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Simple Summary: Despite multiple standardized interpretation criteria (SICs) for imaging response assessment in patients with head and neck squamous cell carcinoma (HNSCC), these systems remain relatively underutilized. This underutilization may in part relate to the fact that the relevant information has been published in disparate journals over multiple decades. This paper aims to review the SICs available for use in interpreting post-treatment FDG PET/CT in patients with HNSCC. We evaluate each SIC in the context of eight desired traits. Selecting a SIC that best matches the needs of one's practice is expected to facilitate multidisciplinary buy-in and maximize the likelihood of successful implementation. Introduction: There is growing interest in the development and application of standardized imaging criteria (SIC), to minimize variability and improve the reproducibility of image interpretation in head and neck squamous cell carcinoma (HNSCC). Methods: "Squamous cell carcinoma" AND "standardized interpretation criteria" OR "radiographic response assessment" were searched using PubMed and Google Scholar for articles published between 2009 and 2024, returning 56 publications. After abstract review, 18 were selected for further evaluation, and 6 different SICs (i.e., PERCIST, Porceddu, Hopkins, NI-RADS, modified Deauville, and Cuneo) were included in this review. Each SIC is evaluated in the context of 8 desired traits of a standardized reporting system. Results: Two SICs have societal endorsements (i.e., PERCIST, NI-RADS); four can be used in the evaluation of locoregional and systemic disease (i.e., PERCIST, Hopkins, NI-RADS, Cuneo), and four have specific categories for equivocal imaging results (i.e., Porceddu, NI-RADS, modified Deauville, and Cuneo). All demonstrated areas for future improvement in the context of the 8 desired traits. Conclusion: Multiple SICs have been developed for and demonstrated value in HNSCC post-treatment imaging; however, these systems remain underutilized. Selecting an SIC with features that best match the needs of one's practice is expected to maximize the likelihood of successful implementation. [ABSTRACT FROM AUTHOR]

Abstract Background Head and neck squamous cell carcinoma (HNSCC) represents the 6th leading cancer worldwide. In most cases, patients present a locally advanced disease at diagnosis and non-surgical curative treatment is considered the standard of care. Nowadays, [18F]FDG PET/CT is a validated tool in post-treatment evaluation, with a high level of evidence. However, to standardize imaging response, several visual scales have been proposed with none of them approved yet. The study’s aim is a head-to-head comparison between the diagnostic performance of the Hopkins criteria, the Deauville score, and the new proposed Cuneo score, to establish their prognostic role. Secondly, we investigate the possible value of semiquantitative analysis, evaluating SUVmax and ΔSUVmax of the lymph node with the highest uptake on the restaging PET scan. Moreover, we also considered morphological features using the product of diameters measured on the co-registered CT images to assess the added value of hybrid imaging. Methods We performed a retrospective analysis on histologically proven HNSCC patients who underwent baseline and response assessment [18F]FDG PET/CT. Post-treatment scans were reviewed according to Hopkins, Deauville, and Cuneo criteria, assigning a score to the primary tumor site and lymph nodes. A per-patient final score for each scale was chosen, corresponding to the highest score between the two sites. Diagnostic performance was then calculated for each score considering any evidence of locoregional progression in the first 3 months as the gold standard. Survival analysis was performed using the Kaplan–Meier method. SUVmax and its delta, as well as the product of diameters of the lymph node with the highest uptake at post-treatment scan, if present, were calculated. Results A total of 43 patients were finally included in the study. Sensitivity, specificity, PPV, NPV, and accuracy were 87%, 86%, 76%, 92%, and 86% for the Hopkins score, whereas 93%, 79%, 70%, 96%, and 84% for the Deauville score, respectively. Conversely, the Cuneo score reached the highest specificity and PPV (93% and 78%, respectively) but the lowest sensitivity (47%), NPV (76%), and accuracy (77%). Each scale significantly correlated with PFS and OS. The ROC analysis of the combination of SUVmax and the product of diameters of the highest lymph node on the restaging PET scan reached an AUC of 0.822. The multivariate analysis revealed the Cuneo criteria and the product of diameters as prognostic factors for PFS. Conclusions Each visual score statistically correlated with prognosis thus demonstrating the reliability of point-scale criteria in HNSCC. The novel Cuneo score showed the highest specificity, but the lowest sensibility compared to Hopkins and Deauville criteria. Furthermore, the combination of PET data with morphological features could support the evaluation of equivocal cases.

Background: Head and neck squamous cell carcinoma (HNSCC) represents the 6th leading cancer worldwide. In most cases, patients present a locally advanced disease at diagnosis and non-surgical curative treatment is considered the standard of care. Nowadays, [18F]FDG PET/CT is a validated tool in post-treatment evaluation, with a high level of evidence. However, to standardize imaging response, several visual scales have been proposed with none of them approved yet. The study's aim is a head-to-head comparison between the diagnostic performance of the Hopkins criteria, the Deauville score, and the new proposed Cuneo score, to establish their prognostic role. Secondly, we investigate the possible value of semiquantitative analysis, evaluating SUVmax and ΔSUVmax of the lymph node with the highest uptake on the restaging PET scan. Moreover, we also considered morphological features using the product of diameters measured on the co-registered CT images to assess the added value of hybrid imaging. Methods: We performed a retrospective analysis on histologically proven HNSCC patients who underwent baseline and response assessment [18F]FDG PET/CT. Post-treatment scans were reviewed according to Hopkins, Deauville, and Cuneo criteria, assigning a score to the primary tumor site and lymph nodes. A per-patient final score for each scale was chosen, corresponding to the highest score between the two sites. Diagnostic performance was then calculated for each score considering any evidence of locoregional progression in the first 3 months as the gold standard. Survival analysis was performed using the Kaplan–Meier method. SUVmax and its delta, as well as the product of diameters of the lymph node with the highest uptake at post-treatment scan, if present, were calculated. Results: A total of 43 patients were finally included in the study. Sensitivity, specificity, PPV, NPV, and accuracy were 87%, 86%, 76%, 92%, and 86% for the Hopkins score, whereas 93%, 79%, 70%, 96%, and 84% for the Deauville score, respectively. Conversely, the Cuneo score reached the highest specificity and PPV (93% and 78%, respectively) but the lowest sensitivity (47%), NPV (76%), and accuracy (77%). Each scale significantly correlated with PFS and OS. The ROC analysis of the combination of SUVmax and the product of diameters of the highest lymph node on the restaging PET scan reached an AUC of 0.822. The multivariate analysis revealed the Cuneo criteria and the product of diameters as prognostic factors for PFS. Conclusions: Each visual score statistically correlated with prognosis thus demonstrating the reliability of point-scale criteria in HNSCC. The novel Cuneo score showed the highest specificity, but the lowest sensibility compared to Hopkins and Deauville criteria. Furthermore, the combination of PET data with morphological features could support the evaluation of equivocal cases. [ABSTRACT FROM AUTHOR]

Lombardoite, ideally Ba2Mn3+(AsO4)2(OH), and aldomarinoite, ideally Sr2Mn3+(AsO4)2(OH), are two new minerals of the arsenbrackebuschite group in the brackebuschite supergroup, discovered in Fe–Mn ore in metaquartzites of the abandoned mine of Valletta, Canosio, Val Maira, Cuneo Province, Piedmont, Italy. They occur as red–brown and orange brown, respectively, as subhedral crystals (< 0.5 mm) in thin masses, associated with quartz, aegirine, baryte, calcite, hematite, muscovite and Mn minerals such as cryptomelane, braunite and manganberzeliite. Both minerals are translucent, have yellow–orange streak and vitreous lustre. Both are brittle. Estimated Mohs hardness is 6–6½ for lombardoite (by analogy to canosioite), and 4½–5 for aldomarinoite (by analogy to tokyoite). Calculated densities are 5.124 g/cm3 for lombardoite and 4.679 g/cm3 for aldomarinoite. Both minerals are biaxial (+). Lombardoite shows 2Vz(meas.) = 78(4)° and is pleochroic with X = yellowish brown, Y = brown and Z = reddish brown (Z > Y > X). Aldomarinoite has 2Vz(meas.) = 67.1(1)°, and is pleochroic with X = brown, Y = brownish orange and Z = yellowish brown (Z > Y > X). Point analyses by electron microprobe using wavelength dispersive spectroscopy resulted in the empirical formula (based on 9 O anions): (Ba1.96Sr0.17Pb0.04Na0.02Ca0.02)Σ2.21(Mn3+0.62Fe3+0.13Al0.06Mg0.11)Σ0.92[(As0.87V0.12P0.01)Σ1.00O4]2(OH) for lombardoite, and (Sr1.93Ca0.21Ba0.04Pb0.01)Σ2.19(Mn3+0.48Al0.35Fe3+0.21Mg0.01)Σ1.05[(As0.92V0.03)Σ0.95O4]2(OH) for aldomarinoite. The absence of H2O was confirmed by Raman spectroscopy and infrared spectroscopy. Both minerals are monoclinic, P21/m, with unit-cell parameters a = 7.8636(1) Å, b = 6.13418(1) Å, c = 9.1197(1) Å, β = 112.660(2)° and V = 405.94(1) Å3, for lombardoite and a = 7.5577(4) Å, b = 5.9978(3) Å, c = 8.7387(4) Å, β = 111.938(6)° and V = 367.43(3) Å3, for aldomarinoite. The eight strongest powder X-ray diffraction lines are [d, Å (Irel) (hkl)]: 6.985 (39) (10 $\bar{1}$), 3.727 (33) (111), 3.314 (100) (21 $\bar{1}$), 3.073 (24) (020), 3.036 (33) (21 $\bar{2}$ , 10 $\bar{3}$), 2.810 (87) (12 $\bar{1}$ , 112), 2.125 (20) (301, 11 $\bar{4}$) and 1.748 (24) (321) for lombardoite and 3.191 (89) (21 $\bar{1}$), 2.997 (45) (020), 2.914 (47) (21 $\bar{2}$ , 10 $\bar{3}$), 2.715 (100) (112), 2.087 (39) (12 $\bar{3}$ , 1.833 (32) (31 $\bar{4}$), 1.689 (36) (321), 1.664 (21) (132) for aldomarinoite. The minerals are isostructural with brackebuschite: infinite chains of edge sharing octahedra running parallel to the b axis and decorated with AsO4 groups are connected along the a and c axes through Ba and Sr atoms in lombardoite and aldomarinoite, respectively. The minerals are named after Bruno Lombardo (1944–2014), geologist and petrologist at C.N.R. (National Research Council of Italy), and Aldo Marino (b. 1942) the mineral collector and founding member of the AMI – Italian Micromineralogical Association. [ABSTRACT FROM AUTHOR]

Moral realism is the doctrine that some propositions asserting that some action is ‘morally’ good (obligatory, bad, or wrong) are true. This paper examines three different definitions of what it is for an action to be ‘morally’ good (with corresponding definitions for ‘morally’ obligatory, bad, or wrong) which would make moral realism a clear and plausible view. The first defines ‘morally good as ‘overall important to do’; and the second defines it as ‘overall important to do for universalizable reasons’. The paper argues that neither of these definitions is adequate; and it develops the view of Cuneo and Shafer-Landau that we need a definition which is partly in terms of paradigm examples of morally good actions, which they call ‘moral fixed points’. Hence the third and final definition is that an action is morally good if it is ‘overall important to do because this follows from a fundamental universalizable principle, belonging to a system of such principles which includes almost all the moral fixed points; when a suggested fundamental principle is one which would be shown to be very probably true by the exercise of reflective equilibrium over many centuries’.

Armellinoite-(Ce), ideally Ca4Ce4+(AsO4)4⋅H2O, is a new mineral discovered in Fe–Mn ore in metaquartzites of the Montaldo mine, Corsaglia Valley, Cuneo Province, Piedmont, Italy. It occurs as very small and rare, pale yellow to brown–yellow pseudo-octahedral translucent crystals hosted by a matrix of quartz, hematite, cryptomelane/hollandite, tilasite, muscovite, braunite and montmorillonite. The mineral is translucent, with white streak and has a resinous to vitreous lustre. It is brittle with irregular fracture and fair cleavage parallel to {110} and {100}. Estimated Mohs hardness is ~3–3.5. Calculated density is 4.29 g⋅cm–3. Armellinote-(Ce) is uniaxial (–), ω = 1.795(5), ɛ = 1.765(5) (white light), non-pleochroic and non-fluorescent. Chemical point analyses by WDS-EPMA yielded the empirical formula (based on 17 O+F anions): A(Ca3.89Th0.08Sr0.02La0.03)Σ4.02B(Ce4+0.76Nd0.13Y0.08Gd0.03Sm0.02Pr0.01Dy0.01Ho0.01)Σ1.05[(As4.00P0.01)Σ4.01O4]4⋅(H2O0.85F0.15)Σ2.00. The presence of H2O was confirmed by Raman spectroscopy. The mineral is tetragonal, I41/a, with single-crystal unit-cell parameters a = 10.749(2), c = 12.030(2) Å and V = 1390.0(6) Å3, with Z = 4. The eight strongest X-ray powder diffraction lines are [d Å (Irel; hkl)]: 7.983 (36; 101), 4.443 (23; 2̄11), 2.957 (100; 3̄12), 2.398 (14; 420), 1.875 (22; 424, 325), 1.728 (19; 3̄16), 1.612 (13; 613) and 1.475 (26; 712, 552). The crystal structure (R1 = 0.0284 for 1275 unique reflections) has isolated TO4 (T = As5+) tetrahedra that link Ca2+- or Ce4+-centred polyhedra via common oxygen ligands to form 2D blocks or double-layered (DL) structural units parallel to (001). Armellinoite-(Ce) is isostructural with pottsite, ideally (Pb3Bi)Bi(VO4)4⋅H2O, and closely related to a larger number of anhydrous synthetic compounds. The mineral is named after the mineral collector Gianluca Armellino (b. 1962), who collected the discovery sample. [ABSTRACT FROM AUTHOR]

After a short illustration of the main geological as well as climatic and vegetational features of the Stura di Demonte Valley, a synthesis of the carabidological researches carried out so far in this area is reported. A topographic catalogue of the 198 Carabid species (Cicindelinae included) recorded from this territory is given, with notes regarding the ecology and the distribution of the most interesting ones. Furthermore, the main observed carabid assemblages are described. [ABSTRACT FROM AUTHOR]

After a short illustration of the main geological as well as climatic and vegetational features of the Corsaglia, Casotto and Mongia Valleys, a synthesis of the carabidological researches carried out so far in this area is reviewed. A topographic catalogue of the 159 Carabid species (Cicindelinae included) recorded from this territory is given, with notes regarding the ecology and the distribution of the most interesting ones. Furthermore, the main observed carabid assemblages are described. [ABSTRACT FROM AUTHOR]

Highlights • The Cunéo and Picot fracture dislocation is an atypical trimalleolar ankle fracture. • Fixation of the posterior malleolus is mandatory. • Diagnosis can be made from plain X-rays. • Fracture instability is not determined by fragment size of the posterior malleolus. Abstract The Cunéo and Picot fracture-dislocation is an atypical trimalleolar fracture-dislocation of the ankle with unique anatomopathologic and radiographic features, which has not been reported in English literature. We report a case of a 42-year-old woman that was diagnosed with a trimalleolar fracture-dislocation and treated surgically with an open reduction and osteosynthesis of the lateral and medial malleolus. At one-month follow-up, X-rays showed secondary displacement of the medial malleolus requiring revision surgery. The patient complained of persisting pain, with X-rays showing no signs of apparent fracture displacement. A CT scan performed after hardware removal 10 months after trauma showed severe ankle arthritis and fracture malunion at the level of the syndesmosis. The patient was retrospectively diagnosed with a Cunéo and Picot fracture-dislocation. The treatment of trimalleolar fractures is discussed, especially regarding the correct indication of synthesis of the posterior malleolus. Cunéo and Picot fractures are usually inherently unstable even if the posterior malleolar fragment may be small and can easily be recognized from standard X-rays. Whenever this type of fracture is not correctly recognized and managed by osteosynthesis of only the medial and lateral malleolus, clinical outcomes and radiographic follow-ups tend to be unsatisfactory. Fixation of the posterior malleolus is indicated in the management of Cunéo and Picot fractures. Level of clinical evidence: 4. [ABSTRACT FROM AUTHOR]

Copyright of Dialogue: Canadian Philosophical Review is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Ground Source Heat Pump (GSHP) is a low carbon heating and cooling technology which can make an important contribution for reaching the ambitious CO 2 reduction targets set by the European Union. The economic and technical suitability of this technology strongly depends on the thermal and hydrogeological properties of the ground at the installation site, which need to be assessed in detail. A common indicator adopted to define such suitability is the geothermal potential, i.e. the thermal power that can be exchanged with the ground through a GSHP with a certain setup. In this paper, we present the assessment and mapping of the shallow geothermal potential in the province of Cuneo, a 6900 km 2 wide county in NW Italy. Geological, hydrogeological and climatic information are collected and processed to estimate the relevant ground properties. The shallow geothermal potential is then estimated with different methods for closed-loop installations (Borehole Heat Exchangers, BHEs) and open-loop installations (Ground Water Heat Pumps, GWHPs) systems in order to identify the most suitable areas for different technologies. The maps of the geothermal potential are an important planning tool for the installation of GSHPs and for the growth of this renewable energy source. [ABSTRACT FROM AUTHOR]

Muscoid larvae were observed on self-medicated dressing material loaded with purulent material taken from a 91-year-old hospital patient. These larvae were identified as Lucilia sericata. However, no larvae were found in the patient's tissues. The observation of larvae on dressings should not automatically lead to a diagnosis of cutaneous myiasis., Competing Interests: All authors declare the absence of conflicts of interest., (Copyright © 2023 SFMTSI.)

Over the last few decades, in Italy as in the rest of EU, both the number of wild ungulates and the volume of traffic have increased significantly. Consequently, ungulate-vehicle collisions have increased with significant costs in human death and injury, animal welfare and material damage. In this study we provide information about temporal patterns of collisions in a subalpine Italian region. We analyzed 1110 reports of accidents that occurred in Cuneo district from January 2008 to December 2011. Most of them were caused by roe deer and wild boar, while red deer, fallow deer and chamois were occasionally involved. Monthly distribution of accidents showed two peaks, with a higher risk of collision during spring mainly related to roe deer and a secondary peak in autumn caused by wild boar. No evident daily variations were noticed. In the case of roe deer, we reported the existence of a primary hourly peak at dusk and another secondary peak at dawn. Wild boar were most frequently involved in collisions during dusk and night. We hypothesized that these temporal distributions are the result of a complex interaction of phenological, behavioral and human-related reasons. Information provided in this study allows us to better understand the dynamics and patterns of wildlife-car collisions and represents an indispensable element for the implementation of any mitigation strategy. [ABSTRACT FROM AUTHOR]

Copyright of Bulletin de la Société de Pathologie Exotique is the property of John Libbey Eurotext Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

A comparison of Giuseppe Bagetti's landscape sketches, watercolours, oil paintings and engravings with contemporary maps and the existing landscape reveals that in the creation of Bagetti's landscapes, narrative played a role that differed in cartographic and artistic representations. The comparison also demonstrates that his images were powerful constructions that were more successful in reflecting a narrative of glorious conquest than was possible through cartography. This paper offers a critical examination of Bagetti's representations of Napoleon's northern Italian campaign, which he sketched and painted between 1802 and 1809. Bagetti's paintings were neither pacifist nor an expression of Piedmontese patriotism but instead were inspired by, and constructed according to, a narrative about the conquest that reflected the views of the French authorities. The narrative found expression in formal written instructions from the central cartographical office in the Dépôt de la guerre, Paris, in verbal and written instructions from Bagetti's immediate superior, Jean François Martinel, and in letters personally addressed to Bagetti from the officer commanding the Depot. It is clear from a careful reading of the correspondence and from a comparison of Bagetti's paintings with both the present landscape and maps made at the time that Bagetti's disputes with his supervisors revolved around protecting his artistic integrity and reputation rather than resisting the authority of a foreign regime. [ABSTRACT FROM AUTHOR]