1. Synchronization influenced by the connection structures of the four subgroups in the suprachiasmatic nucleus.
- Author
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Yang, Jinhua, Gu, Changgui, Zheng, Wenxin, and Xu, Yan
- Abstract
In mammals, there is a central clock that regulates both physiological and behavioral circadian rhythms. This clock is situated within the suprachiasmatic nucleus (SCN), which consists of two nuclei in the mammalian brain. Each nucleus has two subgroups, i.e., the ventral-lateral (VL) part and the dorsal-medial (DM) part, so that a total of four subgroups are within the SCN. Thus far, the connection structures of the four subgroups has not been explored in the experiment due to the lack of technology. In this study, based on the Poincaré model, we examined the effect of the connection structures on the synchronization between the subgroups, which is important for the robust rhythms of the SCN, under constant darkness. Comparing seven structures, we found that the connection of the VL in one nucleus to the DM in another is more conducive to the synchronization, but the connection between the two VL subgroups or between the two DM subgroups across the different nuclei reduces the synchronization degree. Our findings illuminate the influence of the connection structures of the four subgroups on the SCN function. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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