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BACKGROUND: Bibliometrics and visual analyses based on thematic literature are particularly important for understanding the foundation and frontiers of postmenopausal osteoporosis research. OBJECTIVE: To perform bibliometric, citation, and visualization analyses of highly cited SCI papers in postmenopausal osteoporosis research over the last 20 years. METHODS: The top 100 highly cited papers on postmenopausal osteoporosis published between 2003 and 2022 included in SCI-EXPANDED catalog of the Web of Science database were obtained for bibliometric measure and visual analysis using CiteSpace software. RESULTS AND CONCLUSION: The top 100 highly cited papers have a total of 67 377 citations in the Web of Science Core Collection, with an annual average of 49.17 citations per paper. Postmenopausal osteoporosis research primarily involves medical, engineering, biological, and multidisciplinary fields. The subcategories are dominated by endocrinology and metabolism, and medicine: internal medicine. Stable and close cooperative network relationships have been formed globally. United States, University of California System, Cummings, and Steven R are the country, research institution, and author, respectively, with the most highly-cited publications. The frontiers of postmenopausal osteoporosis research mainly include calcium and vitamin D supplementation and fracture risk, clinical studies of bisphosphonates in the treatment of postmenopausal osteoporosis, atypical femur fracture, clinical studies of new drugs and sequential treatment of postmenopausal osteoporosis, predictors of fracture risk, mid- and long-term follow-up of osteoporotic vertebral compression fractures, genetic polymorphisms and hereditary factors, formulation and updating of clinical practice guidelines for postmenopausal osteoporosis. Large cohort studies, high-quality randomized controlled trials, systematic reviews, meta-analyses, and clinical practice guidelines are the great engines that drive the development of clinical research in postmenopausal osteoporosis. We should make efforts in the above areas to improve China’s international influence in the field of osteoporosis. [ABSTRACT FROM AUTHOR]

Critically ill COVID-19 patients may exhibit various clinical symptoms of renal dysfunction including severe Acute Kidney Injury (AKI). Currently, there is a lack of bibliometric analyses on COVID-19-related AKI. The aim of this study is to provide an overview of the current research status and hot topics regarding COVID-19 AKI. The literature was retrieved from the Web of Science Core Collection (WoSCC) database. Subsequently, we utilized Microsoft Excel, VOSviewer, Citespace, and Pajek software to revealed the current research status, emerging topics, and developmental trends pertaining to COVID-19 AKI. This study encompassed a total of 1507 studies on COVID-19 AKI. The United States, China, and Italy emerged as the leading three countries in terms of publication numbers, contributing 498 (33.05%), 229 (15.20%), and 140 (9.29%) studies, respectively. The three most active and influential institutions include Huazhong University of Science and Technology, Wuhan University and Harvard Medical School. Ronco C from Italy, holds the record for the highest number of publications, with a total of 15 papers authored. Cheng YC's work from China has garnered the highest number of citations, totaling 470 citations. The co-occurrence analysis of author keywords reveals that 'mortality', 'intensive care units', 'chronic kidney disease', 'nephrology', 'renal transplantation', 'acute respiratory distress syndrome', and 'risk factors' emerge as the primary areas of focus within the realm of COVID-19 AKI. In summary, this study analyzes the research trends in the field of COVID-19 AKI, providing a reference for further exploration and research on COVID-19 AKI mechanisms and treatment. [ABSTRACT FROM AUTHOR]

Renal microcirculation plays a pivotal role in kidney function by maintaining structural and functional integrity, facilitating oxygen and nutrient delivery, and waste removal. However, a thorough bibliometric analysis in this area remains lacking. Therefore, we aim to provide valuable insights through a bibliometric analysis of renal microcirculation literature using the Web of Science database. We collected renal microcirculation-related publications from the Web of Science database from January 01, 1990, to December 31, 2022. The co-authorship of authors, organizations, and countries/regions was analyzed with VOSviewer1.6.18. The co-occurrence of keywords and co-cited references were analyzed using CiteSpace6.1.R6 software to generate visualization maps. Additionally, burst detection was applied to keywords and cited references to forecast research hotspots and future trends. Our search yielded 7462 publications, with the American Journal of Physiology-Renal Physiology contributing the most articles. The United States, Mayo Clinic, and Lerman Lilach O emerged with the highest publication count, indicating their active collaborations. 'Type 2 diabetes' was the most significant keyword cluster, and 'diabetic kidney disease' was the largest cluster of cited references. 'Cardiovascular outcome' and 'diabetic kidney diseases' were identified as keywords in their burst period over the past three years. Our bibliometric analysis illuminates the contours of nephrology and microcirculation research, revealing a landscape ripe for challenges and the seeds of future scientific innovation. While the trends discerned from the literature emerging opportunities in diagnostic innovation, renal microcirculation research, and precision medicine interventions, their translation to clinical practice is anticipated to be a deliberate process. [ABSTRACT FROM AUTHOR]

Context: traditional chinese Medicine (TCM) is effective as a cancer treatment modality. however, this is the first bibliometric analysis of TCM in lymphoma treatment. Objective: this study explores the current trends and research topics of TCM in treating lymphoma from 2000 to 2023. Materials and methods: We searched within the Web of science core collection (WoSCC) for publications on TCM in lymphoma treatment, spanning 2000 to 2023. subsequently, we employed a comprehensive approach utilizing citespace software and VOSviewer to visually analyze research trends, authors, institutions, co-cited references, and keywords. Results: From January 1, 2000, to august 31, 2023, annual scientific publications on TCM for lymphoma treatment have steadily increased. among the leading institutions in this field, the Beijing University of chinese Medicine and the Fujian Medical University occupied the top positions. Regarding the authors, Jun Peng, Jiumao lin, and hongwei chen emerged as the top three contributors. in the co-citation analysis of references, the top three co-cited references were authored by hanahan D, elmore s, and livak KJ with citations numbered 13, 14, and 17, respectively. in particular, keywords reflecting current emerging trends included 'pathway', 'traditional chinese medicine', 'oxidative stress', and 'macrophage polarization'. Discussion and conclusions: this bibliometric analysis provides a comprehensive overview of TCM for lymphoma treatment. this analysis identified the predominant trends and research topics in the field. the findings are expected to be of significant value for researchers who focus on TCM in lymphoma treatment, helping them better understand the development of this field. [ABSTRACT FROM AUTHOR]

The allergens of allergic rhinitis are diverse and can be broadly categorised as inhalant and ingestible, whereas pollen is an inhalant allergen, and allergic rhinitis due to pollen has received increasing attention in recent decades. The lack of bibliometric analyses, however, poses a challenge to researchers seeking to understand general trends in this field. Literature on pollen-induced allergic rhinitis was searched from 2011 to 2023, with a total of 2,188 articles until 18 April 2024. Through the inclusion and exclusion criteria, 475 articles were finally included in the literature. Publications, countries, institutions, authors, journals, citations and keywords were analysed using VOSviewer and Citespace. Keywords with strong citation bursts were also identified by detailed analyses to identify changes and future trends in research hotspots in the field. Germany has the highest number of publications, followed by the U.S. and France. The Medical University of Vienna International (Med Univ Vienna) is the institution with the largest contribution. Prof Damialis, Athanasios from the School of Biology, Aristotle University of Thessaloniki, Greece, is the most prolific author in this field. By analysing the keywords, three research hotspots were identified: research on the pathogenesis of allergic rhinitis, research on therapeutic modalities of allergic rhinitis and research on AR risk factors and diagnostic methods. In recent years, there has been a shift in the focus of research in this area, suggesting that future research will concentrate on two cutting-edge keywords: "risk" and "airborne pollen". The interest in allergic rhinitis of pollen sensitisation is still rising and considerable collaboration has been formed between authors, journals and countries. There are also a number of very influential and productive research hotspots in this area. It is assumed that new research will continue to be conducted in this area in the future, centred on "risk" and "airborne pollen". [ABSTRACT FROM AUTHOR]

This bibliometric review explores the relationship between financial inclusion and sustainable development. It aims to identify key concepts in this research area and summarize the main findings of previous studies. The study is based on trends in the number of papers, keyword analysis, and an examination of the progression of the research topics over time. It identifies three main clusters of sustainable development—economic, social, and environmental—as well as the top authors, countries, organizations, the most frequently cited papers, reference papers, and journals. The study presents specific trends highlighting the role of financial inclusion in promoting economic growth, reducing income inequality and poverty, and mitigating climate change. This review provides a comprehensive perspective on the role of financial inclusion in sustainable development, emphasizing the need for integrated strategies that combine economic growth, social equity, and environmental sustainability. It recommends ideas for future research to further explore these relationships, providing valuable insights for policymakers and stakeholders in developing inclusive and sustainable development policies. [ABSTRACT FROM AUTHOR]

The rise of immunotherapy provided new approaches to cancer treatment. We aimed to describe the contribution of chimeric antigen receptor T cell immunotherapy to future prospects. We analyzed 8035 articles from the Web of Science Core Collection with CiteSpace that covered with various aspects with countries, institutions, authors, co-cited authors, journals, keywords, and references. The USA was the most prolific country, with the University of Pennsylvania being the most published institution. Among individual authors, June Carl H published the most articles, while Maude SL was the most frequently co-cited author. "Blood" emerged as the most cited journal. Keyword clustering revealed six core themes: "Expression," "Chimeric Antigen Receptor," "Tumor Microenvironment," "Blinatumomab," "Multiple Myeloma," and "Cytokine Release Syndrome." In the process of researching the timeline chart of keywords and references, "Large B-cell lymphoma" was located on the right side of the timeline. In the keyword prominence analysis, we found that the keywords "biomarkers," "pd-1," "antibody drug conjugate," "BCMA," and "chimeric antigen" had high explosive intensity in the recent past. We found that in terms of related diseases, "large B-cell lymphoma" and "cytokine release syndrome" are still difficult problems in the future. In the study of therapeutic methods, "BCMA," "PD-1," "chimeric antigen," and "antibody drug conjugate" deserve more attention from researchers in the future. [ABSTRACT FROM AUTHOR]

Uncertainty in the environment poses a significant challenge for supply chain management, and uncertainty theory is a branch of mathematics that focuses on analyzing uncertain phenomena. In this context, an increasing number of scholars have begun to use the uncertainty theory to study uncertain phenomena in the supply chain management, but there is still a lack of systematic literature reviews and research outlooks in this research field. To fill this gap, this paper provides a comprehensive and systematic review of the relevant literature in the Web of Science database from 2015 to May 2024 using bibliometric analysis and content analysis. First, bibliometric analysis is conducted to visualize the current state of research, including publication trends, keywords, authors, and geographical distribution. Then, through content analysis, the selected literature is categorized into seven subfields according to the research questions, including supply chain pricing decision, supply chain network disruption, supply chain network design, supply chain management considering sales efforts, sustainable supply chain management, supply chain contract design, and general supply chain management. The results indicate that the literature on the supply chain management based on the uncertainty theory is not yet mature. The research has begun to shift from single uncertainty to multidimensional uncertainty and from single-objective decision-making to multi-objective decision-making. The research direction has also shifted towards sustainability and resilience design in supply chain networks, gradually incorporating environmental and social benefits into supply chain decision-making. Based on the results of the bibliometric analysis and content analysis, future research directions are identified and potential related research opportunities are proposed, including the impact of consumer behavior, channel interaction, corporate social responsibility, and logistics service strategies on the supply chain management based on the uncertainty theory. [ABSTRACT FROM AUTHOR]

BACKGROUND: Scoliosis mainly refers to sequence abnormalities in the coronal, sagittal, and axial positions of the spine, with a Cobb angle of ≥ 10°. The patients may experience symptoms such as unequal shoulder height and back asymmetry. Severe cases may affect the patient’s cardiopulmonary function, thereby affecting their daily life. Conservative treatment can control the progression of scoliosis and avoid later surgery. Scoliosis orthosis is currently a commonly used and effective treatment measure in conservative treatment. OBJECTIVE: To summarize and analyze the current research status, hotspots, and trends of scoliosis orthoses both domestically and internationally, providing reference for related research. METHODS: Using bibliometrics and visual analysis as tools, and using a comparison between China and foreign countries as a method, this paper analyzes the literature on scoliosis orthosis journals in the past decade. Based on bibliometrics, the current status of research on scoliosis orthoses is determined. Citespace software is used to analyze key words and identify the current hotspots and future trends in scoliosis orthosis research. RESULTS AND CONCLUSION: (1) At present, the number of literature on scoliosis orthoses is still on a fluctuating upward trend. China and the United States are the main countries for research, with a literature share of over 40%. However, the average citation rate of foreign language literature by Chinese scholars is relatively low. (2) The basic fields of domestic research are mainly surgery and pediatrics, while orthotics and clinical neurology are mainly studied abroad. Among them, there is also a certain number of documents in domestic Chinese medicine, indicating that China is also engaged in the combination of Chinese and Western treatment of scoliosis. The National Natural Science Foundation of China has the highest proportion in the aspect of Chinese and foreign literature, reflecting the importance of the fund attaches to the research of scoliosis orthosis. (3) The authors with the highest number of publications are Qiu Yong and Negrini Stefano, and the most published institutions are the Spinal Surgery Department of Gulou Hospital affiliated to Nanjing University Medical College and UDICE-French Research University. Domestic and foreign authors and institutions have certain communications about this, but not closely, which requires relevant institutions and scholars to further explore and study. (4) From the research hotspots and future trends, the main treatment type is adolescent idiopathic scoliosis, while the production method of the short-column side bending orthosis is three-dimensinoal printing, and the main treatment index is convex progression. The ultimate purpose of treatment is to improve the quality of life of the patients. [ABSTRACT FROM AUTHOR]

BACKGROUND: Spinal cord injury is a serious hazard. Walking dysfunction affects the patients’ quality of life most. Researches on assisted-walking with exoskeleton robots on patients with spinal cord injury have become increasingly active. OBJECTIVE: To map scientific researches of exoskeleton-assisted walking after spinal cord injury using the CiteSpace software, and to discuss the state of art, cutting-edges in the past 10 years, and trends of research in this field, in hope of providing insights for future investigations and clinical applications. METHODS: Using the Web of Science core database to conduct subject term search by Boolean logical operators, the language English was selected, search strategy: TS=“spinal cord injury OR SCI” AND “walk OR walking” AND “robot OR exoskeleton OR (exoskeleton-assisted walking) OR EAW”. The knowledge graph software CiteSpace 6.2.R4 was used to de-emphasize the high-quality literature. The high-quality literature obtained after reweighting was subjected to visualization analysis of hotspots and international frontier trends, such as the number of publications, country/research institution cooperation, high-influence authors/literature co-citation, keyword co-occurrence/clustering/emergence, and the scientific knowledge graph was mapped. RESULTS AND CONCLUSION: (1) A total of 544 high-quality articles were included, and the number of articles and total citation frequency in this field have shown an increasing trend in the past 10 years. (2) The top 3 countries in terms of number of publications are the USA, China, and Italy, and the top 3 research institutions are the U.S. Department of Veterans Affairs, the U.S. Veterans Health Administration, and the Swiss Federal Institute of Technology Domian. (3) The authors with the highest citation frequency (167) and betweenness centrality (0.13) are Professor Esquenazi A, University of Pennsylvania, USA, showing a high influence in this field. (4) The analysis of the top 5 cited documents in terms of citation frequency and betweenness centrality shows that: the current research on walking rehabilitation for spinal cord injury patients equipped with powered exoskeleton devices focuses on the judgment of the safety of walking rehabilitation training in real-life environments such as institutions and homes, analysis of the advantages and disadvantages of walking rehabilitation training, design of individualized training programs, and the advantages and disadvantages of the application of powered exoskeleton devices in assisted walking for patients with complete loss of locomotor function in thoracic vertebrae and the segments below, the factors affecting the effectiveness of assisted walking, and the potential for application. (5) In recent years, research in this field has focused on individuals, gait, powered exoskeleton, body weight support, functional electrical stimulation, rehabilitation, assistive technology, ambulation, recovery, and so on. (6) Early research in this field was mostly applied to stroke patients, and the frontier includes weight loss support, reciprocating gait orthosis, functional electrical stimulation and other technical means. Spinal cord injury exoskeleton-assisted walking rehabilitation research has shown an upward trend in recent years, and the focus of attention to the development of adaptive control as the mechanism of the medical lower extremity exoskeleton equipment, safety enhancement, the application of the potential to tap into the cutting-edge direction of the change, the research and detection means on the joint function of the near-infrared spectroscopic imaging and other highend technologies, focusing on the quality of life of the patient to enhance the ability of athletic training, and to improve the body’s structure of the field of the future hotspots and the frontier of the research. [ABSTRACT FROM AUTHOR]

Background: Multiple sclerosis (MS) is a chronic, progressive autoimmune disease, with increasing attention on the role of B cells in its pathogenesis. Despite this growing interest, a comprehensive analysis of research trends and emerging foci on B cells in MS is currently lacking. In this research, we utilize a bibliometric approach to visualize and analyze research trends and focal points in this field, offering a valuable reference for future mechanistic studies in MS. Methods: We retrieved bibliometric data from the Web of Science Core Collection (WOSCC) for articles published between 2014 and 2023. VOSviewer 1.6.18 and CiteSpace 5.7R3 were used for co-authorship, co-occurrence, and citation analyses to identify key researchers, institutions, countries, and emerging themes in B cell research related to MS. Results: The analysis examined 5,578 articles published in 1,041 journals by 5,337 institutions globally. The United States leads in publication output, with Amit Bar-Or identified as the most influential author, and Frontiers in Immunology as the top journal in the field. Research has increasingly focused on the complex role of B cells in MS, particularly their involvement in the central nervous system (CNS) and mechanisms of anti-B cell therapy. Recent trends point to a growing focus on meningeal inflammation, kinase inhibitors, and Epstein-Barr virus, signaling a shift in research priorities. Conclusion: This bibliometric analysis highlights pivotal research trends, key contributors, and emerging areas of interest in B cell research in MS from 2013 to 2024. The findings underscore the growing recognition of the multifaceted role of B cells in MS pathogenesis, particularly their involvement in the CNS compartment and the potential of targeted therapies. The study identifies meningeal inflammation, Epstein-Barr virus infection, and kinase inhibitors as promising avenues for future research. The analyses driving the in-depth exploration of B cell mechanisms in MS and the development of novel diagnostic and therapeutic strategies provide researchers in the MS field with a comprehensive and objective perspective, serving as a valuable reference for accelerating the translation of basic research findings into clinical applications. [ABSTRACT FROM AUTHOR]

In recent years, the integration of immunotherapy in the treatment of lung cancer has marked a significant evolution in the field. This is evidenced by the surge in the volume of scientific publications, reflecting rapid advances over time. This paper presents a bibliometric analysis of lung cancer and immunotherapy research from January 2012 to December 2022, drawing on the Web of Science literature database and using the citexs data analysis platform to examine the shifts in topic hotspots over the decade. A total of 8,722 publications were retrieved, with annual publication numbers soaring from 79 in 2012 to 2,112 in 2021. The most prolific country in terms of publication volume was China (n = 3,363, 38.56%), with The University of Texas MD Anderson Cancer Center making the most significant institutional contribution (n = 156, 1.79%). Notably, the most productive authors in this domain were Benjamin Besse and Marina Chiara Garassino, who have collectively published 35 articles to date. Predominant research themes include PD1/PDL1, clinical trials, pembrolizumab, nivolumab, and immune checkpoint inhibitors. Moreover, this paper visualizes the analysis of journals, keywords, key genes and targets, and associated diseases, aiming to provide a systematic review and a forward-looking perspective on research in lung cancer and immunotherapy. By exploring current research dynamics and hotspots and identifying areas for improvement, this study seeks to provide valuable insights for future investigations in this burgeoning field. [ABSTRACT FROM AUTHOR]

Background: Traumatic brain injury (TBI) is a critical global health concern characterized by elevated rates of both morbidity and mortality. The pathological and physiological changes after TBI are closely related to microglia. Microglia, the primary immune cells in the brain, are closely linked to the mechanisms and treatment of TBI. With increasing research in this area, this study employs bibliometric analysis to identify current research hotspots and predict future trends. Objective: We decided to perform a bibliometric analysis to provide a comprehensive overview of the advancements in microglia research related to traumatic brain injury. We aim to offer researchers insights into current trends and future research directions. Method: We collected all articles and reviews related to microglia and traumatic brain injury published between 2000 and 2023 from the Web of Science Core Collection. These records were analyzed using VOSviewer, CiteSpace, and the R package "bibliometrix". Results: We retrieved 665 publications from 25 countries, with the majority contributed by the United States and China. The number of publications on traumatic brain injury and microglia has been steadily increasing each year. Our analysis highlighted the Journal of Neurotrauma and the Journal of Neuroinflammation as the most influential journals in this field. Alan I. Faden and David J. Loane are recognized as leading contributors. Keyword analysis indicates that neuroinflammation, microglial polarization, and neurodegenerative diseases are pivotal areas for future research. Conclusion: In recent years, research on TBI-related microglia has proliferated, with current studies primarily focusing on microglial involvement in neuroinflammation, neurodegenerative changes, and microglial polarization following TBI. Since neuroinflammation and neurodegeneration are two hallmark features of TBI, targeting microglia in TBI treatment may become a central focus for future research. [ABSTRACT FROM AUTHOR]

Background: This research aimed to examine the global developing patterns in the treatment of diabetic peripheral neuropathy (DPN) using a bibliometric analysis of published literature. Methods: We extracted publication data from papers published between 2014 and 2024 using a specific topic search in the "Web of Science Core Collection" (WoSCC) database. Various metrics, such as the number of papers, citations, authors, countries, institutions, and references, were collected for analysis. To further explore the data, CiteSpace was employed to examine co-citation patterns among authors, identify collaborative efforts between countries and institutions, and uncover emerging trends using burst keywords and reference analysis. Results: The study encompassed 2,488 publications that exhibited an increasing trend in annual output. Notably, the journal PAIN , the United States, the Pfizer institution, and the author Feldman, EvaL emerged as the most prolific contributors to this research domain. The term "placebo-controlled trial" was the most prominent burst keyword from 2014 to 2017, whereas "spinal cord stimulation" held this distinction in the recent 5-year span. Furthermore, the publication titled "Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis-2015" demonstrated the highest burst in terms of references. Conclusion: This study is the first to objectively reveal the current hotspots and trends in DPN treatment. The results indicate that drug therapy remains the primary first-line treatment for DPN and that future research on DPN treatment will likely focus on "spinal cord stimulation" and "pain management." These findings provide valuable insights into DPN treatment. [ABSTRACT FROM AUTHOR]

Background: Studies exploring the role of ferroptosis in the pathogenesis of breast cancer have proliferated over the past decade, especially in 2023, with a staggering 217 publications in related studies. However, there are still significant gaps in comprehensive scientometric analysis and mapping of scientific studies, especially in terms of temporal and study area tracking, principal investigators, and the emergence of new hotspots. Objective: This study aims to summarize the role of ferroptosis in the development of breast cancer and the latest research results on the ferroptosis-targeted treatment of breast cancer and to use bibliometric methods to draw a visual map to explore future research trends. Methods: On May 11, 2024, this study updated the research progress related to ferroptosis and breast cancer over the past 11 years by retrieving data from January 1, 2014, to May 1, 2024, from the Web of Science database. In this research, many scientific analysis software including VOSviewer, chorddiag R Language Pack, Scimago Graphica, Citespace 6.3.R1, Cluster Profiler, enrichplot, ggplot2 R Language Pack, Cytoscape, and STRING online platform are used to make in-depth scientific analysis and visualization of the measurement results. Results: Statistical analysis of these data showed that China accounted for 74.43% of the total publications, highlighting China's dominant role in research on the relationship between ferroptosis and breast cancer. Several research institutions, including Sun Yat-sen University, Zhejiang University, and Shanghai Jiao Tong University, have achieved impressive results. Efferth, Thomas is the most prominent author in this field and has the highest number of publications in the subfield of oncology. This study clearly shows that ferroptosis plays a crucial role in the development of triple-negative breast cancer, hepatocellular carcinoma, glioma, leukemia, mitochondrial disease, lymphoma, bladder tumors, lung adenocarcinoma, and esophageal tumors. Conclusion: This study provides a comprehensive bibliometric evaluation that deepens our understanding of the role of ferroptosis in the pathogenesis of breast cancer and the current status of targeting ferroptosis for treating breast cancer. Thus, it helps researchers in related fields explore new research directions by comprehensively extracting important information and research hotspots. [ABSTRACT FROM AUTHOR]

Background: Although the number of studies on treatment-resistant schizophrenia (TRS) has been increasing, the global research hotspots and future research trends have not yet been established. Objective: This study identify the hotspots of TRS research and predict future research trends using a bibliometric analysis. Methods: The Web of Science Core Collection was searched using the keyword "TRS", econometric and co-occurrence analyses were conducted using CiteSpace and VOSviewer software, and the results were visualised. PRISMA reporting guidelines were used for this study. Results: In total, 912 publications were included in the analysis. The number of publications on TRS has shown an increasing trend over the past 20 years. The United States and University of London were the countries and institutions with the highest total number of publications, respectively. Schizophrenia Research was the journal with the highest number of articles. American Journal of Psychiatry was the most cited journal. Based on the results of this analysis, cognitive impairment, clozapine-resistant schizophrenia, early-onset schizophrenia, and early recognition of TRS will be hotspots for future research in this field. Conclusion: There has been an upward trend in the number of publications on TRS each year. However, issues such as how to use antipsychotics more efficiently to treat TRS and how to predict the emergence of TRS as early as possible are still in urgent need of research and are current challenges for clinicians. The results of this study not only predict and analyse future research hotspots but also help researchers identify appropriate research directions and partners. [ABSTRACT FROM AUTHOR]

ABSTRACT Background Methods Results Conclusions Acne vulgaris is a chronic inflammatory skin condition, commonly resulting in acne scars. Treating acne scars remains a significant challenge in dermatology. With advancements in laser technology, its clinical use for treating acne scars has been increasing annually. However, bibliometric analysis on laser treatment for acne scars is lacking. This study aims to use bibliometrics to comprehensively understand the development trends and research hotspots in laser treatment for acne scars.Using “acne scar” and “laser” as search terms, literature on laser treatment of acne scars from 2014 to 2024 was retrieved from the Web of Science Core Collection (WoSCC) database. The literature data were visualized using VOSviewers, CiteSpace, and R software, generating maps of countries, research institutions, authors, journals, references, and keywords.The analysis included 536 articles from 46 countries, with the United States and China leading in publications. Publications focusing on laser treatment of acne scars exhibit a consistent growth trend annually. Key research institutions include Mahidol University in Thailand, Cairo University in Egypt, and Hallym University in South Korea. The “Journal of Cosmetic Dermatology” had the highest number of articles in this field, while “Dermatologic Surgery” was the most cited publication. These publications involved contributions from 2135 authors, with Professor Manuskiatti Woraphong from Mahidol University in Thailand being the most prolific author in this field. Research on the efficacy of laser treatment for acne scars is a major focus in this field. Among the different types of lasers, CO2 lasers are the most commonly used. Emerging research focuses include therapies such as platelet‐rich plasma, picosecond laser, trichloroacetic acid, and burn scar.Treatment efficacy is the primary focus of research in the field of laser treatment for acne scars. Platelet‐rich plasma, and novel picosecond lasers, have emerged as hot topics and trends in this research field. However, it is important to note that the impact factors of journals publishing in this field are currently low. Therefore, clinicians must consider and explore strategies for publishing high‐quality clinical research in the future. [ABSTRACT FROM AUTHOR]

Utilizing the Web of Science database as a retrieval source, this study employs CiteSpace software to conduct a visualization analysis of 8380 documents related to outdoor education published from 1994 to 2023. The findings reveal a phased increase in the volume of outdoor education research, with a shift in research themes from environmental governance to environmental education, ultimately concentrating on education for sustainable development that is characterized by significant temporal features. Initially dominated by publications from Europe and North America, the geographical distribution of research has gradually expanded globally. The core research theme centres around environmental education, with experiential education, outdoor learning, and education for sustainable development evolving concurrently. The network structure of research collaboration predominantly involves higher education institutions, with a noticeable shift from limited disciplinary research to interdisciplinary integration across multiple fields. [ABSTRACT FROM AUTHOR]

Textbook research has long been a critical area within the educational academic community. With the ongoing spread of globalization, the significance of educational globalization has become increasingly apparent. Comparative analyses of textbooks from different countries have thus emerged as a popular and critical research topic. In recent years, there has been a growing interest in cross-cultural textbook studies, highlighting the need for a deeper understanding of global disparities in this field. This study compiles essential findings from both domestic and international textbook research, aiming to uncover differences and trends. Using CiteSpace software (V.6.2.R4), a comprehensive visual analysis was conducted through bibliometric and knowledge graph methods, comparing Chinese and international textbook research over the past decade (2013–2023). This paper presents an intuitive visual map of the key dynamics in textbook research. Utilizing a quantitative approach, this study analyzed 1644 and 1478 relevant articles from the Web of Science (WoS) and the China National Knowledge Infrastructure (CNKI) databases, respectively. It examined the annual distribution, core contributors, and institutional co-occurrence of textbook research from 1 January 2013 to 31 December 2023, identifying the distinctive characteristics of textbook research both in China and internationally. Additionally, CiteSpace's built-in algorithm was used to extract keywords and highlight primary research areas, while keyword burst detection was utilized to illustrate developmental trends. The analysis revealed key differences between Chinese and international textbook research in terms of research focus, organizational forms, focal areas, and future development trends. This study also discusses potential future directions in this area, such as establishing a systematic framework for textbook research, fostering a global community of textbook scholars, and integrating localized elements into textbook research. Additionally, it highlights the importance of sustainability in textbook research, emphasizing the need for educational materials that support long-term global educational goals. [ABSTRACT FROM AUTHOR]

Urban transportation data are crucial for smart city development, enhancing traffic management's intelligence, accuracy, and efficiency. This paper conducts a comprehensive investigation encompassing policy analysis, a literature review, concept definition, and quantitative analysis using CiteSpace from both domestic and international perspectives. Urban transportation data comprise multiple dimensions, such as infrastructure status, real-time monitoring, policy planning, and environmental assessment, which originate from various sources and stakeholders. Highly influential authors and active institutions, particularly in the USA, China, Canada, and England, contribute significantly to extensive and collaborative research. Key areas include intelligent transportation, traffic flow prediction, data fusion, and deep learning. Domestic research focuses on practical applications, while international studies delve into interdisciplinary research areas. With advancements in intelligent systems and big data technology, research has evolved from basic data collection to sophisticated methodologies, such as deep learning and spatiotemporal analysis, driving substantial progress. This paper concludes by recommending enhanced data integration, improved privacy and security, fostering big data and AI applications, facilitating policy formulation, and exploring innovative transportation modes, thereby underscoring the importance of urban transportation data in shaping the future of smart cities. The findings provide theoretical and practical guidance for the future intelligence, efficiency, and sustainability of urban transportation systems. [ABSTRACT FROM AUTHOR]

Exploring soil heavy metal sources is of great significance for ensuring the safety of ecological environments and agricultural product safety, as well as for guiding pollution control and management policies. This paper retrieved 452 research papers on soil heavy metal source analysis published over the 2004–2024 period from the Web of Science database. The collected literature was subjected to multidimensional bibliometric analysis using the CiteSpace 6.3.R1. The results showed significantly increasing trends in the scientific outputs and the number of papers on heavy metal source analysis in soils and water over the study period. In addition, related research topics have expanded from single to multiple heavy metal elements in environmental media and have increasingly recognized the impact of water pollution on soil contamination. Research methods have also evolved from basic statistical analysis to complex spatial analysis techniques, covering agricultural and urban soils. Previous related studies have focused on heavy metal pollution in different areas, and related research on heavy metal source analysis has now extended from ecological environments to associated human health risks. The present study provides directions for future related research and guidance for ensuring effective source control of heavy metal pollution and safe utilization of land and water resources. [ABSTRACT FROM AUTHOR]

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Background: Following ischemic stroke, non-neuronal cells within the nervous system play a crucial role in maintaining neurovascular unit functions, regulating metabolic and inflammatory processes of the nervous system. Investigating the functions and regulation of these cells, particularly immune cells, deepens our understanding of the complex mechanisms of neuroinflammation and immune modulation after ischemic stroke and provides new perspectives and methods for immune-related therapy. Methods: The annual distribution, journals, authors, countries, institutions, and keywords of articles published between 2015 and 2024 were visualized and analyzed using CiteSpace and other bibliometric tools. Results: A total of 1,089 relevant articles or reviews were included, demonstrating an overall upward trend; The terms "cerebral ischemia," "immune response," "brain ischemia," "cerebral inflammation," "neurovascular unit," and "immune infiltration," etc. are hot keywords in this field. Conclusion: In recent years, research on immune-related therapy for ischemic stroke has focused on mechanisms of occurrence, protection and repair of the blood-brain barrier (BBB) by non-neuronal cells, and regulation of immunosuppression and inflammation. Among these, reducing BBB disruption to minimize secondary brain damage has become a hotspot. At the same time, the complex roles of immune responses have attracted attention, particularly the balance between regulatory T cells and Th17 cells in regulating neuroinflammation and promoting neurological function recovery, which is crucial to reduce secondary neuronal damage and improve prognosis, potentially establishing a pivotal frontier in this domain of investigation. [ABSTRACT FROM AUTHOR]

Background: Although the application of brain-computer interface (BCI) technology in rehabilitation has been extensively studied, a systematic and comprehensive bibliometric analysis of this area remains lacking. Thus, this study aims to analyze the research progress of BCI technology in rehabilitation through bibliometric methods. Methods: The study retrieved relevant publications on BCI technology in rehabilitation from the Web of Science Core Collection (WoSCC) between January 1, 2004, and June 30, 2024. The search was conducted using thematic queries, and the document types included "original articles" and "review articles." Bibliometric analysis and knowledge mapping were performed using the Bibliometrix package in R software and CiteSpace software. Results: During the study period, a total of 1,431 publications on BCI technology in rehabilitation were published by 4,932 authors from 1,281 institutions across 79 countries in 386 academic journals. The volume of research literature in this field has shown a steady upward trend. The United States of America (USA) and China are the primary contributors, with Eberhard Karls University of Tübingen being the most active research institution. The journal Frontiers in Neuroscience published the most articles, while the Journal of Neural Engineering was the most cited. Niels Birbaumer not only authored the most articles but also received the highest number of citations. The main research areas include neurology, sports medicine, and ophthalmology. The diverse applications of BCI technology in stroke and spinal cord injury rehabilitation, as well as the evaluation of BCI performance, are current research hotspots. Moreover, deep learning has demonstrated significant potential in BCI technology rehabilitation applications. Conclusion: This bibliometric study provides an overview of the research landscape and developmental trends of BCI technology in rehabilitation, offering valuable reference points for researchers in formulating future research strategies. [ABSTRACT FROM AUTHOR]

Objective: Sleep disorder is a common non-motor symptom (NMS) of Parkinson's disease. However, the global research focus on Parkinson's sleep-related disorders (PDSDs) and future trends remains unclear. Currently, there is no bibliometric analysis of PDSDs. We aim to fill this gap, determine the status of current research, and predict future research hotspots. Methods: We selected 1490 publications from the Web of Science Core Collection (WoSCC) database from 2008 to 2023. Based on CiteSpace and VOSviewer, the analysis was performed from the perspectives of the trend in the number of annual publications, countries, institutions, authors, journals, and co-citations. Results: A total of 1490 publications from 590 authors from 409 institutions in 77 countries are included. The United States, China, and the United Kingdom are the leading countries. University College London (UCL) is the most prolific institution. Harvard University is the key for cooperation among institutions. Chaudhuri Kallol Ray is a leader in this field. "Movement Disorders" is the most influential journal. "A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015" is the publication with the highest co-citation intensity. Conclusion: The total volume of publications on PDSDs is on the rise, entering a relatively high-yield stage in 2020. The COVID-19 pandemic and the emergence of new keywords may be the reasons behind this phenomenon. "quality of life" and "circadian rhythm" are the mainstream topics of PDSD research. Daytime sleepiness is the PDSD subtype that has received the most attention. Sleep quality, biomarkers, and neurodegeneration are likely to become future research hotspots. [ABSTRACT FROM AUTHOR]

Background: Cardiovascular diseases (CVD) pose a significant threat to human health due to their high mortality and morbidity rates. Despite advances in treatments, the prevalence and impact of cardiovascular disease continue to increase. Sodium-glucose transporter 2 inhibitors (SGLT2i), initially approved for the treatment of type 2 diabetes, have important research value and promising applications in reducing CVD risk, especially in heart failure (HF) and atherosclerosis patients with cardiovascular disease (ASCVD). This study aims to comprehensively review the latest progress, research trends, cutting-edge hot spots, and future development directions of SGLT2i in the field of CVD through bibliometric analysis. Methods: Articles related to MSCs in cardiovascular diseases were sourced from the Web of Science. The bibliometric analysis was conducted using CiteSpace and VOSviewer, and a knowledge map was created based on the data obtained from the retrieved articles. Results: In this article, we screened 3,476 relevant studies, including 2,293 articles and 1,183 reviews. The analysis found that the number of papers related to the application of SGLT2i in CVD has generally increased, peaking in 2022. The United States and China contributed the largest number of papers, with the United States accounting for 36.97% of the total and also ranking first in terms of the number of citations. However, China's high-quality papers are slightly lacking and need further improvement. Keyword analysis showed that empagliflozin, dapagliflozin, diabetes, and heart failure were the most common terms, reflecting the main research interests in currently published papers in this field. Conclusion: Bibliometric analysis showed a robust and growing interest in the application of SGLT2i for treating CVD. By summarizing the latest progress of SGLT2i in the field of CVD, exploring research hotspots, and looking forward to future research development trends, this article provides valuable insights for thinking about research prospects. [ABSTRACT FROM AUTHOR]

Introduction: Glioma represents the most prevalent primary malignant tumor in the central nervous system, a deeper understanding of the underlying molecular mechanisms driving glioma is imperative for guiding future treatment strategies. Emerging evidence has implicated a close relationship between glioma development and epigenetic regulation. However, there remains a significant lack of comprehensive summaries in this domain. This study aims to analyze epigenetic publications pertaining to gliomas from 2009 to 2024 using bibliometric methods, consolidate the extant research, and delineate future prospects for investigation in this critical area. Methods: For the purpose of this study, publications spanning the years 2009 to 2024 were extracted from the esteemed Web of Science Core Collection (WoSCC) database. Utilizing advanced visualization tools such as CiteSpace and VOSviewer, comprehensive data pertaining to various aspects including countries, authors, author co-citations, countries/regions, institutions, journals, cited literature, and keywords were systematically visualized and analyzed. Results: A thorough analysis was conducted on a comprehensive dataset consisting of 858 publications, which unveiled a discernible trend of steady annual growth in research output within this specific field. The nations of the United States, China, and Germany emerged as the foremost contributors to this research domain. It is noteworthy that von Deimling A and the Helmholtz Association were distinguished as prominent authors and institutions, respectively, in this corpus of literature. A rigorous keyword search and subsequent co-occurrence analysis were executed, ultimately leading to the identification of seven distinct clusters: "epigenetic regulation", "DNA repair", "DNA methylation", "brain tumors", "diffuse midline glioma (DMG)", "U-87 MG" and "epigenomics". Furthermore, an intricate cluster analysis revealed that the primary foci of research within this field were centered around the exploration of glioma pathogenesis and the development of corresponding treatment strategies. Conclusion: This article underscores the prevailing trends and hotspots in glioma epigenetics, offering invaluable insights that can guide future research endeavors. The investigation of epigenetic mechanisms primarily centers on DNA modification, non-coding RNAs (ncRNAs), and histone modification. Furthermore, the pursuit of overcoming temozolomide (TMZ) resistance and the exploration of diverse emerging therapeutic strategies have emerged as pivotal avenues for future research within the field of glioma epigenetics. [ABSTRACT FROM AUTHOR]

Objective: In 2007, entosis was proposed as a form of programmed cell death, distinct from apoptosis. This process involves a living cell (internalized cell) actively invading a neighboring live cell of the same type (host cell), forming a cell-in-cell structure. Recently, entosis has been increasingly associated with cancer, leading to significant advancements in research. Despite this progress, a comprehensive and unbiased review of the current state of entosis research is lacking. This study aims to evaluate the developments in the field of entosis over the past decade and highlight emerging research trends. Materials and methods: We performed a literature search for studies published since the introduction of the entosis concept, using the Web of Science Core Collection database. The bibliometric analysis was conducted using VOSviewer, CiteSpace, Microsoft Excel, and the Bibliometrix R package. Results: A total of 196 articles from 39 countries and 346 institutions were included. Between 2007 and 2024, research on entosis has seen rapid growth, with most publications originating from China and the United States. The United States also leads in total citations, with Memorial Sloan Kettering Cancer Center emerging as the top research institution. Sun Qiang is the most prolific author in this field, while Overholtzer M has the highest number of citations. Current Molecular Medicine has published the most articles related to entosis. Frequently occurring keywords include "entosis," "cannibalism," "autophagy," and "apoptosis." In recent years, keywords such as "phagocytosis," "drug resistance," and "human cancers" have surged, indicating a growing focus on understanding the role of entosis in tumor progression and exploring its potential as a therapeutic target for cancer treatment. Conclusions: This study provides the first bibliometric analysis of entosis, detailing its evolution over the last decade. It highlights critical areas of interest, including the development of inhibitors targeting entosis and their potential clinical applications. This research aims to guide future investigations and serve as a valuable resource for scholars exploring entosis in cancer biology. [ABSTRACT FROM AUTHOR]

Background: Extensive research has been conducted worldwide on non-specific low back pain (NSLBP), some researchers published a bibliometric analysis of NSLBP in 2020, but there have been no supplements or updates since then. Therefore, this study aimed to analyze the research hotspots and frontiers in NSLBP over the last decade. Methods: Primary sources on NSLBP were obtained from the Web of Science Core Collection database from 2014 to 2023. CiteSpace V6.2. R7 (64-bit) and VOSviewer 1.6.19 software were used to analyze the number and centrality of journals, countries, institutions, authors, references, and keywords, and the functions of co-occurrence and clustering were applied to draw a visual knowledge map. Results: In the past decade, the annual publication volume of studies on NSLBP has shown an overall upward trend year by year, with obvious temporal stages and great development potential. In total, 2,103 articles contained six types of literature, with the highest proportion being original research articles (1,633 articles, 77.65%), published in 200 journals. BMC Musculoskeletal Discourses (90 articles, 4.28%) had the highest number of publications, and the British Medical Journal had the highest impact factor (105.7). Furthermore, the United States of America (329 articles, 15.64%) had the highest publication volume, the University of Sydney (139 articles, 6.61%) was the research institution with the highest production, Maher, Chris G (36 articles, 1.71%) was the author with the most published articles, and Hoy, D (571 articles, 27.15%) was the most frequently cited author. The most cited of articles is "Non-specific low back pain" published in the LANCET, with 1,256 citations. Conclusion: This article summarizes the current research status of NSLBP and predicts future research hotspots and frontiers. In recent years, adolescents have become a high-risk group for NSLBP. Pain neuroscience education, motor control, spinal manipulative therapy, and acupuncture are effective means to treat NSLBP. Biomechanics and trunk muscles as entry points are effective ideas for the treatment of NSLBP pain. Furthermore, anxiety, neck pain, non-specific musculoskeletal pain, fibromyalgia, and musculoskeletal disorders are diseases that are closely related to NSLBP. In the future, attention should be paid to the design of research plans, increasing the research intensity of randomized controlled trials, strengthening follow-up, and the timely updating of guidelines, which will result in higher quality and high-level scientific evidence for research on NSLBP. [ABSTRACT FROM AUTHOR]

Background: Researchers gradually focus on the relationship between phage and cancer. Objective: To summarize the research hotspots and trends in the field of bacteriophage and cancer. Methods: The downloaded articles were searched from the Web of Science Core Collection database from January 2008 to June 2023. Bibliometric analysis was carried out through CiteSpace, including the analysis of cooperative networks (country/region, institution, and author), co-citations of references, and key words.Visual analysis of three topics, including gut phage, phage and bacteria, and phage and tumor, was conducted. Results: Overall, the United States and China have the most phage-related research. In terms of gut phage, the future research directions are "gut microbiome", "database" and "microbiota". The bursting citations explored the phage-dominated viral genome to discover its diversity and individual specificity and investigated associations among bacteriome, metabolome, and virome. In terms of phage and bacteria, "lipopolysaccharide" and "microbiota" are future research directions. Future research hotspots should mainly concentrate on the further exploration and application of phage properties. As for phages and tumors, the future research directions should be "colorectal cancer", "protein" and "phage therapy". Future directions are likely to focus on the research on phages in cancer mechanisms, cancer diagnosis, and cancer treatment combined with genetic engineering techniques. Conclusion: Phage therapy would become a hot spot and research direction of tumor and phage research, and the relationship between phage and tumor, especially colorectal cancer (CRC), is expected to be further explored. [ABSTRACT FROM AUTHOR]

The process of urbanization has spurred economic growth and social challenges, necessitating research on public spaces in urban renewal to optimize design, enhance functionality, promote sustainable urban development, and improve residents' quality of life. However, existing studies lack in-depth discussions on development trends and research focal points. This study addresses the gap in existing literature, by conducting a bibliometric analysis using data from the Web of Science Core Collection database from 1 January 2000, to 1 April 2024. Using visualization tools such as VOSviewer and CiteSpace, the study examines publication trends, collaborative networks among countries, institutions, and authors, co-citation relationships among key journals and articles, and emerging research hotspots through keyword analysis. A total of 393 papers were analyzed, with China contributing the highest number (65), followed by the United States (51). Leading contributors include Zazzi Michele and Anguelovski Isabelle. The top three journals for publications are Sustainability, Cities, and Land. Key research trends highlight themes such as space syntax, nature-based solutions, and sustainable transportation. These findings have significant implications for urban planning and policy, suggesting that future urban development strategies should increasingly incorporate sustainable design practices and nature-based solutions to address both environmental and social challenges. By identifying global research trends and highlighting future challenges, this study provides a comprehensive overview that will help policymakers and practitioners in urban planning align their efforts with cutting-edge research and emerging best practices for more sustainable and resilient cities. [ABSTRACT FROM AUTHOR]

Karst landforms are widely distributed around the world, and karst rocky desertification has occurred on a large scale in many countries and regions, causing significant adverse impacts on local natural environments and societies. The improvement and rational use of karst soil is a key aspect of rocky desertification governance. Karst soil science studies are of great value in karst regions and are essential for controlling karst rocky desertification and ecological restoration. In order to understand the research hotspots and the development directions in the field of vulnerable karst soil environment, we undertook bibliometrics citation analysis on 1913 contributions to the literature written in the range from 2001 to 2019 based on the "Web of Science" core collection citation index database. Hopefully, this work will help to set up a scientific foundation for further studies. Using CiteSpace visualization software, we analyzed the distribution of disciplinary categories, reference co-citation clusters, and keyword clusters in the literature. The results show the basic characteristics and evolution of the literature related to karst pedology. We then recognized the main intellectual bases in the domain of karst soil science. This study also revealed the research hotspots and trends in this field. Through a bibliometrics citation analysis of research on karst vulnerable soil environment, the present study provides a quantitative and objective understanding of development directions that have emerged in this field over the past 19 years, offering a reference for future research. [ABSTRACT FROM AUTHOR]

Background: Migraine is a widespread, recurrent primary headache disorder primarily characterized by severe pulsatile headache, typically on one or both sides. It is often accompanied by nausea, vomiting, and hypersensitivity to sound and light. Despite the availability of multiple drugs for migraine management, the condition often becomes chronic due to untimely or irrational drug use, significantly distressing patients and increasing the burden on families and society. Over the past two decades, numerous clinical studies on migraine have been published. This study aimed to provide a comprehensive summary of the current status and trends of migraine clinical trials through bibliometric analysis. Methods: We used visual network tools such as CiteSpace and VOSviewer to perform a knowledge graph analysis of publications related to migraine clinical trials extracted from the WoSCC. Results: This study analyzed 1,129 articles published in 389 journals from 61 countries. The number of publications on migraine clinical trials has steadily increased from 2004 to 2023. The United States and Albert Einstein College of Medicine are the leading countries and institutions in this field, respectively. Richard B. Lipton is the most prolific author, making significant contributions to the research. The journal Headache has the highest number of publications and citations in this area. Keywords such as "efficacy," "RCT," "CGRP," "prophylaxis," "disability," "depression," "questionnaire," and "real-world effectiveness" received significant attention. Conclusion: This study identified reliable research hotspots and provided directions for clinicians. The treatment of migraine continues to be challenging. Future trends may include continued growth in migraine classification, risk factor analysis, and comorbidity studies. Research on CGRP and epigenetics will advance the progress of precision medicine in the migraine field. [ABSTRACT FROM AUTHOR]

Depression is a common psychological complication in osteoarthritis (OA) patients, and its incidence gets more and more attention year by year worldwide. This study investigates the association between OA and depression through a bibliometric analysis of published studies. It aims to identify leading authors, institutions, and countries to highlight research hotspots and suggest potential future directions. We collected publications on OA and depression from 1994 to 2024 using the Web of Science Core Collection (WOSCC) database. Bibliographic information, including authorship, country of origin, citation frequency, and visualizations, was generated using VOSviewer, R software, and CiteSpace. A total of 2,342 articles were identified. The United States led in publications with 906 articles, Boston University was the most prolific institution with 56 publications, BMC Musculoskeletal Disorders was the top journal with 71 publications, and Stefania Maggi was the most productive author with 19 publications. The primary research hotspots identified were: "The relationship between depression and OA," "Disability and prevalence," and "Characteristics of older people suffering depression after OA." Predicted future research frontiers include: "Treating depression in OA patients with multimorbidity," "Psychometric properties of instruments for assessing depression and anxiety in OA patients," "Depression or anxiety in patients with surgical intervention," and "Other mental diseases in OA patients." This bibliometric analysis underscores the importance of understanding the link between OA and depressive disorders, potentially guiding new research directions. [ABSTRACT FROM AUTHOR]

Background: CDK7 has been demonstrated to play a crucial role in the initiation and progression of malignancy. Therefore, targeting CDK7, which regulates the transcription process, has emerged as a new promising approach for treating cancer. Research on CDK7 inhibitors has significantly increased over the past 2 decades, with almost 600 related papers in the Web of Science Core Collection database. To effectively identify future research hotspots and potential future directions, it is crucial to systematically review and visually present the research on this topic from a comprehensive viewpoint, ensuring scientific reliability. Methods: This study performed bibliometric analysis via CiteSpace and VOSviewer scientometrics analysis software to examine data on the publication of articles on CDK7 inhibitors over the past 2 decades; the data included country of publication, author names, institution names, scientific categories, cited journals, and keywords related to the field of CDK7 inhibitors. Results: This bibliometric analysis included 426 publications from 41 different nations, referencing a total of 15,892 sources. Research associated with CDK7 inhibitors has rapidly expanded since 2016, and the US and China are the two countries with the highest publication output among the countries and institutes that produce literature on CDK7 inhibitors. Furthermore, the US is the country that most frequently engages in international cooperation. The evolution of keywords identifying antitumor strategies related to CDK7-mediated cellular transcription processes has been the research focus in recent years. Conclusion: In this study, we identified research efforts and their evolving patterns and predicted advances in the CDK7 inhibitor field. The knowledge structure of CDK7 inhibitors encompasses pharmacological mechanisms, therapeutic targets, and cancer treatment strategies. The primary objectives of contemporary research are to discover the processes underlying cancer progression, identify specific signaling pathways, and develop effective clinical medicines. [ABSTRACT FROM AUTHOR]

Background: Brucellosis is a zoonotic disease caused by Brucella infection, which is common in pastoral areas. Neurological involvement in brucellosis is relatively rare. But since 1993, continuous studies have been reporting neurological complications of brucellosis, collectively referred to as neurobrucellosis. A bibliometric analysis of existing literature outlines current research progress and gaps and provides guidance for the clinical treatment of neurobrucellosis, promoting patient health in the process of guiding clinical practice, and improving their quality of life. Methods: CiteSpace and VOSviewer are software tools to visualize research trends and networks. By selecting specific areas of interest and configuring the right parameters, the tools can visualize past research data. The study retrieved the literature from the Web of Science Core Collection Database and downloaded it in plain text file format. Citespace6.1.6, VOSviewer v1.6.20, and Microsoft Excel 16.59 were used for analyzing the following terms: countries, institutions, authors' cooperation, journals, keywords, and co-citation. Results: There are eight key results. (1) The publication volume shows a general upward trend. (2) Turkey is the country with the highest publication volume and contributing institutions. (3) Giambartolomei GH, Gul HC, and Namiduru M are the authors with the highest number of publications. (4) Neurology is the journal that published the highest number of related articles (n = 12). (5) "Diagnosis," "meningitis," and "features" are the top three frequently occurring keywords. (6) Keyword clusters show "antibiotic therapy" and "cerebrospinal fluid" have future study value. (7) The burst analysis of the keywords also indicates that "cerebrospinal fluid" may become a prominent keyword in future research. (8) The co-citation analysis concludes three categories of the cited articles, which are diagnosis, therapy, and complications, indicating the past research direction. Conclusion: This study highlights the complexity of neurobrucellosis, presenting the need for advanced diagnostic techniques and multifaceted treatment approaches. While antibiotics remain the cornerstone of therapy, the use of corticosteroids to mitigate inflammatory responses shows promise, albeit with concerns about potential sequelae and relapse. Future research should focus on refining therapeutic strategies that address both the direct effects of infection and the broader immunological impacts to improve patient outcomes and quality of life. [ABSTRACT FROM AUTHOR]

Objective: To understand the current study of social anxiety (SA) over the past decade, and to analyze the research hot topics and frontiers in this field. Methods: CiteSpace 6.2.R3 was used to analyze the literature on SA collected in the Web of Science Core Collection database from 2013 to 2023. Results: A total of 9940 literature were included after the screening, and the annual publication volume showed a steady increase. The results emphasize that Zvolensky MJ, Pine DS, and Heimberg RG are important authors in the field of SA. The United States has the highest number of publications, with the University of California System contributing the most. Research hotspots include cognitive impairment, risk factors, complications, neuroimaging, and intervention strategies. SA related to the "theory of mind", "bullying victimization", "mobile phone", "network analysis", "technology", and "satisfaction" are emerging research foci. Conclusion: This study identifies the current situation and trends of SA research, and provides a reference for future research topics and directions. [ABSTRACT FROM AUTHOR]

Objective: To summarize the general situation and focal points of research on the physical activity and mental health of older people over the past 15 years and provide references for future research. Methods: Literature published between January 1, 2009, and December 31, 2023, was retrieved from the Web of Science core database. A bibliometric visualization analysis of countries/regions, institutions, authors, keywords, and references was conducted using CiteSpace6.1.R6. Results: A total of 4,329 articles were included, and the annual number of articles published over the past 15 years showed an upward trend. The articles were primarily from 65 countries/regions and 626 institutions. The most represented country and institution were the USA and the University of Pittsburgh, respectively. Among the authors identified, Schuch and Callow were the most influential. The research focuses on four areas: the psychological effects of physical activity in older people; physical activity intervention approaches to the mental health of older people; physical activity and mental health assessment questionnaires; and the impact of physical activity on multidimensional aging. Research frontiers involve emerging topics such as the assessment and intervention of mental health in older people and the relationship between their physical activity and cognitive function. Conclusion: This study conducted a comprehensive, objective, and visual analysis of publications and revealed the status of relevant studies, trending topics, and trends concerning the physical activity and mental health of older people from 2009 to 2023. We hope that this work will help researchers identify new perspectives on potential collaborators, important topics, and research frontiers. [ABSTRACT FROM AUTHOR]

Utilization and Acceptance of Technology Certain dimensions may predict behavioural intention regarding adopting and utilising technology, according to models. Consequently, these models have been utilised more frequently by researchers worldwide. We indexed 336 pertinent journal articles published from 1995 to 2023 on the Web of Science Core Collection Acceptance and Use of Technology Models in Healthcare implementation. We conducted a quantitative scientometric review of these articles to ascertain the models most frequently used by researchers. The results indicated a substantial surge in articles published in the discipline, particularly since 2005. This growth has been primarily driven by the United States, China, and England, as these three nations have not only cultivated the most productive authors and high-yielding research institutions but have also published many prolific journals. The top three SDG-related publications concerned climate action, affordable and sustainable energy, and excellent health and well-being. Quantitatively supplementing the current qualitative literature, these results offer significant implications and insights for international research utilising technological models. [ABSTRACT FROM AUTHOR]

This bibliometric analysis aimed to map the knowledge network of laminoplasty research. Studies on laminoplasty published from 1982 to 2023 were retrieved from the Web of Science Core Collection (WoSCC). The contributions of countries, institutions, authors, and journals were identified using VOSviewer, Scimago Graphica, and Microsoft Excel. Tendencies, hotspots, and knowledge networks were analyzed and visualized using VOSviewer and CiteSpace. We identified 2577 publications on laminoplasty. The annual number of publications exhibited an overall increasing trend since 2004. Among these, Japan, China, and the United States were the 3 major contributing countries. Keio University, Nagoya University, and Tokyo Medical & Dental University were the 3 most productive institutions. Shiro Imagama ranked first among authors regarding the number of articles, while K Hirabayashi was first among co-cited authors. Spine was the top journal in terms of the number of publications, citations, and co-citations. In addition, the research topics can be divided into 3 clusters: (1) Comparison between laminoplasty and other surgery in outcomes and complications; (2) Axial symptoms in laminoplasty; (3) Sagittal alignment and sagittal balance in laminoplasty. Emerging topics sagittal alignment and sagittal balance in degenerative cervical spondylosis are identified as current research frontiers. This study drew a knowledge map of the top countries, institutions, authors, publications, and journals on laminoplasty over the past 4 decades. The current and future hotspots of laminoplasty focus on sagittal balance, comparison between other surgery in outcomes and complication, and axial symptoms in laminoplasty. [ABSTRACT FROM AUTHOR]

As climate change intensifies and countries actively pursue carbon peaking and carbon neutrality targets, agriculture has emerged as a significant source of carbon emissions. A comprehensive analysis of global agricultural carbon emission research can enhance the agricultural environment and achieve a mutually beneficial outcome for environmental protection and economic development. Despite the evolution of research domains and methodologies, the global context remains closely connected to the current state of the discipline. Drawing on the Web of Science core collection, this paper develops a knowledge network framework, examines the current status and hotspots of agricultural carbon emissions, forecasts future development trends, and analyzes the findings using CiteSpace visualization software. The findings indicate that the number of papers on agricultural carbon emissions has been increasing annually, with minor fluctuations; time series analysis and sustainable development have emerged as the current focal points, and relevant institutions are collaborating increasingly closely. However, cooperation among scholars requires further enhancement. Countries such as China, the United States, and Germany are the primary nations for paper publication. The hotspot analysis reveals a high frequency of keywords such as greenhouse gas emissions and climate change, indicating that research on agricultural carbon emissions has matured and the emphasis has shifted from accounting to management. This paper develops a domain knowledge framework to assist readers in understanding agricultural carbon emission patterns and provide resources for further research. Follow-up studies should enhance both comprehensiveness and breadth, promote interdisciplinary cooperation, provide a scientific foundation for policymakers, and outline future research directions. [ABSTRACT FROM AUTHOR]

Macrofungi (or mushrooms) are essential for agriculture, food, and ecology. Although research on the growth and development of macrofungi (GDM) can provide insights into their biological characteristics and metabolite synthesis mechanisms, further exploration is needed for a systematic and visual analysis of the current research progress on GDM. To comprehensively understand the research status and development trend of GDM, a total of 545 scientific literature related to GDM in the Web of Science Core Collection database from 2008 to 2024 were searched and selected as research objects. The general information (publication year, country, institution, and cited journal) and the specific information (co-authorship, keyword co-occurrence, and references with strong citation bursts) were mined and visualized in detail based on CiteSpace software. These analyses demonstrated that related research is still fashionable, and China is dominant and influential in this field. More frequent and in-depth cooperation among authors, institutions and regions is conducive to promoting the research on GDM. Additionally, the quantity and cluster analyses of keywords and references demonstrated that medicinal/edible macrofungi and sustainable development (e.g. mushroom substrate reuse) may be research hotspots and will remain popular in the coming years. This research aims to supply researchers with up-to-date knowledge and cutting-edge issues related to GDM by providing a visually appealing representations on quantitative GDM studies. [ABSTRACT FROM AUTHOR]

Objective To systematically analyze the literature on ABO-incompatible (ABOi) organ transplantation and explore the research hotspots and trends in this field. Methods CiteSpace software was used for visual analysis of ABOi organ transplantation literature collected from the China National Knowledge Infrastructure, VIP web, Wanfang Data, and the Web of Science Core Collection database from January 1, 2013 to December 31, 2023 after cleaning, including the volume of literature published, authors, countries, institution and keywords. Results A total of 588 valid foreign-language author publications and 85 valid Chinese-language author publications were included. Since 2021, the volume of foreign literature publications has shown a downward trend, while the volume of domestic literature published has generally shown a upward trend. The top two core Chinese authors are Wang Yi and Zhu Zhijun; the top three core authors in foreign literature are Nakatani Tatsuya, Tanabe Kazunari, and Uchida Junji. The most active institution in China is Huazhong University of Science and Technology, followed by Zhejiang University and Sichuan University, with relatively insufficient closeness in cooperation between related institutions. The institutions with the most publications abroad are Ulsan University, Seoul National University and Tokyo Women's Medical University in Japan. The top three countries in English-language literature publications are Japan, Republic Korea, and the United States, and China ranked 5th. Keyword cluster analysis shows that the research focus of at home and abroad is mainly on nine topic clusters including ABOi organ transplantation, cryoprecipitation, kidney transplantation, liver transplantation, blood type antigen detection technology and post-transplant complications. Conclusions At present, The research in the field of ABOi organ transplantation is mainly concentrated on kidney transplantation and liver transplantation, showing an overall positive development trend. In the future, it is expected to further promote development of this field by strengthening international cooperation, expanding research investment and promoting the application of advanced technologies. [ABSTRACT FROM AUTHOR]

Background: Melasma is a prevalent pigmented disease, yet its pathogenesis remains unclear, posing challenges for effective treatment. Bibliometric analysis, a novel approach to literature research, offers the opportunity to evaluate research trends through qualitative and quantitative methods. This study utilizes bibliometric methods to analyze the existing literature on melasma treatment, examining influential publications, institutions, countries, and authors through statistical analysis. Methods: In order to retrieve manuscripts related to the topic of melasma treatment, we conducted a search using the search formula: (TS = (melasma or Chloasma or "mask of pregnancy")) AND TS = (treatment or therapy). We searched through the Web of Science Core Collection database, covering publications from 2000 to 2023. VOSviewer, CiteSpace and the Bibliometric online site (https://bibliometric.com/app) were used to conduct this bibliometric analysis. Our analysis focused on various factors including publications, authors co‐authorship, institutions, countries, citation analysis, keywords co‐occurrence, references co‐citation and journal co‐citation. Results: A total of 943 articles and 200 reviews were published between 2000 and 2023, accumulating a total of 8628 citations. The average number of citations per item was 18.85, and the average number of citations per year was 292.69. The most prolific author, Sungeun Chang, contributed a total of 9 articles. Cario University emerged as the top research institution. The United States led in terms of article publications with a count of 276. In the past 5 years, the research trends in this field have primarily focused on tranexamic acid and epidermal melasma, as indicated by the burst analysis of publications and keywords. Conclusions: The United States continues to lead in terms of institutions and research output. The current emphasis is on the meticulous implementation of tranexamic acid and laser therapy. It is crucial to foster enhanced collaboration among countries, institutions, and authors to facilitate improved research. [ABSTRACT FROM AUTHOR]

This article seeks to evaluate the scientific landscape of the phytoremediation of mine tailings through a series of bibliometric and scientometric techniques. Phytoremediation has emerged as a sustainable approach to remediate metal-contaminated mine waste areas. A scientometric analysis of 913 publications indexed in Web of Science from 1999 to 2023 was conducted using CiteSpace. The results reveal an expanding, interdisciplinary field with environmental sciences as the core category. Keyword analysis of 561 nodes and 2,825 links shows a focus on plant-metal interactions, microbial partnerships, bioavailability, and field validation. Co-citation analysis of 1,032 nodes and 2,944 links identifies seminal works on native species, plant-microbe interactions, and amendments. Temporal mapping of 15 co-citation clusters indicates a progression from early risk assessments and native plant inquiries to integrated biological systems, economic feasibility, and sustainability considerations. Recent trends emphasize multidimensional factors influencing adoption, such as plant-soil-microbe interactions, organic amendments, and field-scale performance evaluation. The findings demonstrate an intensifying translation of phytoremediation from scientific novelty to engineering practice. This quantitative and qualitative analysis of research trends aids in understanding the development of phytoremediation for mine tailings. The results provide valuable insights for researchers and practitioners in this evolving field. [ABSTRACT FROM AUTHOR]

The soil moisture (SM) balance is affected by afforestation. In this study, the CiteSpace software was used to review the literature on the impact of afforestation on SM, and we further present research findings on the Loess Plateau (LP) as follows: (1) the spatio-temporal heterogeneity of SM varies depending on the research scale; (2) the presence of a dried soil layer significantly hinders deep SM recharge; (3) the accumulation of net primary productivity (NPP) may be occurring at the expense of SM. The following research topics are discussed: (1) the recharge and consumption of deep SM in LP; (2) the green water footprint and its shortage of non-crop greenery for evaluating SM allocation and use; (3) the development of inclusive models encompassing different spatial scales to assess the limits of soil water carrying capacity for vegetation (SWCCV). [ABSTRACT FROM AUTHOR]