Search

Your search keyword '"da Silva, Josiane Fernandes"' showing total 13 results
Start Over Author "da Silva, Josiane Fernandes"
13 results on '"da Silva, Josiane Fernandes"'

3. Sodium butyrate modulates adipocyte expansion, adipogenesis, and insulin receptor signaling by upregulation of PPAR-γ in obese Apo E knockout mice

Author

Aguilar, Edenil Costa, da Silva, Josiane Fernandes, Navia-Pelaez, Juliana Maria, Leonel, Alda Jusceline, Lopes, Lorrayne Gonçalves, Menezes-Garcia, Zélia, Ferreira, Adaliene Versiani Matos, Capettini, Luciano dos Santos Aggum, Teixeira, Lilian G., Lemos, Virginia Soares, and Alvarez-Leite, Jacqueline I.

Published
2018
Full Text
View/download PDF

5. Aryl hydrocarbon receptor (AhR) activation contributes to high‐fat diet‐induced vascular dysfunction

Author

da Silva, Josiane Fernandes, primary, Bolsoni, Juliana A., additional, da Costa, Rafael M., additional, Alves, Juliano V., additional, Bressan, Alecsander F. M., additional, Silva, Luiz Eduardo V., additional, Costa, Tiago J., additional, Oliveira, Antonio E. R., additional, Manzato, Carla P., additional, Aguiar, Carlos A., additional, Fazan, Rubens, additional, Cunha, Fernando Q., additional, Nakaya, Helder I., additional, Carneiro, Fernando S., additional, and Tostes, Rita C., additional

Published
2022
Full Text
View/download PDF

8. Lysophosphatidylcholine induces oxidative stress in human endothelial cells via NOX5 activation – implications in atherosclerosis

Author

da Silva, Josiane Fernandes, primary, Alves, Juliano V., additional, Silva-Neto, Julio A., additional, Costa, Rafael M., additional, Neves, Karla B., additional, Alves-Lopes, Rheure, additional, Carmargo, Livia L., additional, Rios, Francisco J., additional, Montezano, Augusto C., additional, Touyz, Rhian M., additional, and Tostes, Rita C., additional

Published
2021
Full Text
View/download PDF

9. Vascular Stress Signaling in Hypertension

Author

Cicalese, Stephanie M., primary, da Silva, Josiane Fernandes, additional, Priviero, Fernanda, additional, Webb, R. Clinton, additional, Eguchi, Satoru, additional, and Tostes, Rita C., additional

Published
2021
Full Text
View/download PDF

11. Oral butyrate reduces oxidative stress in atherosclerotic lesion sites by a mechanism involving NADPH oxidase down-regulation in endothelial cells

Author

Aguilar, Edenil C., primary, Santos, Lana Claudinez dos, additional, Leonel, Alda J., additional, de Oliveira, Jamil Silvano, additional, Santos, Elândia Aparecida, additional, Navia-Pelaez, Juliana M., additional, da Silva, Josiane Fernandes, additional, Mendes, Bárbara Pinheiro, additional, Capettini, Luciano S.A., additional, Teixeira, Lilian G., additional, Lemos, Virginia S., additional, and Alvarez-Leite, Jacqueline I., additional

Published
2016
Full Text
View/download PDF

12. Sex-specific mechanisms of cerebral microvascular BK Ca dysfunction in a mouse model of Alzheimer's disease.

Author

da Silva JF, Polk FD, Martin PE, Thai SH, Savu A, Gonzales M, Kath AM, Gee MT, and Pires PW

Abstract

Background: Cerebral microvascular dysfunction and nitro-oxidative stress are present in patients with Alzheimer's disease (AD) and may contribute to disease progression and severity. Large conductance Ca 2+ -activated K + channels (BK Ca ) play an essential role in vasodilatory responses and maintenance of myogenic tone in resistance arteries. BK Ca impairment can lead to microvascular dysfunction and hemodynamic deficits in the brain. We hypothesized that reduced BK Ca function in cerebral arteries mediates microvascular and neurovascular responses in the 5x-FAD model of AD., Methods: BK Ca activity in the cerebral microcirculation was assessed by patch clamp electrophysiology and pressure myography, in situ Ca 2+ sparks by spinning disk confocal microscopy, hemodynamics by laser speckle contrast imaging. Molecular and biochemical analyses were conducted by affinity-purification assays, qPCR, Western blots and immunofluorescence., Results: We observed that pial arteries from 5-6 months-old male and female 5x-FAD mice exhibited a hyper-contractile phenotype than wild-type (WT) littermates, which was linked to lower vascular BK Ca activity and reduced open probability. In males, BK Ca dysfunction is likely a consequence of an observed lower expression of the pore-forming subunit BKα and blunted frequency of Ca 2+ sparks, which are required for BK Ca activity. However, in females, impaired BK Ca function is, in part, a consequence of reversible nitro-oxidative changes in the BK α subunit, which reduces its open probability and regulation of vascular tone. We further show that BK Ca function is involved in neurovascular coupling in mice, and its dysfunction is linked to neurovascular dysfunction in the model., Conclusion: These data highlight the central role played by BK Ca in cerebral microvascular and neurovascular regulation, as well as sex-dependent mechanisms underlying its dysfunction in a mouse model of AD.

Published
2024
Full Text
View/download PDF

13. Blockade of protease-activated receptor 2 attenuates allergenmediated acute lung inflammation and leukocyte recruitment in mice.

Author

Matos NLA, Oliveira Lima OSC, DA Silva JF, Pin Eros AR, Tavares JC, Lemos VNS, Alves-Filho JC, and Klein A

Subjects
Animals, Disease Models, Animal, Inflammation drug therapy, Inflammation pathology, Leukocytes, Lung pathology, Mice, Mice, Inbred BALB C, Ovalbumin metabolism, Receptor, PAR-2 genetics, Pneumonia drug therapy, Pneumonia metabolism, Pneumonia pathology, Receptor, PAR-2 metabolism
Abstract

Protease-activated receptor (PAR)2 has been implicated in mediating allergic airway inflammation.We investigate the role of PAR2 in lung inflammation and neutrophil and eosinophil recruitment into the lungs in amousemodel of shortterm acute allergic inflammation. Allergic lung inflammation was induced in sensitized BALB/c mice through intranasal instillations of ovalbumin (OVA), and mice were pretreated with the PAR2 antagonist ENMD1068 or with the PAR2-activating peptide (PAR2-AP) 1 hour before each OVA challenge. Bronchoalveolar lavage fluid (BALF) was collected, and the lungs, trachea and lymph nodes were removed after the last challenge to analyze the airway inflammation. PAR2 blockade reduced OVA-induced eosinophil and neutrophil counts, CXCL1, CCL5, amphiregulin, and interleukin (IL)-6 and 13 levels.Moreover, PAR2 blockade reduced OVA-induced PAR2 expression in cells present in BALF 2 hour after OVA challenge, and PAR2-AP acted synergistically with OVA promoting eosinophil recruitment intoBALF and increased IL-4 and IL-13 levels in lymph nodes. Conversely, PAR2 blockade increased IL- 10 levels when compared with OVA-treated mice. Our results provide evidence for a mechanism by which PAR2 meditates acute lung inflammation triggered by multiple exposures to allergen through a modulatory role on cytokine production and vascular permeability implicated in the lung diseases such as asthma.

Published
2022

Catalog

Books, media, physical & digital resources
See catalog results