91 results on '"de Andrade BAB"'
Search Results
2. A retrospective analysis of oral and maxillofacial pathology in a pediatric population from Rio de Janeiro–Brazil over a 75-year period
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Prosdocimo, ML, primary, Agostini, M, additional, Romanach, M, additional, and de Andrade, BAB, additional
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- 2018
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3. Hyperpigmentation of hard palate induced by chloroquine therapy
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de Andrade, BAB, primary, Padron-Alvarado, NA, additional, Muñoz-Campos, EM, additional, Morais, TML, additional, and Martinez-Pedraza, R, additional
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- 2017
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4. Extraskeletal myxoid chondrosarcoma of the masticator space in a pediatric patient
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Romañach, MJ, primary, Carlos, R, additional, Nuyens, M, additional, de Andrade, BAB, additional, and de Almeida, OP, additional
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- 2017
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5. Myeloid sarcoma of the oral cavity: A case report and review of 89 cases from the literature
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de Andrade, BAB, primary, Farneze, RB, additional, Agostini, M, additional, Cortezzi, EB, additional, Abrahão, AC, additional, Cabral, MG, additional, Rumayor, A, additional, and Romañach, MJ, additional
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- 2017
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6. Clear cell variant of calcifying epithelial odontogenic tumor: Case report with immunohistochemical findings
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Turatti, E., primary, Brasil, J., additional, de Andrade, BAB., additional, Romanach, MJ., additional, and de Almeida, OP., additional
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- 2015
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7. Burkitt lymphoma of the jaws in the Amazon region of Brazil
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Rebelo-Pontes, HA., primary, de Abreu, MC., additional, Guimaraes, DM., additional, Fonseca, FP., additional, de Andrade, BAB., additional, de Almeida, OP., additional, Junior, DSP., additional, and Correa-Pontes, FS., additional
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- 2014
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8. Primary oral melanoma: A histopathological and immunohistochemical study of 22 cases of Latin America
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de-Andrade, BAB., primary, Toral-Rizo, VH., additional, Leon, JE., additional, Contreras, E., additional, Carlos, R., additional, Delgado-Azanero, W., additional, Mosqueda-Taylor, A., additional, and de-Almeida, OP., additional
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- 2012
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9. Expression of fatty acid synthase (FASN) in oral nevi and melanoma
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de Andrade, BAB, primary, León, JE, additional, Carlos, R, additional, Delgado-Azañero, W, additional, Mosqueda-Taylor, A, additional, Graner, E, additional, and de Almeida, OP, additional
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- 2011
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10. Oral granular cell tumor: a collaborative clinicopathological study of 61 cases.
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Aragão HHR, Lima LBR, Cavalcante IL, da Silva Neto SS, Turatti E, Cavalcante RB, Gilligan G, Panico R, de Mendonça EF, de Albuquerque-Júnior RLC, Nonaka CFW, Alves PM, de Andrade BAB, and Cunha JLS
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- Humans, Male, Female, Adult, Middle Aged, Adolescent, Child, Aged, Young Adult, Brazil, Granular Cell Tumor pathology, Mouth Neoplasms pathology
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Background: Granular Cell Tumor (GCT) is an uncommon benign lesion in the oral cavity whose pathogenesis remains poorly understood. Due to their infrequent occurrence and similarity to other oral lesions, they are often forgotten during the initial clinical diagnosis. Therefore, understanding its prevalence, clinical and pathological characteristics is crucial for an accurate diagnosis and adequate management., Methods: All cases diagnosed as GCTs in six Brazilian and Argentinian oral diagnostic centers were re-evaluated by HE staining, and clinical, demographic, and histopathological data were collected and evaluated., Results: The series comprised 45 female (73.8%) and 16 male (26.2%), with a 2.8:1 female-to-male ratio and a mean age of 35.3 ± 16.9 years (range: 7-77 years). Most cases occurred on the tongue (n = 49; 81.6%) and presented clinically as asymptomatic papules or nodules (n = 50; 89.3%) with a normochromic (n = 25; 45.5%) or yellowish (n = 11; 20.0%) coloration and sizes ranging from 0.2 to 3.0 cm (mean ± SD: 1.40 ± 0.75 cm). Morphologically, most tumors were characterized by a poorly delimited proliferation (n = 52; 88.1%) of cells typically rounded to polygonal containing abundant, eosinophilic, finely granular cytoplasm. Pustulo-ovoid bodies of Milian were identified in all lesions (n = 61; 100%). Entrapment of skeletal striated muscle (n = 44; 72.1%) and nerve fibers (n = 42; 68.9%) were common findings. Pseudoepitheliomatous hyperplasia (PEH) was observed in 23 cases (39.0%). In only 27.7% of cases (n = 13) there was agreement between the clinical and histopathological diagnosis. Outcome information was available from 16 patients (26.2%), with clinical follow-up ranging from 4 to 36 months (mean 13.3 months), and none developed local recurrence., Conclusions: The clinical and histopathological features of GCTs were consistent with those described in previous studies. In general, these lesions have a predilection for the lateral region of the tongue in adult women. It is essential to consider GCTs in the differential diagnosis of yellow or normochromic papules and nodules in the oral cavity. Histopathological evaluation is essential for the definitive diagnosis and the prognosis is excellent., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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- 2024
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11. Immunohistochemistry and RT-PCR as ancillary tools in the diagnosis of acquired oral syphilis.
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Barreto MEZ, Soares CD, de Andrade MMP, de Oliveira Sales A, Fonseca FP, Abreu LG, Tenório JR, de Arruda JAA, and de Andrade BAB
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Objective: To investigate Treponema pallidum detection using immunohistochemistry (IHC) and reverse transcription-polymerase chain reaction (RT-PCR) assays in acquired oral syphilis (AOS)., Materials and Methods: Thirty-seven paraffin-embedded tissue specimens of AOS (32 secondary and five primary) were analyzed, integrating double-positive serological results with clinicodemographic and histopathological data. T. pallidum presence was semiquantitatively assessed by IHC, while RT-PCR targeted T. pallidum DNA. Sensitivity, specificity, and the area under the curve (AUC) were calculated with 95% confidence intervals (CI)., Results: The study included mostly females (62.2%) with a mean age of 27.1 years. T. pallidum was detected in all samples by IHC, predominantly in the epithelium across all layers (43.2%). RT-PCR identified T. pallidum DNA in 32 cases, with negative results observed in cases of secondary AOS. The AUC for IHC versus disease stage was 62.5% (95% CI: 45.1-77.8), and for RT-PCR, it was 57.8% (95% CI: 40.5-73.8). The AUC comparing IHC to RT-PCR was 83.8% (95% CI: 67.9-93.8)., Conclusion: This study represents the first attempt to evaluate the proposed direct detection algorithm for AOS. IHC and RT-PCR serve as ancillary tools for detecting T. pallidum in both primary and secondary stages of AOS., (© 2024 John Wiley & Sons Ltd.)
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- 2024
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12. Primordial Odontogenic Tumor: A Review of the Literature and Report of Three New Patients.
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Cavalcante IL, Barros CCDS, Sousa Cruz VM, Costa MB, da Silveira Santos DF, de León-Garza B, Parra-Salazar MA, Cruz-Tapia RO, Rodriguez B, Manresa C, Sánchez G, Villarroel-Dorrego M, Turatti E, Cavalcante RB, and de Andrade BAB
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The primordial odontogenic tumor (POT) is a rare mixed odontogenic tumor composed of mesenchymal cells, columnar odontogenic epithelium, and fibromyxoid stroma affecting the posterior mandible of children and adolescents. Herein, we report 3 patients with POT and the clinicopathological features of POT previously reported in the literature. A 12-year-old, 19-year-old, and 4-year-old patient presented an asymptomatic swelling in the posterior maxilla and posterior mandible. Imaging exams revealed radiolucent lesions associated with unerupted teeth. The lesions were surgically removed, and the histopathological examination revealed spindle-to-ovoid mesenchymal cells in a fibromyxoid stroma surfaced by columnar odontogenic epithelial cells with reverse nuclear polarization. Deposition of mineralized tissue was observed. The final diagnosis was POT, and patients did not exhibit signs of recurrence. POT should be included in the differential diagnoses of intraosseous lesions in the posterior mandible in pediatric patients., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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- 2024
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13. Oral lesions of systemic lupus erythematosus: A collaborative Latin American study.
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de Arruda JAA, Villarroel-Dorrego M, Freire CH, Molina-Ávila I, Pimentel-Solá JM, Gilligan G, Piemonte E, Panico R, Panico JCR, Aranda-Romo S, Tejeda-Nava FJ, Israel MS, Cunha JLS, de Medeiros VA, Nonaka CFW, Alves PM, Cavalcante IL, Ventura JVL, de Lima FS, Drumond VZ, Abreu LG, Silva TA, Fonseca FP, Mesquita RA, Martínez-Flores R, Cordero-Torres K, Ahumada-Ossandón R, Guzmán J, Toro R, Xavier-Júnior JCC, Sousa-Neto SS, Arantes DAC, Mendonça EF, Palma VM, de Oliveira MG, Visioli F, Ortega KL, Tenório JR, and de Andrade BAB
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- Humans, Female, Male, Adult, Adolescent, Middle Aged, Young Adult, Child, Aged, Latin America epidemiology, Mouth Mucosa pathology, Biopsy, Lupus Erythematosus, Systemic epidemiology, Lupus Erythematosus, Systemic diagnosis, Mouth Diseases epidemiology, Mouth Diseases etiology, Mouth Diseases pathology
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Background: Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease that may affect the oral mucosa. The variable spectrum of oral lesions observed in SLE can pose challenges in diagnosis, particularly when the lesions occur in isolation. The aim of this study was to describe the oral lesions occurring in patients with SLE from Latin America., Methods: This collaborative record-based study involving 11 oral and maxillofacial pathology and medicine services across Venezuela, Argentina, Chile, Brazil, and Mexico describes the clinicopathological profile of SLE-related oral lesions., Results: Seventy patients with SLE and oral lesions were included in the study. The majority were females (75.7%; female/male ratio: 3.1:1) and white (62.1%), with a mean age of 38.4 years (range: 11-77 years). The most common site of oral lesions was the hard/soft palate (32.0%). Clinically, oral lesions predominantly presented as ulcers (26.6%), erosions (26.6%), and white lesions (23.4%). Isolated oral lesions occurred in 65.2% of individuals, while cutaneous manifestations occurred in 80.3%. The main clinical diagnostic hypothesis in 71.4% of cases was an immune-mediated disease. Oral biopsies followed by histopathological analysis were performed in 50 cases., Conclusion: Oral lesions of SLE exhibit a variety of clinical and histopathological features. A key point in diagnosis is that unusual oral changes without an obvious local cause may indicate a possible systemic condition presenting with oral lesions. A multidisciplinary approach, which includes regular oral examination, is warranted to identify oral lesions and provide treatment., Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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- 2024
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14. Oral solitary fibrous tumors: A collaborative clinicopathologic study of 19 cases.
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Cunha JLS, Cavalcante IL, Barros EF, de Sousa Neto SS, Cavalcante RB, Turatti E, de Mendonça EF, de Albuquerque-Júnior RLC, Anbinder AL, Fragata da Silva D, Duarte IX, Nonaka CFW, Alves PM, de Almeida OP, and de Andrade BAB
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- Humans, Male, Middle Aged, Female, Adult, Aged, Young Adult, STAT6 Transcription Factor analysis, Mouth Mucosa pathology, Mouth Neoplasms pathology, Solitary Fibrous Tumors pathology, Antigens, CD34 analysis
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Objective: To report the clinicopathologic features of 19 oral solitary fibrous tumors (SFTs)., Methods: Clinical data were collected from the records of seven pathology services. All cases were re-evaluated by HE staining and confirmed by immunohistochemistry., Results: The series comprised 11 females (57.9%) and 8 males (42.1%), with a mean age of 47.3 ± 14.7 years (range: 22-71 years) and a 1.3:1 female-to-male ratio. Most tumors affected the buccal mucosa (n = 7; 36.8%) and presented clinically as an asymptomatic solitary submucosal well-circumscribed nodule with coloration similar to the oral mucosa. Morphologically, most SFTs (n = 10; 52.6%) exhibited a classic hybrid pattern characterized by a well-circumscribed proliferation of densely cellular areas alternating with hypocellular areas in a variably collagenous vascular stroma. Remnants of accessory salivary glands were observed in two cases (n = 2; 10.5%). All tumors were positive for STAT6 and CD34 (n = 19; 100%). Outcome information was available from 6 patients (31.6%), with clinical follow-up ranging from 6 to 24 months (mean ± SD, 9.5 ± 6.8 months), and none developed local recurrence., Conclusions: Oral SFTs are rare and often clinically misdiagnosed. Pathologists should consider SFT in the differential diagnosis of oral spindle cell tumors. Accurate diagnosis requires careful morphological evaluation supported by immunohistochemical analysis., (© 2023 Wiley Periodicals LLC.)
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- 2024
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15. Histiocytic sarcoma affecting the oral cavity: a clinical, pathologic and molecular study.
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Legarrea JMA, Alves HS, Chaves RRM, Soares CD, Robinson L, van Heerden WFP, de Andrade BAB, Polti LF, de Souza SF, Gomez RS, de Cáceres CVBL, Vargas PA, and Fonseca FP
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- Humans, Male, Female, Middle Aged, Adult, Biomarkers, Tumor genetics, Aged, Polymerase Chain Reaction, Histiocytic Sarcoma genetics, Histiocytic Sarcoma pathology, Class I Phosphatidylinositol 3-Kinases genetics, Mutation, Proto-Oncogene Proteins p21(ras) genetics, Proto-Oncogene Proteins B-raf genetics, Mouth Neoplasms genetics, Mouth Neoplasms pathology, Immunohistochemistry
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Objective: To investigate the clinicopathological, immunohistochemical and molecular features of histiocytic sarcomas affecting the oral cavity., Methods: Pathology files of two institutions were searched for cases of histiocytic sarcoma, and new H&E-stained slides and immunohistochemistry reactions evaluated for diagnosis confirmation. Molecular screening for KRAS and PIK3CA mutations was performed through polymerase chain reaction (PCR) followed by Sanger sequencing. BRAFp.V600E mutation was assessed by pyrosequencing. Clinical data regarding sex, age, tumor location, systemic manifestations, clinical presentation, follow-up time, treatment applied and status at last follow-up were collected from patients' pathology and medical files., Results: Three cases were retrieved during the period investigated (2000-2023). Two females and one male were affected, with a wide age range, involving the tongue, palate and gingiva. Histopathologically, the neoplasms presented as highly pleomorphic atypical cells distributed diffusely with infiltration of normal structures. All cases demonstrated histiocytic differentiation expressing CD68 and CD163, and a high Ki67 expression. Genetic mutations were evaluated in two cases. One case harboured BRAF-V600E mutation, but not in KRAS and PIK3CA, while the second case did not show mutation in BRAF-V600E, KRAS and PI3KCA. One patient was lost, and two patients died after eight and four months of follow-up., Conclusion: Histiocytic sarcomas involving the oral cavity are extremely rare, and may represent dissemination of a systemic condition. It has an aggressive biological behaviour with a poor overall prognosis., (Copyright © 2024 Elsevier Inc. All rights reserved.)
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- 2024
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16. Clinicopathologic and imaging features of odontogenic myxomas: a multi-institutional study.
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de Melo PRE, de Lima WP, Cavalcante IL, Cruz VMS, Cavalcante RB, Turatti E, Sousa-Neto SS, Mendonça EF, de Abreu de Vasconcellos SJ, Júnior PA, Nonaka CFW, de Albuquerque Júnior RLC, Alves PM, de Andrade BAB, and Cunha JLS
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Purpose: This study aims to report clinicopathologic and imaging features of odontogenic myxomas (OM), highlighting uncommon findings., Methods: Clinicopathologic and imaging data of OMs diagnosed in the five Brazilian diagnostic pathology centers were collected and analyzed., Results: The series comprised 42 females (68.9%) and 19 males (31.1%), with a 2.2:1 female-to-male ratio and a mean age of 34.5±15.4 years (range: 4-80). Clinically, most OMs presented as painless intraoral swelling (n = 36; 70.6%) in the mandible (n=37; 59.7%). Multilocular lesions (n=30; 83.3%) were more common than unilocular lesions (n=6; 16.7%). There was no statistically significant difference between the average size of unilocular and multilocular OMs (p=0.2431). The borders of OMs were mainly well-defined (n=24; 66.7%) with different degrees of cortication. Only seven tumors caused tooth resorption (15.9%), while 24 (54.5%) caused tooth displacement. Cortical bone perforation was observed in 12 (38.7%) cases. Morphologically, OMs were characterized mainly by stellate or spindle-shaped cells in a myxoid background (n=53; 85.5%). Surgical resection was the most common treatment modality (n=15; 65.2%), followed by conservative surgery (n=8; 34.8%). Outcomes were available in 20 cases (32.3%). Seven of these patients had local recurrence (35%). Enucleation was the treatment with the highest recurrence rate (4/7; 57.1%)., Conclusions: OM has a predilection for the posterior region of the jaws of female adults. Despite their bland morphological appearance, they displayed diverse imaging features. Clinicians must include the OM in the differential diagnosis of osteolytic lesions of the jaws. A long follow-up is needed to monitor possible recurrences., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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- 2024
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17. Uremic Stomatitis: A Latin American Case Series and Literature Review.
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de Arruda JAA, Monteiro JLGC, Barreto MEZ, Villarroel-Dorrego M, Gilligan G, Panico R, Calcia TBB, Lara SMC, Silva AMO, Aranda-Romo S, Tejeda-Nava FJ, Israel MS, Silva TA, and de Andrade BAB
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- Humans, Male, Female, Adult, Middle Aged, Latin America epidemiology, Renal Dialysis, Uremia pathology, Uremia complications, Stomatitis pathology, Stomatitis etiology
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Background: Uremic stomatitis is often unfamiliar to healthcare professionals. This study presents five cases of uremic stomatitis, providing a comprehensive analysis of their demographic distribution, clinicopathological features, and management strategies based on existing literature., Methods: Data were collected from centers across Brazil, Argentina, Venezuela, and Mexico. Electronic searches were conducted in five databases supplemented by manual scrutiny and gray literature., Results: The series consisted of three men and two women with a mean age of 40.2 years. Lesions mostly appeared as white plaques, particularly on the tongue (100%). The median blood urea level was 129 mg/dL. Histopathological analysis revealed epithelial changes, including acanthosis and parakeratosis, with ballooned keratinocytes in the suprabasal region. Oral lesions resolved subsequent to hemodialysis in three cases (75%). Thirty-seven studies comprising 52 cases of uremic stomatitis have been described hitherto. Most patients were male (65.4%) with a mean age of 43.6 years. Clinically, grayish-white plaques (37.3%) and ulcers/ulcerations (28.9%) were common, particularly on the tongue (30.9%). Hemodialysis was performed on 27 individuals. The resolution rate of oral lesions was 53.3%., Conclusion: Earlier recognition of uremic stomatitis, possibly associated with long-term uremia, holds the potential to improve outcomes for patients with undiagnosed chronic kidney disease., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2024
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18. Oral Lesions of Immune-Mediated and Autoimmune Diseases: A 12-year Experience at a Single Brazilian Referral Center.
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Amaral-Sobrinho LFD, Lima FS, Santos DBDN, Cavalcante IL, de Arruda JAA, Netto JNS, Andrade NS, de Andrade BAB, and Tenório JR
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- Humans, Female, Retrospective Studies, Middle Aged, Male, Cross-Sectional Studies, Brazil epidemiology, Aged, Adult, Young Adult, Aged, 80 and over, Adolescent, Autoimmune Diseases pathology, Mouth Diseases pathology
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Background: Oral lesions of immune-mediated and autoimmune diseases have been well-documented, but studies from Brazil are limited. The varied spectrum of oral lesions within this demographic group poses challenges to clinicians, particularly when they occur in isolation. This study aimed to evaluate the occurrence, clinical characteristics, and management of patients with oral lesions of immune-mediated and autoimmune diseases at a single center in Brazil., Methods: A retrospective cross-sectional study was conducted from 2010 to 2022. Clinicodemographic data, histopathological features, and treatment modalities were analyzed descriptively and analytically., Results: Of the 3,790 oral and maxillofacial lesions diagnosed, 160 (4.2%) were confirmed as immune-mediated or autoimmune diseases. The population surveyed predominantly consisted of women (73.7%), with a mean age of 60.2 years. Oral lichen planus (51.3%), mucous membrane pemphigoid (MMP) (23.7%), and pemphigus vulgaris (PV) (19.4%) were the most prevalent lesions. The buccal mucosa (59.4%) was predominantly affected, with pain reported in 46.2% of cases, notably in individuals with PV and MMP. The average time to disease stabilization post-local and/or systemic corticosteroid therapy was 15.8 months for systemic lupus erythematosus, 8.7 months for MMP, and 6.5 months for PV., Conclusion: Although oral lesions related to immune-mediated and autoimmune diseases are uncommon, their diverse clinicopathological aspects require multidisciplinary management., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2024
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19. Characterization of ectopic germinal centers in Sjögren's syndrome (SS) and non-SS non-sicca patients.
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Silva EV, de Andrade BAB, Silveira HA, Rocha EM, Chahud F, Brunaldi MO, Bufalino A, and León JE
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- Humans, Female, Middle Aged, Male, Choristoma pathology, Adult, Sjogren's Syndrome complications, Germinal Center pathology
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- 2024
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20. Congenital Juvenile Xanthogranuloma in the Perioral Region: A Case Image.
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Maldonado A, Muñoz R, Alarcon N, Ventura JVL, de Andrade BAB, Villarroel-Dorrego M, and de Arruda JAA
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- Humans, Male, Infant, Xanthogranuloma, Juvenile pathology, Xanthogranuloma, Juvenile congenital
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Juvenile xanthogranuloma (JXG) is the most common form of non-Langerhans cell histiocytosis in childhood. It often presents with cutaneous involvement and exhibits a predilection for the head and neck region. This article illustrates a case of congenital JXG in a 5-month-old boy, characterized by a solitary, well-circumscribed nodule above the left upper lip. Histopathologically, the lesion exhibited histiocytes with eosinophilic cytoplasm and Touton giant cells. Immunohistochemistry revealed histiocytes positive for CD68 and Factor XIIIa, while negative for S-100 protein. Clinicians should become familiar with the broad clinical spectrum of cutaneous JXG, particularly its congenital presentation, in order to ensure timely and accurate management., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2024
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21. Conservative management of multiple odontogenic keratocysts in a child with nevoid basal cell carcinoma syndrome: A case report.
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de Arruda JAA, de Lima KFA, de Oliveira Filho OV, Simonato LE, de Andrade BAB, and Tomo S
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Background: Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant multisystemic disorder characterized by the presence of multiple odontogenic keratocysts (OKC), which are a hallmark feature of the syndrome. The treatment of these OKC poses challenges due to their high recurrence rates and the myriad of management options available., Case Report: We describe here a case of NBCCS diagnosed in an 11-year-old girl who presented with multiple OKC in the jaws. Chest and cranial radiographs showed no abnormalities in the ribs and the cerebral falx, respectively. Cephalometric analysis indicated mandibular retrusion, a skeletal class II relationship, and a convex profile. The treatment approach involved a personalized strategy tailored for each cyst, comprising marsupialization followed by enucleation. This approach aimed to minimize surgical trauma and to reduce the risk of recurrence. The patient underwent regular follow-up appointments, demonstrating successful outcomes with no signs of recurrence or de novo OKC observed over a 32-month period., Conclusion: Clinicians should consider lesion characteristics and patient cooperation when determining treatment strategies for the optimization of outcomes for children and adolescents with NBCCS and multiple OKC., (© 2024 Special Care Dentistry Association and Wiley Periodicals LLC.)
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- 2024
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22. Comment on "A case report on a nasal and oral cavity involving large solitary fibrous tumor and comprehensive review of case literature".
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Cunha JLS, de Andrade BAB, and León JE
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- Humans, Mouth, Nose, Case Reports as Topic, Review Literature as Topic, Solitary Fibrous Tumors diagnosis
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Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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- 2024
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23. Melanotic Neuroectodermal Tumor of Infancy: A Case Image.
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Monsalve R, Arias C, Vélez H, Villarroel-Dorrego M, de Arruda JAA, and de Andrade BAB
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- Humans, Infant, Cheek pathology, Maxilla pathology, Neuroectodermal Tumor, Melanotic diagnosis, Neuroectodermal Tumor, Melanotic pathology, Neuroectodermal Tumor, Melanotic surgery
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Melanotic neuroectodermal tumor of infancy (MNTI) is a rare benign neoplasm that can be mistaken for malignancies due to its unfamiliarity among clinicians and aggressive clinical appearance. We herein contributed by reporting an additional case of MNTI characterized by an extensive extraoral protrusion in a 2-month-old infant. The lesion involved the anterior maxilla, cheek, and infraorbital region, resulting the displacement of the nose to the contralateral side, and measuring approximately 10 cm in size. Surgical resection of the lesion was performed. After a 6-month follow-up, the patient has shown no evidence of recurrence. The rapid growth and aggressive behavior of MNTI emphasize the importance of an early diagnosis and prompt intervention in order to achieve favorable outcomes., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2024
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24. BubR1 and cyclin B1 immunoexpression in pleomorphic adenoma and polymorphous adenocarcinoma of minor salivary glands.
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Cavalcante IL, Silva Barros CCD, Colares DF, Cruz VMS, de Andrade BAB, Nonaka CFW, Rabenhorst SHB, and Cavalcante RB
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- Humans, Cyclin B1 metabolism, Retrospective Studies, Salivary Glands, Minor pathology, Adenocarcinoma pathology, Adenoma, Pleomorphic metabolism, Salivary Gland Neoplasms pathology
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The immunoexpression of BubR1 and cyclin B1 in pleomorphic adenoma (PA) and polymorphic adenocarcinoma (PAC) in minor salivary glands is poorly studied. Thus, a retrospective and observational study was performed to provide a better understanding of the role and immunopositivity patterns of these proteins in these lesions. Sixteen cases of PA and 16 cases of PAC were selected. Parenchyma cells were submitted to quantitative immunohistochemical analysis through the labeling index. Cytoplasmic immunoexpression of BubR1 was observed in neoplastic cells from all analyzed PA and PAC cases. All PA cases and 93.7% of PAC exhibited nuclear immunoexpression of BubR1. Higher cytoplasmic and nuclear immunoexpression of BubR1 was observed in PAC (p = 0.001 and p = 0.122, respectively). Cytoplasmic immunoexpression of cyclin B1 was observed in all cases of PA and PAC, with a higher labeling index in the latter (p < 0.001). There was a significant positive correlation between nuclear and cytoplasmic BubR1 immunoexpressions (p < 0.001) in PA and a significant negative correlation between BubR1 and cyclin B1 cytoplasmic immunoexpressions (p = 0.014) in PAC. The higher cytoplasmic and nuclear immunoexpression of BubR1 in PACs suggests the continuous maintenance of neoplastic cells in the cell cycle and migration. Higher immunoexpression of cyclin B1 supports this lesion's enhanced proliferative and migration ability., Competing Interests: Declaration of Competing Interest The authors disclosed no potential conflicts of interest., (Copyright © 2023. Published by Elsevier GmbH.)
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- 2024
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25. Orofacial Manifestations in a Middle-Aged Woman with Cowden Syndrome: A Case Image.
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de Arruda JAA, Freire CH, Leite TDB, Noce CW, Cavalcante IL, Vogel JO, Mesquita RA, Tenório JR, and de Andrade BAB
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- Adult, Middle Aged, Female, Humans, Gingiva pathology, PTEN Phosphohydrolase genetics, Hamartoma Syndrome, Multiple complications, Hamartoma Syndrome, Multiple pathology, Skin Neoplasms pathology, Skin Diseases, Papilloma
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A 56-year-old Brazilian woman sought dental care, presenting with multiple asymptomatic papillomatous lesions with a coalescent pattern and intermingled cobblestone-like clefts along the alveolar ridge and marginal and attached gingivae. Multiple whitish papules were also observed on the face, neck, and limbs. Incisional biopsies of these lesions were performed. Microscopically, the skin lesion revealed epithelial clear cells and intraepithelial keratinization with areas of orthokeratosis, while the gingival lesions showed a parakeratinized stratified squamous epithelium with collagenous connective tissue. These features were consistent with those of a trichilemmoma and fibroepithelial hyperplasia, respectively. This article illustrates a case of Cowden syndrome (CS), a rare multisystem genetic condition in which both cutaneous and mucosal tissues were affected. Fewer than 40 cases of CS with oral involvement affecting middle-aged adults have been documented hitherto., (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2023
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26. Clinicopathological Features of Metastasis to the Oral and Maxillofacial Region-Multicenter Study.
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Kirschnick LB, Schuch LF, Gondak R, Rivero ERC, Gomes APN, Etges A, Tarquinio SBC, Mesquita RA, Caldeira PC, da Costa AAS, Mendonça EF, Dos Santos JN, Smit C, Robinson L, Tager EMJR, Mosqueda-Taylor A, Pontes HAR, de Andrade BAB, Fonseca TC, Abrahão AC, Agostini M, Romañach MJ, Alves FA, Jaguar GC, de Mendonça NF, Pinto MBR, da Silva LC, Lopes MA, Vargas PA, van Heerden W, Abreu LG, Martins MD, and Vasconcelos ACU
- Subjects
- Male, Humans, Female, Middle Aged, Retrospective Studies, Mouth Neoplasms pathology, Adenocarcinoma secondary, Breast Neoplasms pathology, Oral Ulcer
- Abstract
Background: This study aimed to investigate the clinicopathological features of metastases in the oral and maxillofacial regions., Methods: In this retrospective study, biopsy records were obtained from referral centers for oral and maxillofacial diagnosis in Brazil, Guatemala, Mexico, and South Africa., Results: A total of 120 cases were evaluated. Of these, 53.78% affected female patients, with a mean age of 57.64 years. Intraosseous lesions were more frequent, particularly in the posterior region of the mandible (49.58%). Clinically, most cases presented with symptomatic swelling, with an average evolution time of 25 months. The clinical diagnostic hypothesis in most instances was that of a malignant lesion. Breast cancer was the most common primary tumor location in females, while lung origin was most common in males. In most cases, the primary cancer was an adenocarcinoma (44.73%). The follow-up period was available for 29 cases, and out of these, 20 had died due to the disease., Conclusion: Although this is a rare condition, clinicians should be aware that any oral lesions have the possibility of being metastatic, particularly in individuals with a previous history of cancer. The findings from this study could assist clinicians in prompt diagnosing these lesions and subsequent conducting oncologic assessments and treatment., (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2023
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27. Squamous Odontogenic Tumor in the Posterior Region of Maxilla.
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Cunha JLS, de Andrade BAB, Cavalcante IL, Freire CH, de Almeida Freire N, Antero SAF, Pires FR, and Israel MS
- Subjects
- Male, Humans, Adult, Maxilla pathology, Epithelium pathology, Odontogenic Tumor, Squamous pathology, Odontogenic Tumors pathology, Ameloblastoma pathology
- Abstract
Squamous odontogenic tumor (SOT) is a rare benign but locally infiltrative tumor often misdiagnosed as other entities, such as ameloblastoma and squamous cell carcinoma, due to overlapping morphological findings. We document here the clinicopathological and imaging findings of an aggressive intraosseous SOT in the posterior left region of the maxilla in a 25-year-old male patient. On intraoral examination, the tumor extended from the region of the left lateral incisor to the upper left premolar and was covered by reddish mucosa, with discrete areas of ulceration. Imaging exams revealed an osteolytic lesion causing thinning, erosion, and buccal and lingual cortical plate perforation associated with an impacted canine. Microscopically, the tumor showed a proliferation of islands of well-differentiated squamous epithelium in a variably collagenized background. The peripheral cells of the islands were flat or slightly cuboidal and did not exhibit nuclei with peripheral palisade and reverse polarization. The diagnosis of SOT was rendered. The patient underwent surgical resection and has been under clinical follow-up for approximately 12 months with no signs of recurrence. A careful morphological evaluation is essential to avoid misdiagnosis and ensure a satisfactory treatment approach., (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2023
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28. Clinical diagnostic approach for oral lymphomas: a multi-institutional, observational study based on 107 cases.
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de Oliveira EM, de Cáceres CVBL, Santos-Silva AR, Vargas PA, Lopes MA, Pontes HAR, Pontes FSC, Mesquita RA, de Sousa SF, Abreu LG, Xavier JCC Júnior,, de Andrade BAB, Lacerda JCT, Resende RG, Tomasi RA, and Fonseca FP
- Subjects
- Humans, Necrosis, Pain, Lymphoma, Large B-Cell, Diffuse, Palatal Neoplasms diagnosis
- Abstract
Objective: To evaluate oral lymphomas' clinical manifestations and investigate whether clinical features are associated with lymphoma subtypes., Study Design: Oral lymphomas with at least 1 representative clinical image were evaluated. They were classified according to their microscopic grade (high vs low), predominant cell size (small vs medium/large), and cellular lineage (B cell vs T cell). Clinical images were described according to tumor location, number, swelling, ulcer, necrosis, telangiectasia, predominant color, and lobulation. Lymphomas affecting the palate were compared with salivary gland tumors (SGTs) affecting this location., Results: Data from 107 cases were included. High-grade subtypes (80.4%), with medium/large-sized cells (52.3%), and diagnosed as diffuse large B cell lymphomas (29%) predominated. High-grade lymphomas often presented as painful, ulcerative, and osteolytic diseases (P < .05). Tumors predominantly composed of medium/large-sized cells were associated with painful lesions, ulcerated, with necrosis and bone destruction (P < .05). When only palate tumors were considered, multiple and bilateral lesions, the presence of pain, ulceration, and necrosis were significantly more associated with a diagnosis of lymphoma than SGT (P < .001)., Conclusion: High-grade oral lymphomas are more associated with destructive presentation than low-grade subtypes, and bilateral lesions in the palate are more associated with a lymphoma diagnosis than SGT., (Copyright © 2023 Elsevier Inc. All rights reserved.)
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- 2023
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29. Adverse Reactions Associated with Dermal Fillers in the Oral and Maxillofacial Region: A Venezuelan Experience.
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Rosendy G, Cavalcante IL, Barros CCDS, López-Labady J, González N, Pérez-Alfonzo R, González MG, Freire CH, de Arruda JAA, de Andrade BAB, and Villarroel-Dorrego M
- Subjects
- Humans, Female, Middle Aged, Aged, Retrospective Studies, Cross-Sectional Studies, Venezuela epidemiology, Biocompatible Materials adverse effects, Foreign-Body Reaction chemically induced, Foreign-Body Reaction pathology, Hyaluronic Acid adverse effects, Dermal Fillers adverse effects, Cosmetic Techniques adverse effects
- Abstract
Background: Dermal facial fillers are increasingly popular. Published reports on the clinical and histopathologic characteristics related to adverse reactions to dermal fillers in the facial region have been relatively well documented. This study adds to the literature on adverse reactions to injected filler in the oral and maxillofacial region in a South American population., Methods: A retrospective, descriptive cross-sectional study (2019-2020) was performed. The study population was a dermatology service in Venezuela. Clinical and histopathologic features of patients with adverse effects were documented., Results: A total of 35 cases of adverse reactions associated with cosmetic filler procedures were diagnosed during the analyzed period; of these, six cases (17.1%) involved the oral and maxillofacial region. All cases occurred in women. The mean age at diagnosis was 59.3 years (58-73). In three cases, dermal fillers were used in different locations on the face, while three involved the lips. Five patients exhibited adverse reactions to lip filler. All six cases were histopathologically diagnosed as foreign body reactions to injected material. Four and two cases revealed microscopic features compatible with hyaluronic acid and polymethylmethacrylate, respectively., Conclusion: Reflecting the dramatic increase in cosmetic procedures with soft tissue fillers, this study contributed by reporting six cases of foreign body reaction involving the oral and maxillofacial region, confirmed with biopsy and histopathology., (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2023
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30. No NFATC2 fusion in simple bone cyst of the jaw.
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Ong SLM, Gomes IP, Baelde HJ, Passador-Santos F, de Andrade BAB, Briaire-de Bruijn IH, Cavalcante IL, Schreuder WH, Cleton-Jansen AM, Cleven AHG, Szuhai K, Gomes CC, and Bovée JVMG
- Subjects
- Humans, Bone Cysts genetics, Odontogenic Tumors genetics, NFATC Transcription Factors genetics
- Abstract
Aims: Simple Bone Cysts (SBCs) predominantly occur in long bones and 59% harbour NFATC2 rearrangements. Jaw SBC is rare and was previously referred to as traumatic bone cyst. It can rarely occur in association with cemento-osseous dysplasia (COD). To determine whether jaw SBCs represent the same entity as SBC of the long bones, or if they have a different molecular signature, we collected 48 jaw SBC cases of 47 patients to assess NFATC2 rearrangement., Methods and Results: Out of the 48 cases, 36 could be used for fluorescence in-situ hybridization (FISH), of which nine (two of which associated with COD) were successful using an NFATC2 split probe. The remaining cases failed to show adequate FISH signals. All nine cases lacked NFATC2 rearrangement and five of these showed no detectable gene fusions using Archer FusionPlex., Conclusion: In our study, NFATC2 rearrangement is absent in solitary jaw SBC (n = 7) and COD-associated SBC (n = 2). Our findings suggest that SBC presenting in the jaw is molecularly different from SBC in long bones. Future molecular studies may confirm the absence of clonal molecular aberrations in SBC of the jaw which would support a non-neoplastic, reactive origin., (© 2023 The Authors. Histopathology published by John Wiley & Sons Ltd.)
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- 2023
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31. Congenital Melanotic Macule of the Tongue: Report of Two Cases and Literature Review.
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de Arruda JAA, Gómez R, Bracho V, Cavalcante IL, Pérez-Alfonzo R, Villarroel-Dorrego M, and de Andrade BAB
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- Male, Child, Humans, Infant, Newborn, Infant, Female, Tongue pathology, Pigmentation, Melanosis congenital, Melanosis diagnosis, Melanosis pathology, Pigmentation Disorders pathology, Tongue Diseases diagnosis, Tongue Diseases pathology
- Abstract
Background: Congenital melanotic macule of the tongue (CMMT) has been described as a distinct entity, despite its unknown etiology. However, the diagnosis and management of affected newborns may challenge clinicians and pediatric dentists., Methods: We document here the clinicopathological findings of two additional cases of CMMT. A literature review of CMMT reports identified across PubMed, Web of Science, Embase, and Scopus was also conducted., Results: The patients, 2- and 4 month-old Venezuelan boys, respectively, presented at birth with a single or multiple dark-brown-pigmented macule exclusively on the dorsum of the tongue. Histopathological features revealed increased melanin pigmentation in the basal epithelial layer with overlying hyperkeratosis and pigment-laden subepithelial macrophages with normal morphological appearance. Nine studies comprising 17 cases of CMMT have been described hitherto. Most cases were from the USA and France (n = 6 each). Twelve (70.6%) patients were males, eight (50%) were white, and median age was 2.7 months. CMMT presented as brownish to black, solitary or multiple pigmentations located in the right or left region of the dorsum of the tongue, ranging in size from 3.0 to 30.0 mm., Conclusion: An important feature for the diagnosis of CMMT is the information about the manifestation at birth and consequent proportional growth. This report intends to draw the attention of pediatricians and dentists to this apparently underdiagnosed condition for decision-making and management of affected newborns., (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2023
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32. Mucosal Leishmaniasis of the lip: Report of an Exuberant case in a Young man.
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de Arruda JAA, Tomo S, Cunha JLS, Guevara JR, Martínez I, Reyes O, Bracho V, Sanchez C, de Andrade BAB, and Villarroel-Dorrego M
- Subjects
- Male, Humans, Young Adult, Adult, Lip parasitology, Lip pathology, Meglumine Antimoniate therapeutic use, Skin parasitology, Skin pathology, Leishmaniasis, Mucocutaneous drug therapy, Leishmaniasis, Mucocutaneous diagnosis, Leishmania braziliensis
- Abstract
Background: Leishmaniasis is a tropical disease caused by protozoan parasites of the genus Leishmania. Mucosal leishmaniasis has been described as secondary to the cutaneous form; however, isolated mucosal involvement can also occur. Specifically, mucosal leishmaniasis of the lip is poorly described and its diagnosis challenges clinicians., Methods: We herein report a case of mucosal leishmaniasis affecting the lower lip without cutaneous involvement in a 20-year-old Venezuelan man. The patient had no relevant past medical history. Clinically, a mass-like lesion with ulcerations and crusts was observed., Results: Microscopically, the lesion was composed of granulomatous inflammation along with macrophages containing intracytoplasmic inclusions similar to round-shaped Leishmania. The species Leishmania (Viannia) braziliensis was confirmed. Treatment with meglumine antimonate was effective. The lesion healed satisfactorily, and no side effects or recurrences were observed., Conclusion: Clinicians should be aware of isolated forms of mucosal leishmaniasis of the lip, even in cases where the cutaneous lesion is undetected or clinically manifests as self-limiting. Knowing the endemic areas in the scenario of the dynamics of the ecoepidemiology of leishmaniasis is also essential for surveillance and counselling of the population., (© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2023
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33. Idiopathic gingival papillokeratosis with crypt formation: a clinicopathological entity in the young population?
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Romo SA, de Arruda JAA, Nava FJT, Martínez LEM, Cavalcante IL, and de Andrade BAB
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- Humans, Gingiva pathology, Mouth Diseases pathology
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- 2023
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34. Oral paracoccidioidomycosis: a retrospective study of 95 cases from a single center and literature review.
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de Oliveira LLC, de Arruda JAA, Marinho MFP, Cavalcante IL, Abreu LG, Abrahão AC, Romañach MJ, de Andrade BAB, and Agostini M
- Subjects
- Middle Aged, Humans, Male, Female, Aged, Retrospective Studies, Brazil, Gingiva, Palate pathology, Paracoccidioidomycosis diagnosis, Paracoccidioidomycosis pathology
- Abstract
Background: The ecoepidemiological panorama of paracoccidioidomycosis (PCM) is dynamic and still ongoing in Brazil. In particular, data about the oral lesions of PCM are barely explored. The aim of this study was to report the clinicopathological features of individuals diagnosed with oral PCM lesions at an oral and maxillofacial pathology service in Rio de Janeiro, Brazil, in the light of a literature review., Material and Methods: A retrospective study was conducted on oral biopsies obtained from 1958 to 2021. Additionally, electronic searches were conducted in PubMed, Embase, Scopus, Web of Science, Latin American and Caribbean Center on Health Sciences Information, and Brazilian Library of Dentistry to gather information from large case series of oral PCM., Results: Ninety-five cases of oral PCM were surveyed. The manifestations were more frequent among males (n=86/90.5%), middle-aged/older adults (n=54/58.7%), and white individuals (n=40/51.9%). The most commonly affected sites were the gingiva/alveolar ridge (n=40/23.4%) and lip/labial commissure (n=33/19.3%); however, one (n=40/42.1%) or multiple sites (n=55/57.9%) could also be affected. In 90 (94.7%) patients, "mulberry-like" ulcerations/moriform appearance were observed. Data from 21 studies (1,333 cases), mostly Brazilian (90.5%), revealed that men (92.4%; male/female: 11.8:1) and individuals in the fifth and sixth decades of life were the most affected (range: 7-89 years), with the gingiva/alveolar ridge, palate, and lips/labial commissure being the sites most frequently affected., Conclusions: The features of oral PCM lesions are similar to those reported in previous studies from Latin America. Clinicians should be aware of the oral manifestations of PCM, with emphasis on the clinicodemographic aspects and differential diagnoses, especially considering the phenomenon of the emergence of reported cases in rural and/or urban areas of Brazil.
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- 2023
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35. Lymphomas Affecting the Sublingual Glands: A Clinicopathological Study.
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de Araújo GR, Morais-Perdigão AL, de Cáceres CVBL, Lopes MA, Aguirre-Urizar JM, Carlos R, Tager EMJR, van Heerden WFP, Robinson L, Pontes HAR, de Andrade BAB, Soares CD, Gomez RS, and Fonseca FP
- Subjects
- Adult, Humans, Sublingual Gland pathology, Lymphoma, B-Cell, Marginal Zone pathology, Lymphoma, Large B-Cell, Diffuse pathology, Salivary Gland Neoplasms pathology, Lymphoma, Follicular, Lymphoma, Mantle-Cell
- Abstract
Background: Lymphomas affecting the sublingual glands are extremely rare and very few case reports are currently available. Therefore, the aim of the current study is to describe the clinicopathological features of a series of lymphomas involving the sublingual glands., Methods: Cases diagnosed in four pathology services were assessed and the formalin-fixed paraffin-embedded tissue blocks were retrieved for diagnosis confirmation. Clinical data were obtained from patients' medical files., Results: We obtained seven cases of lymphomas in the sublingual glands, representing two follicular lymphomas, two diffuse large B cell lymphomas not otherwise specified (DLBCL NOS), two extranodal marginal zone B cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphomas) and one mantle cell lymphoma (MCL). In all cases the tumor cells infiltrated the glandular parenchyma, although in two of them the neoplastic cells were located more superficially and permeated the glandular acini and ducts. Clinically, the tumors presented as asymptomatic nodules and two patients (affected by DLBCL NOS and MCL) died, while the other five patients remained alive at last follow-up., Conclusion: Lymphomas affecting the sublingual glands are usually of the mature B cell lineage, often represent low-grade subtypes and may clinically resemble other more common lesions in the floor of the mouth like salivary gland tumors., (© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2023
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36. Gingival rhabdomyosarcoma mimicking a non-neoplastic proliferative lesion: A diagnostic challenge.
- Author
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Cavalcante IL, Cunha JLS, da Silva CCB, Nonaka CFW, Cavalcante ER, de Almeida OP, Ribeiro NRB, Turatti E, Cavalcante RB, and de Andrade BAB
- Subjects
- Female, Humans, Adult, Gingiva pathology, Diagnosis, Differential, Biomarkers, Tumor analysis, Rhabdomyosarcoma diagnosis, Rhabdomyosarcoma surgery, Sarcoma pathology, Soft Tissue Neoplasms
- Abstract
Rhabdomyosarcoma (RMS) is a soft tissue sarcoma that develops from skeletal striated muscle cells. RMSs are exceedingly rare in the oral cavity, particularly in the gingiva. Herein, we reported the clinicopathological and immunohistochemical features of a rare case of RMS in a 30-year-old female presenting clinically as a painful polypoid nodule on the mandibular gingiva. Microscopically, the tumor showed atypical spindle cells with elongated nuclei and eosinophilic cytoplasm arranged in a fascicular pattern. In focal areas, the tumor cells exhibited rhabdomyoblastic differentiation. Immunohistochemistry showed strong positivity for desmin, myogenin (scattered cells), and MyoD1. The patient underwent surgical resection followed by postoperative complementary radio- and chemotherapy. However, the patient had a local recurrence seven months after the initial treatment. She was submitted to a total mandibulectomy associated with adjuvant radiotherapy. However, she died two months after reoperation due to complications secondary to radiation therapy. Because of the rarity in the oral cavity and non-specific signs and symptoms, the clinical diagnosis of RMS is difficult and often overlooked. Therefore, careful histopathological and immunohistochemistry analysis of these tumors is essential to correct diagnosis. Early surgical excision with tumor-free margins and prolonged follow-up are strongly recommended., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier Ltd. All rights reserved.)
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- 2023
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37. Lingual metastasis as the first presentation of clear cell renal cell carcinoma: Report of a rare case clinically mimicking a benign lesion.
- Author
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Kalinin Y, Correia-Neto IJ, do Nascimento SV, de Branco Gonçaves VC, de Andrade BAB, Nonaka CFW, Alves PM, and Cunha JLS
- Subjects
- Female, Humans, Middle Aged, Prognosis, Immunohistochemistry, Biomarkers, Tumor metabolism, Carcinoma, Renal Cell diagnosis, Carcinoma, Renal Cell pathology, Kidney Neoplasms diagnosis
- Abstract
Metastases in the oral cavity are rare and frequently associated with widespread disease and poor prognosis. Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma (RCC), known for its propensity for metastatic spread. The diagnosis of oral metastases from ccRCC is challenging, especially when the patient has no history of primary neoplasm. Herein, we reported a rare metastatic ccRCC in a 58-year-old female presenting clinically as a painless nodule on the tongue mimicking a benign lesion. Microscopically, the tumor showed a proliferation of clear cells organized in nests with a predominantly lobular arrangement. The dense connective tissue stroma was highly vascularized, exhibiting some areas with a hyalinized aspect. Immunohistochemistry showed focal positivity for pan-cytokeratin AE1/AE3 and strong positivity for CK8, CK18, epithelial membrane antigen (EMA), vimentin, and CD10. S-100 protein, HMB-45, CK7, and CK20 were negative. The definitive diagnosis was metastatic ccRCC. The treatment was initiated with sunitinib. However, the disease progressed, and the patient was submitted to palliative care. Despite the low survival rate of patients with metastases, the clinician's experience in identifying an oral metastatic lesion may reveal undiagnosed primary tumors and provide better prognosis and survival rates., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022. Published by Elsevier Ltd.)
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- 2023
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38. Psammomatoid juvenile ossifying fibroma of frontal sinus - surgical and reconstructive approach.
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Tenório JR, Bártholo PRA, Romañach MJ, Abrahão AC, Agostini M, and de Andrade BAB
- Abstract
Psammomatoid juvenile ossifying fibroma (PJOF) is a benign fibro-osseous lesion that mainly affects the paranasal sinuses and periorbital bones. It may cause significant esthetic and functional impairment. Herein, we describe the diagnosis and surgical approach of an extensive PJOF arising in the frontal sinus of a young male. After complete lesion removal and histopathological confirmation, the bone defect was repaired with a customized polymethylmethacrylate implant. PJOF may present aggressive clinical behavior. The excision of extensive PJOF in the orbitofrontal area can result in significant esthetic defects. Polymethacrylate implants restore functionally and esthetically the involved area., Competing Interests: Conflict of interest: None., (Copyright © 2022 The Authors.)
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- 2022
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39. Oral squamous cell carcinoma clinically resembling BRONJ.
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Marinho MFP, Marinho MCFL, de Andrade BAB, Pinto MAVR, Abrahão AC, Romañach MJ, and Agostini M
- Subjects
- Administration, Oral, Diphosphonates, Humans, Squamous Cell Carcinoma of Head and Neck, Bisphosphonate-Associated Osteonecrosis of the Jaw, Bone Density Conservation Agents, Carcinoma, Squamous Cell diagnosis, Head and Neck Neoplasms, Mouth Neoplasms diagnosis, Osteonecrosis
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- 2022
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40. A mass on the hard palate of an HIV-positive patient: clinical presentation.
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Cunha JLS, de Oliveira EF, de Andrade BAB, do Nascimento Medeiros SD, Sales AO, de Almeida OP, and Soares CD
- Subjects
- Humans, Palate, Palate, Hard, Cleft Palate, HIV Seropositivity, Palatal Neoplasms
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- 2022
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41. Acquired oral syphilis: A multicenter study of 339 patients from South America.
- Author
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de Andrade BAB, de Arruda JAA, Gilligan G, Piemonte E, Panico R, Molina Ávila I, Pimentel Sola JM, Carmona Lorduy MC, Pupo Marrugo S, Sánchez Tatis AS, Werner LC, Abrahão AC, Agostini M, Buoro L, Israel MS, Freire NA, Lima LA, Abrantes TC, Cunha JLS, Pérez-de-Oliveira ME, Roza ALOC, Vargas PA, Lopes MA, Santos-Silva AR, de Almeida OP, Pontes FSC, Pontes HAR, Rondanelli BM, Villarroel-Dorrego M, Bologna-Molina R, Derderian N, Sánchez-Romero C, Abreu LG, Fonseca FP, Mesquita RA, Gomez RS, Martínez-Flores R, Delgado-Azañero W, Alves ATNN, Lourenço SQC, Coimbra C, Polignano GAC, Assunção Júnior JNR, Souto GR, Souza PEA, Horta MCR, González-Arriagada WA, and Romañach MJ
- Subjects
- Adult, Brazil epidemiology, Humans, Male, Palate, Hard, Retrospective Studies, Young Adult, Mouth Diseases diagnosis, Mouth Diseases drug therapy, Mouth Diseases epidemiology, Syphilis diagnosis, Syphilis drug therapy, Syphilis epidemiology
- Abstract
Objective: To report the clinicopathologic features of acquired oral syphilis cases in South American countries., Materials and Methods: Clinical data were retrospectively collected from the records of 18 oral diagnostic services in Argentina, Brazil, Chile, Colombia, Venezuela, Uruguay, and Peru. Serologies of nontreponemal and treponemal tests were used for diagnosis., Results: The series comprised 339 cases of acquired oral syphilis. Secondary syphilis ranked as the most common stage (86.7%). Lesions were more frequent among males (58.0%) and young adults with a mean age of 33.3 years. Individuals aged 20-29 years were most affected (35.3%). The most commonly involved sites were the tongue (31.6%), lip/labial commissure (25.1%), and hard/soft palate (20.4%). Clinically, acquired oral syphilis usually presented as mucous patches (28.4%), papules (25.7%), and ulcers (18.1%). Skin manifestations occurred in 67.7% of individuals, while lymphadenopathy and fever were observed in 61.3% and 11.6% of all subjects, respectively. Most patients were treated with the benzathine penicillin G antibiotic., Conclusion: This report validates the spread of acquired oral syphilis infection among young adults in South America. Our directives include accessible diagnostic tools for proper disease screening, surveillance, and counselling of affected individuals, especially in low- and middle-income countries., (© 2021 Wiley Periodicals LLC.)
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- 2022
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42. Focal lymphocytic sialadenitis and ectopic germinal centers in oral reactive lesions and primary Sjögren's syndrome: a comparative study.
- Author
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Silva EV, Almeida LY, Bortoletto KC, Quero IB, Jacomini FC, de Andrade BAB, Silveira HA, Duarte A, Petean FC, Rocha EM, Ribeiro-Silva A, Carlos R, and León JE
- Subjects
- Biopsy, Germinal Center, Humans, Lymphocytes metabolism, Sialadenitis complications, Sialadenitis pathology, Sjogren's Syndrome complications
- Abstract
Focal lymphocytic sialadenitis (FLS), an important diagnostic criterion for Sjögren's syndrome (SS) diagnosis, can also be observed when assessing minor salivary gland (mSG) biopsies from healthy asymptomatic individuals (non-SS patients). Fifty cases of primary SS (pSS group) and 31 cases of oral reactive lesions (non-SS non-sicca group) containing also typical FLS features, were assessed by morphological and immunohistochemical (CD10, CD23 and Bcl-6) analysis, aiming at the detection of GCs. All pSS cases showed FLS with focus score (FS) ≥ 1. In the non-SS non-sicca group, 12, 10 and 9 cases showed FLS with FS ≥ 1, FLS with FS < 1 and FLS associated with chronic sclerosing sialadenitis with FS < 1, respectively. The morphological analysis revealed similar frequency of GCs in pSS (20%) and non-SS non-sicca group (19%). The area (p = 0.052) and largest diameter (p = 0.245) of GCs were higher in pSS than non-SS non-sicca group. The FS and number of foci were significantly higher in pSS than non-SS non-sicca group with FS < 1. Immunohistochemistry confirmed all morphological findings (GCs showing CD23 and Bcl-6 positivity, with variable CD10 expression) and additionally in 3 and 1 cases of the pSS and non-SS non-sicca group, respectively. Moreover, another 6 and 2 cases of the pSS and non-SS non-sicca group with FS ≥ 1, respectively, showed positivity only for CD23. FLS can also be observed when assessing oral reactive lesions, which showed similar frequency of GCs with those found in pSS patients. Further studies, including functional analysis of lymphocytic populations and GCs in FLS, are encouraged., (© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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- 2022
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43. Intraosseous rhabdomyosarcoma of the maxilla with TFCP2 fusion: A rare aggressive subtype with predilection for the gnathic bones.
- Author
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Silva Cunha JL, Cavalcante IL, da Silva Barros CC, Alves PM, Nonaka CFW, Albuquerque AFM, de Almeida OP, de Andrade BAB, and Cavalcante RB
- Subjects
- Biomarkers, Tumor, DNA-Binding Proteins genetics, Female, Gene Fusion, Humans, In Situ Hybridization, Fluorescence, Transcription Factors genetics, Maxilla pathology, Rhabdomyosarcoma diagnosis, Rhabdomyosarcoma pathology
- Abstract
Rhabdomyosarcomas (RMS) are malignant tumors with skeletal muscle differentiation extremely rare in intraosseous sites. We reported a rare case of an aggressive intraosseous RMS found in the maxilla of a 17-year-old female patient with five months of evolution. Computed tomography revealed a large osteolytic lesion extending from tooth 21 to 27, causing buccal and lingual cortical plate perforation. Microscopically, the lesion showed a proliferation of spindle-shaped cells with elongated nuclei and eosinophilic cytoplasm, arranged in an interlaced fascicle pattern. The nuclei ranged from vesicular with distinct nucleoli to hyperchromatic. A focal component of plump to epithelioid cells with a moderate amount of eosinophilic cytoplasm was seen at the periphery of the tumor. The immunohistochemical analysis revealed positivity for desmin, MyoD1, and myogenin (scattered cells). S-100, SOX10, HMB45, β-catenin, and CD34 were negative. Ki-67 was positive in 30% of tumor cells. Fluorescence in situ hybridization (FISH) analysis showed the presence of a FUS-TFCP2 fusion. The diagnosis was intraosseous RMS with TFCP2 fusion. Surgical excision followed by chemo- and radiotherapy was carried out; however, the patient died of disease nine months after the treatment. Because of the rarity and non-specific signs and symptoms, the clinical diagnosis of intraosseous RMS is difficult and often overlooked. Therefore, careful histopathological evaluation, supported by immunohistochemical and molecular analysis, is essential to correct diagnosis. Early surgical excision with tumor-free margins and prolonged follow-up are strongly recommended., (Copyright © 2022 Elsevier Ltd. All rights reserved.)
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- 2022
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44. CD30 Expression in Oral and Oropharyngeal Diffuse Large B Cell Lymphoma, not Otherwise Specified.
- Author
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Morais-Perdigão AL, Rodrigues-Fernandes CI, Araújo GR, Soares CD, de Andrade BAB, Martins MD, Vargas PA, Pontes HAR, Pires FR, Burbano RMR, and Fonseca FP
- Subjects
- Humans, Immunohistochemistry, Oropharynx chemistry, Oropharynx pathology, Prognosis, Ki-1 Antigen analysis, Ki-1 Antigen therapeutic use, Lymphoma, Large B-Cell, Diffuse pathology
- Abstract
Diffuse large B cell lymphoma, not otherwise specified (DLBCL, NOS) is the most frequent non-Hodgkin lymphoma subtype. This aggressive neoplasm may variably express the CD30 protein, which may be used as a therapeutic target for this tumor. However, CD30 expression in DLBCL NOS arising from the oral cavity and the oropharynx has not been investigated. Therefore, this study aims to determine the frequency of CD30 expression and its prognostic significance for patients affected by oral/oropharyngeal DLBCL NOS. Fifty cases were retrieved from pathology files and submitted to immunohistochemistry against CD30. Reactivity was accessed by two oral pathologists using two cut-off values (> 0% and > 20% of tumor cells) to determine positivity in each case. Clinical data were obtained from the patients' medical files to investigate the prognostic potential of the protein. Seven high-grade B cell lymphomas and two EBV-positive DLBCL NOS were identified. We found one CD30-positive case in each of these two groups of lymphomas. Among the remaining 41 DLBCL NOS, other four cases (three in the oral cavity and one in the oropharynx) were positive for CD30, but only two expressed the protein in > 20% of tumor cells, both in the oral cavity. Survival analysis demonstrated that CD30-positive cases had a higher five-year overall survival rate (75%) than CD30-negative cases (32.3%), although a statistically significant result was not achieved (p = 0.19). Only a minor subset of oral and oropharyngeal DLBCL NOS express CD30 and these patients seems to have a higher survival rate., (© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2022
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45. Oral Juvenile Xanthogranuloma: A Clinicopathological, Immunohistochemical and BRAF V600E Study of Five New Cases, with Literature Review.
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Mota CP, Silva Cunha JL, Magalhães MCSV, Israel MS, Freire NA, Dos Santos ERC, Canedo NHS, Agostini M, Abrahão AC, de Andrade BAB, Romañach MJ, and de Sousa SF
- Subjects
- Adolescent, Adult, Aged, Brazil, Female, Humans, Male, Middle Aged, Mutation, Proto-Oncogene Proteins B-raf genetics, Young Adult, Xanthogranuloma, Juvenile diagnosis, Xanthogranuloma, Juvenile genetics, Xanthogranuloma, Juvenile metabolism
- Abstract
Juvenile xanthogranuloma (JXG) is the most common form of non-Langerhans cell histiocytosis and oral mucosal involvement is exceedingly rare. Histiocytic disorders harbor activating mutations in MAPK pathway, including the report of BRAF V600E in JXG of extracutaneous site. However, no information is available for oral JXG. Herein, the clinicopathological and immunohistochemical features of five new oral JXG were evaluated in conjunction with literature review. Also, we assessed the BRAF V600E in oral samples. Five oral JXG were retrieved from pathology archives. Morphological and immunohistochemical analyses were performed. The BRAF V600E status was determined with TaqMan allele-specific qPCR. The series comprised of three female and two male patients, most of them adults, with a median age of 39 years (range 13-68 years). Clinically, the lesions appeared as asymptomatic solitary nodules, measuring until 2.5 cm, with more incident to the buccal mucosa. Morphologically, most of the cases presented classical histological features of JXG, with histiocytic cells consistent with the non-Langerhans cell immunophenotype. BRAF V600E was not detected in the cases tested. This is the first and largest published series of oral JXG affecting adults and a Brazilian population. The molecular pathogenesis of oral JXG remains unknown. Clinicians and pathologists must recognize JXG to avoid misdiagnoses with oral benign or malignant lesions., (© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2022
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46. A dome-shaped nodule on unattached alveolar mucosa.
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de Andrade BAB, Silva Cunha JL, Abrahão AC, Agostini M, Corrêa Roza ALO, de Almeida OP, de Castro LA, and Romañach MJ
- Subjects
- Humans, Retrospective Studies, Mucous Membrane, Tomography, Optical Coherence
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- 2022
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47. Oral cancer diagnosis during the COVID-19 pandemic in an oral pathology laboratory in Rio de Janeiro, Brazil.
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Abrantes TC, Bezerra KT, Silva CN, Costa LC, Cabral MG, Agostini M, de Andrade BAB, Abrahão AC, and Romañach MJ
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- Brazil epidemiology, Humans, Pandemics, Pathology, Oral, COVID-19, Mouth Neoplasms diagnosis, Mouth Neoplasms epidemiology
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- 2022
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48. Oral Lymphoepithelial Cyst: A Collaborative Clinicopathologic Study of 132 Cases from Brazil.
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Cunha JLS, Roza ALOC, Cruz VMS, Ribeiro JL, Cavalcante IL, Cavalcante RB, Anbinder AL, Abrahão AC, de Andrade BAB, Romañach MJ, Pires FR, Dos Santos-Silva AR, Lopes MA, Vargas PA, Soares CD, and de Almeida OP
- Subjects
- Adult, Brazil epidemiology, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Retrospective Studies, S100 Proteins, Cysts, Oral Ulcer
- Abstract
The oral lymphoepithelial cyst (OLC) is an uncommon lesion whose pathogenesis remains poorly understood. The aim of this study was to report the clinicopathologic features of the OLCs and to verify a possible association between OLCs and subgemmal neurogenous plaque (SNP) in the posterior lateral region of the tongue. A retrospective descriptive cross-sectional study was carried out. A total of 106,282 biopsy records of oral and maxillofacial lesions from six oral pathology services in Brazil were analyzed. All cases of OLCs were reviewed, and clinical and histopathological data were collected. Immunohistochemical reactions for S-100 protein were performed to confirm the diagnosis of SNP. Among all lesions, there were 132 (0.11%) cases of OLCs. The series comprised 83 females (62.9%) and 49 males (37.1%), with a 1.7:1 female-to-male ratio and a mean age of 45.8 ± 17.7 years. Most cases involved the tongue (n = 80; 62.0%) and presented clinically as asymptomatic papules or nodules with a yellow or whitish color. Microscopically, most of the cysts were entirely lined by parakeratinized stratified epithelium (n = 89; 67.4%) and filled with desquamated cells, keratin debris, amorphous eosinophilic material, and inflammatory cells in varying amounts. Connection with the epithelium of oral mucosa was observed in 18 cases (13.6%). SNP was found in 9/80 (11.2%) cases involving the tongue. The clinical and demographic features of OLCs were similar to those described in previous studies. Overall, this lesion has a predilection for the posterior region of the tongue of female adults. Clinicians must include the OLC in the differential diagnosis of yellow/white papules and nodules of the oral cavity., (© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2022
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49. Leiomyoma and Leiomyosarcoma (Primary and Metastatic) of the Oral and Maxillofacial Region: A Clinicopathological and Immunohistochemical Study of 27 Cases.
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de Araújo GR, Costa SFDS, Mesquita RA, Gomez RS, Dos Santos JN, Pontes HAR, de Andrade BAB, Romañach MJ, Agostini M, Vargas PA, de Cáceres CVBL, Santos-Silva AR, Ribeiro ACP, Brandão TB, Tomasi RA, Ferreyra RS, de Almeida OP, and Fonseca FP
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- Biomarkers, Tumor, Calmodulin-Binding Proteins, Female, Humans, Male, Middle Aged, Retrospective Studies, Leiomyoma diagnosis, Leiomyoma pathology, Leiomyosarcoma diagnosis, Leiomyosarcoma pathology, Smooth Muscle Tumor pathology, Uterine Neoplasms diagnosis, Uterine Neoplasms pathology
- Abstract
Smooth muscle neoplasms represent an important group of lesions which is rare in the oral cavity. Leiomyoma (LM) is benign smooth muscle/pericytic tumor usually presenting as non-aggressive neoplasm, while leiomyosarcoma (LMS) represents its malignant counterpart. The rarity of these lesions, together with its unspecific clinical presentation and a variable histopathological appearance, lead to a broad list of differential diagnoses, hampering their diagnoses. Therefore, in this study we describe the clinical and microscopic features of a series of oral and maxillofacial LMs and LMSs. A retrospective search from 2000 to 2019 was performed and all cases diagnosed as LM and LMS affecting the oral cavity and gnathic bones were retrieved. Clinical and demographic data were obtained from the patients' pathology records, while microscopic features and immunohistochemistry were reviewed and completed when necessary to confirm the diagnoses. Twenty-two LMs and five LMSs were obtained. In the LM group, males predominated, with a mean age of 45.7 years. The upper lip was the most affected site, and 18 cases were classified as angioleiomyomas and four as solid LM. In the LMS group, females predominated, with a mean age of 47.6 years. The mandible was the most affected site. Diffuse proliferation of spindle cells, with necrosis and mitotic figures, were frequent microscopic findings. LMs and LMSs were positive for α-smooth muscle actin, HHF-35 and h-caldesmon. In conclusion, oral LM/LMS are uncommon neoplasms with the latter usually presenting as metastatic disease. H&E evaluation may be very suggestive of oral LMs, but h-caldesmon staining is strongly recommended to confirm LMS diagnosis., (© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2022
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50. Oral lymphatic malformations: A multicenter study of 208 cases and literature review.
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Meirelles DP, do Couto AM, Silva LVO, Abreu LG, de Sousa SCOM, Custódio M, Tarquinio SBC, Batista AC, Mendonça EF, Libório-Kimura TN, Louredo BVR, Romañach MJ, de Andrade BAB, Nonaka CFW, Alves PM, de Sena LSB, Mesquita RA, and de Aguiar MCF
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- Aged, Biopsy, Brazil, Female, Humans, Male, Multicenter Studies as Topic, Tongue, Tongue Diseases
- Abstract
Background: To evaluate the frequency and analyze demographic and clinical characteristics of individuals with a histopathological diagnosis of oral lymphatic malformations (OLMs)., Methods: A multicenter study was performed, collecting biopsy record data from a consortium of Brazilian Oral and Maxillofacial Pathology Centers. A review was also conducted to compare this data with cases already available in the literature., Results: This study retrieved 208 cases of OLM in the multicenter study and 1035 cases in the literature review. In both, OLMs affected male and female individuals equally, with the most affected site being the tongue. Individuals ≥60 years of age were uncommonly affected. Symptomatic and larger lesions were more commonly reported in the literature review., Conclusions: This study comprises the largest sample of OLMs to date. OLMs are rare conditions, without sex predilection. The elderly proved to be less frequently affected, and the tongue is the most commonly affected site., (© 2021 Wiley Periodicals LLC.)
- Published
- 2021
- Full Text
- View/download PDF
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