An innovation ecosystem is characterised by numerous interactions between its various components. Jackson (2010) argues that it is critical to manage and expand the benefits of this ecosystem, which requires mapping and creating metrics to identify gaps in its performance, and possibly correcting bottlenecks. The proper functioning of an innovation ecosystem is a necessary condition to increase the chances of successful innovative activities, thereby improving the likelihood of creating jobs and providing better conditions for the prosperity of a society. The Global Innovation Index (GII), created jointly by Cornell University and the World Intellectual Property Organization (WIPO), measures various dimensions of the innovation ecosystem in different countries. The index tracks innovation input, which is related to a favourable innovation environment (such as Institutions, Human Resources, Research, Infrastructure, Market Sophistication and Business Sophistication) and innovation output, which in turn is associated with proper innovation outcomes (Products of Knowledge and Technology; Creative Products). Based on the GII metrics, our research aims to investigate the possible relationship between input and output in the innovation ecosystem. Using annual country data, we estimate a quantile regression model to identify the (hypothesised) structural relationship between innovation input and output. The model includes control variables such as GDP (PPP) per capita. Our findings show that innovation input has a significant and positive effect on innovation output. This result confirms the main hypothesis and is similar to the findings of Dutta and Benavente (2011), Dutta, Benavente and Wunsch-Vincent (2012), Dutta, Benavente and Wunsch-Vincent (2013), Dutta et al (2014), Dutta et al (2015), Dutta et al (2016) and Dutta et al (2017). In addition, the more we move to the left tail of the innovation output distribution, the higher is the effect of innovation input. These findings are useful for national innovation policies, since they emphasise the need to promote better innovation incentives. [ABSTRACT FROM AUTHOR]