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2. Exploring the antiviral potential of justicidin B and four glycosylated lignans from Phyllanthus brasiliensis against Zika virus: A promising pharmacological approach

Author

Ferraz, Ariane Coelho, Gomes, Paulo Wender P., Menegatto, Marília Bueno da Silva, Lima, Rafaela Lameira Souza, Guimarães, Pedro Henrique, Reis, José Diogo Evangelista, Carvalho, Alice Rhelly Veloso, Pamplona, Sônia das Graças Santa Rosa, Muribeca, Abraão de Jesus Barbosa, de Magalhães, José Carlos, Yoshioka e Silva, Consuelo Yumiko, da Silva, Milton Nascimento, and Magalhães, Cintia Lopes de Brito

Published
2024
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3. plantMASST - Community-driven chemotaxonomic digitization of plants

Author

Gomes, Paulo Wender P., primary, Mannochio-Russo, Helena, additional, Schmid, Robin, additional, Zuffa, Simone, additional, Damiani, Tito, additional, Quiros-Guerrero, Luis-Manuel, additional, Caraballo-Rodriguez, Andres Mauricio, additional, Zhao, Haoqi Nina, additional, Yang, Heejung, additional, Xing, Shipei, additional, Charron-Lamoureux, Vincent, additional, Chigumba, Desnor N., additional, Sedio, Brian E., additional, Myers, Jonathan A., additional, Allard, Pierre-Marie, additional, Harwood, Thomas V., additional, Tamayo-Castillo, Giselle, additional, Kang, Kyo Bin, additional, Defossez, Emmanuel, additional, Koolen, Hector H. F., additional, da Silva, Milton Nascimento, additional, e Silva, Consuelo Yumiko Yoshioka, additional, Rasmann, Sergio, additional, Walker, Tom W. N., additional, Glauser, Gaetan, additional, Chaves-Fallas, Jose Miguel, additional, David, Bruno, additional, Kim, Hyunwoo, additional, Lee, Kyu Hyeong, additional, Kim, Myeong Ji, additional, Choi, Won Jun, additional, Keum, Young-Sam, additional, de Lima, Emilly J. S. P., additional, de Medeiros, Livia Soman, additional, Bataglion, Giovana A., additional, Costa, Emmanoel V., additional, da Silva, Felipe M. A., additional, Carvalho, Alice Rhelly V., additional, Reis, Jose Diogo E., additional, Pamplona, Sonia, additional, Jeong, Eunah, additional, Lee, Kyungha, additional, Kim, Geum Jin, additional, Kil, Yun-Seo, additional, Nam, Joo-Won, additional, Choi, Hyukjae, additional, Han, Yoo Kyong, additional, Park, Si Young, additional, Lee, Ki Yong, additional, Hu, Changling, additional, Dong, Yilun, additional, Sang, Shengmin, additional, Morrison, Colin R., additional, Borges, Ricardo Moreira, additional, Teixeira, Andrew Magno, additional, Lee, Seo Yoon, additional, Lee, Bum Soo, additional, Jeong, Se Yun, additional, Kim, Ki Hyun, additional, Rutz, Adriano, additional, Gaudry, Arnaud, additional, Bruelhart, Edouard, additional, Kappers, Iris F., additional, Karlova, Rumyana, additional, Meisenburg, Mara, additional, Berdaguer, Roland, additional, Tello, J. Sebastian, additional, Henderson, David, additional, Cayola, Leslie, additional, Wright, S. Joseph, additional, Allen, David N., additional, Anderson-Teixeira, Kristina J., additional, Baltzer, Jennifer L., additional, Lutz, James A., additional, McMahon, Sean M., additional, Parker, Geoffrey G., additional, Parker, John D., additional, Northen, Trent R., additional, Bowen, Benjamin P., additional, Pluskal, Tomas, additional, van der Hooft, Justin J. J., additional, Carver, Jeremy J., additional, Bandeira, Nuno, additional, Pullman, Benjamin S., additional, Wolfender, Jean-Luc, additional, Kersten, Roland D., additional, Wang, Mingxun, additional, and Dorrestein, Pieter C., additional

Published
2024
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4. Aqueous extract of Swietenia macrophylla leaf exerts an anti-inflammatory effect in a murine model of Parkinson’s disease induced by 6-OHDA

Author

Cardoso, Váldina Solimar Lopes, primary, Valente-Amaral, Anderson, additional, Monteiro, Rayan Fidel Martins, additional, Meira, Clarina Loius Silva, additional, de Meira, Natália Silva, additional, da Silva, Milton Nascimento, additional, Pinheiro, João de Jesus Viana, additional, Bastos, Gilmara de Nazareth Tavares, additional, Felício, João Soares, additional, and Yamada, Elizabeth Sumi, additional

Published
2024
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5. Desenvolvimento tecnológico de formas farmacêuticas à base de Varronia multispicata (Cham.) Borhidi para tratamento da dor e de distúrbios inflamatórios

Author

Vilela, Williana Torres, primary, Da Silva, Maria José Cristiane, additional, Da Silva, Amanda Correia, additional, Rolim Neto, Pedro José, additional, Da Silva, Milton Nascimento, additional, E Silva, Consuelo Yumiko Yoshioka, additional, Júnior, Enéas de Andrade Fontes, additional, and Da Silva, Rosali Maria Ferreira, additional

Published
2024
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7. Obtainment of the spray-dried extracts of Peperomia pellucida L. (H.B.K.) using different atomization temperatures: physicochemical characterization and technological development for pharmaceutical applications

Author

da Silva, Rosali Maria Ferreira, Gomes, Thays Cristiane Barbosa Lucena, Campos, Adriana Fernandes, Vilela, Williana Tôrres, Silva, Pollyne Amorim, Sales, Victor de Albuquerque Wanderley, de Medeiros Schver, Giovanna Christinne Rocha, da Silva, Keyla Emmanuelle Ramos, Costa, Salvana Priscylla Manso, de Souza, Fábio Santos, de Freitas, Manolo Cleiton Costa, Arruda, Mara Sílvia Pinheiro, da Silva, Milton Nascimento, and Rolim Neto, Pedro José

Published
2021
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8. Putative Identification of New Phragmaline-Type Limonoids from the Leaves of Swietenia macrophylla King: A Case Study Using Mass Spectrometry-Based Molecular Networking.

Author

Reis, José Diogo E., Gomes, Paulo Wender P., Sá, Paulo R. da C., Pamplona, Sônia das G. S. R., Silva, Consuelo Yumiko Y. e, da Silva, Maria Fátima das G. F., Bishayee, Anupam, and da Silva, Milton Nascimento

Subjects
LIMONOIDS, MOLECULAR weights, MASS spectrometry, SOCIAL networks, NATURAL products
Abstract

Swietenia macrophylla King is a plant commonly known as Brazilian mahogany. The wood from its stem is highly prized for its exceptional quality, while its leaves are valued for their high content of phragmalin-type limonoids, a subclass of compounds known for their significant biological activities, including antimalarial, antitumor, antiviral, and anti-inflammatory properties. In this context, twelve isolated limonoids from S. macrophylla leaves were employed as standards in mass spectrometry-based molecular networking to unveil new potential mass spectrometry signatures for phragmalin-type limonoids. Consequently, ultra-performance liquid chromatography coupled with high-resolution mass spectrometry was utilized for data acquisition. Subsequently, the obtained data were analyzed using the Global Natural Products Social Molecular Networking platform based on spectral similarity. In summary, this study identified 24 new putative phragmalin-type limonoids for the first time in S. macrophylla. These compounds may prove valuable in guiding future drug development efforts, leveraging the already established biological activities associated with limonoids. [ABSTRACT FROM AUTHOR]

Published
2023
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9. Antibacterial Activity from Momordica charantia L. Leaves and Flavones Enriched Phase

Author

Muribeca, Abraão de Jesus B., primary, Gomes, Paulo Wender P., additional, Paes, Steven Souza, additional, da Costa, Ana Paula Alves, additional, Gomes, Paulo Weslem Portal, additional, Viana, Jéssica de Souza, additional, Reis, José Diogo E., additional, Pamplona, Sônia das Graças Santa R., additional, Silva, Consuelo, additional, Bauermeister, Anelize, additional, Santos, Lourivaldo da Silva, additional, and da Silva, Milton Nascimento, additional

Published
2022
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10. Margaritaria nobilis L.F. (Phyllanthaceae): Ethnopharmacology and Application of Computational Tools in the Annotation of Bioactive Molecules

Author

Santiago, Johan Carlos C., primary, Albuquerque, Carlos Alberto B., additional, Muribeca, Abraão de Jesus B., additional, Sá, Paulo Roberto C., additional, Pamplona, Sônia das Graças Santa R., additional, Silva, Consuelo Yumiko Y. e, additional, Ribera, Paula Cardoso, additional, Fontes-Júnior, Enéas de Andrade, additional, and da Silva, Milton Nascimento, additional

Published
2022
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11. Margaritaria nobilis L.f. (Phyllanthaceae) Ethanolic Extract: Low Acute Oral Toxicity and Antinociceptive Activity.

Author

Camara, Fabiana Menezes S., da Conceição, Brenda Costa, Cardoso, Eloise Karoline S., Santiago, Johan Carlos C., Albuquerque, Carlos Alberto B., Pereira, Washington L., Monteiro, Marta C., Yoshioka e Silva, Consuelo Y., da Silva, Milton Nascimento, Maia, Cristiane F., and Fontes-Junior, Eneas A.

Subjects
TANNINS, ORAL drug administration, WEIGHT gain, WATER consumption, ANIMAL locomotion, ACID derivatives, LIQUID chromatography-mass spectrometry
Abstract

Margaritaria nobilis L.f. (Phyllanthaceae), a native Brazilian tree occurring mainly in the Amazon, is used in folk medicine for the treatment of abscesses (bark) and cancer-like symptoms (leaves). The present study evaluates the safety of its acute oral administration and its effects on nociception and plasma leakage. The chemical constitution of the leaf's ethanolic extract is determined by ultra-performance liquid chromatography–high-resolution mass spectrometry (LC-MS. Its acute oral toxicity is evaluated in female rats at a dose of 2000 mg/kg, evaluating the occurrence of deaths and Hippocratic, behavioral, hematological, biochemical, and histopathological changes, as well as food and water consumption and weight gain. Antinociceptive activity is evaluated in male mice with acetic-acid-induced peritonitis (APT) and formalin (FT) tests. An open field (OF) test is performed to verify possible interferences in the animals' consciousness or locomotion. LC-MS analysis shows the presence of 44 compounds classified as phenolic acid derivatives, flavonoids and O-glycosylated derivatives, and hydrolyzable tannins. No deaths or significant behavioral, histological, or biochemical changes are observed in the toxicity assessment. In nociception tests, M. nobilis extract significantly reduces abdominal contortions in APT, demonstrating selectivity for inflammatory components (FT second phase), not interfering in neuropathic components (FT first phase) or consciousness and locomotion levels in OF. Additionally, M. nobilis extract inhibits plasma acetic-acid-induced leakage. These data demonstrate the low toxicity of M. nobilis ethanolic extract, as well as its effectiveness in modulating inflammatory nociception and plasma leakage, possibly related to the flavonoids and tannins present in its composition. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Leishmanicidal activity of Piper marginatum Jacq. from Santarém-PA against Leishmania amazonensis

Author

Macêdo, Caroline Gomes, primary, Fonseca, Maria Yasmin Nogueira, additional, Caldeira, Antônia Djane, additional, Castro, Santana Pinto, additional, Pacienza-Lima, Wallace, additional, Borsodi, Maria Paula Gonçalves, additional, Sartoratto, Adilson, additional, da Silva, Milton Nascimento, additional, Salgado, Claudio Guedes, additional, Rossi-Bergmann, Bartira, additional, and Castro, Kelly Christina Ferreira, additional

Published
2020
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13. Chemical profiling of Curatella americana Linn leaves by UPLC-HRMS and its wound healing activity in mice

Author

Fujishima, Mayara Amoras Teles, primary, Sá, Dayse Maria Cunha, additional, Lima, Carolina Miranda de Sousa, additional, Bittencourt, José Adolfo H. M., additional, Pereira, Washington Luiz Assunção, additional, Muribeca, Abraão de Jesus Barbosa, additional, e Silva, Consuelo Yumiko Yoshioka, additional, da Silva, Milton Nascimento, additional, de Sousa, Francisco Fábio Oliveira, additional, dos Santos, Cleydson B. R., additional, and da Silva, Jocivania Oliveira, additional

Published
2020
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14. Chemical Composition, Toxicity, Antinociceptive, and Anti-Inflammatory Activity of Dry Aqueous Extract of Varronia multispicata (Cham.) Borhidi (Cordiaceae) Leaves

Author

Lopes, Klaylton, primary, Oliveira, Juliana, additional, Sousa-Junior, Fabio J. C., additional, Santos, Túlio da F., additional, Andrade, Débora, additional, Andrade, Sara L., additional, Pereira, Washington L., additional, Gomes, Paulo Wender P., additional, Monteiro, Marta C., additional, e Silva, Consuelo Y. Yoshioka, additional, da Silva, Milton Nascimento, additional, Maia, Cristiane F., additional, and Fontes-Júnior, Enéas A., additional

Published
2019
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15. Plants used to treat snakebites in Santarém, western Pará, Brazil: An assessment of their effectiveness in inhibiting hemorrhagic activity induced by Bothrops jararaca venom

Author

de Moura, Valéria Mourão, primary, Freitas de Sousa, Luciana A., additional, Cristina Dos-Santos, Maria, additional, Almeida Raposo, Juliana Divina, additional, Evangelista Lima, Aline, additional, de Oliveira, Ricardo Bezerra, additional, da Silva, Milton Nascimento, additional, and Veras Mourão, Rosa Helena, additional

Published
2015
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18. Limonoids of the Phragmalin Type from Swietenia macrophyllaand Their Chemotaxonomic Significance

Author

da Silva, Milton Nascimento, Arruda, Mara Silvia Pinheiro, Castro, Kelly Christina F., da Silva, M. Fátima das G. F., Fernandes, João B., and Vieira, Paulo C.

Abstract

Species of Swieteniaelaborate limonoid chemistry along only one route, which leads to the mexicanolide type in most species and the phragmalin type in S. mahogani. A hexane extract from leaves of S. macrophyllaafforded six new phragmalins with a 8,9,30-ortho-ester unit, namely, 6-O-acetylswietephragmin E (1), 3β-O-destigloyl-3β-O-benzoyl-6-O-acetylswietephragmin E (2), 12α-acetoxyswietephragmin C (3), 3β-O-destigloyl-3β-O-benzoyl-12α-acetoxyswietephragmin C (4), 12α-acetoxyswietephragmin D (5), and 3β-O-destigloyl-3β-O-benzoyl-12α-acetoxyswietephragmin D (6). This appears to be the first record of phragamalins from S. macrophylla, and this study shows the potential of tricyclic [3.3.12,10.11,4]-decane limonoids as taxonomically useful chemical markers in the Meliaceae.

Published
2008
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19. plantMASST - Community-driven chemotaxonomic digitization of plants.

Author

Gomes PWP, Mannochio-Russo H, Schmid R, Zuffa S, Damiani T, Quiros-Guerrero LM, Caraballo-Rodríguez AM, Zhao HN, Yang H, Xing S, Charron-Lamoureux V, Chigumba DN, Sedio BE, Myers JA, Allard PM, Harwood TV, Tamayo-Castillo G, Kang KB, Defossez E, Koolen HHF, da Silva MN, E Silva CYY, Rasmann S, Walker TWN, Glauser G, Chaves-Fallas JM, David B, Kim H, Lee KH, Kim MJ, Choi WJ, Keum YS, de Lima EJSP, de Medeiros LS, Bataglion GA, Costa EV, da Silva FMA, Carvalho ARV, Reis JDE, Pamplona S, Jeong E, Lee K, Kim GJ, Kil YS, Nam JW, Choi H, Han YK, Park SY, Lee KY, Hu C, Dong Y, Sang S, Morrison CR, Borges RM, Teixeira AM, Lee SY, Lee BS, Jeong SY, Kim KH, Rutz A, Gaudry A, Bruelhart E, Kappers IF, Karlova R, Meisenburg M, Berdaguer R, Tello JS, Henderson D, Cayola L, Wright SJ, Allen DN, Anderson-Teixeira KJ, Baltzer JL, Lutz JA, McMahon SM, Parker GG, Parker JD, Northen TR, Bowen BP, Pluskal T, van der Hooft JJJ, Carver JJ, Bandeira N, Pullman BS, Wolfender JL, Kersten RD, Wang M, and Dorrestein PC

Abstract

Understanding the distribution of hundreds of thousands of plant metabolites across the plant kingdom presents a challenge. To address this, we curated publicly available LC-MS/MS data from 19,075 plant extracts and developed the plantMASST reference database encompassing 246 botanical families, 1,469 genera, and 2,793 species. This taxonomically focused database facilitates the exploration of plant-derived molecules using tandem mass spectrometry (MS/MS) spectra. This tool will aid in drug discovery, biosynthesis, (chemo)taxonomy, and the evolutionary ecology of herbivore interactions.

Published
2024
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