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Background: Early adversity increases the risk for mental and physical disorders as well as premature death. Epigenetic processes, and altered epigenetic aging in particular, might mediate these effects. While the literature that examined links between early adversity and epigenetic aging is growing, results have been heterogeneous.Objective: In the current work, we explored the link between early adversity and epigenetic aging in a sample of formerly out-of-home placed young adults.Method: A total of N = 117 young adults (32% women, age mean = 26.3 years, SD = 3.6 years) with previous youth residential care placements completed the Childhood Trauma Questionnaire (CTQ) and the Life Events Checklist (LEC-R) and provided blood samples for the analysis of DNA methylation using the Illumina Infinium MethylationEPIC BeadChip Microarray. Epigenetic age was estimated using Hovarths and Hannums epigenetic clocks. Furthermore, Hovarths and Hannums epigenetic age residuals were calculated as a proxy of epigenetic aging by regressing epigenetic age on chronological age. The statistical analysis plan was preregistered (https://osf.io/b9ev8).Results: Childhood trauma (CTQ) was negatively associated with Hannums epigenetic age residuals, β = -.23, p = .004 when controlling for sex, BMI, smoking status and proportional white blood cell type estimates. This association was driven by experiences of physical neglect, β = -.25, p = .001. Lifetime trauma exposure (LEC-R) was not a significant predictor of epigenetic age residuals.Conclusion: Childhood trauma, and physical neglect in particular, was associated with decelerated epigenetic aging in our sample. More studies focusing on formerly institutionalized at-risk populations are needed to better understand which factors affect stress-related adaptations following traumatic experiences.

Childhood trauma is closely tied to adult depression, but the neurobiological mechanisms remain unclear. Previous studies suggested associations between depression and large-scale brain networks such as the Ventral Attention Network (VAN) and Somatosensory Motor Network (SMN). This study hypothesized that functional connectivity (FC) within and between these networks mediates the link between childhood trauma and adult depression. The Childhood Trauma Questionnaire (CTQ) assessed developmental experiences, and the Hamilton Rating Scale for Depression (HAMD-17) gauged depressive symptoms. Resting-state functional magnetic resonance imaging (fMRI) analyzed FC within and between the VAN and SMN. Depression group exhibited significantly higher HAMD and CTQ scores, as well as elevated FC within the VAN and between the VAN and SMN (P < 0.05). Positive correlations were found between HAMD total score and FC within the VAN (P < 0.05, r = 0.35) and between the VAN and SMN (P < 0.05, r = 0.34), as well as with CTQ total score (P < 0.05, r = 0.27). Positive correlations were also observed between CTQ total score and FC within the VAN (P < 0.05, r = 0.31) and between the VAN and SMN (P < 0.05, r = 0.29). In the mediation model, FC within and between the VAN and SMN significantly mediated childhood trauma and depression. The cross-sectional design limits causal inference. The sample size for different trauma types is relatively small, urging caution in generalizing findings. The study underscores the association between depression severity, VAN dysfunction, abnormal VAN-SMN FC, and childhood trauma. These findings contribute to understanding the neurobiological mechanisms underlying childhood trauma and depression. • Ventral attention and sensorimotor network connectivity changes are characteristic of MDD compared to healthy controls. • Childhood trauma affects the ventral attention and sensorimotor network functional connectivity. • The ventral attention and sensorimotor networks mediate the link between childhood trauma and depression. [ABSTRACT FROM AUTHOR]

Negative birth experiences are common. It is yet unclear which women may be most at risk already before pregnancy. Childhood trauma and non-autonoumous/unresolved attachment state of mind may affect how women experience giving birth. This study used longitudinal data to test childhood trauma and attachment state of mind as predictors of birth experience in at-risk sample of primipara women (N = 193). The Adverse Childhood Experiences questionnaire and the Adult Attachment interview were administered during pregnancy, and women reported about their birth experience three months postpartum. Partial Least Square Structural Equation Modelling was applied to answer the research questions. Childhood physical neglect and parental substance abuse were predictive of a more negative birth experience, while attachment state of mind was not associated with how women experienced giving birth. Cross-validation suggests that these findings may be considered externally valid. Further research using validated measures on birth experience are needed. [ABSTRACT FROM AUTHOR]

AbstractResearch on intergenerational trauma (IGT) indicates a link between parent and offspring PTSD symptoms. Studies suggest that parents’ PTSD symptoms could contribute to harsh parenting practices, such as childhood maltreatment, in turn increasing risk for PTSD symptoms in their offspring. However, the potential mediating role of cumulative and subtypes of offspring childhood trauma in intergenerational PTSD symptom transmission, along with the impact of parental sex, remain understudied. This cross-sectional study examined whether the link between parent and offspring PTSD symptoms among survivors of the 1994 genocide against the Tutsi in Rwanda to their offspring was mediated by cumulative and subtypes of offspring childhood trauma, and how these relationships vary by parental sex. Adult children of genocide survivors, all born after the genocide (N = 166; Mage=23.03, SD = 1.94; 47.6% female), completed an online survey. We performed a series of models investigating childhood trauma as a mediator of maternal and paternal IGT transmission. We found significant indirect effects of maternal PTSD symptoms on offspring secondary PTSD symptoms via sexual abuse and physical neglect, and of paternal PTSD symptoms on offspring secondary PTSD symptoms via cumulative childhood trauma, sexual abuse, and physical abuse. The findings demonstrate variation in IGT via childhood trauma subtypes and parental sex. Future research, including longitudinal and multi-informant studies, should examine these sources of variation further to provide insight into how interventions could be tailored to prevent and mitigate the intergenerational transmission of PTSD symptoms. [ABSTRACT FROM AUTHOR]

Recent research has highlighted cerebellar involvement in cognition and several psychiatric conditions such as mood and anxiety disorders and schizophrenia. Attention‐deficit/hyperactivity disorder and autism spectrum disorder have been linked to reduced cerebellar volume as well. Cerebellar alterations are frequently present after early adversity in humans and animals, but a systematic integration of results is lacking. To this end, a systematic literature search was conducted in PubMed, Web of Science, and EBSCO databases using the keywords "early adversity OR early life stress" AND "cerebellum OR cerebellar." A total of 45 publications met the inclusion criteria: 25 studies investigated human subjects and 20 reported results from animal models. Findings in healthy subjects show bilateral volume reduction and decreased functional connectivity within the cerebellum and between the cerebellum and frontal regions after adversity throughout life, especially when adversity was assessed with the Childhood Trauma Questionnaire. In clinical populations, adults demonstrate increased cerebellar volume and functional connectivity after adversity, whereas pediatric patients show reduced cerebellar volume. Animal findings reveal cerebellar alterations without necessarily co‐occurring pathological behavior, highlighting alterations in stress hormone receptor levels, cell density, and neuroinflammation markers. Cerebellar alterations after early adversity are robust findings across human and animal studies and occur independent of clinical symptoms. [ABSTRACT FROM AUTHOR]

Objective: Despite advancements in understanding panic disorder (PD), its etiology and pathogenesis remain elusive, particularly concerning the influence of psychosocial factors. This study aims to explore the mediating roles of neuroticism and anxiety sensitivity (AS) in the relationship between childhood trauma and PD severity. Methods: We conducted a cross-sectional analysis involving 84 individuals diagnosed with PD and 112 age- and gender-matched healthy controls (HC). Childhood trauma was assessed using the validated Childhood Trauma Questionnaire (CTQ), while anxiety sensitivity levels were measured using the Anxiety Sensitivity Index-3 (ASI-3). Neuroticism was evaluated using the Chinese Big Five Personality Inventory (CBF-PI-B). The severity of PD was determined using the Panic Disorder Severity Scale (PDSS). Statistical analysis encompassed both correlation and mediation techniques to thoroughly examine the relationships among childhood trauma, neuroticism, AS, and PD severity. Results: Individuals with PD exhibited significantly higher CTQ, ASI-3, and neuroticism scores compared to HC (all P<0.05). Within the PD group, strong positive correlations were found between CTQ scores, ASI-3 scores, neuroticism levels, and PDSS scores, with correlation coefficients ranging from 0.336 to 0.504 (all P<0.001). Additionally, our results indicated that neuroticism and AS acted as mediating factors in the relationship between childhood trauma and the severity of PD, with the 95% confidence interval for the indirect effects ranging from 0.028 to 0.116. Conclusion: This study highlights that PD patients exhibit significantly higher levels of childhood trauma, neuroticism, and AS compared to HC. Furthermore, childhood trauma indirectly influences PD severity through a chain mediation involving neuroticism and AS. These findings suggest the importance of psychological factors in moderating the impact of early adverse experiences on the development and progression of PD. [ABSTRACT FROM AUTHOR]

Background: Premenstrual Syndrome (PMS) and Premenstrual Dysphoric Disorder (PMDD), collectively known as Premenstrual Disorders (PMDs), cause significant distress and functional impairment, and premenstrual exacerbation (PME) affects a large proportion of women with psychiatric diagnoses. Childhood trauma is one factor that may contribute to PMD/PME risk. This study examines the relationship between childhood trauma and PMDs, PME, and non-PMD psychiatric illness. Methods: This study is a secondary analysis of data from a prospective cohort. Participants completed self-assessments on childhood trauma using the Childhood Traumatic Event Scale (CTE-S) and on premenstrual symptoms using the Premenstrual Symptoms Screening Tool (PSST). Psychiatric diagnoses were assessed through structured clinical interviews. Participants were divided into four groups based on their PSST scores and psychiatric illness status: (1) Premenstrual Disorders (PMDs; moderate to severe PMS and PMDD), (2) PME, (3) psychiatric controls (PC; individuals with psychiatric illness but no significant premenstrual symptoms), and (4) healthy controls (HC; individuals with no psychiatric illness and no significant premenstrual symptoms). Statistical analyses, including ANOVA, Tukey's HSD test, Fisher's exact test, and logistic regression, were conducted to examine differences among the groups. Results: Data from 391 participants were analyzed. Participants with PME and PC reported a higher quantity and severity of childhood traumatic events compared to HCs (p <.05). There was a weak but significant correlation between childhood trauma and premenstrual symptom burden across all groups (R = .18, p <.001). Within-group analysis revealed moderate correlations between childhood trauma and premenstrual symptoms driven by the PMD group (R = .42, p = .01). Conclusions: The findings underscore the impact of childhood traumatic events on mental health and premenstrual symptoms and highlight the need for additional research to explore the underlying mechanisms linking childhood trauma to the continuum of premenstrual disorders, to improve the efficacy of trauma-focused interventions for affected individuals. [ABSTRACT FROM AUTHOR]

Studies on bipolar disorder (BD) have suggested that exposure to childhood trauma (CT) and rapid cycling BD (RC-BD) are associated with earlier onset and overall worse prognosis. The association between CT exposure and RC-BD in patients from low/middle-income countries has not been sufficiently characterized. Therefore, we performed a case–control study of patients with RC-BD (n = 35), patients without RC-BD (n = 35), and healthy controls (HC) (n = 105) in a low/middle-income country, Colombia, to evaluate CT exposure and RC-BD for clinical associations. We reported a significant number of patients with RC-BD exposed to physical abuse and/or sexual abuse compared with patients without RC-BD during the course of illness. In addition, CT exposure and RC-BD were associated with an earlier age of onset and delayed diagnosis and treatment. In the future, recognition of early CT exposure in populations at risk for BD may help tailor precise interventions and thus change the course of illness and worse prognosis. [ABSTRACT FROM AUTHOR]

AbstractPurposeMaterials and methodsResultsConclusionTo explore the differences in mental health symptom profiles, trauma profiles, childhood trauma and comorbidities in patients with PTSD and those without PTSD.A cross-sectional study was carried out on 110 adult patients with trauma backgrounds attending a mental health outpatient clinic in Southern Oslo, Norway. In addition to self- report questionnaires, several standardized validated diagnostic tools were used to assess mental disorders. Multiple linear regression models were used to assess the association between trauma history, the mental health symptom profile of the patients, and PTSD diagnosis. Bivariate logistic regression was used to examine if childhood trauma/adversities were associated with PTSD.Patients diagnosed with PTSD had significantly higher rates of comorbid major depressive disorder, panic disorder, agoraphobia disorder, and social phobia compared to those without PTSD. We also found a positive association between PTSD diagnosis and all the different mental health symptoms domains of the Symptom Checklist-90-Revised instrument. When adjusted for age, gender, education, smoking habits, immigration, relationship, and employment status, these associations persisted with varying effects. We did not find any association between PTSD and childhood trauma/adversities, however, sexual abuse trended towards an association.Adult trauma patients with PTSD may have more comorbid disorders and mental health symptoms. Childhood trauma may be less critical for the PTSD diagnosis in this group. In clinical practice, personalized treatment plans addressing both the symptom burden and its comorbidities may be beneficial. [ABSTRACT FROM AUTHOR]

Childhood trauma, including emotional neglect, emotional abuse, physical abuse, and sexual abuse, may contribute to borderline personality features like affective instability, identity problems, negative relationships, and self-harm. This study aims to explore how different types of childhood trauma affect these features in bipolar versus unipolar depressive disorders. We included 839 participants of the Netherlands Study of Depression and Anxiety (NESDA) with a lifetime diagnosis of major depressive disorder single episode (MDD S; N = 443), recurrent major depressive disorder (MDD-R; N = 331), or bipolar disorder (BD; N = 65). Multivariate regression was used to analyze data from the Childhood Trauma Interview and borderline features (from the self-report Personality Assessment Inventory). On average, participants were 48.6 years old (SD: 12.6), with 69.2 % being women, and 50.3 % of participants assessed positive for childhood trauma. Adjusted analyses revealed that participants diagnosed with BD, followed by MDD-R, exhibited the highest number of borderline personality features. Additionally, within the entire group, a strong association was found between childhood trauma, especially emotional neglect, and the presence of borderline personality features. Given the high prevalence of childhood trauma and borderline personality features, screening for these factors in individuals with mood disorders is crucial. Identifying these elements can inform and enhance the management of the often fluctuating and complex nature of these comorbid conditions, leading to more effective and tailored treatment strategies. • Highest number of BPF was observed in BD followed by MD-recurrend and finally MD-single episode. • This order (BD > MD-recurrent > MD-single episode) was observed for all four main domains of BPD. • Within each diagnostic category, participants with a history of CT consistently showed higher average scores for BPF. • Emotional neglect was the most strongly associated factor, with the total number of BPF and its four main subscale scores. [ABSTRACT FROM AUTHOR]

Objective: The aim of this study was to investigate whether a potential moral cognitive impairment (failure in understanding moral rules) exists in patients with schizophrenia (SCZ) and to explore the effect of childhood trauma (CT) on moral cognition in a group of patients with SCZ. Methods: A total of 99 patients with SCZ and 102 healthy controls (HCs) were included in this study. The Childhood Trauma Questionnaire-Short Form (CTQ) was administered to assess childhood trauma experiences in both groups, while the Moral Identity Measure (MIM) and the Moral Foundations Questionnaire (MFQ) were applied for a comparative evaluation of moral cognition across the two groups. The Positive and Negative Syndrome Scale (PANSS) was administered to assess the psychopathology. Results: Patients with schizophrenia had significantly greater CTQ scores than HCs (42.77 ± 13.50 vs. 29.11 ± 4.25, t=9.697, p<0.001). The prevalence of childhood trauma (χ2 = 58.452, p<0.001) and history of aggressive behaviors (χ2 = 23.565, p=0.001) among patients with SCZ were greater than that among HCs. In addition, the scores of moral cognition (MIM: 61.82 ± 15.12 vs. 70.88 ± 8.87, p=0.001; MFQ: 87.24 ± 22.30 vs. 112.62 ± 23.42, p=0.045) in the SCZ group was lower than that in the HC group after controlling for the influence of CT covariates. The MFQ score was negatively correlated with the CTQ score, the emotional abuse (EA) score, the physical abuse (PA) score and the physical neglect (PN) score in SCZ patients. Among HCs, the MFQ score was positively correlated with the CTQ score, as well as with the dimensions of physical abuse (PA) and emotional Neglect (EN). Multiple linear regression analyses revealed that impaired moral cognition performance was significantly predicted by the CTQ score (beta=-0.235, p=0.034, 95% CI -0.743 to -0.031) in patients with SCZ but was significantly predicted by years of education (beta=-0.392, p<0.001, 95% CI -4.783 to -1.876), alcohol use (beta=0.210, p=0.023, 95% CI 2.191 to 29.399) and the CTQ score (beta=0.184, p=0.046, 95% CI 0.019 to 1.928) in HCs. CTQ moderated the effect of SCZ on MFQ (B = 0.516); Simple tests revealed that the group effect on the MFQ was B=12.306 at the lower level(-1SD) and B = 54.089 at the higher level(+1SD) of the CTQ scores. Conclusions: SCZ patients exhibit impaired moral cognition. The contribution of CT to the presence of moral cognitive impairments seems to be independent of psychopathology. [ABSTRACT FROM AUTHOR]

Background: Mental health problems among adolescents are a common concern globally. However, its relationship with childhood trauma is not clearly understood from the existing studies. Therefore, this study aims to explore the relationships among childhood trauma, mental health, self-control, and internet addiction in Chinese vocational high school students. Methods: A cross-sectional survey was conducted among vocational high school students in China from October 2020 to December 2020. Standardized questionnaires were used to collect basic information regarding childhood trauma, self-control, psychological state, and social demographics. A structural equation model was used to study the relationships among internet addiction, self-control, childhood trauma, and mental health. Results: A total of 3368 individuals participated in the study. The results revealed the mediating effects of poor self-control and internet addiction on the association between childhood trauma and mental health. Conclusions: Internet addiction and low self-control play mediating roles in childhood trauma and mental health. Clarifying these relationships will help formulate better-targeted interventions to improve the mental health of Chinese vocational high school students and aid in interventions to treat and prevent mental health problems. [ABSTRACT FROM AUTHOR]

Background: Due to a concerning rise in reported cases of childhood abuse in India, this study was initiated with the aim of uncovering the social determinants contributing to childhood trauma. Moreover, the second objective of the study was to discuss substance use initiation and patterns among children with cumulative trauma. Method: As a result, an in-depth interview served as a primary source of viewpoints to examine the essential objective. The study was conducted on children with a history of abuse. Twenty-eight children in the age group of 13–18 years (Mage = 16) residing in child-care institutes in Assam were taken into consideration. Results: Content analysis indicated child care and education, parental divorce or remarriage, domestic violence, family mental illness, household substance misuse, parental health, parental crime, poverty, and sexual and physical violence as social determinants of health for childhood trauma. Children reported using alcohol, marijuana, tobacco, cough syrup, inhalants such as paint, and glue, chewables such as betel nut and Gutka (chewing tobacco), and pharmaceutical tablets. Initiation and pattern of substance use among early initiators were likely to be encouraged by detrimental peer influence, indicating substance abuse as normal behavior and the family's role in shaping children's pattern of substance use. Problematic patterns of substance use were identified, for instance, health consequences, neglect of responsibilities, and increased daily frequency. Conclusion: The results of this study may offer practical insights for healthcare professionals, enhancing their comprehension and addressing the social determinants of health indicating trauma and referring them to appropriate treatments. A holistic approach, which encompasses the collaboration of policymakers and healthcare providers, is vital for fostering health equity, thereby potentially preventing child abuse, childhood trauma and subsequent recidivism of substance use. [ABSTRACT FROM AUTHOR]

Background: There is considerable evidence supporting the elevated risk of mental health problems in individuals with evening chronotype relative to those with morning or intermediate chronotypes. Recent data, however, suggest that this risk may be explained, at least partially, by poor sleep quality. Methods: This study aimed to further clarify the roles of chronotype and sleep quality in mental health outcomes (depression, anxiety, stress) in young individuals (18–40 years) living in the UK (n = 185) or Germany (n = 209). Results: Consistent with our recent observations in a comparable North Indian sample, we found that poor quality of sleep had significantly positive associations with adverse mental health outcomes both in the UK and Germany-based samples. Significant associations between evening chronotype and poor mental health were also evident, but these associations were fully mediated by poor quality of sleep in both samples. Conclusions: These observations suggest that efforts to identify sleep disruption in a timely manner and promotion of good sleep may prevent mental health problems, especially in individuals with evening chronotype and other known risks for mental disorders. [ABSTRACT FROM AUTHOR]

Self‐reported lost memory of child sexual abuse (CSA) can be mistaken for "repressed memory." Based on our longitudinal studies of memory and disclosure in child maltreatment victims who are now adults, we discuss findings relevant to "repressed memory cases." We examined relations between self‐report of temporarily lost memory of CSA (subjective forgetting) and memory accuracy for maltreatment‐related experiences (objective memory). Across two studies involving separate samples, we find evidence for memory suppression rather than repression: (1) Most adults who claimed temporary lost memory of CSA reported memory suppression and clarified that they could have remembered the event if asked; (2) subjective forgetting was positively associated with accurate objective memory for maltreatment‐related experiences. Subjective forgetting was also related to increased adult trauma symptoms and related to childhood non‐disclosure of CSA. Moreover, trauma‐related psychopathology mediated the relation between non‐disclosure and subjective forgetting. Implications for psychological theory and repressed memory cases are discussed. Self‐reported forgetting of child sexual abuse (CSA) may be misattributed to repressed memory. Using evidence from two longitudinal studies with separate maltreatment samples, we identify memory suppression as a more viable explanation than repression for CSA memory that has been reportedly lost and then retrieved. Important relations between self‐reported lost memory of CSA, accuracy of abuse‐related memory, childhood non‐disclosure of CSA, and adult trauma symptoms emerged, with significant legal implications. [ABSTRACT FROM AUTHOR]

Background: Black and Latino youth are disproportionately affected by trauma from community violence, but to date, few data support the benefit of evidence-based treatments for these youth or of including peer support to engage these youth in mental health services. Objective: From 2018 until 2020, a hospital and community-based violence intervention program in Philadelphia pilot tested the integration of home and community-based Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) with peer services and case management for youth impacted by community violence. This study describes the implementation of this intervention. Method: Data was gathered by querying the program's database. The Child Post Traumatic Stress Symptom Severity Scale (CPSS-SR-5) and the Short Mood and Feelings Questionnaire (SMFQ) were utilized to evaluate the participants' pre- and post-intervention assessment of PTSD and depression. The sample (N = 50) consisted of Black and Latino youth, mean age 14. Results: Twenty-nine (58%) completed TF-CBT, and 82% met peer and case management goals. Youth who completed therapy showed significant improvement in both PTSD and depression symptoms at post-test. Conclusion: To our knowledge, this is the first study describing the implementation of home and community-based TF-CBT with peer support and case management. The study's limitations and need for further research are discussed. Plain language summary: Black and Latino youth are disproportionally affected by violence across US cities. Mental health research is needed to evaluate how to engage these youth in mental health services and provide effective and culturally relevant trauma treatment. This research describes the experiences of 50 children and adolescents (ages 8–18) who participated in this pilot tested health services intervention using their electronic health records to access de-identified information and present youths' demographics, services received, and clinical outcomes. Specifically, we describe ways in which the intervention was culturally relevant to the participants' lived experiences. Services delivered consisted of the integration of Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) with peer services and case management for youth impacted by community violence. Services were provided by licensed social workers and certified peer specialists at a hospital and community-based (i.e., youth's home, school) violence intervention program (HVIP). Our results indicate that this intervention shows preliminary efficacy for decreasing post-traumatic stress disorder (PTSD) and depression symptoms for Black & Latino youth impacted by ongoing violence. This real-world study lays out a blueprint for implementing similar programs. The study has several limitations, and we discuss the need for additional research. [ABSTRACT FROM AUTHOR]

Adolescents exposed to childhood trauma are at an elevated risk for social anxiety. However, the physiological mechanisms linking childhood trauma and adolescents' social anxiety remain poorly understood. This study examined whether cardiovascular reactivity to acute social stress was a mechanism underlying this association. Participants were Chinese adolescents (N = 172; Mage = 12.95). They first reported their childhood trauma and social anxiety using the Childhood Trauma Questionnaire and the Social Interaction Anxiety Scale. They then participated in a social stress task, during which their cardiovascular data [heart rate (HR) and systolic and diastolic blood pressure (SBP, DBP)] were monitored. The results showed that high levels of childhood trauma were associated with blunted HR, SBP, and DBP reactivity, which in turn were associated with high levels of social anxiety. Mediation analysis indicated that childhood trauma was indirectly associated with social anxiety via blunted cardiovascular reactivity. The findings suggest that blunted cardiovascular reactivity may serve as a physiological pathway linking childhood trauma and adolescents' social anxiety. [ABSTRACT FROM AUTHOR]

Biological mechanisms underlying anxiety proneness (AP), the tendency to react fearfully to stressors due to the belief that experiencing anxiety has harmful consequences, remain unclear. Epigenetic mechanisms, such as microRNAs (small, non‐coding RNAs 19–20 nucleotides long), may be contributory. This study investigated AP‐associated differences in microRNA expression among South African adolescents with variable exposure to childhood trauma (CT). AP was assessed using a composite score reflecting trait anxiety and anxiety sensitivity, while CT exposure was assessed with the Childhood Trauma Questionnaire. High‐quality total RNA (n = 88) extracted from whole blood underwent microRNA‐sequencing. Differential microRNA expression analysis was conducted with DESeq2 in R, messenger RNA target prediction analysis was performed using TargetScan and DIANA‐microT, and the DIANA mirPATH tool was used for KEGG pathway analysis. The majority of participants were female (75.86%) with an average age of 15 (±1.19) years. MicroRNA expression analysis identified upregulation of hsa‐miR‐28‐5p and downregulation of hsa‐miR‐502‐3p and hsa‐miR‐500a‐3p in high‐AP individuals, irrespective of CT. Four KEGG pathways, each with ≥10% of their constituent genes predicted to be targets of the differentially expressed microRNAs, were identified and were enriched for genes involved in calcineurin and glutamate signalling. These findings suggest that epigenetically mediated effects on neuronal function contribute to the molecular aetiology of AP. [ABSTRACT FROM AUTHOR]

This study explored the relationship between childhood trauma and sex addiction among a sample of adult men (N = 149). Thirty‐eight (25.5%) men screened positive for sex addiction, whereas 111 (74.5%) did not. Using descriptive discriminant analysis, we found that four subscales of early trauma predicted risk of sex addiction group membership to varying degrees, accounting for 22.3% of the variance explained. Sexual and emotional abuse accounted for the most variance explained in the group differences, whereas physical abuse and, to a lesser extent, general trauma also contributed to the group differences. Implications of the study findings are discussed. [ABSTRACT FROM AUTHOR]

This study aimed to explore the pathway from childhood trauma to nonsuicidal self-injury (NSSI) in adolescents with major depressive disorder (MDD) and to examine the chain-mediating role of psychological resilience and depressive symptoms in this pathway. A total of 391 adolescents with MDD were recruited in the present study. The Chinese version of the Childhood Trauma Questionnaire—Short Form (CTQ-SF), the Chinese version of the Symptoms Check List-90 (SCL-90), the Chinese version of the Conner-Davidson Resilience Scale (CD-RISC), and the Ottawa Self-Injury Inventory Chinese Revised Edition (OSIC) were used to evaluate childhood trauma, depressive symptoms, psychological resilience and NSSI, respectively. Our results showed that 60.87% of adolescents with MDD had NSSI in the past month. Childhood trauma frequency was negatively correlated with psychological resilience but positively correlated with depressive symptoms and NSSI severity in adolescents with MDD. The stepwise logistic regression analysis identified that age, childhood trauma and depressive symptoms could independently predict the occurrence of NSSI, and the three-step hierarchical regression showed that childhood trauma, psychological resilience and depressive symptoms were all significantly associated with NSSI frequency in adolescents with MDD. Furthermore, the chain-mediation analysis revealed that psychological resilience and depression serially mediated the relationship between childhood trauma and NSSI in adolescents with MDD. Interventions targeted at improving resilience and depression may mitigate the impact of childhood trauma severity on NSSI risk in adolescents with MDD. [ABSTRACT FROM AUTHOR]

In patients with psychosis, rates of tobacco smoking and childhood trauma are significantly higher compared to the general population. Childhood trauma has been proposed as a risk factor for tobacco smoking. However, little is known about the relationship between childhood trauma and smoking in psychosis. In a subsample of the Genetic Risk and Outcome of Psychosis study (760 patients with psychosis, 991 unaffected siblings, and 491 healthy controls), tobacco smoking was assessed using the Composite International Diagnostic Interview and childhood trauma was measured with the Childhood Trauma Questionnaire. Logistic regression models were used to assess associations between trauma and smoking, while correcting for confounders. Positive associations were found between total trauma, abuse, and neglect, and an increased risk for smoking in patients, while correcting for age and gender (ORtrauma 1.77, 95% CI 1.30–2.42, p < 0.001; ORabuse 1.69, 95% CI 1.23–2.31, p = 0.001; ORneglect 1.48, 95% CI 1.08–2.02, p = 0.014). In controls, total trauma and abuse were positively associated with smoking, while correcting for age and gender (ORtrauma 2.40, 95% CI 1.49–3.88, p < 0.001; ORabuse 2.02, 96% CI 1.23–3.32, p = 0.006). All associations lost their significance after controlling for additional covariates and multiple testing. Findings suggest that the association between childhood trauma and tobacco smoking can be mainly explained by confounders (gender, cannabis use, and education) in patients with psychosis. These identified aspects should be acknowledged in tobacco cessation programs. [ABSTRACT FROM AUTHOR]

The first purpose of this study was to determine the course of dissociation among patients with borderline personality disorder (BPD) and personality-disordered comparison subjects (OPD) over 24 years of prospective follow-up. The second purpose was to determine clinically meaningful predictors of dissociation among patients with BPD. The Dissociative Experiences Scale (DES) was administered to 290 patients with BPD and 72 personality-disordered comparison subjects at baseline, and then once every two years over 24 years of prospective follow-up. Baseline predictors were assessed with the Revised Childhood Experiences Questionnaire (CEQ-R), the SCID-I, and the Shipley Institute of Living Scale. Time-varying predictors were assessed at baseline and every subsequent two years by means of the Abuse History Interview (AHI). Patients with BPD had higher baseline dissociation scores than personality-disordered comparison subjects. Whilst dissociation decreased significantly over time for both patient groups, the BPD group showed a steeper decline. Severity of childhood sexual abuse, adult history of rape, adult history of partner violence, and IQ were multivariate predictors of dissociation among patients with BPD. Taken together, the present findings suggest that a combination of interpersonal trauma exposure and cognitive abilities may contribute to the severity of dissociation in adult patients with BPD. [ABSTRACT FROM AUTHOR]

Adult survivors of childhood sexual abuse (CSA) may experience emotional, social, and psychological difficulties, heightened due to the interpersonal nature of harm. Despite the demonstrated effectiveness of trauma-focused treatments in the West, a culturally specific understanding of the needs of and treatments for survivors in South Asia is still in its infancy. The study aimed to systematically review research findings on the mental health impacts of CSA on adult survivors and current treatment approaches and their efficacy and acceptability in South Asia. Seven databases (Scopus, Ovid, CINAHL, ProQuest, EThOS, Google Scholar, and Dogpile) and five peer-reviewed South Asian journals were searched from inception until March 30, 2023. Searches included participants who were adult survivors of CSA of South Asian origin residing in South Asia. Studies on their mental health, different treatments, and the efficacy and acceptability of these treatments were included. Quality assessment tools were used to appraise the quality of included studies. The results were synthesized narratively. A total of 3,362 records were retrieved, and 24 articles were included in the final review. Twenty studies reported mental health impacts of CSA on adult survivors, four studies reported current treatments offered, and two studies were on recovery. However, no study focused on the efficacy or acceptability of the treatments being delivered. Even though the needs of adult CSA survivors in South Asia have been partly identified, there is very little research into the treatments for them. [ABSTRACT FROM AUTHOR]

Purpose: To compare the prevalence of emotional and physical intimate partner violence (IPV) across pregnancy and the first year postpartum in those with and without clinical depression and assess the association between maternal childhood trauma, current stressful life events and depression and IPV over the perinatal period. Methods: Data were obtained from 505 pregnant women from the Mercy Pregnancy and Emotional Wellbeing Study (MPEWS), a cohort study with data collected across pregnancy until 12 months postpartum. Maternal antenatal depression was measured using the Structured Clinical Interview for DSM-IV (SCID-IV) with repeat measurement of perinatal depressive symptoms using the Edinburgh Postnatal Depression Scale (EPDS). Trauma was measured using the Childhood Trauma Questionnaire, and experiences of physical and emotional intimate partner violence using items in the Stressful Life Events Scale. Results: Women experiencing IPV across the perinatal period were significantly more likely to score over 13 on the EPDS (p <.001) at each timepoint in pregnancy and the postpartum and physical IPV was associated with clinical depression. Further, a history of childhood trauma and current additional stressful life events were significantly associated with reporting current IPV in the perinatal period. Conclusions: This study confirmed the risk factors of childhood trauma and current stressful life events for reporting experiences of IPV in the perinatal period. Furthermore, women experiencing IPV reported higher depressive symptoms, providing evidence supporting the value of assessing those women who screen higher on the EPDS for IPV. Together these findings also support trauma informed care across pregnancy and the postpartum. [ABSTRACT FROM AUTHOR]

Childhood adversity is linked to psychological, behavioral, and physical health problems, including obesity and cardiometabolic disease. Epigenetic alterations are one pathway through which the effects of early life stress and adversity might persist into adulthood. Epigenetic mechanisms have also been proposed to explain why cardiometabolic health can vary greatly between individuals with similar Body Mass Index (BMIs). We evaluated two independent cross-sectional cohorts of adults without known medical illness, one of which explicitly recruited individuals with early life stress (ELS) and control participants (n = 195), and the other a general community sample (n = 477). In these cohorts, we examine associations between childhood adversity, epigenetic aging, and metabolic health. Childhood adversity was associated with increased GrimAge Acceleration (GAA) in both cohorts, both utilizing a dichotomous yes/no classification (both p < 0.01) as well as a continuous measure using the Childhood Trauma Questionnaire (CTQ) (both p < 0.05). Further investigation demonstrated that CTQ subscales for physical and sexual abuse (both p < 0.05) were associated with increased GAA in both cohorts, whereas physical and emotional neglect were not. In both cohorts, higher CTQ was also associated with higher BMI and increased insulin resistance (both p < 0.05). Finally, we demonstrate a moderating effect of BMI on the relationship between GAA and insulin resistance where GAA correlated with insulin resistance specifically at higher BMIs. These results, which were largely replicated between two independent cohorts, suggest that interactions between epigenetics, obesity, and metabolic health may be important mechanisms through which childhood adversity contributes to long-term physical and metabolic health effects. [ABSTRACT FROM AUTHOR]

Childhood trauma is a risk factor for self-harm/suicidal behavior, but research on the potential association linking sleep quality and anxiety symptoms to childhood trauma and self-harm attempt is limited. The aim of this study was to describe the mediating role of sleep quality and anxiety symptoms between childhood trauma and self-harm attempt, and to provide a scientific basis for the prevention of self-harm behaviors. This study ultimately included 11,063 study participants who participated in the baseline survey of this large prospective cohort study of the UK Biobank. We used structural equation modeling (SEM) to analyze the chain mediating role of sleep quality and anxiety symptoms in childhood trauma and self-harm attempt while controlling for covariates. A total of 19.58 % of study participants self-reported self-harm attempt. Sleep quality was negatively correlated with childhood trauma, anxiety symptoms, and self-harm attempt (p < 0.01). Childhood trauma, anxiety symptoms, and self-harm attempt were positively correlated (p < 0.01). In addition, after adjusting for confounders, anxiety symptoms were able to partially mediate the association between childhood trauma and self-harm attempt (effect value: 0.042, p < 0.01), and sleep quality and anxiety symptoms can chain mediate the association between childhood trauma and self-harm attempt (effect value:0.002, p < 0.01), with a total mediating effect of 65.67 % of the total effect. Subgroup analyses further showed that the mediating effects of sleep quality and anxiety symptoms on childhood trauma and self-harm attempt differed across age, gender, ethnicity, and smoking and drinking subgroups. This study found a complex relationship between childhood trauma, sleep quality, anxiety symptoms, and self-harm attempt, with sleep quality and anxiety symptoms mediating the relationship between childhood trauma and self-harm attempt. Multiple avenues of intervention, such as the provision of professional psychological interventions and timely monitoring, should be used to improve the sleep quality and mental health of individuals with traumatic childhood experiences and to prevent the occurrence of emotionally harmful behaviors such as self-harm/suicide. • Childhood trauma can negatively influence anxiety symptoms and self-harm attempt, and positively influence sleep quality. Anxiety symptoms can positively influence self-harm attempt. Sleep quality can negatively influence self-harm attempt and anxiety symptoms. • Anxiety symptoms were able to partially mediate the association between childhood trauma and self-harm attempt. And sleep quality and anxiety symptoms can chain mediate the association between childhood trauma and self-harm attempt. • Subgroup analyses showed that the mediating effects of sleep quality and anxiety symptoms on childhood trauma and self-harm attempt differed across characteristics. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Modern Science is the property of Alcide De Gasperi University of Euroregional Economy and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This study aimed to investigate the associations of childhood trauma and its facets with depressive symptoms in depressed adolescents during the post COVID-19 epidemic, and explore the potential mediating role of social peer rejection in these associations. A total of 413 adolescents with depressive disorders completed the Chinese version of the Child Trauma Questionnaire Short Form, the Social Peer Rejection, and the Children’s Depression Inventory. Childhood trauma (β = 0.42, p < 0.01) and social peer rejection (β = 0.18, p < 0.01) were positively related to depressive symptoms, after adjustment for demographic factors. Furthermore, social peer rejection partly mediated the relationship between childhood trauma and depressive symptoms, and the mediation effect ratio was 17.0% (p < 0.001). This study found that childhood trauma and social peer rejection are both risk factors for depressive symptoms, and social peer rejection played a mediating role in the relationship between childhood trauma and depressive symptoms. [ABSTRACT FROM AUTHOR]

This study explores the impact of life course socioeconomic status (SES) and childhood trauma on depressive symptoms in Chinese middle-aged and older adults, while also examining the role of chronic diseases and implications for social work practice. Using data from 9,942 participants, structural equation was established to investigate these relationships. Results reveals that low childhood SES positively affects depressive symptoms through low SES in mid-to-late life (std. β = 0.168, p < .001), and domestic child abuse negatively impacts depressive symptoms through low SES in mid-to-late life (std. β=-0.020, p < .001). Additionally, experiencing peer bullying is directly associated with depressive symptoms (std. β = 0.145, p < .001). Exposure to domestic violence is directly related to depressive symptoms (std. β = 0.078, p < .001) and indirectly leads to more severe depressive symptoms through chronic disease (std. β = 0.023, p < .001). Social workers in healthcare settings can utilize these findings to better understand risk factors for depression and provide trauma-informed care and economic assistance across the life course. Additional training for social workers on the lasting impacts of childhood adversity is warranted. By intervening at both individual and policy levels, social work practitioners can help break cycles of poverty and poor health stemming from childhood. [ABSTRACT FROM AUTHOR]

Recent research has primarily focused on elucidating the role of specific cognitive vulnerability factors in the intricate relationship between childhood trauma and depression. To advance existing research by integrating two prominent cognitive theories of depression (the Beck's cognitive theory and hopelessness theory), this study proposed a moderated mediation model aimed at investigating the mediating role of the sense of control and the moderating effect of rumination in this complex association. A sample of 1,091 college students (comprising 436 males; age range 17–25) was recruited through poster advertisements and a snowball sampling approach. Participants voluntarily engaged in the study and completed a battery of assessments, including measures of depression, childhood trauma, sense of control, and rumination. Our findings suggest that childhood trauma affects depression not only directly but also indirectly through the mediating influence of the sense of control. Furthermore, the result reveals that the mediating role of the sense of control is moderated by the intensity of rumination. Specifically, this mediating effect is more pronounced among college students with higher levels of rumination. The outcomes of this investigation provide prospective empirical support, suggesting that the loss of control and rumination may serve as viable targets for preventative and interventional measures in addressing depression among individuals who have experienced childhood trauma. This research enhances our understanding of the intricate interplay between cognitive determinants and depression, informing future research in this critical domain of mental health. [ABSTRACT FROM AUTHOR]

This article explores the opportunities for client and therapist when somatic therapies and psychotherapy are brought together. Through a case study I illustrate how understandings and interventions from Intersubjective Self Psychology, Somatic Experiencing®, and Integral Somatic Psychology™ all supported the client’s emergence from profoundly somatised childhood traumatic loss, allowing them to restore thwarted developmental processes, rebuild affect tolerance, process their grief, and inhabit their life in new ways. I explicate how a deeply embodied psychotherapeutic relationship, where the conversations between the client and therapist’s bodies are held at the centre of the therapeutic relationship, can support reducing client re-traumatisation in therapy, meet early developmental needs, re-link affective layers allowing somatic and psychological (re)integration. I also explore the impact on, and possibilities for, the therapist of combining somatics and psychotherapeutic principles and techniques. [ABSTRACT FROM AUTHOR]

We aimed to examine whether positive and negative coping styles mediated the influences of childhood trauma on NSSI or depressive severity in adolescents with major depressive disorder (MDD). The Children's Depression Inventory (CDI), the Ottawa Self-Injury Inventory Chinese Revised Edition (OSIC), the short-form Childhood Trauma Questionnaire (CTQ-SF), and the Simplified Coping Style Questionnaire (SCSQ) were evaluated in 313 adolescents with MDD. MDD adolescents with NSSI had higher CTQ-SF total score, emotional and sexual abuse subscale scores, but lower CDI total and subscale scores compared to the patients without NSSI. The multiple linear regression analysis revealed that emotional abuse (β = 0.075, 95 % CI: 0.042–0.107) and ineffectiveness (β = −0.084, 95 % CI: −0.160 ∼ −0.009) were significantly associated with the frequency of NSSI in adolescents with MDD, but emotional abuse (β = 0.884, 95 % CI: 0.570–1.197), sexual abuse (β = 0.825, 95 % CI: 0.527–1.124) and negative coping style (β = 0.370, 95 % CI: 0.036–0.704) were independently associated with the depressive severity in these adolescents. Furthermore, the mediation analysis demonstrated that positive coping style partially mediates the effect of childhood trauma on NSSI (Indirect effect = 0.002, 95 % bootCI: 0.001–0.004), while the negative coping style partially mediates the relationship between childhood trauma and depressive severity (Indirect effect = 0.024, 95 % bootCI: 0.005–0.051) in adolescents with MDD. A cross-sectional design, the retrospective self-reported data, the small sample size. Our findings suggest that coping styles may serve as mediators on the path from childhood trauma to NSSI or depressive severity in MDD adolescents. • Adolescent depressive patients with nonsuicidal self-injury (NSSI) had higher level of childhood maltreatment compared to patients without. • Childhood maltreatment is positively correlated to the NSSI and depressive severity in adolescents with major depressive disorder. • The coping style can mediate the effect of childhood trauma on NSSI and depressive severity in depressive adolescents. [ABSTRACT FROM AUTHOR]

Background: Childhood trauma history has frequently been linked to eating disorders (EDs); nevertheless, the scientific literature calls for extending knowledge regarding mediators between EDs and childhood trauma. This study explored whether ED symptoms and early maladaptive schemas were more severe in ED patients with severe childhood trauma than in ED patients with no/mild childhood trauma and whether early maladaptive schemas mediated the relationship between childhood trauma and ED symptom severity. Methods: Data were extracted from the Regional Centre for Eating Disorders registry at the University Hospital of Verona. The extracted data included self-reported data, including the Eating Disorder Inventory-3 score, Young Schema Questionnaire score, Childhood Experience and Experience of Care and Abuse Questionnaire score, and sociodemographic and clinical information on the ED outpatients seeking care. A mediation analysis using the structural equation modeling procedure was conducted. Results: Forty-two outpatients, 31% of whom exhibited severe childhood trauma, satisfied the criteria for registry data extraction. The severity of ED symptoms, as well as the early maladaptive schemas' scores for emotional deprivation, defectiveness, failure, vulnerability, insufficient self-control, and negativity, were greater in ED outpatients with severe childhood trauma. Furthermore, early maladaptive schemas related to defectiveness, failure, and negativity had a mediating role in the relationship between severe childhood trauma and ED symptom severity. Conclusions: This exploratory study provides preliminary evidence about the importance of early maladaptive schemas in the relationship between trauma history and ED psychopathology. In addition, ED symptoms may represent a dysfunctional attempt to avoid unpleasant emotions associated with schema activation. The results support the need to consider early maladaptive schemas in the treatment of traumatized patients with ED symptoms. Study limitations, research and clinical implications are discussed. Plain English summary: Eating disorder psychopathology was found to be related to a history of trauma. Nonetheless, our understanding of the mediators of the relationship between childhood trauma and eating disorders remains to be improved. The current study revealed that certain early maladaptive schemas (i.e., defectiveness, failure, and negativity) mediated the relationship between childhood trauma and eating disorder symptoms and that outpatients who experienced severe childhood trauma reported more severe eating disorder symptoms and greater severity of certain early maladaptive schemas, such as emotional deprivation, defectiveness, failure, vulnerability, insufficient self-control, and negativity. Our findings support the need to consider early maladaptive schemas in the treatment of traumatized patients with eating disorders. [ABSTRACT FROM AUTHOR]

The 33-item Childhood Trauma Questionnaire (CTQ-33) is a recently developed tool expanded from the 28-item Childhood Trauma Questionnaire (CTQ-28) to assess childhood trauma events, which showed good test-retest reliability over 2 weeks. However, little is known regarding the factor structure and long-term test-retest reliability of the CTQ-33. To fill such a gap, this study investigated the factorial validity of the CTQ-33 and test-retest reliability of the scale over a relatively long interval of 1 year. Data on demographics, the CTQ-33 scores, and mental health statuses such as depressive/anxiety symptoms were collected in Chinese adolescents (n = 188) twice across a one-year period. Results of the confirmatory factor analysis (CFA) revealed that the Chinese version of CTQ-33 has close factor validity when compared to the original CTQ-28 in college students. Furthermore, the total and most subscale scores of the CTQ-33 have fair to good test-retest reliability (intra-class correlation coefficients >0.6 for the total score, and > 0.4 for most subscales), except for the physical abuse subscale. Moreover, we replicated previous findings of significant positive relationships between levels of different childhood trauma subtypes using the CTQ-33. These findings provide initial evidence supporting that the CTQ-33 is overall reliable to assess childhood traumatic events in adolescents over relatively long intervals. [ABSTRACT FROM AUTHOR]

Maladaptive eating attitudes that are common among nonclinical emerging adults may constitute an intense vulnerability for various eating disorders. Although the association between childhood trauma and adulthood eating problems has been widely established, the need for further knowledge of the explanatory role of emotional mechanisms in the relationship remains. Therefore, the study aimed to examine the mediator roles of self-disgust and body shame in the association between childhood trauma and maladaptive eating attitudes. The study sample comprised 397 volunteered women aged between 18 and 25 (M = 21.89, SD = 2.11). The Childhood Trauma Questionnaire, Self-Disgust Scale - Revised Form, Objectified Body Consciousness Scale, and Eating Attitudes Test were administered online for data collection. The results of the correlation analysis revealed a positive relationship among childhood trauma, self-directed disgust, body shame, and disordered eating attitudes. The serial model was also significant, indicating that both self-disgust and body shame independently and together fully mediated the association between childhood trauma and maladaptive eating attitudes. These findings point to the importance of assessing early life traumas and emotional maintaining factors for comprehensive case conceptualizations and preventive and therapeutic applications. [ABSTRACT FROM AUTHOR]

Objective: Childhood traumas (CT), particularly sexual abuse, are linked with sexual dysfunction and reduced sexual satisfaction. This study explores the association between CT, anxiety, and sexual satisfaction in individuals with erectile dysfunction (ED). Method: The study cohort consisted of 93 patients with ED and 95 control group volunteers. Participants completed self-report forms on demographic data and sexual histories, along with the Childhood Trauma Questionnaire (CTQ), the State and Trait Anxiety Inventory (STAI), and the Golombok-Rust Inventory of Sexual Satisfaction (GRISS). Results: Forty participants from the ED groups also had a co-diagnosis of premature ejaculation (PE). Those with co-morbid PE were categorized as a separate group (ED + PE). Physical abuse, sexual abuse, and minimization as measured by the CTQ, along with impotence, infrequency, and dissatisfaction as measured by the GRISS, were significantly lower in the control group compared to the ED and ED + PE groups (p<0.001). Anxiety scores were significantly different between the ED + PE group and both the ED and control groups (p<0.001). A history of childhood sexual abuse was linked to avoidance behavior (p<0.05). Significant correlations were observed between emotional maltreatment and PE (p<0.05), impotence and minimization (p<0.001), impotence and psychical neglect (p<0.05), and tactile avoidance and emotional neglect (p<0.01). Conclusion: This study highlights the importance of CT, including types other than sexual abuse, in contributing to sexual dysfunction and diminished satisfaction. [ABSTRACT FROM AUTHOR]

Objective: This study aims to explore the interconnections between social anxiety disorder (SAD), adverse childhood experiences, and pathological narcissism. Methods: The study included 66 patients diagnosed with SAD according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria and 55 healthy controls. All participants were assessed using The Liebowitz Social Phobia Scale (LSAS), Childhood Trauma Questionnaire (CTQ), Hypersensitive Narcissism Scale (HSNS), and Narcissistic Personality Inventory-16 (NPI-16) scales. Statistical analyses included descriptive statistics, Student’s t-test, Chi-squared test, correlation tests to examine relationships between variables, and logistic regression to identify significant predictors of SAD, particularly focusing on the role of childhood trauma and narcissistic traits. Results: The SAD patients had significantly higher scores on the CTQ total and subscales, as well as on the HSNS, compared to the healthy control group (p < .001). Additionally, there was a positive correlation between LSAS scores and both CTQ (r=.585, p < .01) and HSNS scores (r=.582, p < .01). However, no significant association was found between NPI-16 scores and LSAS or CTQ scores (r=-.064, p>.05). Conclusion: This study highlights the increased levels of narcissistic pathology and history of childhood trauma in SAD patients. Vulnerable narcissism emerges as a key factor in SAD, emphasizing the need for comprehensive treatment approaches considering childhood trauma and narcissistic vulnerability. [ABSTRACT FROM AUTHOR]

Early-life adversity increases the risk of health problems. Interventions supporting protective and responsive caregiving offer a promising approach to attenuating adversity-induced changes in stress-sensitive biomarkers. This study tested whether participation in an evidence-based dyadic psychosocial intervention, child-parent psychotherapy (CPP), was related to lower epigenetic age acceleration, a trauma-sensitive biomarker of accelerated biological aging that is associated with later health impairment, in a sample of children with trauma histories. Within this quasi-experimental, repeated-measures study, we examined epigenetic age acceleration at baseline and postintervention in a low-income sample of children receiving CPP treatment (n = 45; age range = 2-6 years; 76% Latino) compared with a weighted, propensity-matched community-comparison sample (n = 110; age range = 3-6 years; 40% Latino). Baseline epigenetic age acceleration was equivalent across groups. However, posttreatment, epigenetic age acceleration in the treatment group was lower than in the matched community sample. Findings highlight the potential for a dyadic psychosocial intervention to ameliorate accelerated biological aging in trauma-exposed children. [ABSTRACT FROM AUTHOR]

This study investigates the childhood traumas of individuals who experienced parental death in childhood or adolescence in Turkey. Participants (n = 382; 63.1% female and 36.9% male; MAGE=29.41, SD = 9.6) are composed of individuals who lost either or both of their parents before the age of 18. The findings indicated that there is a significant difference between the subdimensions of Childhood Trauma Questionaire and the study variables including gender, marital status, educational status, number of siblings, gender of the deceased parent, the caregiver after the parental death, relationship with the surviving parent and the age at the time of parental death (p <.05). The results further show that individuals who lost their parents before the age of 10, who lost their mothers, and who received care from other relatives instead of parents are exposed to more neglect and abuse. By identifying childhood traumas in individuals and examining related variables, the findings contribute trauma-informed social work practices. Based on the results, it is recommended that school social work programs focus on monitoring the relationship between caregivers and children, as well as enhancing the psychosocial well-being of students. These programs can also serve as a means to raise awareness among professionals and students. [ABSTRACT FROM AUTHOR]

Childhood trauma is associated with poor health outcomes in adulthood, largely due to the impact of chronic stress on the body. Fortunately, there are certain protective characteristics, such as constraint (i.e., impulse control, inhibition, and avoidance of unconventional behavior and risk) and cognitive reappraisal (i.e., reframing circumstances in a more positive light). In the present study, we investigated the interaction between childhood trauma, resilience, and neural correlates of emotion processing. Participants responded to survey questions regarding childhood trauma and resilient characteristics. They were later invited to passively view neutral, unpleasant, and pleasant images while their brain activity was recorded via electroencephalography (EEG). We analyzed two event-related potential (ERP) components of interest: the Early Posterior Negativity (EPN) and Late Positive Potential (LPP). We found that childhood trauma was associated with decreased constraint and reduced sensitivity to unpleasant images (i.e., decreased LPP amplitude differences between neutral and unpleasant images as compared to controls). Further, constraint predicted increased sensitivity to pleasant images. In a hierarchical linear regression analysis, we found that constraint moderated the relation between childhood trauma and emotion processing, such that it predicted increased sensitivity to unpleasant images for adults with childhood trauma in particular. Childhood trauma and cognitive reappraisal independently predicted decreased sensitivity to unpleasant images, (i.e., decreased LPP amplitude differences between neutral and unpleasant images). Our findings suggest that childhood trauma and resilient characteristics independently and interactively influence emotion processing. [ABSTRACT FROM AUTHOR]

Trauma-informed care (TIC) is a relatively new topic in the Estonian child protection system, but it has become the particular focus of substitute care. The Estonian child protection system focuses on protecting children from maltreatment, and neglects the adult carers' right to adequate information about the child's trauma experience. This makes trauma-informed care vague. This article is based on focus groups conducted for a wider study that aims to develop the basis for a TIC training course for foster parents and staff members working as direct caregivers in residential substitute care. The foster parents and staff members participated in four focus groups, with special attention on their experiences with TIC. The participants eagerly shared their experiences, and thematic narrative analysis was used during the data analysis. The central theme of the participants' stories was the need for information about the child's traumatic past. The findings indicate that a complex interplay exists between the needs of children entering substitute care and the capacity of the foster parents and residential care staff to meet those needs. It is complicated for a child to heal from trauma if the child's past is hidden from their carers. This could result in re-traumatisation and hinder the child from making sense of past trauma. Estonia's child protection system needs greater awareness of the impact of trauma on the child's behaviour and how to help the child heal. This is directly connected to the need for clear and precise information, which is one of the basic rights of the child. [ABSTRACT FROM AUTHOR]

While psychopathy has been a topic of interest in the psychological field for a long time, it is still unclear which developmental factors are related to its onset. Theories have suggested that experiencing trauma in childhood may contribute to the development of psychopathic traits. Experiencing trauma may also contribute to the development of an insecure attachment style, which in turn might cause the emergence of psychopathic traits. The current study investigated links between experiencing childhood trauma and the three psychopathy domains of the Extended Levenson Self-Report Psychopathy scale (E-LSRP; Egocentricity, Callousness, and Antisocial), and whether these links were mediated by the four insecure attachment dimensions of the Attachment Style Questionnaire (ASQ; Need for Approval, Preoccupation with Relationships, Relationships as Secondary, and Discomfort with Closeness), in a large sample of non-clinical participants (N = 2023, Mage = 32.7, 70.0% female). The results suggested that Relationships as Secondary, but not Discomfort with Closeness, positively mediated the relationship between childhood trauma and the three domains of psychopathy, while Need for Approval negatively mediated this relationship. Preoccupation with Relationships was a significant mediator in the links between childhood trauma and both the Egocentricity and Antisocial domains, but not the Callousness domain. The current findings suggested that there might be both shared and differential mechanisms linking childhood trauma and psychopathic traits through insecure attachment styles. These findings can guide further investigations in longitudinal research. [ABSTRACT FROM AUTHOR]

Background: The enduring and detrimental impact of childhood trauma on later health and well-being is now well established. However, research on the relationship between childhood trauma and depressive symptoms, along with the potential risk and protective factors, is insufficient in the context of Chinese college student population. Methods: Data on childhood trauma, depressive symptoms, resilience, and subjective well-being were collected through surveys conducted with 367 Chinese university students. The data collected in this study were analyzed using SPSS 26.0 and PROCESS 3.5. Results: The results revealed that subjective well-being mediated the relationship between childhood trauma and depressive symptoms among college students, with direct and indirect effects accounting for 59.46% and 40.54% of the total effect, respectively. The pathway process between subjective well-being and depressive symptoms was moderated by resilience, whereby an increase in resilience levels corresponded to a gradual escalation in the predictive power of subjective well-being on depressive symptoms. Conclusion: The study indicates that childhood trauma significantly and positively predicts depressive symptoms among college students, and it can also directly predict depressive symptoms through the mediating effect of subjective well-being. Elevating levels of psychological resilience and subjective well-being among college students can mitigate depression and promote psychological well-being. From the perspective of positive psychology, the present study provides a new perspective for the prevention and intervention of depressive symptoms among college students. [ABSTRACT FROM AUTHOR]

Copyright of Health Psychology is the property of American Psychological Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background During the last decades, an abundance of studies has investigated childhood adversity in relation to psychosis. This systematic review critically examines the methodologies employed to investigate childhood adversity in psychosis over the past decade, including operational definitions, measurement tools and characteristics, and psychometric properties of instruments used in these studies. Study Design This systematic review followed the PRISMA guidelines (registration number CRD42022307096), and the search used the following electronic databases: PsychINFO, SCOPUS, Web of Science, African Index Medicus (AIM), LILACS, CINAHL, EMBASE, and MEDLINE. The search included variations and combinations of the terms targeting childhood adversity and psychosis. Study Results Out of 585 identified studies published between 2010 and 2023, 341 employed a validated instrument to investigate childhood adversity. Our findings show "childhood trauma" being the most frequently examined construct, followed by "child maltreatment" or "child abuse." The short version of the Childhood Trauma Questionnaire was the dominant instrument. Physical abuse, emotional abuse, and sexual abuse were most frequently investigated, and indeed the field appears generally to focus on child abuse and neglect over other adversities. Significant psychometric heterogeneity was observed in the selection and summarization of instrument items, with only 59% of studies documenting original psychometric validation and 22% reporting reliability in their datasets. Conclusion This review highlights substantial methodological heterogeneity in the field, pointing out biases in the research on childhood adversity and psychosis. These findings underline the need for standardized definitions and high-quality measurement tools to enhance the validity of future research in this area. [ABSTRACT FROM AUTHOR]

Objective: The present study aimed to investigate the moderating role of family communication patterns in the relationship between childhood trauma and the tendency toward addiction in adolescent boys. Methods and Materials: The research method was descriptive-correlational. The statistical population consisted of all adolescents aged 12 to 17 years, from seventh to twelfth grade, in the year 2023. The research sample included 380 individuals selected through multistage cluster sampling. They were evaluated using the Ahvaz Addiction Tendency Questionnaire, the Childhood Trauma Questionnaire (CTQ), and the Revised Family Communication Patterns (RFCP) questionnaire. Data analysis was performed using SPSS 21 software at both descriptive and inferential levels, and hypothesis testing was conducted using hierarchical regression analysis. Findings: The results showed a positive and significant relationship between dimensions of childhood trauma and the tendency toward addiction (p ≤ 0.05), as well as a positive and significant relationship between conformity and the tendency toward addiction (p ≤ 0.05). However, there was a negative and significant relationship between conversation orientation and the tendency toward addiction (p ≤ 0.05). Additionally, family communication patterns moderated the relationship between physical abuse and the tendency toward addiction, as well as the relationship between emotional abuse and the tendency toward addiction. However, family communication patterns did not moderate the relationship between physical neglect and the tendency toward addiction, nor the relationship between emotional neglect and the tendency toward addiction. Family communication patterns did moderate the relationship between sexual abuse and the tendency toward addiction. Conclusion: It can be concluded that family communication patterns mediate the relationship between childhood trauma and the tendency toward addiction in adolescent boys. [ABSTRACT FROM AUTHOR]

The purpose of this study is to investigate the relationship between mindfulness, childhood trauma, and suicide, specifically focusing on the mediating role of cognitive bias. Suicide is a pressing issue that poses a significant threat to public health in society, and understanding the factors that contribute to it is crucial. The research design employed in this study is a correlation-based structural equation model. A total of 370 students from the second level of secondary school in Iran city were selected as participants using an available sampling method during the academic year of 2023. To gather data, several questionnaires were utilized, including the Kentucky Mindfulness Questionnaire, Bernstein et al.'s Childhood Trauma Questionnaire (1994), Hammachi and Ozturk's Cognitive Bias Questionnaire (2004), and the Multi-attitude Suicidal Tendency Questionnaire (MAST). Data analysis was conducted using SPSS-23 and Amos software, encompassing both descriptive and inferential levels. The findings of this research revealed several significant relationships. Firstly, there is a positive and significant direct path from childhood trauma to cognitive bias. Secondly, mindfulness has a negative and significant direct path to cognitive bias. Thirdly, childhood trauma has a direct and significant path to suicide. Additionally, cognitive bias has a positive and significant path to suicidality, while mindfulness has a negative and significant path to suicide. Moreover, there are positive and significant indirect paths from suicide to childhood trauma and negative and significant indirect paths from suicide to mindfulness. In conclusion, this study highlights the importance of mindfulness and cognitive bias as variables related to adolescent suicide. Adolescents who have experienced childhood trauma are more likely to consider suicide as a solution when faced with life problems. These findings emphasize the need for interventions and support systems that address mindfulness, cognitive bias, and childhood trauma to prevent and mitigate the risk of suicide among adolescents.

Abstract Background Mental health problems among adolescents are a common concern globally. However, its relationship with childhood trauma is not clearly understood from the existing studies. Therefore, this study aims to explore the relationships among childhood trauma, mental health, self-control, and internet addiction in Chinese vocational high school students. Methods A cross-sectional survey was conducted among vocational high school students in China from October 2020 to December 2020. Standardized questionnaires were used to collect basic information regarding childhood trauma, self-control, psychological state, and social demographics. A structural equation model was used to study the relationships among internet addiction, self-control, childhood trauma, and mental health. Results A total of 3368 individuals participated in the study. The results revealed the mediating effects of poor self-control and internet addiction on the association between childhood trauma and mental health. Conclusions Internet addiction and low self-control play mediating roles in childhood trauma and mental health. Clarifying these relationships will help formulate better-targeted interventions to improve the mental health of Chinese vocational high school students and aid in interventions to treat and prevent mental health problems.

Kumru &Scedil;enya&scedil;ar Meterelliyoz,1 Özlem Ba&scedil; Uluyol2 1Department of Psychiatry, Bakirkoy Prof. Mazhar Osman Training and Research Hospital for Psychiatry, Neurology, and Neurosurgery, Istanbul, Turkey; 2Department of Psychiatry, Sancaktepe &Scedil;ehit Prof. Dr. Ilhan Varank Training and Research Hospital, Istanbul, TurkeyCorrespondence: Kumru &Scedil;enya&scedil;ar Meterelliyoz, Department of Psychiatry, Bakirkoy Prof. Dr. Mazhar Osman Training and Research Hospital for Psychiatry, Neurology, and Neurosurgery, Zuhuratbaba Mah. Ak&inodot;l Hastanesi Cd. 25/2, Bak&inodot;rköy, Istanbul, 34147, Turkey, Tel +902124091515, Email kumrusenyasar@gmail.comPurpose: Depression is one of the most common public health problems. Considering the frequency of childhood trauma in people with depressive symptoms, determining mediating factors is important in understanding the relationship between them. Our study aimed to evaluate the mediating effect of anxiety sensitivity, one of the cognitive structures that plays a role in the etiology and maintenance of psychopathologies, on depression symptoms of childhood traumas.Patients and Methods: The study included 110 participants aged between 18 and 65, diagnosed with depression, and applied to the psychiatry outpatient clinic. Of the participants, 35 were male and 75 were female. The majority of participants were in the 18– 25 age group (39.1%), followed by a smaller percentage in the 25– 35 age group (32.7%). The Beck Depression Inventory (BDI-I), Childhood Trauma Questionnaire (CTQ), and Anxiety Sensitivity Index (ASI-3) were administered to participants between 15 February and 15 April 2024.Results: When the sample was examined according to the history of depressive symptoms, it was found that the score of the cognitive subscale of ASI-3 and the scores of the physical neglect, emotional neglect, and emotional abuse subscales of the CTQ were significantly higher in the group with depressive symptoms. When the mediating effect of the scores of “Emotional neglect”, “Physical neglect”, and “Emotional abuse” subscales of CTQ, and the score of “Cognitive” subscale of ASI-3 score was examined with regression models, it was found that the history of emotional neglect and abuse in childhood predicted depressive symptoms through the cognitive sub-group of AS.Conclusion: In our study, it was shown that childhood trauma, which could cause a person to evaluate stressful life events as more depressogenic and the formation of negative cognitions about themselves and the world, predicted the severity and occurrence of depressive symptoms through fear of cognitive dysfunction.Keywords: childhood trauma, depression, anxiety sensitivity