Search

Your search keyword '"de Bont, Eveline S.J.M."' showing total 197 results
Start Over Author "de Bont, Eveline S.J.M."
197 results on '"de Bont, Eveline S.J.M."'

3. Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3

Author

Villegas, Florian, Lehalle, Daphné, Mayer, Daniela, Rittirsch, Melanie, Stadler, Michael B., Zinner, Marietta, Olivieri, Daniel, Vabres, Pierre, Duplomb-Jego, Laurence, De Bont, Eveline S.J.M., Duffourd, Yannis, Duijkers, Floor, Avila, Magali, Geneviève, David, Houcinat, Nada, Jouan, Thibaud, Kuentz, Paul, Lichtenbelt, Klaske D., Thauvin-Robinet, Christel, St-Onge, Judith, Thevenon, Julien, van Gassen, Koen L.I., van Haelst, Mieke, van Koningsbruggen, Silvana, Hess, Daniel, Smallwood, Sebastien A., Rivière, Jean-Baptiste, Faivre, Laurence, and Betschinger, Joerg

Published
2019
Full Text
View/download PDF

4. Identification of Two Protein-Signaling States Delineating Transcriptionally Heterogeneous Human Medulloblastoma

Author

Zomerman, Walderik W., Plasschaert, Sabine L.A., Conroy, Siobhan, Scherpen, Frank J., Meeuwsen-de Boer, Tiny G.J., Lourens, Harm J., Guerrero Llobet, Sergi, Smit, Marlinde J., Slagter-Menkema, Lorian, Seitz, Annika, Gidding, Corrie E.M., Hulleman, Esther, Wesseling, Pieter, Meijer, Lisethe, van Kempen, Leon C., van den Berg, Anke, Warmerdam, Daniël O., Kruyt, Frank A.E., Foijer, Floris, van Vugt, Marcel A.T.M., den Dunnen, Wilfred F.A., Hoving, Eelco W., Guryev, Victor, de Bont, Eveline S.J.M., and Bruggeman, Sophia W.M.

Published
2018
Full Text
View/download PDF

17. Data from VEGFC Antibody Therapy Drives Differentiation of AML

Author

Kampen, Kim R., primary, Scherpen, Frank J.G., primary, Mahmud, Hasan, primary, ter Elst, Arja, primary, Mulder, André B., primary, Guryev, Victor, primary, Verhagen, Han J.M.P., primary, De Keersmaecker, Kim, primary, Smit, Linda, primary, Kornblau, Steven M., primary, and De Bont, Eveline S.J.M., primary

Published
2023
Full Text
View/download PDF

20. Supplementary Table 3 from Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery

Author

Sikkema, Arend H., primary, Diks, Sander H., primary, den Dunnen, Wilfred F.A., primary, ter Elst, Arja, primary, Scherpen, Frank J.G., primary, Hoving, Eelco W., primary, Ruijtenbeek, Rob, primary, Boender, Piet J., primary, de Wijn, Rik, primary, Kamps, Willem A., primary, Peppelenbosch, Maikel P., primary, and de Bont, Eveline S.J.M., primary

Published
2023
Full Text
View/download PDF

23. Supplementary Table 2 from Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery

Author

Sikkema, Arend H., primary, Diks, Sander H., primary, den Dunnen, Wilfred F.A., primary, ter Elst, Arja, primary, Scherpen, Frank J.G., primary, Hoving, Eelco W., primary, Ruijtenbeek, Rob, primary, Boender, Piet J., primary, de Wijn, Rik, primary, Kamps, Willem A., primary, Peppelenbosch, Maikel P., primary, and de Bont, Eveline S.J.M., primary

Published
2023
Full Text
View/download PDF

24. Supplementary Figure 3 from Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery

Author

Sikkema, Arend H., primary, Diks, Sander H., primary, den Dunnen, Wilfred F.A., primary, ter Elst, Arja, primary, Scherpen, Frank J.G., primary, Hoving, Eelco W., primary, Ruijtenbeek, Rob, primary, Boender, Piet J., primary, de Wijn, Rik, primary, Kamps, Willem A., primary, Peppelenbosch, Maikel P., primary, and de Bont, Eveline S.J.M., primary

Published
2023
Full Text
View/download PDF

26. Supplementary Figure 2 from Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery

Author

Sikkema, Arend H., primary, Diks, Sander H., primary, den Dunnen, Wilfred F.A., primary, ter Elst, Arja, primary, Scherpen, Frank J.G., primary, Hoving, Eelco W., primary, Ruijtenbeek, Rob, primary, Boender, Piet J., primary, de Wijn, Rik, primary, Kamps, Willem A., primary, Peppelenbosch, Maikel P., primary, and de Bont, Eveline S.J.M., primary

Published
2023
Full Text
View/download PDF

27. Supplementary Figure 1 from Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery

Author

Sikkema, Arend H., primary, Diks, Sander H., primary, den Dunnen, Wilfred F.A., primary, ter Elst, Arja, primary, Scherpen, Frank J.G., primary, Hoving, Eelco W., primary, Ruijtenbeek, Rob, primary, Boender, Piet J., primary, de Wijn, Rik, primary, Kamps, Willem A., primary, Peppelenbosch, Maikel P., primary, and de Bont, Eveline S.J.M., primary

Published
2023
Full Text
View/download PDF

28. Supplementary Table 1 from Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery

Author

Sikkema, Arend H., primary, Diks, Sander H., primary, den Dunnen, Wilfred F.A., primary, ter Elst, Arja, primary, Scherpen, Frank J.G., primary, Hoving, Eelco W., primary, Ruijtenbeek, Rob, primary, Boender, Piet J., primary, de Wijn, Rik, primary, Kamps, Willem A., primary, Peppelenbosch, Maikel P., primary, and de Bont, Eveline S.J.M., primary

Published
2023
Full Text
View/download PDF

29. Supplementary Table 4 from Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery

Author

Sikkema, Arend H., primary, Diks, Sander H., primary, den Dunnen, Wilfred F.A., primary, ter Elst, Arja, primary, Scherpen, Frank J.G., primary, Hoving, Eelco W., primary, Ruijtenbeek, Rob, primary, Boender, Piet J., primary, de Wijn, Rik, primary, Kamps, Willem A., primary, Peppelenbosch, Maikel P., primary, and de Bont, Eveline S.J.M., primary

Published
2023
Full Text
View/download PDF

30. Supplementary Figure 4 from Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery

Author

Sikkema, Arend H., primary, Diks, Sander H., primary, den Dunnen, Wilfred F.A., primary, ter Elst, Arja, primary, Scherpen, Frank J.G., primary, Hoving, Eelco W., primary, Ruijtenbeek, Rob, primary, Boender, Piet J., primary, de Wijn, Rik, primary, Kamps, Willem A., primary, Peppelenbosch, Maikel P., primary, and de Bont, Eveline S.J.M., primary

Published
2023
Full Text
View/download PDF

33. Clinical relevance of proteomic profiling in de novo pediatric acute myeloid leukemia: a Children’s Oncology Group study

Author

Hoff, Fieke W., van Dijk, Anneke D., Qiu, Yihua, Hu, Chenyue W., Ries, Rhonda E., Ligeralde, Andrew, Jenkins, Gaye N., Gerbing, Robert B., Gamis, Alan S., Aplenc, Richard, Kolb, E. Anders, Alonzo, Todd A., Meshinchi, Soheil, Qutub, Amina A., de Bont, Eveline S.J.M., Horton, Terzah M., and Kornblau, Steven M.

Abstract

Pediatric acute myeloid leukemia (AML) remains a fatal disease for at least 30% of patients, stressing the need for improved therapies and better risk stratification. As proteins are the unifying feature of (epi)genetic and environmental alterations, and are often targeted by novel chemotherapeutic agents, we studied the proteomic landscape of pediatric AML. Protein expression and activation levels were measured in 500 bulk leukemic patients’ samples and 30 control CD34+ cell samples, using reverse phase protein arrays with 296 strictly validated antibodies. The multistep MetaGalaxy analysis methodology was applied and identified nine protein expression signatures (PrSIG), based on strong recurrent protein expression patterns. PrSIG were associated with cytogenetics and mutational state, and with favorable or unfavorable prognosis. Analysis based on treatment (i.e., ADE vs. ADE plus bortezomib) identified three PrSIG that did better with ADE plus bortezomib than with ADE alone. When PrSIG were studied in the context of cytogenetic risk groups, PrSIG were independently prognostic after multivariate analysis, suggesting a potential value for proteomics in combination with current classification systems. Proteins with universally increased (n=7) or decreased (n=17) expression were observed across PrSIG. Certain proteins significantly differentially expressed from normal could be identified, forming a hypothetical platform for personalized medicine.

Published
2022

39. High-frequency type I/II mutational shifts between diagnosis and relapse are associated with outcome in pediatric AML: implications for personalized medicine

Author

Bachas, Costa, Schuurhuis, Gerrit Jan, Hollink, Iris H.I.M., Kwidama, Zinia J., Goemans, Bianca F., Zwaan, C. Michel, van den Heuvel-Eibrink, Marry M., de Bont, Eveline S.J.M., Reinhardt, Dirk, Creutzig, Ursula, de Haas, Valerie, Assaraf, Yehuda G., Kaspers, Gertjan J.L., and Cloos, Jacqueline

Published
2010
Full Text
View/download PDF

45. Chemotherapy treatment in pediatric patients with acute myeloid leukemia receiving antimicrobial prophylaxis leads to a relative increase of colonization with potentially pathogenic bacteria in the gut

Author

van Vliet, Michel J., Tissing, Wim J.E., Dun, Catharina A.J., Meessen, Nico E.L., Kamps, Willem A., de Bont, Eveline S.J.M., and Harmsen, Hermie J.M.

Subjects
Chemotherapy -- Complications and side effects, Chemotherapy -- Demographic aspects, Chemotherapy -- Research, Antibiotics -- Physiological aspects, Antibiotics -- Demographic aspects, Antibiotics -- Research, Microbiota (Symbiotic organisms) -- Research, Cancer -- Chemotherapy, Cancer -- Complications and side effects, Cancer -- Demographic aspects, Cancer -- Research, Health, Health care industry
Published
2009

Catalog

Books, media, physical & digital resources
See catalog results