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14. Loopstoornissen

Author

van Doorn, P. A., van Schaik, I. N., de Bie, R. M. A., Visser, J., van de Warrenburg, B. P. C., Vermeulen, M., Bindels, P. J. E., editor, and Vermeulen, M., editor

Published
2010
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15. Tremor

Author

de Bie, R. M. A., Bindels, P. J. E., editor, and Vermeulen, M., editor

Published
2010
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16. Thalamic local field potentials recorded using the deep brain stimulation pulse generator

Author

Buijink, A. W. G., Piña-Fuentes, D. A., Stam, M. J., Bot, M., Schuurman, P. R., van den Munckhof, P., van Rootselaar, A. F., de Bie, R. M. A., Beudel, M., Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Neurosurgery, Neurology, Graduate School, ANS - Neurodegeneration, ANS - Systems & Network Neuroscience, ANS - Brain Imaging, and APH - Aging & Later Life

Subjects
Neurology, Physiology (medical), Tremor, Deep brain stimulation, Essential tremor, Closed-loop, Neurology (clinical), Adaptive, nervous system diseases
Abstract

Background: Essential tremor (ET) is one of the most common movement disorders, and continuous deep brain stimulation (DBS) is an established treatment for medication-refractory cases. However, the need for increasing stimulation intensities, with unpleasant side effects, and DBS tolerance over time can be problematic. The advent of novel DBS devices now provides the opportunity to longitudinally record LFPs using the implanted pulse generator, which opens up possibilities to implement adaptive DBS algorithms in a real-life setting. Methods: Here we report a case of thalamic LFP activity recorded using a commercially available sensing-enabled DBS pulse generator (Medtronic Percept PC). Results: In the OFF-stimulation condition, a peak tremor frequency of 3.8 Hz was identified during tremor evoking movements as assessed by video and accelerometers. Activity at the same and supraharmonic frequency was seen in the frequency spectrum of the LFP data from the left vim nucleus during motor tasks. Coherence analysis showed that peripherally recorded tremor was coherent with the LFP signal at the tremor frequency and supraharmonic frequency. Conclusion: This is the first report of recorded tremor-related thalamic activity using the electrodes and pulse generator of an implanted DBS system. Larger studies are needed to evaluate the clinical potential of these fully implantable systems, and ultimately pulse generators with sensing-coupled algorithms driving stimulation, to really close the loop.

Published
2022

18. Posteroventral Pallidotomy in Movement Disorders

Author

Schuurman, P. R., de Bie, R. M. A., Speelman, J. D., Bosch, D. A., Reulen, H.-J., editor, Steiger, H.-J., editor, Ostertag, C. B., editor, Thomas, D. G. T., editor, Bosch, A., editor, Linderoth, B., editor, and Broggi, G., editor

Published
1997
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20. Relaxin-2 during pregnancy according to glycemia, continence status, and pelvic floor muscle function.

Author

Prudencio, Caroline Baldini, Nunes, Sthefanie Kenickel, Pinheiro, Fabiane Affonso, Filho, Carlos Isaias Sartorão, Antônio, Flávia Ignácio, de Aquino Nava, Guilherme Thomaz, Rudge, Marilza Vieira Cunha, Barbosa, Angélica Mércia Pascon, Diamater Study Group, Calderon, I. M. P., Souza, F. P., Berghmans, B., de Bie, R., Thabane, L., Junginger, B., Graeff, C. F. O., Magalhães, C. G., Costa, R. A., Lima, S. A. M., and Kron-Rodrigues, M. R.

Subjects
PELVIC floor, GESTATIONAL diabetes, URINARY incontinence in women, PREGNANT women, URINARY incontinence, MUSCLE strength
Abstract

Introduction and hypothesis: To investigate relaxin-2 concentration comparing gestational diabetes mellitus (GDM) and non-GDM patients during pregnancy according to urinary incontinence (UI) and pelvic function status. Methods: This is a cross-sectional study evaluating 282 pregnant women from 24 weeks of gestation. The participants were divided into two groups, non-GDM and GDM, according to American Diabetes Association's diabetes mellitus gestational threshold. In addition, according to subanalysis, both groups were subdivided according to the presence of pregnancy-specific urinary incontinence: non-GDM continent, non-GDM incontinent, GDM continent, and GDM incontinent. All participants filled in questionnaires on clinical, obstetric, and urinary continence status (International Consultation on Incontinence Questionnaire-Short Form, ICIQ-SF, and Incontinence Severity Index, ISI), followed by pelvic floor muscle evaluation by the PERFECT scheme in which strength, endurance, and speed of contractions were evaluated. Results: Serum relaxin-2 concentrations were significantly lower in pregnant women with pregnancy-specific urinary incontinence in both non-GDM and GDM patients, but GDM showed the lowest concentration. In addition, the stratification of the groups according to pelvic floor muscle strength showed that pregnant patients with GDM and modified Oxford scale 0–2 had significantly lower levels than those who were non-GDM and GDM with Modified Oxford Scale 3–5. Relaxin-2 level was much lower in GDM incontinent pregnant women with MOS 0–2 compared to the other three groups. Conclusions: Lower relaxin-2 concentration was associated with the presence of pregnancy-specific urinary incontinence, but the combination of GDM, pregnancy-specific urinary incontinence, and lower levels of pelvic floor strength led to lower levels of relaxin-2 compared to the other three groups. [ABSTRACT FROM AUTHOR]

Published
2022
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49. Alterations in the structural characteristics of rectus abdominis muscles caused by diabetes and pregnancy: A comparative study of the rat model and women

Author

Vesentini, Giovana [UNESP], Barbosa, Angélica M.P. [UNESP], Damasceno, Débora C. [UNESP], Marini, Gabriela [UNESP], Piculo, Fernanda [UNESP], Matheus, Selma M.M. [UNESP], Hallur, Raghavendra L.S. [UNESP], Nunes, Sthefanie K. [UNESP], Catinelli, Bruna B. [UNESP], Magalhães, Claudia G. [UNESP], Costa, Roberto [UNESP], Abbade, Joelcio F. [UNESP], Corrente, José E. [UNESP], Calderon, Iracema M.P. [UNESP], Rudge, Marilza V.C. [UNESP], Souza, F. P. [UNESP], Hijas, A., Sobrevia, L., Palma, M. S. [UNESP], Graeff, C. F.O. [UNESP], Arni, R. K. [UNESP], Herculano, R. D. [UNESP], Salvadori, D. F. [UNESP], Dal Pai Silva, M. [UNESP], Lima, S. A.M. [UNESP], Emanueli, C., Felisbino, S. [UNESP], Barbosa, W. [UNESP], Atallah, A., Girão, M. J.B., Di Bella, Z., Uchoa, S. M., Payão, S., Berghman, B., De Bie, R., Junginger, B., Alves, F. C.B. [UNESP], Rossignoli, P. S. [UNESP], Prudencio, C. B. [UNESP], Orlandi, M. I.G. [UNESP], Gonçalves, M. I. [UNESP], Sarmento, B. V. [UNESP], Pinheiro, F. A. [UNESP], Sartorão, C. I. [UNESP], Quiroz, S. B.C.V. [UNESP], Reyes, D. R.A. [UNESP], Enriquez, E. M.A. [UNESP], Oliveira, R. G. [UNESP], Floriano, J. F. [UNESP], Marcondes, J. P.C. [UNESP], Costa, S. M.B. [UNESP], Dangió, T. D. [UNESP], Pascon, T. [UNESP], Melo, J. V.F. [UNESP], Takano, L. [UNESP], Reis, F. V.D.S. [UNESP], Caldeirão, T. D. [UNESP], Carr, A. M. [UNESP], Garcia, G. A. [UNESP], Rabadan, G. B. [UNESP], Bassin, H. C.M., Suyama, K. S. [UNESP], Damasceno, L. N. [UNESP], Takemoto, M. L.S. [UNESP], Menezes, M. D. [UNESP], Bussaneli, D. G. [UNESP], Nogueira, V. K.C. [UNESP], Lima, P. R. [UNESP], Lourenço, I. O. [UNESP], Marostica De Sá, J. [UNESP], Megid, R. A. [UNESP], Caruso, I. P. [UNESP], Rasmussen, L. T., Prata, G. M., Arantes, M. A. [UNESP], Ferraz, G. A.R. [UNESP], Camargo, L. P. [UNESP], Kron, M. R. [UNESP], Nunes, H. R.C. [UNESP], Universidade Estadual Paulista (Unesp), Universidade Sagrado Coração, Case Western Reserve University, Pontificia Universidad Catolica de Chile, Imperial College London, Universidade Federal de São Paulo (UNIFESP), Universidade Católica de Pernambuco, Faculdade de Medicina de Marília, Maastrich University, Charité Universitätsmedizin Berlin, Universidade do Sagrado Coração, and Faculdades Integradas de Bauru

Subjects
Male, Maternal Health, Rectus Abdominis, Biochemistry, 0302 clinical medicine, Endocrinology, Pregnancy, Animal Cells, Medicine and Health Sciences, Rectus abdominis muscle, Musculoskeletal System, Abdominal Muscles, Glucose tolerance test, 030219 obstetrics & reproductive medicine, Multidisciplinary, medicine.diagnostic_test, Muscles, Obstetrics and Gynecology, Animal Models, Gestational diabetes, Experimental Organism Systems, Immunohistochemistry, Medicine, Female, Anatomy, Cellular Types, medicine.drug, Research Article, Adult, medicine.medical_specialty, Endocrine Disorders, Science, 030209 endocrinology & metabolism, Research and Analysis Methods, Muscle Fibers, 03 medical and health sciences, Fetus, Internal medicine, Diabetes mellitus, medicine, Diabetes Mellitus, Animals, Humans, Rats, Wistar, Gestational Diabetes, business.industry, Body Weight, Biology and Life Sciences, Proteins, Cell Biology, Glucose Tolerance Test, Skeletal Muscle Fibers, medicine.disease, Streptozotocin, Diabetes, Gestational, Disease Models, Animal, Skeletal Muscles, Metabolic Disorders, Animal Studies, Women's Health, business, Collagens
Abstract

Made available in DSpace on 2020-12-12T02:01:51Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-04-01 Associação Brasileira de Saúde Coletiva Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Background and objective In the present study, we compared the effect of diabetic pregnancy on the rectus abdominis muscle (RAM) in humans and rats. We hypothesized that our animal model could provide valuable information about alterations in the RAM of women with Gestational Diabetes (GDM). Method Newborns female rats (n = 10/group) were administered streptozotocin (100 mg/kg body weight) subcutaneously and were mated on reaching adulthood, to develop the mild hyperglycemic pregnant (MHP) rat model. At the end of pregnancy, the mothers were sacrificed, and the RAM tissue was collected. Pregnant women without GDM (non-GDM group; n = 10) and those diagnosed with GDM (GDM group; n = 8) and undergoing treatment were recruited, and RAM samples were obtained at C-section. The RAM architecture and the distribution of the fast and slow fibers and collagen were studied by immunohistochemistry. Results No statistically significant differences in the maternal and fetal characters were observed between the groups in both rats and women. However, significant changes in RAM architecture were observed. Diabetes in pregnancy increased the abundance of slow fibers and decreased fast fiber number and area in both rats and women. A decrease in collagen distribution was observed in GDM women; however, a similar change was not observed in the MHP rats. Conclusion Our results indicated that pregnancy- associated diabetes- induced similar structural adaptations in the RAM of women and rats with slight alterations in fiber type number and area. These findings suggest that the MHP rat model can be used for studying the effects of pregnancy-associated diabetes on the fiber structure of RAM. Perinatal Diabetes Research Center University Hospital Botucatu Medical School Univ. Estadual Paulista-UNESP Department of Gynecology and Obstetrics São Paulo State University (UNESP) Botucatu Medical School Department of Physiotherapy and Occupational Therapy São Paulo State University (UNESP) School of Philosophy and Sciences Department of Health Sciences Universidade Sagrado Coração Department of Anatomy São Paulo State University (UNESP) Institute of Biosciences Department of Biostatistics São Paulo State University (UNESP) Bioscience Institute Universidade Estadual Paulista Case Western Reserve University Pontificia Universidad Catolica de Chile Imperial College London Universidade Federal de São Paulo Universidade Católica de Pernambuco Faculdade de Medicina de Marília Maastrich University Charité Universitätsmedizin Berlin Universidade do Sagrado Coração Faculdades Integradas de Bauru Perinatal Diabetes Research Center University Hospital Botucatu Medical School Univ. Estadual Paulista-UNESP Department of Gynecology and Obstetrics São Paulo State University (UNESP) Botucatu Medical School Department of Physiotherapy and Occupational Therapy São Paulo State University (UNESP) School of Philosophy and Sciences Department of Anatomy São Paulo State University (UNESP) Institute of Biosciences Department of Biostatistics São Paulo State University (UNESP) Bioscience Institute Universidade Estadual Paulista FAPESP: #2014/26852-6 FAPESP: #2016/01743-5 FAPESP: #2016/09710-9

Published
2019

50. Levodopa en ziekteprogressie bij de ziekte van Parkinson

Author

Suwijn, S. R., Verschuur, C. V. M., Boel, J. A., Post, Bart, Bloem, B. R., van Hilten, B. J., van Laar, T., Tissingh, G., Munts, A. G., de Bie, R. M. A., Movement Disorder (MD), Amsterdam Neuroscience - Neurodegeneration, Graduate School, Amsterdam Movement Sciences, AMS - Restoration & Development, Neurology, Paediatric Neurology, and APH - Aging & Later Life

Published
2019

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