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21 results on '"da Silva Duarte, Alberto Jose"'

7. Dysfunctional purinergic signaling correlates with disease severity in COVID-19 patients.

Author

Julia Pietrobon, Anna, Andrejew, Roberta, Alberca Cust ódio, Ricardo Wesley, de Mendonça Oliveira, Luana, Nathali Scholl, Juliete, Emidio Teixeira, Franciane Mouradian, de Brito, Alves, Glaser, Talita, Kazmierski, Julia, Goffinet, Christine, Claudia Turdo, Anna, Yendo, Tatiana, Aoki, Valeria, Figueiró, Fabricio, Battastini, Ana Maria, Ulrich, Henning, Benard, Gill, da Silva Duarte, Alberto Jose, and Sato, Maria Notomi

Subjects
COVID-19, B cells, T cells, CELL analysis, THERAPEUTICS
Abstract

Ectonucleotidases modulate inflammatory responses by balancing extracellular ATP and adenosine (ADO) and might be involved in COVID-19 immunopathogenesis. Here, we explored the contribution of extracellular nucleotide metabolism to COVID-19 severity in mild and severe cases of the disease. We verified that the gene expression of ectonucleotidases is reduced in the whole blood of patients with COVID-19 and is negatively correlated to levels of CRP, an inflammatory marker of disease severity. In line with these findings, COVID-19 patients present higher ATP levels in plasma and reduced levels of ADO when compared to healthy controls. Cell type-specific analysis revealed higher frequencies of CD39+ T cells in severely ill patients, while CD4+ and CD8 + expressing CD73 are reduced in this same group. The frequency of B cells CD39+CD73+ is also decreased during acute COVID-19. Interestingly, B cells from COVID-19 patients showed a reduced capacity to hydrolyze ATP into ADP and ADO. Furthermore, impaired expression of ADO receptors and a compromised activation of its signaling pathway is observed in COVID-19 patients. The presence of ADO in vitro, however, suppressed inflammatory responses triggered in patients' cells. In summary, our findings support the idea that alterations in the metabolism of extracellular purines contribute to immune dysregulation during COVID-19, possibly favoring disease severity, and suggest that ADO may be a therapeutic approach for the disease. [ABSTRACT FROM AUTHOR]

Published
2022
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8. SARS-CoV-2 recombinant proteins stimulate distinct cellular and humoral immune response profiles in samples from COVID-19 convalescent patients

Author

Silva, Laís Teodoro da, primary, Ortega, Marina Mazzilli, additional, Tiyo, Bruna Tiaki, additional, Viana, Isabelle Freire Tabosa, additional, Lima, Tayná Evily de, additional, Tozetto-Mendoza, Tania Regina, additional, Oliveira, Luanda Mara da Silva, additional, Teixeira, Franciane Mouradian Emidio, additional, Lins, Roberto Dias, additional, Almeida, Alexandre de, additional, Mendes-Correa, Maria Cassia, additional, da Silva Duarte, Alberto Jose, additional, and Oshiro, Telma Miyuki, additional

Published
2021
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9. Distinct patterns of regeneration of central memory, effector memory and effector TCD8+ cell subsets after different hematopoietic cell transplant types: Possible influence in the recovery of anti-cytomegalovirus immune response and risk for its reactivation

Author

Ferrari, Valeria, Rodrigues Cacere, Camila, Machado, Clarisse Martins, Pannuti, Claudio Sérgio, Dulley, Frederico Luiz, Barros, José Carlos Antonio, da Silva Duarte, Alberto José, and Benard, Gil

Published
2006
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11. Revisiting human IL-12R(beta)1 deficiency: a survey of 141 patients from 30 countries

Author

de Beaucoudrey, Ludovic, Samarina, Arina, Bustamante, Jacinta, Cobat, Aurelie, Boisson-Dupuis, Stephanie, Feinberg, Jacqueline, Al-Muhsen, Saleh, Janniere, Lucile, Rose, Yoann, de Suremain, Maylis, Kong, Xiao-Fei, Filipe-Santos, Orchidee, Chapgier, Ariane, Picard, Capucine, Fischer, Alain, Dogu, Figen, Ikinciogullari, Aydan, Tanir, Gonul, Al-Hajjar, Sami, Al-Jumaah, Suliman, Frayha, Husn H., AlSum, Zobaida, Al-Ajaji, Sulaiman, Alangari, Abdullah, Al-Ghonaium, Abdulaziz, Adimi, Parisa, Mansouri, Davood, Ben-Mustapha, Imen, Yancoski, Judith, Garty, Ben-Zion, Rodriguez-Gallego, Carlos, Caragol, Isabel, Kutukculer, Necil, Kumararatne, Dinakantha S., Patel, Smita, Doffinger, Rainer, Exley, Andrew, Jeppsson, Olle, Reichenbach, Janine, Nadal, David, Boyko, Yaryna, Pietrucha, Barbara, Anderson, Suzanne, Levin, Michael, Schandene, Liliane, Schepers, Kinda, Efira, Andre, Mascart, Francoise, Matsuoka, Masao, Sakai, Tatsunori, Siegrist, Claire-Anne, Frecerova, Klara, Bluetters-Sawatzki, Renate, Bernhoft, Jutta, Freihorst, Joachim, Baumann, Ulrich, Richter, Darko, Haerynck, Filomeen, De Baets, Frans, Novelli, Vas, Lammas, David, Vermylen, Christiane, Tuerlinckx, David, Nieuwhof, Chris, Pac, Malgorzata, Haas, Walther H., Muller-Fleckenstein, Ingrid, Fleckenstein, Bernhard, Levy, Jacob, Raj, Revathi, Cohen, Aileen Cleary, Lewis, David B., Holland, Steven M., Yang, Kuender D., Wang, Xiaochuan, Wang, Xiaohong, Jiang, Liping, Yang, Xiqiang, Zhu, Chaomin, Xie, Yuanyuan, Lee, Pamela Pui Wah, Chan, Koon Wing, Chen, Tong-Xin, Castro, Gabriela, Natera, Ivelisse, Codoceo, Ana, King, Alejandra, Bezrodnik, Liliana, Di Giovani, Daniela, Gaillard, Maria Isabel, de Moraes-Vasconcelos, Dewton, Grumach, Anete Sevciovic, da Silva Duarte, Alberto Jose, Aldana, Ruth, Espinosa-Rosales, Francisco Javier, Bejaoui, Mohammed, Bousfiha, Ahmed Aziz, El Baghdadi, Jamila, Ozbek, Namik, Aksu, Guzide, Keser, Melike, Somer, Ayper, Hatipoglu, Nevin, Aydogmus, Cigdem, Asilsoy, Suna, Camcioglu, Yildiz, Gulle, Saniye, Ozgur, Tuba T., Ozen, Meteran, Oleastro, Matias, Bernasconi, Andrea, Mamishi, Setareh, Parvaneh, Nima, Rosenzweig, Sergio, Barbouche, Ridha, Pedraza, Sigifredo, Lau, Yu Lung, Ehlayel, Mohammad S., Fieschi, Claire, Abel, Laurent, Sanal, Ozden, and Casanova, Jean-Laurent

Subjects
Interleukin-12 -- Physiological aspects, Interleukin-12 -- Abnormalities, Mycobacterial infections -- Risk factors, Mycobacterial infections -- Distribution, Mycobacterial infections -- Surveys, Disease susceptibility -- Surveys, Mendel's law -- Analysis, Company distribution practices
Published
2010

19. Demodex Folliculorum and Chronic Granulomatous Disease

Author

Grumach, Anete Sevciovic, primary, Constantino-Silva, Rosemeire Navickas, additional, Nico, Marcelo Mentha, additional, Correa, Alexandre, additional, Zeckcer, Israel, additional, Oliveira, Joao Bosco, additional, da Silva Duarte, Alberto Jose, additional, and Moraes-Vasconcelos, Dewton, additional

Published
2007
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20. Hereditary Angiodema (HAE) in Brazil: Registry of 100 Cases

Author

Grumach, Anete Sevciovic, primary, Pinto, Jorge Andrade, additional, Correa, Alexandre Pires, additional, Moraes-Vasconcelos, Dewton, additional, Constabtino-Silva, Rosemeire Navickas, additional, Valle, Sollange, additional, Mansour, Eli, additional, Vilela, Maria Marluce, additional, da Silva Duarte, Alberto Jose, additional, and Rivitti, Evandro, additional

Published
2007
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21. Warning Signs for Primary Immunodeficiences Investigation in Hospitalized Patients

Author

Moraes-Vasconcelos, Dewton, primary, Moraes-Vasconcelos, Dewton, additional, Oliveira, Joao Bosco, additional, Correa, Alexandre, additional, Constantino-Silva, Rosemeire Navickas, additional, Orii, Noemia, additional, Barros, Noac Chuffi, additional, do Socorro Ferrao, Maria, additional, Dellanegra, Marinella, additional, and da Silva Duarte, Alberto Jose, additional

Published
2007
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