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536 results on '"davies, colin"'

4. MRI studies of complex fluids and microchannel flows

Author

Davies, Colin John Stephen

Subjects
620.106
Abstract

This thesis considers the use of NMR (Nuclear Magnetic Resonance) in investigating both the formulation, using microchannels, and characterisation of complex fluids using NMR techniques. Multiphase microchannel flows have many applications and understanding the hydrodynamics and mass transfer is essential for developing such systems. Time-averaged velocity images of the parallel flow of PDMS (polydimethylsiloxane) and water in a 500 μm x 250 μm microchannel were compared with an analytical solution and simulations. This was extended into imaging multiphase flows in a smaller (250 μm x 100 μm) microchannel. Poor signal-to-noise levels in this geometry led to the adoption of a spatially- and chemical-shift-resolved propagator acquisition. This was used to differentiate two different flow regimes: parallel flow and droplet production. RheoNMR is the use of NMR techniques in the study of rheology. Time-averaged velocity imaging was used to image a shear-banding micellar solution, cetylpyridinum chloride with sodium salicylate (CPyC1 / NaSal) in sodium chloride brine, in a variety of standard rheological geometries. The fast velocity measurement sequence GERVAIS was used to measure starting and stopping of flows of the CPyC1 / NaSal solution in a wide-gap Couette cell; these were compared to similar experiments performed using PDMS. The propagation of an elastic wave across the cell was seen during start-up and an unusual rebounding oscillation was evident in the stopped flow experiments in the CPyC1 sample. The fast diffusion measurement sequence, Difftrain, was modified to reduce the achievable incremental observation time (at the expense of slightly reduced chemical resolution). This was applied to two case studies: measuring the surface-to-volume ratio of a model porous medium and the droplet sizing of oil-in-water emulsions manufactured with fast-diffusing oils. Finally, NMR relaxometry and diffusometry were used to investigate a phase transition in the structure of a sample of a commercial face cream.

Published
2009

5. Inferring differential subcellular localisation in comparative spatial proteomics using BANDLE

Author

Lilley, Kathryn, Crook, oliver, Breckels, lisa, Kirk, paul, christopher, josie, davies, colin, Gatto, laurent, Crook, Oliver M [0000-0001-5669-8506], Davies, Colin TR [0000-0002-3156-543X], Breckels, Lisa M [0000-0001-8918-7171], Christopher, Josie A [0000-0001-7077-4894], Gatto, Laurent [0000-0002-1520-2268], Kirk, Paul DW [0000-0002-5931-7489], Lilley, Kathryn S [0000-0003-0594-6543], Apollo - University of Cambridge Repository, Davies, Colin T R [0000-0002-3156-543X], and Kirk, Paul D W [0000-0002-5931-7489]

Subjects
Proteomics, Proteome, Bayes Theorem, Mass Spectrometry, Subcellular Fractions
Abstract

The steady-state localisation of proteins provides vital insight into their function. These localisations are context speci c with proteins translocating between di erent subcellular niches upon perturbation of the subcellular environment. Di erential localisation, that is a change in the steady-state subcellular location of a protein, provides a step towards mechanistic in- sight of subcellular protein dynamics. High-accuracy high-throughput mass spectrometry-based methods now exist to map the steady-state localisation and re-localisation of proteins. Here, we describe a principled Bayesian approach, BANDLE, that uses these data to compute the probability that a protein di erentially localises upon cellular perturbation. Extensive simula- tion studies demonstrate that BANDLE reduces the number of both type I and type II errors compared to existing approaches. Application of BANDLE to several datasets recovers well- studied translocations. In an application to cytomegalovirus infection, we obtain insights into the rewiring of the host proteome. Integration of other high-throughput datasets allows us to provide the functional context of these data.

Published
2022
Full Text
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6. The role of pre-operative endotoxin core antibody (EndoCAb) status in outcome following cardiac surgery and approaches to elevating EndoCAb

Author

Hamilton-Davies, Colin

Subjects
617.4
Abstract

Multiple organ failure is thought to be the end-stage of a spectrum of complications related to activation of the body's inflammatory system by a series of triggers. It is also a major cause of death in intensive care units and can arise in patients following elective high-risk surgery. Endotoxin is one such trigger and evidence has demonstrated its presence in excess during the course of surgery involving cardiopulmonary bypass. This thesis examines previous endotoxin-related research into the field of sepsis and high-risk surgery and explores the hypothesis that the patient's own endogenous immunity to the core moiety of endotoxin may influence the post-operative outcome following cardiac surgery. Intra-operative monitoring consisted of both routine and non-routine methods of haemodynamic assessment and indicators of gut perfusion. In my initial observational study on patients undergoing first-time cardiac valve replacement and the follow-up collaborational study with Duke University Medical Centre patients were pre-operatively Parsonnet risk scored. It was found that in both studies pre-operative IgM endotoxin core antibody (EndoCAb) levels were predictive of the development of post-operative complications independent of the Parsonnet risk score. In the initial study where gastrointestinal tonometry was used as a monitor it was found that by combining the preoperative IgM EndoCAb levels with the end-surgery gastrointestinal intramucosal:arterial PCO2 gap the previously quoted poor specificity of the tonometer for detecting complications could be markedly improved. Also in the initial study where plasma markers of neutrophil and contact activation were measured it was demonstrated that certain markers indicated a greater degree of activation in the 25% of patients with the lowest pre-operative IgM EndoCAb levels. Peri-operative usage of blood products was also found to be higher in those patients with lower pre-operative EndoCAb levels. The remainder of this thesis concentrates on examining methods of elevating EndoCAb by means of active and passive immunisation and also studying the effect of various grades of exercise on the EndoCAb status of volunteers.

Published
1998

9. MTWAPA MEMORIES.

Author

Davies, Colin

Subjects
NOSTALGIA, ANECDOTES, FISHING, HOLIDAYS, COASTS
Abstract

The article focuses on the author's nostalgic recollections of Mtwapa in the 1950s, encompassing memories of the Sinton family, the Epstein-owned house situated near Jumba Ruins, and amusing anecdotes about the locals, fishing adventures, ferry rides, and quirky characters like Jacko Heath. It mentions vivid descriptions and anecdotes depict a bygone era filled with idyllic holidays, unique characters, and magical moments along the coast of Mtwapa.

Published
2023

12. Almost the last word.

Author

Follows, Mike, Davies, Colin, Rundle, Simon, Kuhns, Brad, Strong, Simon, Sommerville, Barbara, Keshav, Nicole, Northover, James, and Fothergill, Pauline

Subjects
*LABORATORY rats, *EARTH'S orbit, *DOMESTIC animals, *CATS, *SURFACE of the earth
Abstract

Holding hands If every human lined up facing north with their arms outstretched and touching, at what latitude would this closed circle be? Nicole Keshav Cambridge, UK I believe people do raise many domesticated rats for lab use, and a few of these domesticated rats become pets. Mike Follows Sutton Coldfield, West Midlands, UK If the world's population stood on the equator with outstretched arms and fingers touching, there would be enough people to circle Earth more than 300 times. [Extracted from the article]

Published
2023

13. Inferring differential subcellular localisation in comparative spatial proteomics using BANDLE

Author

UCL - SSS/DDUV/CBIO - Computational Biology and Bioinformatics, Crook, Oliver M., Davies, Colin T. R., Breckels, Lisa M., Christopher, Josie A., Gatto, Laurent, Kirk, Paul D. W., Lilley, Kathryn S., UCL - SSS/DDUV/CBIO - Computational Biology and Bioinformatics, Crook, Oliver M., Davies, Colin T. R., Breckels, Lisa M., Christopher, Josie A., Gatto, Laurent, Kirk, Paul D. W., and Lilley, Kathryn S.

Abstract

The steady-state localisation of proteins provides vital insight into their function. These localisations are context specific with proteins translocating between different subcellular niches upon perturbation of the subcellular environment. Differential localisation, that is a change in the steady-state subcellular location of a protein, provides a step towards mechanistic insight of subcellular protein dynamics. High-accuracy high-throughput mass spectrometry-based methods now exist to map the steady-state localisation and re-localisation of proteins. Here, we describe a principled Bayesian approach, BANDLE, that uses these data to compute the probability that a protein differentially localises upon cellular perturbation. Extensive simulation studies demonstrate that BANDLE reduces the number of both type I and type II errors compared to existing approaches. Application of BANDLE to several datasets recovers well-studied translocations. In an application to cytomegalovirus infection, we obtain insights into the rewiring of the host proteome. Integration of other high-throughput datasets allows us to provide the functional context of these data.

Published
2022

15. Inferring differential subcellular localisation in comparative spatial proteomics using BANDLE

Author

Crook, Oliver M, Davies, Colin TR, Breckels, Lisa M, Christopher, Josie A, Gatto, Laurent, Kirk, Paul DW, Lilley, Kathryn S, Crook, Oliver M [0000-0001-5669-8506], Davies, Colin TR [0000-0002-3156-543X], Breckels, Lisa M [0000-0001-8918-7171], Christopher, Josie A [0000-0001-7077-4894], Gatto, Laurent [0000-0002-1520-2268], Kirk, Paul DW [0000-0002-5931-7489], Lilley, Kathryn S [0000-0003-0594-6543], Apollo - University of Cambridge Repository, and UCL - SSS/DDUV/CBIO - Computational Biology and Bioinformatics

Subjects
Proteomics, Multidisciplinary, Proteome, article, General Physics and Astronomy, Bayes Theorem, Genetics and Molecular Biology, 631/114/1314, General Chemistry, 631/45/475, Mass Spectrometry, General Biochemistry, Genetics and Molecular Biology, 631/553/2714, General Biochemistry, 631/1647/296, Subcellular Fractions
Abstract

The steady-state localisation of proteins provides vital insight into their function. These localisations are context specific with proteins translocating between different sub-cellular niches upon perturbation of the subcellular environment.Differential localisation, that is a change in the steady-state subcellular location of a protein, provides a step towards mechanistic insight of subcellular protein dynamics. Aberrant localisation has been implicated in a number of pathologies, thusdifferential localisationmay help characterise disease states and facilitate rational drug discovery by suggesting novel targets. High-accuracy high-throughput mass spectrometry-based methods now exist to map the steady-state localisation and re-localisation of proteins. Here, we propose a principled Bayesian approach, BANDLE, that uses these data to compute the probability that a protein differentially localises upon cellular perturbation, as well quantifying the uncertainty in these estimates. Furthermore, BANDLE allows information to be shared across spatial proteomics datasets to improve statistical power. Extensive simulation studies demonstrate that BANDLE reduces the number of both type I and type II errors compared to existing approaches. Application of BANDLE to datasets studying EGF stimulation and AP-4 dependent localisation recovers well studied translocations, using only two-thirds of the provided data. Moreover, we potentially implicate TMEM199 with AP-4 dependent localisation. In an application to cytomegalovirus infection, we obtain novel insights into the rewiring of the host proteome. Integration of high-throughput transcriptomic and proteomic data, along with degradation assays, acetylation experiments and a cytomegalovirus intcractome allows us to provide the functional context of these data.

Published
2021

17. Evolving for difference

Author

Bevege, Ross, Davies, Colin, Harnetty, Kate, and Victory, Michael

Published
2013

21. Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19:The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial

Author

Angus, Derek C, Derde, Lennie, Al-Beidh, Farah, Annane, Djillali, Arabi, Yaseen, Beane, Abigail, van Bentum-Puijk, Wilma, Berry, Lindsay, Bhimani, Zahra, Bonten, Marc, Bradbury, Charlotte, Brunkhorst, Frank, Buxton, Meredith, Buzgau, Adrian, Cheng, Allen C, de Jong, Menno, Detry, Michelle, Estcourt, Lise, Fitzgerald, Mark, Goossens, Herman, Green, Cameron, Haniffa, Rashan, Higgins, Alisa M, Horvat, Christopher, Hullegie, Sebastiaan J, Kruger, Peter, Lamontagne, Francois, Lawler, Patrick R, Linstrum, Kelsey, Litton, Edward, Lorenzi, Elizabeth, Marshall, John, McAuley, Daniel, McGlothin, Anna, McGuinness, Shay, McVerry, Bryan, Montgomery, Stephanie, Mouncey, Paul, Murthy, Srinivas, Nichol, Alistair, Parke, Rachael, Parker, Jane, Rowan, Kathryn, Sanil, Ashish, Santos, Marlene, Saunders, Christina, Seymour, Christopher, Turner, Anne, van de Veerdonk, Frank, Venkatesh, Balasubramanian, Zarychanski, Ryan, Berry, Scott, Lewis, Roger J, McArthur, Colin, Webb, Steven A, Gordon, Anthony C, Writing Committee for the REMAP-CAP Investigators, Angus, Derek, Cheng, Allen, De Jong, Menno, Gordon, Anthony, Lawler, Patrick, Webb, Steve, Campbell, Lewis, Forbes, Andrew, Gattas, David, Heritier, Stephane, Higgins, Lisa, Peake, Sandra, Presneill, Jeffrey, Seppelt, Ian, Trapani, Tony, Young, Paul, Bagshaw, Sean, Daneman, Nick, Ferguson, Niall, Misak, Cheryl, Hullegie, Sebastiaan, Pletz, Mathias, Rohde, Gernot, Rowan, Kathy, Alexander, Brian, Basile, Kim, Girard, Timothy, Huang, David, Vates, Jennifer, Beasley, Richard, Fowler, Robert, McGloughlin, Steve, Morpeth, Susan, Paterson, David, Venkatesh, Bala, Uyeki, Tim, Baillie, Kenneth, Duffy, Eamon, Fowler, Rob, Hills, Thomas, Orr, Katrina, Patanwala, Asad, Tong, Steve, Netea, Mihai, Bihari, Shilesh, Carrier, Marc, Fergusson, Dean, Goligher, Ewan, Haidar, Ghady, Hunt, Beverley, Kumar, Anand, Laffan, Mike, Lawless, Patrick, Lother, Sylvain, McCallum, Peter, Middeldopr, Saskia, McQuilten, Zoe, Neal, Matthew, Pasi, John, Schutgens, Roger, Stanworth, Simon, Turgeon, Alexis, Weissman, Alexandra, Adhikari, Neill, Anstey, Matthew, Brant, Emily, de Man, Angelique, Lamonagne, Francois, Masse, Marie-Helene, Udy, Andrew, Arnold, Donald, Begin, Phillipe, Charlewood, Richard, Chasse, Michael, Coyne, Mark, Cooper, Jamie, Daly, James, Gosbell, Iain, Harvala-Simmonds, Heli, Hills, Tom, MacLennan, Sheila, Menon, David, McDyer, John, Pridee, Nicole, Roberts, David, Shankar-Hari, Manu, Thomas, Helen, Tinmouth, Alan, Triulzi, Darrell, Walsh, Tim, Wood, Erica, Calfee, Carolyn, O’Kane, Cecilia, Shyamsundar, Murali, Sinha, Pratik, Thompson, Taylor, Young, Ian, Bihari, Shailesh, Hodgson, Carol, Laffey, John, McAuley, Danny, Orford, Neil, Neto, Ary, Lewis, Roger, McGlothlin, Anna, Miller, Eliza, Singh, Vanessa, Zammit, Claire, van Bentum Puijk, Wilma, Bouwman, Wietske, Mangindaan, Yara, Parker, Lorraine, Peters, Svenja, Rietveld, Ilse, Raymakers, Kik, Ganpat, Radhika, Brillinger, Nicole, Markgraf, Rene, Ainscough, Kate, Brickell, Kathy, Anjum, Aisha, Lane, Janis-Best, Richards-Belle, Alvin, Saull, Michelle, Wiley, Daisy, Bion, Julian, Connor, Jason, Gates, Simon, Manax, Victoria, van der Poll, Tom, Reynolds, John, van Beurden, Marloes, Effelaar, Evelien, Schotsman, Joost, Boyd, Craig, Harland, Cain, Shearer, Audrey, Wren, Jess, Clermont, Giles, Garrard, William, Kalchthaler, Kyle, King, Andrew, Ricketts, Daniel, Malakoutis, Salim, Marroquin, Oscar, Music, Edvin, Quinn, Kevin, Cate, Heidi, Pearson, Karen, Collins, Joanne, Hanson, Jane, Williams, Penny, Jackson, Shane, Asghar, Adeeba, Dyas, Sarah, Sutu, Mihaela, Murphy, Sheenagh, Williamson, Dawn, Mguni, Nhlanhla, Potter, Alison, Porter, David, Goodwin, Jayne, Rook, Clare, Harrison, Susie, Williams, Hannah, Campbell, Hilary, Lomme, Kaatje, Williamson, James, Sheffield, Jonathan, van’t Hoff, Willian, McCracken, Phobe, Young, Meredith, Board, Jasmin, Mart, Emma, Knott, Cameron, Smith, Julie, Boschert, Catherine, Affleck, Julia, Ramanan, Mahesh, D’Souza, Ramsy, Pateman, Kelsey, Shakih, Arif, Cheung, Winston, Kol, Mark, Wong, Helen, Shah, Asim, Wagh, Atul, Simpson, Joanne, Duke, Graeme, Chan, Peter, Cartner, Brittney, Hunter, Stephanie, Laver, Russell, Shrestha, Tapaswi, Regli, Adrian, Pellicano, Annamaria, McCullough, James, Tallott, Mandy, Kumar, Nikhil, Panwar, Rakshit, Brinkerhoff, Gail, Koppen, Cassandra, Cazzola, Federica, Brain, Matthew, Mineall, Sarah, Fischer, Roy, Biradar, Vishwanath, Soar, Natalie, White, Hayden, Estensen, Kristen, Morrison, Lynette, Smith, Joanne, Cooper, Melanie, Health, Monash, Shehabi, Yahya, Al-Bassam, Wisam, Hulley, Amanda, Whitehead, Christina, Lowrey, Julie, Gresha, Rebecca, Walsham, James, Meyer, Jason, Harward, Meg, Venz, Ellen, Williams, Patricia, Kurenda, Catherine, Smith, Kirsy, Smith, Margaret, Garcia, Rebecca, Barge, Deborah, Byrne, Deborah, Byrne, Kathleen, Driscoll, Alana, Fortune, Louise, Janin, Pierre, Yarad, Elizabeth, Hammond, Naomi, Bass, Frances, Ashelford, Angela, Waterson, Sharon, Wedd, Steve, McNamara, Robert, Buhr, Heidi, Coles, Jennifer, Schweikert, Sacha, Wibrow, Bradley, Rauniyar, Rashmi, Myers, Erina, Fysh, Ed, Dawda, Ashlish, Mevavala, Bhaumik, Litton, Ed, Ferrier, Janet, Nair, Priya, Buscher, Hergen, Reynolds, Claire, Santamaria, John, Barbazza, Leanne, Homes, Jennifer, Smith, Roger, Murray, Lauren, Brailsford, Jane, Forbes, Loretta, Maguire, Teena, Mariappa, Vasanth, Smith, Judith, Simpson, Scott, Maiden, Matthew, Bone, Allsion, Horton, Michelle, Salerno, Tania, Sterba, Martin, Geng, Wenli, Depuydt, Pieter, De Waele, Jan, De Bus, Liesbet, Fierens, Jan, Bracke, Stephanie, Reeve, Brenda, Dechert, William, Chassé, Michaël, Carrier, François Martin, Boumahni, Dounia, Benettaib, Fatna, Ghamraoui, Ali, Bellemare, David, Cloutier, Ève, Francoeur, Charles, Lamontagne, François, D’Aragon, Frédérick, Carbonneau, Elaine, Leblond, Julie, Vazquez-Grande, Gloria, Marten, Nicole, Wilson, Maggie, Albert, Martin, Serri, Karim, Cavayas, Alexandros, Duplaix, Mathilde, Williams, Virginie, Rochwerg, Bram, Karachi, Tim, Oczkowski, Simon, Centofanti, John, Millen, Tina, Duan, Erick, Tsang, Jennifer, Patterson, Lisa, English, Shane, Watpool, Irene, Porteous, Rebecca, Miezitis, Sydney, McIntyre, Lauralyn, Brochard, Laurent, Burns, Karen, Sandhu, Gyan, Khalid, Imrana, Binnie, Alexandra, Powell, Elizabeth, McMillan, Alexandra, Luk, Tracy, Aref, Noah, Andric, Zdravko, Cviljevic, Sabina, Đimoti, Renata, Zapalac, Marija, Mirković, Gordan, Baršić, Bruno, Kutleša, Marko, Kotarski, Viktor, Vujaklija Brajković, Ana, Babel, Jakša, Sever, Helena, Dragija, Lidija, Kušan, Ira, Vaara, Suvi, Pettilä, Leena, Heinonen, Jonna, Kuitunen, Anne, Karlsson, Sari, Vahtera, Annukka, Kiiski, Heikki, Ristimäki, Sanna, Azaiz, Amine, Charron, Cyril, Godement, Mathieu, Geri, Guillaume, Vieillard-Baron, Antoine, Pourcine, Franck, Monchi, Mehran, Luis, David, Mercier, Romain, Sagnier, Anne, Verrier, Nathalie, Caplin, Cecile, Siami, Shidasp, Aparicio, Christelle, Vautier, Sarah, Jeblaoui, Asma, Fartoukh, Muriel, Courtin, Laura, Labbe, Vincent, Leparco, Cécile, Muller, Grégoire, Nay, Mai-Anh, Kamel, Toufik, Benzekri, Dalila, Jacquier, Sophie, Mercier, Emmanuelle, Chartier, Delphine, Salmon, Charlotte, Dequin, PierreFrançois, Schneider, Francis, Morel, Guillaume, L’Hotellier, Sylvie, Badie, Julio, Berdaguer, Fernando Daniel, Malfroy, Sylvain, Mezher, Chaouki, Bourgoin, Charlotte, Megarbane, Bruno, Voicu, Sebastian, Deye, Nicolas, Malissin, Isabelle, Sutterlin, Laetitia, Guitton, Christophe, Darreau, Cédric, Landais, Mickaël, Chudeau, Nicolas, Robert, Alain, Moine, Pierre, Heming, Nicholas, Maxime, Virginie, Bossard, Isabelle, Nicholier, Tiphaine Barbarin, Colin, Gwenhael, Zinzoni, Vanessa, Maquigneau, Natacham, Finn, André, Kreß, Gabriele, Hoff, Uwe, Friedrich Hinrichs, Carl, Nee, Jens, Hagel, Stefan, Ankert, Juliane, Kolanos, Steffi, Bloos, Frank, Petros, Sirak, Pasieka, Bastian, Kunz, Kevin, Appelt, Peter, Schütze, Bianka, Kluge, Stefan, Nierhaus, Axel, Jarczak, Dominik, Roedl, Kevin, Weismann, Dirk, Frey, Anna, Klinikum Neukölln, Vivantes, Reill, Lorenz, Distler, Michael, Maselli, Astrid, Bélteczki, János, Magyar, István, Fazekas, Ágnes, Kovács, Sándor, Szőke, Viktória, Szigligeti, Gábor, Leszkoven, János, Collins, Daniel, Breen, Patrick, Frohlich, Stephen, Whelan, Ruth, McNicholas, Bairbre, Scully, Michael, Casey, Siobhan, Kernan, Maeve, Doran, Peter, O’Dywer, Michael, Smyth, Michelle, Hayes, Leanne, Hoiting, Oscar, Peters, Marco, Rengers, Els, Evers, Mirjam, Prinssen, Anton, Bosch Ziekenhuis, Jeroen, Simons, Koen, Rozendaal, Wim, Polderman, F, de Jager, P, Moviat, M, Paling, A, Salet, A, Rademaker, Emma, Peters, Anna Linda, de Jonge, E, Wigbers, J, Guilder, E, Butler, M, Cowdrey, Keri-Anne, Newby, Lynette, Chen, Yan, Simmonds, Catherine, McConnochie, Rachael, Ritzema Carter, Jay, Henderson, Seton, Van Der Heyden, Kym, Mehrtens, Jan, Williams, Tony, Kazemi, Alex, Song, Rima, Lai, Vivian, Girijadevi, Dinu, Everitt, Robert, Russell, Robert, Hacking, Danielle, Buehner, Ulrike, Williams, Erin, Browne, Troy, Grimwade, Kate, Goodson, Jennifer, Keet, Owen, Callender, Owen, Martynoga, Robert, Trask, Kara, Butler, Amelia, Schischka, Livia, Young, Chelsea, Lesona, Eden, Olatunji, Shaanti, Robertson, Yvonne, José, Nuno, Amaro dos Santos Catorze, Teodoro, de Lima Pereira, Tiago Nuno Alfaro, Neves Pessoa, Lucilia Maria, Castro Ferreira, Ricardo Manuel, Pereira Sousa Bastos, Joana Margarida, Aysel Florescu, Simin, Stanciu, Delia, Zaharia, Miahela Florentina, Kosa, Alma Gabriela, Codreanu, Daniel, Marabi, Yaseen, Al Qasim, Eman, Moneer Hagazy, Mohamned, Al Swaidan, Lolowa, Arishi, Hatim, Muñoz-Bermúdez, Rosana, Marin-Corral, Judith, Salazar Degracia, Anna, Parrilla Gómez, Francisco, Mateo López, Maria Isabel, Rodriguez Fernandez, Jorge, Cárcel Fernández, Sheila, Carmona Flores, Rosario, León López, Rafael, de la Fuente Martos, Carmen, Allan, Angela, Polgarova, Petra, Farahi, Neda, McWilliam, Stephen, Hawcutt, Daniel, Rad, Laura, O’Malley, Laura, Whitbread, Jennifer, Kelsall, Olivia, Wild, Laura, Thrush, Jessica, Wood, Hannah, Austin, Karen, Donnelly, Adrian, Kelly, Martin, O’Kane, Sinéad, McClintock, Declan, Warnock, Majella, Johnston, Paul, Gallagher, Linda Jude, Mc Goldrick, Clare, Mc Master, Moyra, Strzelecka, Anna, Jha, Rajeev, Kalogirou, Michael, Ellis, Christine, Krishnamurthy, Vinodh, Deelchand, Vashish, Silversides, Jon, McGuigan, Peter, Ward, Kathryn, O’Neill, Aisling, Finn, Stephanie, Phillips, Barbara, Mullan, Dee, Oritz-Ruiz de Gordoa, Laura, Thomas, Matthew, Sweet, Katie, Grimmer, Lisa, Johnson, Rebekah, Pinnell, Jez, Robinson, Matt, Gledhill, Lisa, Wood, Tracy, Morgan, Matt, Cole, Jade, Hill, Helen, Davies, Michelle, Antcliffe, David, Templeton, Maie, Rojo, Roceld, Coghlan, Phoebe, Smee, Joanna, Mackay, Euan, Cort, Jon, Whileman, Amanda, Spencer, Thomas, Spittle, Nick, Kasipandian, Vidya, Patel, Amit, Allibone, Suzanne, Genetu, Roman Mary, Ramali, Mohamed, Ghosh, Alison, Bamford, Peter, London, Emily, Cawley, Kathryn, Faulkner, Maria, Jeffrey, Helen, Smith, Tim, Brewer, Chris, Gregory, Jane, Limb, James, Cowton, Amanda, O’Brien, Julie, Nikitas, Nikitas, Wells, Colin, Lankester, Liana, Pulletz, Mark, Birch, Jenny, Wiseman, Sophie, Horton, Sarah, Alegria, Ana, Turki, Salah, Elsefi, Tarek, Crisp, Nikki, Allen, Louise, McCullagh, Iain, Robinson, Philip, Hays, Carole, Babio-Galan, Maite, Stevenson, Hannah, Khare, Divya, Pinder, Meredith, Selvamoni, Selvin, Gopinath, Amitha, Pugh, Richard, Menzies, Daniel, Mackay, Callum, Allan, Elizabeth, Davies, Gwyneth, Puxty, Kathryn, McCue, Claire, Cathcart, Susanne, Hickey, Naomi, Ireland, Jane, Yusuff, Hakeem, Isgro, Graziella, Brightling, Chris, Bourne, Michelle, Craner, Michelle, Watters, Malcolm, Prout, Rachel, Davies, Louisa, Pegler, Suzannah, Kyeremeh, Lynsey, Arbane, Gill, Wilson, Karen, Gomm, Linda, Francia, Federica, Brett, Stephen, Sousa Arias, Sonia, Elin Hall, Rebecca, Budd, Joanna, Small, Charlotte, Birch, Janine, Collins, Emma, Henning, Jeremy, Bonner, Stephen, Hugill, Keith, Cirstea, Emanuel, Wilkinson, Dean, Karlikowski, Michal, Sutherland, Helen, Wilhelmsen, Elva, Woods, Jane, North, Julie, Sundaran, Dhinesh, Hollos, Laszlo, Coburn, Susan, Walsh, Joanne, Turns, Margaret, Hopkins, Phil, Smith, John, Noble, Harriet, Depante, Maria Theresa, Clarey, Emma, Laha, Shondipon, Verlander, Mark, Williams, Alexandra, Huckle, Abby, Hall, Andrew, Cooke, Jill, Gardiner-Hill, Caroline, Maloney, Carolyn, Qureshi, Hafiz, Flint, Neil, Nicholson, Sarah, Southin, Sara, Nicholson, Andrew, Borgatta, Barbara, Turner-Bone, Ian, Reddy, Amie, Wilding, Laura, Chamara Warnapura, Loku, Agno Sathianathan, Ronan, Golden, David, Hart, Ciaran, Jones, Jo, Bannard-Smith, Jonathan, Henry, Joanne, Birchall, Katie, Pomeroy, Fiona, Quayle, Rachael, Makowski, Arystarch, Misztal, Beata, Ahmed, Iram, KyereDiabour, Thyra, Naiker, Kevin, Stewart, Richard, Mwaura, Esther, Mew, Louise, Wren, Lynn, Willams, Felicity, Innes, Richard, Doble, Patricia, Hutter, Joanne, Shovelton, Charmaine, Plumb, Benjamin, Szakmany, Tamas, Hamlyn, Vincent, Hawkins, Nancy, Lewis, Sarah, Dell, Amanda, Gopal, Shameer, Ganguly, Saibal, Smallwood, Andrew, Harris, Nichola, Metherell, Stella, Lazaro, Juan Martin, Newman, Tabitha, Fletcher, Simon, Nortje, Jurgens, Fottrell-Gould, Deirdre, Randell, Georgina, Zaman, Mohsin, Elmahi, Einas, Jones, Andrea, Hall, Kathryn, Mills, Gary, Ryalls, Kim, Bowler, Helen, Sall, Jas, Bourne, Richard, Borrill, Zoe, Duncan, Tracey, Lamb, Thomas, Shaw, Joanne, Fox, Claire, Moreno Cuesta, Jeronimo, Xavier, Kugan, Purohit, Dharam, Elhassan, Munzir, Bakthavatsalam, Dhanalakshmi, Rowland, Matthew, Hutton, Paula, Bashyal, Archana, Davidson, Neil, Hird, Clare, Chhablani, Manish, Phalod, Gunjan, Kirkby, Amy, Archer, Simon, Netherton, Kimberley, Reschreiter, Henrik, Camsooksai, Julie, Patch, Sarah, Jenkins, Sarah, Pogson, David, Rose, Steve, Daly, Zoe, Brimfield, Lutece, Claridge, Helen, Parekh, Dhruv, Bergin, Colin, Bates, Michelle, Dasgin, Joanne, McGhee, Christopher, Sim, Malcolm, Hay, Sophie Kennedy, Henderson, Steven, Phull, Mandeep-Kaur, Zaidi, Abbas, Pogreban, Tatiana, Rosaroso, Lace Paulyn, Harvey, Daniel, Lowe, Benjamin, Meredith, Megan, Ryan, Lucy, Hormis, Anil, Walker, Rachel, Collier, Dawn, Kimpton, Sarah, Oakley, Susan, Rooney, Kevin, Rodden, Natalie, Hughes, Emma, Thomson, Nicola, McGlynn, Deborah, Walden, Andrew, Jacques, Nicola, Coles, Holly, Tilney, Emma, Vowell, Emma, Schuster-Bruce, Martin, Pitts, Sally, Miln, Rebecca, Purandare, Laura, Vamplew, Luke, Spivey, Michael, Bean, Sarah, Burt, Karen, Moore, Lorraine, Day, Christopher, Gibson, Charly, Gordon, Elizabeth, Zitter, Letizia, Keenan, Samantha, Baker, Evelyn, Cherian, Shiney, Cutler, Sean, Roynon-Reed, Anna, Harrington, Kate, Raithatha, Ajay, Bauchmuller, Kris, Ahmad, Norfaizan, Grecu, Irina, Trodd, Dawn, Martin, Jane, Wrey Brown, Caroline, Arias, Ana-Marie, Craven, Thomas, Hope, David, Singleton, Jo, Clark, Sarah, Rae, Nicola, Welters, Ingeborg, Hamilton, David Oliver, Williams, Karen, Waugh, Victoria, Shaw, David, Puthucheary, Zudin, Martin, Timothy, Santos, Filipa, Uddin, Ruzena, Somerville, Alastair, Tatham, Kate Colette, Jhanji, Shaman, Black, Ethel, Dela Rosa, Arnold, Howle, Ryan, Tully, Redmond, Drummond, Andrew, Dearden, Joy, Philbin, Jennifer, Munt, Sheila, Vuylsteke, Alain, Chan, Charles, Victor, Saji, Matsa, Ramprasad, Gellamucho, Minerva, Creagh-Brown, Ben, Tooley, Joe, Montague, Laura, De Beaux, Fiona, Bullman, Laetitia, Kersiake, Ian, Demetriou, Carrie, Mitchard, Sarah, Ramos, Lidia, White, Katie, Donnison, Phil, Johns, Maggie, Casey, Ruth, Mattocks, Lehentha, Salisbury, Sarah, Dark, Paul, Claxton, Andrew, McLachlan, Danielle, Slevin, Kathryn, Lee, Stephanie, Hulme, Jonathan, Joseph, Sibet, Kinney, Fiona, Senya, Ho Jan, Oborska, Aneta, Kayani, Abdul, Hadebe, Bernard, Orath Prabakaran, Rajalakshmi, Nichols, Lesley, Thomas, Matt, Worner, Ruth, Faulkner, Beverley, Gendall, Emma, Hayes, Kati, Hamilton-Davies, Colin, Chan, Carmen, Mfuko, Celina, Abbass, Hakam, Mandadapu, Vineela, Leaver, Susannah, Forton, Daniel, Patel, Kamal, Paramasivam, Elankumaran, Powell, Matthew, Gould, Richard, Wilby, Elizabeth, Howcroft, Clare, Banach, Dorota, Fernández de Pinedo Artaraz, Ziortza, Cabreros, Leilani, White, Ian, Croft, Maria, Holland, Nicky, Pereira, Rita, Zaki, Ahmed, Johnson, David, Jackson, Matthew, Garrard, Hywel, Juhaz, Vera, Roy, Alistair, Rostron, Anthony, Woods, Lindsey, Cornell, Sarah, Pillai, Suresh, Harford, Rachel, Rees, Tabitha, Ivatt, Helen, Sundara Raman, Ajay, Davey, Miriam, Lee, Kelvin, Barber, Russell, Chablani, Manish, Brohi, Farooq, Jagannathan, Vijay, Clark, Michele, Purvis, Sarah, Wetherill, Bill, Dushianthan, Ahilanandan, Cusack, Rebecca, de Courcy-Golder, Kim, Smith, Simon, Jackson, Susan, Attwood, Ben, Parsons, Penny, Page, Valerie, Zhao, Xiao Bei, Oza, Deepali, Rhodes, Jonathan, Anderson, Tom, Morris, Sheila, Xia Le Tai, Charlotte, Thomas, Amy, Keen, Alexandra, Digby, Stephen, Cowley, Nicholas, Southern, David, Reddy, Harsha, Campbell, Andy, Watkins, Claire, Smuts, Sara, Touma, Omar, Barnes, Nicky, Alexander, Peter, Felton, Tim, Ferguson, Susan, Sellers, Katharine, Bradley-Potts, Joanne, Yates, David, Birkinshaw, Isobel, Kell, Kay, Marshall, Nicola, Carr-Knott, Lisa, Writing Committee for the REMAP-CAP Investigators, Menon, David [0000-0002-3228-9692], Apollo - University of Cambridge Repository, Medical Microbiology and Infection Prevention, and AII - Infectious diseases

Subjects
Male, Hydrocortisone, Anti-Inflammatory Agents, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], 01 natural sciences, law.invention, 0302 clinical medicine, Randomized controlled trial, law, Adrenal Cortex Hormones, Clinical endpoint, Medicine, 030212 general & internal medicine, Hydrocortisone/administration & dosage, Original Investigation, 2. Zero hunger, Mortality rate, Shock, Covid19, General Medicine, Middle Aged, Intensive care unit, 3. Good health, Intensive Care Units, Treatment Outcome, Early Termination of Clinical Trials, Corticosteroid, Female, Coronavirus Infections, medicine.drug, Adult, medicine.medical_specialty, Respiration, Artificial/statistics & numerical data, medicine.drug_class, Anti-Inflammatory Agents/administration & dosage, Pneumonia, Viral, UNCOVER, Adrenal Cortex Hormones/therapeutic use, 03 medical and health sciences, Betacoronavirus, All institutes and research themes of the Radboud University Medical Center, Internal medicine, Humans, 0101 mathematics, Adverse effect, Pandemics, business.industry, SARS-CoV-2, 010102 general mathematics, COVID-19, Odds ratio, Coronavirus Infections/drug therapy, Pneumonia, Viral/drug therapy, Respiration, Artificial, COVID-19 Drug Treatment, Shock/drug therapy, Human medicine, business
Abstract

Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited.Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19.Design, Setting, and Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020.Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (n = 143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (n = 152), or no hydrocortisone (n = 108).Main Outcomes and Measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%).Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (n = 137), shock-dependent (n = 146), and no (n = 101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively.Conclusions and Relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions.Trial Registration: ClinicalTrials.gov Identifier: NCT02735707.

Published
2020

25. Human spare parts and patentability.

Author

Davies, Colin and Edwards, Christopher

Subjects
Patent law -- Evaluation, Stem cells -- Intellectual property, United Kingdom. Patents Act 1977
Published
2004

26. Grow up Peter Pan!

Author

Davies, Colin and Davis, Rhiannon

Subjects
Copyright law -- Interpretation and construction, United Kingdom. Copyright, Designs and Patents Act 1988
Published
2003

28. Temporal Proteomic Analysis of Herpes Simplex Virus 1 Infection Reveals Cell-Surface Remodeling via pUL56-Mediated GOPC Degradation

Author

Soh, Timothy K., primary, Davies, Colin T.R., additional, Muenzner, Julia, additional, Hunter, Leah M., additional, Barrow, Henry G., additional, Connor, Viv, additional, Bouton, Clément R., additional, Smith, Cameron, additional, Emmott, Edward, additional, Antrobus, Robin, additional, Graham, Stephen C., additional, Weekes, Michael P., additional, and Crump, Colin M., additional

Published
2020
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30. British oil policy in the Middle East, 1919-1932

Author

Davies, Colin and Kiernan, V. G.

Subjects
338.2, British oil policy, Middle East, Petroleum industry and trade
Abstract

The aim of this thesis is to explain and analyse Britain's policy with regard to oil and the control of oil sources in the Middle East during the period 1919 to 1932. A great many books, articles, and some theses have been written on Middle Eastern oil, dealing with various aspects of the subject, but none has specifically aimed to explain in detail British oil policy between 1919 and 1932. The nearest approach to it is probably to be found in B. Shwadran's "The Middle East, Oil and the Great Powers" (New York, 1955), which was written, however, from an American point of view, and without access to British Government archives. It is hoped, therefore, that this present work may help to fill this gap and, also, that it may help to dispel the many inaccurate (and often wildly fanciful) notions about Britain's Middle Eastern oil policy which have long been current. The term "Middle East" in this context includes Persia, Iraq, Syria, Lebanon, Palestine, Transjordan, the Arabian Peninsula, and Egypt, but most attention has been given to Iraq, since it was on Iraq that the main international oil controversies of the period centred. The Persian oil situation has been discussed in some detail, but no attempt at an exhaustive account has been made, since there is already a great deal of well-informed literature written on the subject. It has been found necessary to restrict the scope of the thesis to the main theme of British oil policy, avoiding any detailed treatment of the wider issues with which British oil policy was interwoven. Thus the purely diplomatic aspects of the many issues with which the oil questions were involved are not covered in any detail. In particular, no systematic attempt has been made to place Britain's oil policy in the context of its foreign policy as a whole, either in the Middle East or elsewhere, nor has any attempt been made to examine in full the oil policies (or general strategies in the Middle East) of countries other than Britain. There are several reasons for these limitations of scope. Firstly, the practical reason that, for reasons of space, no single thesis could deal adequately with all the diplomatic and other issues which were connected with British oil policy during the period under consideration. Secondly, adequate treatment of these peripheral issues would necessitate a full programme of research into the archives of the several different countries concerned, in particular those of the French Government and of the United States Government. Apart from the fact that such a programme of work would hardly be practicable in the time available, there is the added consideration that, in particular, French Government archives for the period are still closed. Of relevance to this aspect of the matter, too, is the fact that published works which might be expected to yield much information on, for example, French Middle Eastern oil policy, simply do not contain sufficient relevant information to fill satisfactorily the gap left by the non-availability of French Government archives. A third reason for restricting the scope of the thesis is the need for lucidity. In order to keep what is itself a highly complicated theme reasonably clear, much pruning of materials not absolutely central to the main theme has had to be done, sometimes with the result that issues of great importance in themselves, but having only an indirect link with the central theme, have been given only scant treatment.

Published
1974

31. A time delay ultrasonic imaging system

Author

Davies, Colin J. S.

Subjects
621.3994, Pattern recognition & image processing
Abstract

The design and construction of a time delay ultrasonic imaging system is described. After describing previous and existing methods of ultrasonic imaging, the probable advantages of relative simplicity in comparison with phased arrays, avoidance of side lobes, improved resolution and the disadvantages of ambiguity and distortion of the time delay system are discussed. Polyvinylidene fluoride (PVF2) is used as a transducer material because its high damping enables one to produce single cycle ultrasonic pulses in water and its flexibility enables it to be formed into a curved surface. The properties of PVF2 as a transducer are examined both by library search and by practical experiment. Schlieren images are shown of the ultrasonic wave front emanating from PVF2. A system for imaging under water is designed that comprises one transmitting and four receiving transducers. These are made from PVF2 film on a cylindrical nylon backing, and construction methods are given. The system is controlled by a Rockwell AIM 65 desk top computer and the image is shown on a television screen. The design of both hardware and software is discussed, and methods are suggested for later improvement. The imaging system is demonstrated using four receiving transducers, and the improvement that can be achieved using more transducers is shown by simulating eight receivers. It is shown that, while the time delay system suffers from spurious images caused by ambiguities, it is free from the effect of side lobes because of the short pulse used. The design of a sectioned transducer that should reduce the number of ambiguities is outlined. In the system demonstrated, the image repetition period is two minutes, but with improved computation, this could be reduced to ten seconds or less. The problems envisaged in imaging in metal are discussed and methods of overcoming them are suggested.

Published
1982
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32. A Hough transform for detecting the location and orientation of three-dimensional surfaces via color encoded spots

Author

Davies, Colin J. and Nixon, Mark S.

Subjects
Transformations (Mathematics) -- Usage, Surfaces -- Research, Image processing -- Research
Abstract

Video-rate three-dimensional (3-D) acquisition is desirable, in particular for capturing the mouth's shape when modeling the vocal tract. In a new structured light technique, scenes are illuminated by an array of circular spots which are color encoded to resolve spatial ambiguity. The position and shape of the imaged spots depend on the location and orientation of the illuminated 3-D surface. We present a novel 3-D Hough transform (HT) to detect 3-D surface location and orientation via the imaged spots, with voting constraints applied to maximize potential accuracy. This new technique is demonstrated to successfully extract the 3-D data for a moving face from images acquired at video-rate.

Published
1998

34. Relationship of preoperative antiendotoxin core antibodies and adverse outcomes following cardiac surgery

Author

Bennett-Guerrero, Elliott, Ayuso, Liza, Hamilton-Davies, Colin, White, William D., Barclay, G. Robin, Smith, Peter K., King, Sally A., Muhlbaier, Lawrence H., Newman, Mark F., and Mythen, Michael G.

Subjects
Endotoxins -- Physiological aspects, Heart, Surgery -- Complications
Abstract

Measuring the level of IgM antibodies against endotoxin may predict which patients will develop complications from heart surgery. Endotoxin is a component of bacteria and may initiate an inflammatory response in surgical patients. Researchers measured the levels of IgM and IgG antibodies to endotoxin (EndoCAb) in 301 patients before they had heart surgery. Following surgery, 11.3% of the patients developed a complication. Those with low IgM EndoCAb levels were more likely to develop a complication even after adjusting for other risk factors., Objective.--To test the hypothesis that low serum antiendotoxin core antibody (EndoCAb) level is an independent predictor of adverse outcome following cardiac surgery. Design,-- Prospective, blinded, cohort study. Setting.--Tertiary care medical center. Subjects.--A total of 301 patients undergoing coronary artery bypass graff surgery and/or valvular heart surgery. Design.--Preoperative serum was assayed for IgM EndoCAb, IgG EndoCAb, total IgM, and total IgG levels. Known preoperative risk factors were assessed, and patients were assigned a risk score using a validated method. Main Outcome Measure--A major complication, defined as either in-hospital death or postoperative length of stay greater than 10 days. Results.---Overall, a major complication occurred in 34 patients (11.3%). Lower IgM EndoCAb level independently predicted (P--.002) increased risk of major complication over and above the effects of preoperative risk score (P=.02), total IgG level (P--.07), and all other known perioperative risk factors. In contrast, IgG EndoCAb and total IgM concentrations did not predict outcome. No association existed between risk score and level of IgM EndoCAb. Conclusion.--There is marked preoperative variability in humoral immunity against endotoxin core, which is not accounted for by differences in known preoperative risk factors. In this study, low levels of IgMEndoCAb were an important independent predictor of adverse postoperative outcome, which supports the theory that endotoxemia is a cause of postoperative morbidity. JAMA. 1997;277:646-650

Published
1997

35. FCUK morality: let's make some money.

Author

Davies, Colin

Subjects
Trademark law -- Interpretation and construction, Decency standards -- Laws, regulations and rules, Government regulation
Published
2006

36. Cambridge credo

Author

Davies, Colin

Subjects
Cambridge, England -- Buildings and facilities, Theaters -- Design and construction, Architecture and design industries, Business, Design and construction, Buildings and facilities
Abstract

A new theatre for Emmanuel College in Cambridge displays an astutely crafted material richness combined with a highly innovative structure. This is a typical Hopkins building. More than that it [...]

Published
1996

37. LETTERS

Author

Jensen, Robert E., Lee, Christopher P., Norton, N. M., Ploumis, Eric J., Beachley, Charles E., Kornbluth, David, Davies, Colin R., Averbuck, Philip, Carrns, Douglas M., Gill, Richard H., and Woodlin, Peter H.

Published
1993

42. Big blue

Author

Davies, Colin

Subjects
Marseille, France -- Buildings and facilities, Architects -- Works, Buildings -- Design and construction, Architecture and design industries, Business, Design and construction, Buildings and facilities, Works
Abstract

Will Alsop's first major commission is a regional government headquarters in Marseilles that combines civic grandeur and political symbolism in a bravura interplay of form and technology. Will Alsop likes [...]

Published
1994

43. Glyndebourne

Author

Davies, Colin

Subjects
Sussex, England -- Buildings and facilities, Glyndebourne Festival Opera -- Buildings and facilities, Building -- Methods, Architecture -- Methods, Theaters -- Design and construction, Architecture and design industries, Business, Design and construction, Buildings and facilities, Methods
Abstract

Glyndebourne Opera, as an institution, is full of ambiguities and contradictions. it brings a cosmopolitan, urban art form to a local, rural setting; it is both formal and informal, both [...]

Published
1994

44. French connection

Author

Davies, Colin

Subjects
Airport terminals -- Design and construction, Architectural firms -- Contracts, Public architecture -- Criticism and interpretation, Richard Rogers Partnership Ltd. -- Contracts
Published
1993

45. Carre culturel

Author

Davies, Colin

Subjects
Libraries -- Design and construction, Art museums -- Design and construction, Public architecture -- Criticism and interpretation
Published
1993

46. Sleeping partners

Author

Davies, Colin

Subjects
Dormitories -- Design and construction, Architecture -- Criticism and interpretation
Published
1993

49. Sleight of hand

Author

Davies, Colin

Subjects
Public architecture -- Design and construction, Apartment houses -- Design and construction, Allies and Morrison -- Practice
Published
1992

50. The abbey habit

Author

Davies, Colin

Subjects
Public architecture -- Design and construction
Published
1992

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