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2. IGF2/ApaI polymorphism associated with birth weight in children of the region of Petrolina-PE, Brazil.

Author

de Mascena Diniz Maia, Paula F. C., da Silva, Tamiris M. E., Angelo, Hildson D., e Silva, Laís W., Gondim Martins, Danyelly B., Maia, Maria de Mascena Diniz, and de Lima Filho, José L.

Subjects
*SOMATOMEDIN A, *FETAL development, *BIRTH weight, *LOW birth weight, *GENETIC polymorphisms
Abstract

Insulin-like growth factor 2 ( IGF2) gene has an important role in fetal growth. It was investigated association of the IGF2/ApaI polymorphism with low birth weight and normal birth weight (as control) in children attended in Hospital Dom Malan Petrolina, PE-Brazil. The genotype frequencies did not differ statistically between low birth weight (AA = 16.22%, AG = 43.24%, GG = 40.54%) and control (AA = 20% AG = 35%, GG= 45% groups) and the allele frequencies were not significantly different ( p > 0.05).The observed genotype frequencies in both groups did not deviate significantly from Hardy-Weinberg equilibrium. Then, no significant correlation was found for this polymorphism in the population studied. [ABSTRACT FROM AUTHOR]

Published
2013
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