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A study of 103 2nd diabetes mellitus inpatients was carried out with the help of the composite test (clinical scales TSS and NIS LL + 7 EMG-characteristics of the leg peripheral nerves’ state) for diagnosing and establishing stages of diabetic polyneuropathy. In 75% of patients distal symmetric sensor-motor diabetic polyneuropathy is detected, from them – in 33% subclinical stage. In 30 patients with subclinical stage of the diabetic polyneuropathy treatment by Actovegin® was conducted for 5 months: 10 infusions 250.00 ml of 20%-solution and then administration of Actovegin® tablets at a dosage 200 mg 3 tpd. At examination after the course of treatment improvement of the capillary blood flow, increase of density of thin fibers in epidermis and skin (punch-biopsy), content of endothelium in the skin, activation of neoanginesis. Discussing the literature data and own findings a conclusion about effectiveness of Actovegin® in the 2nd diabetes mellitus patients with polyneuropathy, including at a subclinical stage.

New prospects associated with the use of laser radiation of different wavelengths in the ultraviolet (365 nm) and the green emission spectrum (525 nm) have appeared in recent years. The high prevalence of the trophic leg ulcers necessitates the search for more effective methods of conservative treatment., Purpose of the Study: Development and scientific justification for the low-intensity laser radiation of different wavelengths combined use in patients with trophic leg ulcers and chronic venous insufficiency (CVI)., Material and Methods: 102 patients with trophic leg ulcers and CVI were examined. They were divided into 3 equal groups using simple randomization. Patients in the control group received only traditional conservative therapy; comparison group - traditional conservative therapy and an intravenous laser blood irradiation (ILBI) (λ - 635 nm); the main group - traditional conservative therapy and different wavelengths laser therapy (LT) course., Results and Conclusion: A more significant improvement in the clinical condition occurred under the influence of the course application of combined different wavelengths laser therapy in patients with trophic venous leg ulcers. Compared to patients who received traditional conservative therapy and in combination with ILBI 635 nm, the speed of reparative regeneration of trophic ulcers increased, the time for cleansing trophic ulcers from devitalized tissues was reduced. Computer capillaroscopy data showed that the positive effect of laser exposure on all parts of the microcirculation underlies its therapeutic efficacy.