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3 results on '"complex ano-rectal fistula"'

1. Non cross-linked equine collagen (Salvecoll-E gel) for treatment of complex ano-rectal fistula.

Author

Maternini, M., Guttadauro, A., Mascagni, D., Milito, G., Stuto, A., Renzi, A., Ripamonti, L., Bottini, C., Nudo, R., Del Re, L., and Gabrielli, F.

Abstract

Fistula-in-ano is one of the most commonly presenting anorectal diseases. Sphincter sparing treatment options should be considered in patients with complex fistulas. Salvecoll-E gel is a native collagen deantigenated and purified, non-cross-linked equine dermal extract, with an amino acid composition identical to human collagen. The multicentric trial study was a prospective, single-arm observational clinical study with the objective to assess the efficacy of Salvecoll-E gel for anal fistula repair in 70 patients. All patients had undergone preliminary surgical treatment consisting of positioning of a draining loosing seton that was maintained for a period of 4–6 weeks. After seton removal, a gentle debridement and washing of the fistula track was performed. The scar tissue was removed from the internal orifice. Internal opening was covered by a side-to side mucosal suture. Salvecoll-E was injected through the external opening into the fistula track, the external opening it has been opened. Twelve months after surgery, 55 patients demonstrated a clinically healed fistula (78,5%), 15 patients have a recurrence (21,5%). Most of the recurrences were observed in the first 6 months of treatment (13/15, 86.6%). We don't observe any worsening in CCF score. The results obtained at 1 year certainly seem satisfactory and in line with the best results published in literature using mini-invasive techniques. Salvecoll-E gel is a promising non-invasive technique for conservative treatment of anal fistulas, it's well tolerated by the patients and, in case of recurrence, reinjection or all other known techniques are feasible. [ABSTRACT FROM AUTHOR]

Published
2020
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2. Non cross-linked equine collagen (Salvecoll-E gel) for treatment of complex ano-rectal fistula

Author

Maternini, M, Guttadauro, A, Mascagni, D, Milito, G, Stuto, A, Renzi, A, Ripamonti, L, Bottini, C, Nudo, R, Del Re, L, Gabrielli, F, Maternini M., Guttadauro A., Mascagni D., Milito G., Stuto A., Renzi A., Ripamonti L., Bottini C., Nudo R., Del Re L., Gabrielli F., Maternini, M, Guttadauro, A, Mascagni, D, Milito, G, Stuto, A, Renzi, A, Ripamonti, L, Bottini, C, Nudo, R, Del Re, L, Gabrielli, F, Maternini M., Guttadauro A., Mascagni D., Milito G., Stuto A., Renzi A., Ripamonti L., Bottini C., Nudo R., Del Re L., and Gabrielli F.

Abstract

Background: Fistula-in-ano is one of the most commonly presenting anorectal diseases. Sphincter sparing treatment options should be considered in patients with complex fistulas. Salvecoll-E gel is a native collagen deantigenated and purified, non-cross-linked equine dermal extract, with an amino acid composition identical to human collagen. Methods: The multicentric trial study was a prospective, single-arm observational clinical study with the objective to assess the efficacy of Salvecoll-E gel for anal fistula repair in 70 patients. All patients had undergone preliminary surgical treatment consisting of positioning of a draining loosing seton that was maintained for a period of 4–6 weeks. After seton removal, a gentle debridement and washing of the fistula track was performed. The scar tissue was removed from the internal orifice. Internal opening was covered by a side-to side mucosal suture. Salvecoll-E was injected through the external opening into the fistula track, the external opening it has been opened. Results: Twelve months after surgery, 55 patients demonstrated a clinically healed fistula (78,5%), 15 patients have a recurrence (21,5%). Most of the recurrences were observed in the first 6 months of treatment (13/15, 86.6%). We don't observe any worsening in CCF score. The results obtained at 1 year certainly seem satisfactory and in line with the best results published in literature using mini-invasive techniques. Conclusion: Salvecoll-E gel is a promising non-invasive technique for conservative treatment of anal fistulas, it's well tolerated by the patients and, in case of recurrence, reinjection or all other known techniques are feasible.

Published
2020

3. Non cross-linked equine collagen (Salvecoll-E gel) for treatment of complex ano-rectal fistula

Author

Adolfo Renzi, D. Mascagni, L. Del Re, R. Nudo, C. Bottini, G. Milito, Francesco Gabrielli, Lorenzo Ripamonti, Matteo Maternini, Angelo Guttadauro, Angelo Stuto, Maternini, M, Guttadauro, A, Mascagni, D, Milito, G, Stuto, A, Renzi, A, Ripamonti, L, Bottini, C, Nudo, R, Del Re, L, and Gabrielli, F

Subjects
Anal fistula, EQUINE COLLAGEN, medicine.medical_specialty, Fistula, medicine.medical_treatment, lcsh:Surgery, Non cutting technique, Anal Canal, Complex ano-rectal fistula, 03 medical and health sciences, 0302 clinical medicine, Suture (anatomy), Recurrence, Mini-invasive treatment, Medicine, Animals, In patient, Horses, Prospective Studies, Rectal fistula, Anus Diseases, Debridement, business.industry, complex ano-rectal fistula, mini-invasive treatment, non cutting technique, animals, anus diseases, collagen, fistula, horses, organ sparing treatments, prospective studies, rectal diseases, recurrence, treatment outcome, anal canal, lcsh:RD1-811, medicine.disease, Surgery, medicine.anatomical_structure, Rectal Diseases, Treatment Outcome, 030220 oncology & carcinogenesis, Sphincter, 030211 gastroenterology & hepatology, Collagen, business, Organ Sparing Treatments
Abstract

Summary: Background: Fistula-in-ano is one of the most commonly presenting anorectal diseases. Sphincter sparing treatment options should be considered in patients with complex fistulas. Salvecoll-E gel is a native collagen deantigenated and purified, non-cross-linked equine dermal extract, with an amino acid composition identical to human collagen. Methods: The multicentric trial study was a prospective, single-arm observational clinical study with the objective to assess the efficacy of Salvecoll-E gel for anal fistula repair in 70 patients. All patients had undergone preliminary surgical treatment consisting of positioning of a draining loosing seton that was maintained for a period of 4–6 weeks. After seton removal, a gentle debridement and washing of the fistula track was performed. The scar tissue was removed from the internal orifice. Internal opening was covered by a side-to side mucosal suture. Salvecoll-E was injected through the external opening into the fistula track, the external opening it has been opened. Results: Twelve months after surgery, 55 patients demonstrated a clinically healed fistula (78,5%), 15 patients have a recurrence (21,5%). Most of the recurrences were observed in the first 6 months of treatment (13/15, 86.6%). We don't observe any worsening in CCF score. The results obtained at 1 year certainly seem satisfactory and in line with the best results published in literature using mini-invasive techniques. Conclusion: Salvecoll-E gel is a promising non-invasive technique for conservative treatment of anal fistulas, it's well tolerated by the patients and, in case of recurrence, reinjection or all other known techniques are feasible. Keywords: Complex ano-rectal fistula, Non cutting technique, Mini-invasive treatment

Published
2019

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