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The fragrance industry plays a key role in the global economy, producing a wide range of personal care and household products. However, some fragrance ingredients have been linked to allergic reactions in sensitive people, and their concentrations are regulated at the European level. For this reason, reliable, rapid, and sustainable analytical methods are needed to rapidly detect and quantify these compounds. Recently, a new class of hydrophobic eutectic solvents (HES) has been introduced; they consist of natural terpenoids or phenolic compounds that can be used as hydrogen bond donors (HBD) and acceptors (HBA), and they are more suitable for GC applications due to their higher volatility. In this study, a dispersive liquid–liquid microextraction (DLLME) approach is proposed for the analysis and quantification of a range of allergens in hydroalcoholic perfumes. The optimized method requires only 50 µL of a natural HES (thymol–eugenol), which is readily dispersed by vortexing in 2 mL of sample. After centrifugation, the HES rich phase is diluted in 400 µL EtOH and directly injected into the GC-FID system. The proposed method has been successfully applied in the analysis and quantification of commercial fragrances, demonstrating good enrichment of target allergens and suitability for aqueous matrices analysis. [ABSTRACT FROM AUTHOR]

The fragrance industry plays a key role in the global economy, producing a wide range of personal care and household products. However, some fragrance ingredients have been linked to allergic reactions in sensitive people, and their concentrations are regulated at the European level. For this reason, reliable, rapid, and sustainable analytical methods are needed to rapidly detect and quantify these compounds. Recently, a new class of hydrophobic eutectic solvents (HES) has been introduced; they consist of natural terpenoids or phenolic compounds that can be used as hydrogen bond donors (HBD) and acceptors (HBA), and they are more suitable for GC applications due to their higher volatility. In this study, a dispersive liquid–liquid microextraction (DLLME) approach is proposed for the analysis and quantification of a range of allergens in hydroalcoholic perfumes. The optimized method requires only 50 µL of a natural HES (thymol–eugenol), which is readily dispersed by vortexing in 2 mL of sample. After centrifugation, the HES rich phase is diluted in 400 µL EtOH and directly injected into the GC-FID system. The proposed method has been successfully applied in the analysis and quantification of commercial fragrances, demonstrating good enrichment of target allergens and suitability for aqueous matrices analysis.

Abstract: The present research is based on the concept of using a 10 m × 0.1 mm id column for cryogenic‐modulation fast comprehensive two‐dimensional gas chromatography with quadrupole mass spectrometry. Specifically, an 8.9 m × 0.1 mm id low‐polarity column was used as the first dimension, and a 1.1 m × 0.1 mm id medium‐polarity column was used as the second dimension. The main scope of the investigation was to develop a high peak‐capacity method, with an analysis time of approximately 10 min. Various aspects related to method optimization are discussed, as well as separation parameters such as peak capacity (in each dimension, and as a total value), first‐dimension sample capacity, peak widths, modulation ratio, sensitivity enhancement, and number of spectra per peak. The fast approach was evaluated in applications involving a mixture of cosmetic allergens and a sample of perfume. The approach proposed enables high‐resolution separations in a short time (across the C8–C23 alkane range), as well as a considerable reduction of the consumption of gases for modulation cooling and heating. [ABSTRACT FROM AUTHOR]