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The ever-growing 1.15 million new cases of cancer on a yearly basis alone in India is a major cause of concern for the experts and researchers working in various biomedical organizations. The advent of modern text engineering strategies and NLP techniques can play a crucial role in the discovery and analysis of pre-existing knowledge present in the cancer related biomedical archives. The available 10 Cancer hallmarks can provide key insights and make significant impact in the ongoing cancer research. It is extremely important to identify and classify required information due to time and resource crunch which needs to be quickly accessed. This article introduces a novel machine learning framework called Cancer Hallmark Classification and Topic Modeling (CHCTM), designed for supervised learning. The CHCTM framework is capable of semantically learning, categorizing, and extracting significant topics and their combinations related to the hallmarks of cancer (HoC) from a dataset comprising 1499 PubMed documents. The key contributions of this research include the creation of an innovative ensemble classification model using a meta-classifier based on Random Forest (RF). Additionally, it introduces an Enhanced Latent Dirichlet Allocation (ELDA) topic modeling strategy to generate relevant mixtures of topics. The performance of the CHCTM framework is evaluated using precision, recall, accuracy, and F-score parameters. Comparative analysis with other biomedical baseline methods reveals an 8% improvement in F-score. The coherence values acquired for ELDA are tallied and weighted against PLSA and LDA models to demonstrate the effectiveness of this approach. [ABSTRACT FROM AUTHOR]

This paper presents an interpretable, spiking neural classifier (IpT-SNC) with time-varying weights. IpT-SNC uses a two-layered spiking neural network (SNN) architecture in which weights of synapses are modeled using amplitude-modulated, time-varying Gaussian functions. Self-regulated particle swarm optimization (SRPSO) is used to update the amplitude, width, and centers of the Gaussian functions and thresholds of neurons in the output layer. IpT-SNC has been developed to improve the interpretability of spiking neural networks. The time-varying weights in IpT-SNC allow us to describe the rationale behind predictions in terms of specific input spikes. The performance of IpT-SNC is evaluated on ten benchmark datasets in the UCI machine learning repository and compared with the performance of other learning algorithms. According to the performance results, IpT-SNC enhances classification performance on testing datasets from a minimum of 0.5% to a maximum of 7.7%. The significance level of IpT-SNC with other learning algorithms is evaluated using statistical tests like the Friedman test and the paired t-test. Furthermore, on the challenging real-world BCI (Brain Computer Interface) competition IV dataset, IpT-SNC outperforms current classifiers by about 8% in terms of classification accuracy. The results indicate that IpT-SNC has better generalization performance than other algorithms. [ABSTRACT FROM AUTHOR]

Background: Liquid biopsy represents a major development in cancer research, with significant translational potential. Similarly, it is increasingly recognized that multi-omic molecular approaches are a powerful avenue through which to understand complex and heterogeneous disease biology. We hypothesize that merging these two promising frontiers of cancer research will improve the discriminatory capacity of current models and allow for improved clinical utility. Methods: We have compiled a cohort of patients with glioblastoma, brain metastasis, and primary central nervous system lymphoma. Cell-free methylated DNA immunoprecipitation (cfMeDIP) and shotgun proteomic profiling was obtained from the cerebrospinal fluid (CSF) of each patient and used to build tumour-specific classifiers. Results: We show that the DNA methylation and protein profiles of cerebrospinal fluid can be integrated to fully discriminate lymphoma from its diagnostic counterparts with perfect AUC of 1 (95% confidence interval 1–1) and 100% specificity, significantly outperforming single-platform classifiers. Conclusions: We present the most specific and accurate CNS lymphoma classifier to date and demonstrates the synergistic capability of multi-platform liquid biopsies. This has far-reaching translational utility for patients with newly diagnosed intra-axial brain tumours. [ABSTRACT FROM AUTHOR]

Cardio Vascular Diseases (CVD) has become a serious concern for humans as fatalities rate due to CVD are increasing at an alarming pace. With the aid of machine learning techniques, heart illnesses can be predicted much earlier, and therapy or dietary changes can prevent deaths. By combining predictions from various individual models, the machine learning technique known as ensemble learning improves forecasting accuracy and resiliency. In this work, a Super Learner Ensemble Model is used where the base learners are a diverse combination of linear, probabilistic, bagging, boosting and stacking models. To improve the performance of the Super Learner Ensemble Model, an Optimized Super Learner Ensemble Model (OSLEM) is proposed, where optimal selection of base learners in the ensemble is done based on the pairwise disagreement accuracy diversity measure of classifiers in each best fitness whale obtained by different iterations of Whale Optimization Algorithm (WOA). ModifiedBoostARoota (MBAR), a wrapper feature selection technique is used to choose the most significant features of six different heart datasets and the proposed OSLEM modelled on the selected features exhibits high performance compared to other existing ensemble models. [ABSTRACT FROM AUTHOR]

Background: Malassezia yeasts are almost universally present on human skin worldwide. While they can cause diseases such as pityriasis versicolor, their implication in skin homeostasis and pathophysiology of other dermatoses is still unclear. Their analysis using native microscopy of skin tape strips is operator dependent and requires skill, training and significant amounts of hands‐on time. Objectives and Methods: To standardise and improve the speed and quality of diagnosis of Malassezia in skin tape strip samples, we sought to create an artificial intelligence‐based algorithm for this image classification task. Three algorithms, each using different internal architectures, were trained and validated on a manually annotated dataset of 1113 images from 22 samples. Results: The Vision Transformer‐based algorithm performed the best with a validation accuracy of 94%, sensitivity of 94.0% and specificity of 93.5%. Visualisations providing insight into the reasoning of the algorithm were presented and discussed. Conclusion: Our image classifier achieved very good performance in the diagnosis of the presence of Malassezia yeasts in tape strip samples of human skin and can therefore improve the speed and quality of, and access to this diagnostic test. By expanding data sources and explainability, the algorithm could also provide teaching points for more novice operators in future. [ABSTRACT FROM AUTHOR]

Manual investigation of chest radiography (CXR) images by physicians is crucial for effective decision-making in COVID-19 diagnosis. However, the high demand during the pandemic necessitates auxiliary help through image analysis and machine learning techniques. This study presents a multi-threshold-based segmentation technique to probe high pixel intensity regions in CXR images of various pathologies, including normal cases. Texture information is extracted using gray co-occurrence matrix (GLCM)-based features, while vessel-like features are obtained using Frangi, Sato, and Meijering filters. Machine learning models employing Decision Tree (DT) and Random Forest (RF) approaches are designed to categorize CXR images into common lung infections, lung opacity (LO), COVID-19, and viral pneumonia (VP). The results demonstrate that the fusion of texture and vessel-based features provides an effective ML model for aiding diagnosis. The ML model validation using performance measures, including an accuracy of approximately 91.8% with an RF-based classifier, supports the usefulness of the feature set and classifier model in categorizing the four different pathologies. Furthermore, the study investigates the importance of the devised features in identifying the underlying pathology and incorporates histogram-based analysis. This analysis reveals varying natural pixel distributions in CXR images belonging to the normal, COVID-19, LO, and VP groups, motivating the incorporation of additional features such as mean, standard deviation, skewness, and percentile based on the filtered images. Notably, the study achieves a considerable improvement in categorizing COVID-19 from LO, with a true positive rate of 97%, further substantiating the effectiveness of the methodology implemented. Graphic Abstract [ABSTRACT FROM AUTHOR]

The problem of distinguishing the terms "classification attribute", "motivational attribute", "semantic attribute" arose in connection with the active development of cognitive linguistics and the expansion of its terminology. The article describes for the first time approaches to understanding terms in a comparative aspect. The author analyzes dictionary definitions, consistently identifying classification, motivational, semantic features of lexemes, demonstrating the differences between these features. The author comes to the conclusion that the terms "classification attribute", "motivational attribute", "semantic attribute" differ functionally, their use is due to the paradigm and the field of linguistics in which the researcher works. Purpose. The purpose of the study is to distinguish the terms "classification attribute", "motivational attribute", "semantic attribute". Materials and methods. The material for the study was contexts with these terms extracted from scientific papers on cognitive linguistics, word formation, theoretical semantics, as well as dictionary entries. The descriptive and comparative methods, and method of theoretical analysis, were used. Results. The results of the study showed that the terms "motivational attribute", "semantic attribute", "classification attribute" differ functionally. The study of motivational attribute is aimed at identifying linguistic patterns. The study of semantic attribute is aimed at describing lexical (linguistic) meanings. The analysis of classification attribute aims to identify extralinguistic, namely cognitively significant information about the objects of reality. Practical implications. The results of the study can be used in lexicographic and translation practice, in research on issues of nomination, lexical meaning and linguistic categorization.

Abstract Data categorization is a top concern in medical data to predict and detect illnesses; thus, it is applied in modern healthcare informatics. In modern informatics, machine learning and deep learning models have enjoyed great attention for categorizing medical data and improving illness detection. However, the existing techniques, such as features with high dimensionality, computational complexity, and long-term execution duration, raise fundamental problems. This study presents a novel classification model employing metaheuristic methods to maximize efficient positives on Chronic Kidney Disease diagnosis. The medical data is initially massively pre-processed, where the data is purified with various mechanisms, including missing values resolution, data transformation, and the employment of normalization procedures. The focus of such processes is to leverage the handling of the missing values and prepare the data for deep analysis. We adopt the Binary Grey Wolf Optimization method, a reliable subset selection feature using metaheuristics. This operation is aimed at improving illness prediction accuracy. In the classification step, the model adopts the Extreme Learning Machine with hidden nodes through data optimization to predict the presence of CKD. The complete classifier evaluation employs established measures, including recall, specificity, kappa, F-score, and accuracy, in addition to the feature selection. Data related to the study show that the proposed approach records high levels of accuracy, which is better than the existing models.

Human Activity Recognition (HAR), alongside Ambient Assisted Living (AAL), are integral components of smart homes, sports, surveillance, and investigation activities. To recognize daily activities, researchers are focusing on lightweight, cost-effective, wearable sensor-based technologies as traditional vision-based technologies lack elderly privacy, a fundamental right of every human. However, it is challenging to extract potential features from 1D multi-sensor data. Thus, this research focuses on extracting distinguishable patterns and deep features from spectral images by time-frequency-domain analysis of 1D multi-sensor data. Wearable sensor data, particularly accelerator and gyroscope data, act as input signals of different daily activities, and provide potential information using time-frequency analysis. This potential time series information is mapped into spectral images through a process called use of 'scalograms', derived from the continuous wavelet transform. The deep activity features are extracted from the activity image using deep learning models such as CNN, MobileNetV3, ResNet, and GoogleNet and subsequently classified using a conventional classifier. To validate the proposed model, SisFall and PAMAP2 benchmark datasets are used. Based on the experimental results, this proposed model shows the optimal performance for activity recognition obtaining an accuracy of 98.4% for SisFall and 98.1% for PAMAP2, using Morlet as the mother wavelet with ResNet-101 and a softmax classifier, and outperforms state-of-the-art algorithms. [ABSTRACT FROM AUTHOR]

Objective: Panic disorder is a modestly heritable condition. Currently, diagnosis is based only on clinical symptoms; identifying objective biomarkers and a more reliable diagnostic procedure is desirable. We investigated whether people with panic disorder can be reliably diagnosed utilizing combinations of multiple polygenic scores for psychiatric disorders and their intermediate phenotypes, compared with single polygenic score approaches, by applying specific machine learning techniques. Methods: Polygenic scores for 48 psychiatric disorders and intermediate phenotypes based on large-scale genome-wide association studies (n = 7556–1,131,881) were calculated for people with panic disorder (n = 718) and healthy controls (n = 1717). Discrimination between people with panic disorder and healthy controls was based on the 48 polygenic scores using five methods for classification: logistic regression, neural networks, quadratic discriminant analysis, random forests and a support vector machine. Differences in discrimination accuracy (area under the curve) due to an increased number of polygenic score combinations and differences in the accuracy across five classifiers were investigated. Results: All five classifiers performed relatively well for distinguishing people with panic disorder from healthy controls by increasing the number of polygenic scores. Of the 48 polygenic scores, the polygenic score for anxiety UK Biobank was the most useful for discrimination by the classifiers. In combinations of two or three polygenic scores, the polygenic score for anxiety UK Biobank was included as one of polygenic scores in all classifiers. When all 48 polygenic scores were used in combination, the greatest areas under the curve significantly differed among the five classifiers. Support vector machine and logistic regression had higher accuracy than quadratic discriminant analysis and random forests. For each classifier, the greatest area under the curve was 0.600 ± 0.030 for logistic regression (polygenic score combinations N = 14), 0.591 ± 0.039 for neural networks (N = 9), 0.603 ± 0.033 for quadratic discriminant analysis (N = 10), 0.572 ± 0.039 for random forests (N = 25) and 0.617 ± 0.041 for support vector machine (N = 11). The greatest areas under the curve at the best polygenic score combination significantly differed among the five classifiers. Random forests had the lowest accuracy among classifiers. Support vector machine had higher accuracy than neural networks. Conclusions: These findings suggest that increasing the number of polygenic score combinations up to approximately 10 effectively improved the discrimination accuracy and that support vector machine exhibited greater accuracy among classifiers. However, the discrimination accuracy for panic disorder, when based solely on polygenic score combinations, was found to be modest. [ABSTRACT FROM AUTHOR]

Deep convolutional neural networks often perform poorly when faced with datasets that suffer from quantity imbalances and classification difficulties. Despite advances in the field, existing two-stage approaches still exhibit dataset bias or domain shift. To counter this, a phased progressive learning schedule has been proposed that gradually shifts the emphasis from representation learning to training the upper classifier. This approach is particularly beneficial for datasets with larger imbalances or fewer samples. Another new method a coupling-regulation-imbalance loss function is proposed, which combines three parts: a correction term, focal loss, and LDAM loss. This loss is effective in addressing quantity imbalances and outliers, while regulating the focus of attention on samples with varying classification difficulties. These approaches have yielded satisfactory results on several benchmark datasets, including Imbalanced CIFAR10, Imbalanced CIFAR100, ImageNet-LT, and iNaturalist 2018, and can be easily generalized to other imbalanced classification models. Deep convolutional neural networks often perform poorly when faced with datasets that suffer from quantity imbalances and classification difficulties. Despite advances in the field, existing two-stage approaches still exhibit dataset bias or domain shift. To counter this, a phased progressive learning schedule has been proposed that gradually shifts the emphasis from representation learning to training the upper classifier. This approach is particularly beneficial for datasets with larger imbalances or fewer samples. Another new method a coupling-regulation-imbalance loss function is proposed, which combines three parts: a correction term, focal loss, and LDAM loss. This loss is effective in addressing quantity imbalances and outliers, while regulating the focus of attention on samples with varying classification difficulties. These approaches have yielded satisfactory results on several benchmark datasets, including Imbalanced CIFAR10, Imbalanced CIFAR100, ImageNet-LT, and iNaturalist 2018, and can be easily generalized to other imbalanced classification models. [ABSTRACT FROM AUTHOR]

Classification is a significant step in many applications like image classifications, text recognition, categorization of speech, facial expression classification and so on. And the features fed to the classifier affects the accuracy or performance. The components or patterns of an item in a picture that assist to identify it are termed as features of an item. In computer vision and image processing, the feature carries the information about the content of an image. In classification challenges, the process of extracting features from an object is essential. There are several techniques or features which are used. This paper gives an explanation of different types of feature extraction techniques or methodologies that are used to extract the features out of an image along with classification. Here the facial expressions images are taken. Support vector machine and K-Nearest Neighbor classifier are taken to classify the facial expressions images. The image features used here are local binary pattern (LBP), entropy and histogram of oriented gradients (HOG). The CK+ 48 image dataset is taken here and the MATLAB software is used to obtain the results. The features are extracted and fed to the classifiers. The results show a better accuracy when one feed the three features (LBP, HOG, and entropy) simultaneously. According to the results it is concluded that the accuracy or performance of a classifier depends on the selection of the features of an image or we can say that the classification results are dependent on selected features and classifiers. [ABSTRACT FROM AUTHOR]

Agriculture is the primary source of income for the majority of the Indian farming community. Plantation crops play a significant part in improving the farmers' economic condition. The proposed work aims to develop a system model for prognostic reasoning by analyzing the impact of fertilizer and irrigation on areca nut crop yield, as well as to predict diseases that may affect areca nut palms using data analytics and a formal statistical approach. The dataset is constructed by interacting with the farmers in the Mangaluru region of Karnataka, India. To find the optimal features, the formal statistical test chi-square is applied. The performance of various classifiers, such as Logistic Regression, Nave Bayes, Support Vector Machine, Decision Tree, and Random Forest, is examined during prognostic reasoning. For disease prediction and crop yield, the decision tree outperformed other classifiers with an accuracy of 96% and 95.86%, respectively. The most significant irrigation type and fertilizer for increasing areca nut crop yield are also identified. [ABSTRACT FROM AUTHOR]

Data categorization is a top concern in medical data to predict and detect illnesses; thus, it is applied in modern healthcare informatics. In modern informatics, machine learning and deep learning models have enjoyed great attention for categorizing medical data and improving illness detection. However, the existing techniques, such as features with high dimensionality, computational complexity, and long-term execution duration, raise fundamental problems. This study presents a novel classification model employing metaheuristic methods to maximize efficient positives on Chronic Kidney Disease diagnosis. The medical data is initially massively pre-processed, where the data is purified with various mechanisms, including missing values resolution, data transformation, and the employment of normalization procedures. The focus of such processes is to leverage the handling of the missing values and prepare the data for deep analysis. We adopt the Binary Grey Wolf Optimization method, a reliable subset selection feature using metaheuristics. This operation is aimed at improving illness prediction accuracy. In the classification step, the model adopts the Extreme Learning Machine with hidden nodes through data optimization to predict the presence of CKD. The complete classifier evaluation employs established measures, including recall, specificity, kappa, F-score, and accuracy, in addition to the feature selection. Data related to the study show that the proposed approach records high levels of accuracy, which is better than the existing models. [ABSTRACT FROM AUTHOR]

Coffee is one of the most important agricultural commodities. Agroforestry systems (AFS) are increasingly used in coffee cultivation because of environmental benefits, adaptability of the systems, and economic profits. However, identifying the spatial distribution of AFS through remote sensing continues to be challenging. The current systematic review focuses on the accuracies obtained and the computational methods and satellite data used in mapping coffee AFS between 2000 and 2020. To facilitate the analysis, we ordered the mapped AFS into five classes according to their density and species composition of shade trees. The Kruskal-Wallis test was applied to evaluate significative differences among classes. Both shade-tree densities and species composition affected the accuracy level. The worst results were obtained in AFS retaining many woody species from the original forest and high tree density (user accuracy <0.5). About the methods, maximum likelihood was the most widely used with very variable results; some non-parametric methods such as CART, ISODATA, RF, SMA, and SVM presented consistently high accuracy (>0.75). High spatial resolution multispectral imagery was suitable for mapping AFS; very few studies were found with radar imagery, so it would be desirable to increase its use combined with optical data. [ABSTRACT FROM AUTHOR]

This article presents a computer vision-based approach to switching electric locomotive power supplies as the vehicle approaches a railway neutral section. Neutral sections are defined as a phase break in which the objective is to separate two single-phase traction supplies on an overhead railway supply line. This separation prevents flashovers due to high voltages caused by the locomotives shorting both electrical phases. The typical system of switching traction supplies automatically employs the use of electro-mechanical relays and induction magnets. In this paper, an image classification approach is proposed to replace the conventional electro-mechanical system with two unique visual markers that represent the 'Open' and 'Close' signals to initiate the transition. When the computer vision model detects either marker, the vacuum circuit breakers inside the electrical locomotive will be triggered to their respective positions depending on the identified image. A Histogram of Oriented Gradient technique was implemented for feature extraction during the training phase and a Linear Support Vector Machine algorithm was trained for the target image classification. For the task of image segmentation, the Circular Hough Transform shape detection algorithm was employed to locate the markers in the captured images and provided cartesian plane coordinates for segmenting the Object of Interest. A signal marker classification accuracy of 94% with 75 objects per second was achieved using a Linear Support Vector Machine during the experimental testing phase. [ABSTRACT FROM AUTHOR]

With the help of advancements in connected technologies, social media and networking have made a wide open platform to share information via audio, video, text, etc. Due to the invention of smartphones, video contents are being manipulated day-by-day. Videos contain sensitive or personal information which are forged for one's own self pleasures or threatening for money. Video falsification identification plays a most prominent role in case of digital forensics. This paper aims to provide a comprehensive survey on various problems in video falsification, deep learning models utilised for detecting the forgery. This survey provides a deep understanding of various algorithms implemented by various authors and their advantages, limitations thereby providing an insight for future researchers. [ABSTRACT FROM AUTHOR]

Many philosophers hold that generics (i.e., unquantified generalizations) are pervasive in communication and that when they are about social groups, this may offend and polarize people because generics gloss over variations between individuals. Generics about social groups might be particularly common on Twitter (X). This remains unexplored, however. Using machine learning (ML) techniques, we therefore developed an automatic classifier for social generics, applied it to 1.1 million tweets about people, and analyzed the tweets. While it is often suggested that generics are ubiquitous in everyday communication, we found that most tweets (78%) about people contained no generics. However, tweets with generics received more “likes” and retweets. Furthermore, while recent psychological research may lead to the prediction that tweets with generics about political groups are more common than tweets with generics about ethnic groups, we found the opposite. However, consistent with recent claims that political animosity is less constrained by social norms than animosity against gender and ethnic groups, negative tweets with generics about political groups were significantly more prevalent and retweeted than negative tweets about ethnic groups. Our study provides the first ML-based insights into the use and impact of social generics on Twitter. [ABSTRACT FROM AUTHOR]

The presence of overlapping mangoes and leaves makes the segmentation process inaccurate. In addition, the variation in colour, texture, shape, temperature and shadow effects of the real conditioned image makes segmentation even more complex. The presence of outliers would further affect the classification accuracy. Many studies have reported the deep learning-based technique, but those methods failed to provide an effective solution due to the high processing stage and limited data usage. Hence, this work introduces a machine learning-based technique that reduces the problem of time-consuming predictions. This work aims to estimate the defected region of mangoes by enhanced segmentation and optimal feature selection to enhance classification accuracy. To detect mango fruit defects, initially, the collected mango images are pre-processed to smoothen and reduce image noise. This is achieved using the guided Gabor bilateral filter; the technique can reduce image noise without information loss. Then the obtained pre-processed image is segmented by considering the defect as a region of interest. The segmentation is achieved using the fuzzy level set method (FLSM), which creates clusters for an image's dynamic variation. Then, the features are extracted using the dual-tree complex transform (DT-CT) and the optimal features are selected using the metaheuristic algorithm adaptive tunicate swarm optimizer (ATSO). The obtained optimal features are used for the detection process, which uses an Extreme Gradient Tree boost classifier (EGTBoost) classifier and the output is generated using vote-based classification. This classifier accurately classifies the diseased and healthy mangoes. The experimentation is carried out on the Kaggle and the real-time datasets. The accuracy and precision values achieved by the proposed model are 0.969 and 0.986 on the Kaggle dataset, respectively. [ABSTRACT FROM AUTHOR]

Cyber-attacks using malicious uniform resource locator (URL) propagation are very common and serious. Statistics indicate that there is a need to research and apply techniques and methods for identifying and preventing malicious URLs. The main objective of this research is to train machine learning models on selected dataset to predict phishing websites based on URL-related features. The accuracy level of each model is measured and compared. Finally, the best performing model will be used to develop a web application that provide internet users with an easy way to check suspicious URLs. We have used five different machine learning models to classify URLs as legitimate or phishing, these models are eXtreme Gradient Boosting (XGBoost), k-nearest neighbors (KNN), support vector machine (SVM), Decision Tree, and Random Forest. Finally, we used Voting Classifier to combine the work of Random Forest (RF) algorithm with other two models, Gaussian Naive Bayes, and Logistic Regression, to check if we can increase the accuracy of RF as suggested in the literature, but we found that the accuracy of RF alone was higher than the accuracy of the combined models. This project can be implemented as a browser extension or mobile application to classify suspicious URLs to legitimate or phishing with the use of the saved model. [ABSTRACT FROM AUTHOR]

Introduction: While meaningless gross motor imitation (GMI) is a common challenge for children diagnosed with autism spectrum disorder (ASD), this topic has not attracted much attention and few appropriate test paradigms have been developed. Methods: The current study proposed a wrist rotation imitation (WRI) task (a meaningless GMI assignment), and established a WRI ability evaluation system using low-cost wearable inertial sensors, which acquired the simultaneous data of acceleration and angular acceleration during the WRI task. Three metrics (i.e., total rotation time, rotation amplitude, and symmetry) were extracted from those data of acceleration and angular acceleration, and then were adopted to construct classifiers based on five machine learning (ML) algorithms, including k-nearest neighbors, linear discriminant analysis, naive Bayes, support vector machines, and random forests. To illustrate our technique, this study recruited 49 ASD children (aged 3.5-6.5 years) and 59 age-matched typically developing (TD) children. Results: Findings showed that compared with TD children, those with ASD may exhibit shorter total rotation time, lower rotation amplitude, and weaker symmetry. This implies that children with ASD might exhibit decreased WRI abilities. The classifier with the naive Bayes algorithm outperformed than other four algorithms, and achieved a maximal classification accuracy of 88% and a maximal AUC value of 0.91. Two metrics (i.e., rotation amplitude and symmetry) had high correlations with the gross and fine motor skills [evaluated by Gesell Developmental Schedules-Third Edition and Psychoeducational Profile-3 (PEP-3)]. While, the three metrics had no significant correlation with the visual-motor imitation abilities (evaluated by the subdomain of PEP-3) and the ASD symptom severity [evaluated by the Childhood Autism Rating Scale (CARS)] . Discussion: The strengths of this study are associated with the low-cost measurement system, correlation between the WRI metrics and clinical measures, decreased WRI abilities in ASD, and high classification accuracy. [ABSTRACT FROM AUTHOR]

The current existing classifiers for distinguishing malignant from benign pulmonary nodules is limited by effectiveness or clinical practicality. In our study, we aimed to develop and validate a gene classifier for lung cancer diagnosis. To identify the genes involved in this process, we used the weighted gene co-expression network analysis to analyze gene expression datasets from Gene Expression Omnibus (GEO). We identified the three most relevant modules associated with malignant nodules and performed functional enrichment analysis on them. The results indicated significant involvement in metabolic, immune-related, cell cycle, and viral-related processes. All three modules showed enrichment in metabolic reprogramming pathways. Based on these genes, we intersected genes from the three modules with metabolic reprogramming-related genes and further intersected with differentially expressed genes to get 78 genes. After machine learning algorithms and manual selection, we finally got a nine-gene classifier consisting of SEC24D, RPSA, PSME3, PSMD8, PSMB7, NCOA1, MED12, LPCAT1, and AKR1C3. Our developed and validated classifier-based model demonstrated good discrimination, with an area under the curve (AUC) of 0.763 in the development cohort, 0.744 in the internal validation cohort, and 0.718 in the external validation cohort, and outperformed previous clinical models. Moreover, the addition of nodule size improved the predictive capability of the classifier. We further verify the expression of the gene in the classifier using TCGA lung cancer samples and found eight of the genes showed significant differential expression in lung adenocarcinoma while all nine genes showed significant differential expression in lung squamous carcinoma. Our findings underscore the significance of metabolic reprogramming pathways in patients with malignant pulmonary nodules, and our gene classifier can assist clinicians in differentiating benign from malignant pulmonary nodules in clinical settings.

Background: For pediatric patients with solid abdominal tumors, early diagnosis can guide clinical treatment decisions, and comprehensive preoperative evaluation is essential to reduce surgical risk. The aim of this study was to explore the feasibility of multiphase enhanced CT-based transformer in the early diagnosis of tumors and prediction of surgical risk events (SRE). Methods: A total of 496 pediatric patients with solid abdominal tumors were enrolled in the study. With Swin transformer, we constructed and trained two Swin-T models based on preoperative multiphase enhanced CT for personalized prediction of tumor type and SRE status. Subsequently, we comprehensively evaluated the performance of each model and constructed four benchmark models for performance comparison. Results: There was no significant difference in SRE status between tumor types. In the diagnostic task, areas under the receiver operating characteristic curves (AUC) of the Swin-T model were 0.987 (95 % CI, 0.973–0.997) and 0.844 (95 % CI, 0.730–0.940) in the training and validation cohorts, respectively. In predicting SRE, AUCs of the Swin-T model were 0.920 (95 % CI, 0.885–0.948) and 0.741 (95 % CI, 0.632–0.838) in the training and test cohorts, respectively. The Swin-T model achieved the best performance in both classification tasks compared to benchmark models. Conclusion: The Swin-T model is a promising tool to assist pediatricians in the differential diagnosis of abdominal tumors and in comprehensive preoperative evaluation.