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Hippo pathway is an evolutionarily conserved signaling pathway comprising a series of MST/LATS kinase complexes. Its key transcriptional coactivators YAP and TAZ regulate transcription factors such as TEAD family to direct gene expression. The regulation of Hippo pathway, especially the nuclear level change of YAP and TAZ, significantly influences the cell fate switching from proliferation to differentiation, regeneration, and postinjury repair. This review outlines the main findings of Hippo pathway in peripheral nerve development, regeneration, and tumorigenesis, especially the studies in Schwann cells. We also summarize other roles of Hippo pathway in damage repair of the peripheral nerve system and discuss the potential future research which probably contributes to novel therapeutic strategies. [ABSTRACT FROM AUTHOR]

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Lung epithelial cells play a protective role in the respiratory system. However, various pathological factors such as infection, trauma, and inflammation can lead to damage to lung epithelial cells, causing lung diseases. T cells play a key role in lung epithelial cells damage and repair, and participate in these processes by contacting with respiratory epithelial cells or releasing of various cytokines. Different subpopulations of T cells are responsible for enhancing anti-inflammatory responses, clearing infections, and promoting angiogenesis and epithelial cell proliferation. This review aims to summarize the role of T cells in lung epithelial cell damage and repair, as well as the mechanisms involved in the development and remission of lung diseases.