.

Organisaties zijn al decennia druk bezig met het stroomlijnen en opnieuw inrichten van bedrijfsprocessen en het management ervan. Dit artikel behandelt de centrale vraag: welke maatregelen in de organisatiestructuur zijn effectief als een organisatie wil sturen op haar bedrijfsprocessen? Zo kiezen organisaties voor de inbedding van procesmanagement in de organisatiestructuur, bijvoorbeeld voor procesmanagers, proceseigenaren en/of matrixstructuren. In dit artikel wordt een typologie gepresenteerd van oplossingen in de structuur van organisaties voor procesgericht werken. Dit artikel is niet alleen interessant voor organisatie- en bedrijfskundigen, maar ook voor accountants en informatiedeskundigen. Immers de keuze voor een oplossing in de organisatiestructuur heeft ingrijpende gevolgen voor het besturingsmodel en de informatievoorziening van de organisatie.

The prognostic value of microsatellite instability (MSI), as well as other histological characteristics such as lymphovascular invasion (LI), perineural invasion (PNI) and extramural vascular invasion (EMVI), is unclear in colorectal mucinous carcinoma (MC). This study aims to determine the relevance of these factors in MC patients and analyses the role of MSI in stage III MC patients treated with adjuvant chemotherapy. A cohort of 650 patients diagnosed with stages I–IV colonic MC from 2000 to 2010 was selected from PALGA, the nationwide Dutch pathology databank. Histopathology was revised and mismatch repair (MMR) status determined. Univariate and multivariate survival analyses were performed. Deficient MMR (dMMR) was found in 33% of MCs and correlated with female gender and right-sidedness, but also with lower tumour stage (stages I/II: 73.2 versus 47%; P < 0.0001) and the absence of EMVI (9.7 versus 23.7%; P < 0.0001) and PNI (5.6 versus 12.7%; P = 0.005). On univariate analysis OS was better for dMMR MC than for proficient MMR (pMMR) MC (median OS of 9.7 versus 5.0 years; P = 0.009), but MMR status was no longer a relevant prognostic factor on multivariate analysis [hazard ratio (HR) = 0.91, 95% confidence interval (CI) = 0.70– 1.18]. Stage III MC patients benefited from adjuvant chemotherapy, and dMMR status was associated with better OS in this group (HR = 0.35, 95% CI = 0.13– 0.94). EMVI, LI and PNI, but not MMR, status are independent prognostic factors for survival in MC patients. Stage III MC patients benefit from adjuvant chemotherapy and dMMR status is associated with improved survival when adjuvant chemotherapy is given. [ABSTRACT FROM AUTHOR]

Discusses the role of the Commission of the European Communities (CEC) in the development of the electronic information industry in Europe. Activities aimed at libraries are described; the IMPACT program for developing the market for information services is explained; and problems of multilingualism are addressed. (LRW)

Cabauw lidar data were used for the development of several new methods, as well as in the validation of new techniques based on other sensor data. The potential of the site that is equipped with a suite of in-situ and remote sensing equipment provides the possibility to develop new methods, and test them using independent observations. Examples are shown for several recent campaigns conducted at the site, new methods developed using lidar data, and for satellite validation, including preparation for future missions.

Folate deficiency has been associated with colorectal cancer risk and may be involved in colorectal carcinogenesis through increased chromosome instability, gene mutations, and aberrant DNA methylation. Within the Netherlands Cohort Study on diet and cancer, we investigated the associations between dietary folate intake and colorectal cancer risk with ([APC.sup.+]) and without ([APC.sup.-]) truncating APC mutations, accounting for hMLH1 expression and K-ras mutations. In total, 528 cases and 4200 subcohort members were available for data analyses of the study cohort (n = 120,852) from a follow-up period between 2.3 and 7.3 y after baseline. Adjusted gender-specific incidence rate ratios (RR) over tertiles of folate intake were calculated in case-cohort analyses for colon and rectal cancer. Although relatively high folate intake was not associated with overall colorectal cancer risk, it reduced the risk of APC colon tumors in men (RR 0.58, 95% CI 0.32-1.05, [P.sub.trend] 0.06 for the highest vs. lowest tertile of folate intake). In contrast, it was positively associated with [APC.sub.+] colon tumors in men (highest vs. lowest tertile: RR 2.77, 95% Cl 1.29-5.95, [P.sub.trend] = 0.008) and was even stronger when the lack of hMLH1 expression and K-ras mutations were excluded (RR 3.99, 95% Cl 1.43-11.14, [P.sub.trend] = 0.007). Such positive associations were not observed among women; nor was folate intake associated with rectal cancer when APC mutation status was taken into account. Relatively high folate consumption reduced the risk of [APC.sup.-] colon tumors, but folate intake was positively associated with [APC.sup.+] colon tumors among men. These opposite results may indicate that folate enhances colorectal carcinogenesis through a distinct APC mutated pathway.