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3 results on '"chronic excessive alcohol consumption"'

1. Clinical Significance of Gamma-Glutamyltranspeptidase Combined with Carbohydrate-Deficient Transferrin for the Assessment of Excessive Alcohol Consumption in Patients with Alcoholic Cirrhosis

Author

Akihiko Shibamoto, Tadashi Namisaki, Junya Suzuki, Takahiro Kubo, Satoshi Iwai, Fumimasa Tomooka, Soichi Takeda, Yuki Fujimoto, Masahide Enomoto, Koji Murata, Takashi Inoue, Koji Ishida, Hiroyuki Ogawa, Hirotetsu Takagi, Daisuke Kaya, Yuki Tsuji, Takahiro Ozutsumi, Yukihisa Fujinaga, Masanori Furukawa, Norihisa Nishimura, Yasuhiko Sawada, Koh Kitagawa, Shinya Sato, Hiroaki Takaya, Kosuke Kaji, Naotaka Shimozato, Hideto Kawaratani, Kei Moriya, Takemi Akahane, Akira Mitoro, and Hitoshi Yoshiji

Subjects
chronic excessive alcohol consumption, prediction accuracy, carbohydrate-deficient transferrin, gamma-glutamyltranspeptidase, alcoholic cirrhosis, Medicine
Abstract

Background: This study aimed to compare the diagnostic performance of carbohydrate-deficient transferrin (CDT) and gamma-glutamyltranspeptidase (γ-GTP) to assess the single and combined benefits of these biological markers for the detection of chronic excessive alcohol consumption in patients with alcoholic cirrhosis. Methods: Biological markers were determined in blood samples from patients with alcoholic cirrhosis (drinking group, n = 35; nondrinking group, n = 81). The prediction accuracy of %CDT alone, γ-GTP alone, and their combination for the detection of excessive alcohol consumption was determined in patients with alcoholic cirrhosis. Results: Serum total bilirubin, alanine aminotransferase, aspartate aminotransferase, γ-GTP, and alkaline phosphatase levels and %CDT were significantly higher and serum albumin levels were significantly lower in the drinking group than in the nondrinking group. The combination of %CDT and γ-GTP compared with %CDT or γ-GTP alone showed a higher prediction accuracy. The combination of %CDT and γ-GTP exhibited a higher specificity than γ-GTP alone. However, in terms of sensitivity, no significant difference was found between single or combined markers. Conclusions: The combination of %CDT and γ-GTP is considered a useful biomarker of chronic excessive alcohol consumption in patients with alcoholic cirrhosis.

Published
2021
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2. Clinical Significance of Gamma-Glutamyltranspeptidase Combined with Carbohydrate-Deficient Transferrin for the Assessment of Excessive Alcohol Consumption in Patients with Alcoholic Cirrhosis

Author

Soichi Takeda, Kosuke Kaji, Hitoshi Yoshiji, Yuki Fujimoto, Koji Ishida, Masanori Furukawa, Takashi Inoue, Norihisa Nishimura, Takemi Akahane, Akihiko Shibamoto, Daisuke Kaya, Junya Suzuki, Takahiro Kubo, Masahide Enomoto, Koji Murata, Yasuhiko Sawada, Kei Moriya, Fumimasa Tomooka, Hirotetsu Takagi, Satoshi Iwai, Yukihisa Fujinaga, Takahiro Ozutsumi, Koh Kitagawa, Yuki Tsuji, Hideto Kawaratani, Naotaka Shimozato, Shinya Sato, Akira Mitoro, Hiroaki Takaya, Tadashi Namisaki, and Hiroyuki Ogawa

Subjects
medicine.medical_specialty, Alcoholic liver disease, Carbohydrate deficient transferrin, Serum albumin, chronic excessive alcohol consumption, Gastroenterology, Article, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, prediction accuracy, Clinical significance, In patient, 030212 general & internal medicine, carbohydrate-deficient transferrin, General Environmental Science, chemistry.chemical_classification, biology, business.industry, alcoholic cirrhosis, General Engineering, medicine.disease, chemistry, gamma-glutamyltranspeptidase, Transferrin, biology.protein, General Earth and Planetary Sciences, Biomarker (medicine), Alkaline phosphatase, Medicine, 030211 gastroenterology & hepatology, business
Abstract

Background: This study aimed to compare the diagnostic performance of carbohydrate-deficient transferrin (CDT) and gamma-glutamyltranspeptidase (γ-GTP) to assess the single and combined benefits of these biological markers for the detection of chronic excessive alcohol consumption in patients with alcoholic cirrhosis. Methods: Biological markers were determined in blood samples from patients with alcoholic cirrhosis (drinking group, n = 35, nondrinking group, n = 81). The prediction accuracy of %CDT alone, γ-GTP alone, and their combination for the detection of excessive alcohol consumption was determined in patients with alcoholic cirrhosis. Results: Serum total bilirubin, alanine aminotransferase, aspartate aminotransferase, γ-GTP, and alkaline phosphatase levels and %CDT were significantly higher and serum albumin levels were significantly lower in the drinking group than in the nondrinking group. The combination of %CDT and γ-GTP compared with %CDT or γ-GTP alone showed a higher prediction accuracy. The combination of %CDT and γ-GTP exhibited a higher specificity than γ-GTP alone. However, in terms of sensitivity, no significant difference was found between single or combined markers. Conclusions: The combination of %CDT and γ-GTP is considered a useful biomarker of chronic excessive alcohol consumption in patients with alcoholic cirrhosis.

Published
2021

3. Caveats against an improper use of hair testing to support the diagnosis of chronic excessive alcohol consumption, following the 'Consensus' of the Society of Hair Testing 2009 [Forensic Science International 196 (2010) 2]

Author

Franco Tagliaro, Guido Viel, Santo Davide Ferrara, and Federica Bortolotti

Subjects
hair testing, Societies, Scientific, Forensic Science, Injury control, Alcohol Drinking, Consensus Development Conferences as Topic, Poison control, chronic excessive alcohol consumption, Suicide prevention, Occupational safety and health, Pathology and Forensic Medicine, Forensic Toxicology, Injury prevention, medicine, Humans, Ethanol, business.industry, Fatty Acids, Human factors and ergonomics, Central Nervous System Depressants, Esters, medicine.disease, Excessive alcohol consumption, Forensic science, Substance Abuse Detection, Alcoholism, Medical emergency, business, Law, Biomarkers, Hair
Published
2010

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