1. Topical and systemic use of Joannesia princeps vell. LC seed oil in acute pain and inflammation induced by different agents.
- Author
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Conceição de Souza M, Hubner JT, Gonçalves GM, Ferreira da Costa Fernandes T, Laureano-Melo R, da Silva Côrtes W, Gonçalves L, de Assis da Silva F, and Marinho BG
- Subjects
- Acute Pain metabolism, Administration, Topical, Analgesics isolation & purification, Animals, Anti-Inflammatory Agents isolation & purification, Carrageenan toxicity, Dose-Response Relationship, Drug, Edema chemically induced, Edema drug therapy, Edema metabolism, Inflammation chemically induced, Inflammation drug therapy, Inflammation metabolism, Male, Mice, Pain Measurement drug effects, Pain Measurement methods, Plant Extracts isolation & purification, Plant Oils isolation & purification, Seeds, Acute Pain drug therapy, Analgesics administration & dosage, Anti-Inflammatory Agents administration & dosage, Euphorbiaceae, Plant Extracts administration & dosage, Plant Oils administration & dosage
- Abstract
Ethnopharmacological Relevance: Joannesia princeps (SOJP) has been used in folk medicine as anthelmintic treatment and cutaneous wound healing., Aim of the Study: The purpose of this study is to evaluate the pharmacological activity of seed oil of Joannesia princeps, administered systemically and topically, on acute pain and inflammation., Materials and Methods: Male swiss mice were treated orally and topically with seed oil of Joannesia princeps in models of acute pain (acetic acid-induced abdominal writhing, formalin-induced licking behaviour and tail flick tests) and acute inflammation (carrageenan- and histamine-induced paw oedema; arachidonic acid-, capsaicin- and croton oil-induced ear oedema and air pouch tests), besides the open field model in the motor performance evaluation., Results: Seed oil of Joannesia princeps showed systemic action against acute pain in abdominal writhing test (37% and 56% inhibition in the number of writhes at doses of 30 and 100 mg/kg, respectively) and in the second phase of formalin-induced licking behaviour test (29%, 47 and 52% inhibition in the licking time at doses of 10, 30 and 100 mg/kg, respectively), as well as reducing croton oil-induced ear oedema by 72%, leukocyte recruitment and production of TNF-α and IL-6 in the air pouch tests. In addition, topical administration of SOJP inhibited carrageenan-induced paw oedema by 39% at dose of 500 μg/paw and inhibited histamine-induced oedema by 43 and 52% at doses of 300 and 500 μg/paw, respectively. SOJP also decreased croton oil-induced ear oedema by 67% at dose of 500 μg/paw and arachidonic acid-induced ear oedema by 63% at dose of 500 μg/paw, reducing the production of TNF-α, IL-1β and MIP2 in both. In addition, no adverse effects were observed at doses up to 2000 mg/kg., Conclusions: Seed oil of Joannesia princeps presents antinociceptive and anti-inflammatory actions through its topical and systemic administration, promoted by inhibition of leukocyte recruitment and cytokine production (TNF-α, IL-1β, IL-6 and MIP-2)., (Copyright © 2020. Published by Elsevier B.V.)
- Published
- 2021
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