Search

Your search keyword '"da Silva Barcelos, Luciola"' showing total 10 results
Start Over Author "da Silva Barcelos, Luciola"
10 results on '"da Silva Barcelos, Luciola"'

2. Types and Origin of Stem Cells

Author

da Silva Barcelos, Lucíola, Castro, Pollyana Ribeiro, Straessler, Elisabeth Tamara, Kränkel, Nicolle, Navarro, Tulio Pinho, editor, Minchillo Lopes, Lara Lellis Navarro, editor, and Dardik, Alan, editor

Published
2021
Full Text
View/download PDF

5. Role of the suppressor of cytokine signaling 2 (SOCS2) during meningoencephalitis caused by Bovine herpesvirus 5 (BoHV-5)

Author

Aparecida Silva Barbosa, Aline, Freitas Versiani, Alice, Fonseca da Cunha Sousa, Larissa, Silva de Miranda, Aline, Gasparini, Marcela Ribeiro, Brant, Fátima, Silva, Daniele Gonçalves, Luisa Quintino-de-Carvalho, Iracema, Marianetti Soriani, Frederico, Guimarães da Fonseca, Flávio, César Vasconcelos, Anilton, da Silva Barcelos, Lucíola, Martins Teixeira, Mauro, Lúcio Teixeira, Antônio, Machado, Fabiana Simão, Barbosa-Stancioli, Edel Figueiredo, and Rachid, Milene Alvarenga

Published
2016
Full Text
View/download PDF

10. The 5-lipoxygenase (5-LOX) Inhibitor Zileuton Reduces Inflammation and Infarct Size with Improvement in Neurological Outcome Following Cerebral Ischemia

Author

Costa Silva, Bruno, Silva de Miranda, Aline, Guimaraes Rodrigues, Flavia, Leticia Malheiros Silveira, Ana, Henrique de Souza Resende, Gustavo, Flavio Dutra Moraes, Marcio, Carlos Pinheiro de Oliveira, Antonio, Martins Parreiras, Patricia, da Silva Barcelos, Luciola, Martins Teixeira, Mauro, Simao Machado, Fabiana, Lucio Teixeira, Antonio, and Alvarenga Rachid, Milene

Abstract

Stroke is one of the most frequent causes of death and disability worldwide causing a major clinical and socioeconomic impact. Although the pathophysiology of brain ischemia and reperfusion is complex, the inflammatory process plays an important role in pathogenesis, contributing to the expansion of brain injury. The 5-lipoxygenase (5-LOX) is a key enzyme in the biosynthesis of the leukotrienes and has been implicated and in the central nervous system (CNS) disorders such as Alzheimer's disease and acute ischemic stroke. Zileuton, a selective 5-LOX inhibitor, has antiinflammatory properties and exerts an inhibitory effect on inflammatory diseases. The objective of this study was to evaluate the effects of blocking 5-LOX activity in a murine model of transient and global brain ischemia. Zileuton improved neurological deficits and significantly decrease volume and density of lesion, compared to vehicle-ischemic animals measured by magnetic resonance imaging (MRI). In addition, the blockage of 5-LOX reduced infarct area and histopathological changes. Furthermore, by enzyme immunoassay (ELISA) increased brain levels of tumor necrosis factor-alpha (TNFalpha), interferon-gamma (IFN-gamma), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), chemokine (C-X-C motif) ligand 1 (CXCL1), chemokine (C-C motif) ligand 3 (CCL3) and chemokine (C-C motif) ligand 5 (CCL5) were detected in the vehicle-ischemic group, whereas in Zileuton-ischemic group presented reduction of these mediators. The concentration of the antiinflammatory cytokine interleukin-10 (IL-10) was increased after 5-LOX inhibition. Our results suggest that Zileuton decreases brain damage and reduces inflammatory cytokines expression in the CNS which contributes, at least in part, to improve the neurological outcome of brain ischemia.

Published
2015

Catalog

Books, media, physical & digital resources
See catalog results