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Copyright of Chemical Engineering (China) / Huaxue Gongcheng is the property of Hualu Engineering Science & Technology Co Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

During the steam flooding of extra heavy oil, expansion of steam chamber is difficult and erosion channels appear, which is different from conventional heavy oil. The thermochemical composite system composed of steam, foam and viscosity reducer can effectively improve the development effect of extra heavy oil reservoirs. However, during the thermochemical composite flooding, the rheological characteristics of extra heavy oil and the influence of erosion channels on oil displacement mechanism are not yet researched. Taking the extra heavy oil reservoir in Block X of the Chunfeng Oilfield as an example, experimental research on the rheological properties and thermochemical composite flooding of extra heavy oil model with erosion channel is conducted. Firstly, the influence of thermochemical composite system on the rheological properties of extra heavy oil is evaluated. Then, a one-dimensional (1D) sand-pack model with erosion channel is used to conduct thermochemical composite flooding experiments, comparing the recovery of steam flooding, foam assisted steam flooding, viscosity reducer assisted steam flooding, and composite flooding (foam and viscosity reducer assisted steam flooding). Finally, a two-dimensional (2D) sand-pack model with erosion channel is used to conduct thermochemical composite flooding experiments, comparing the recovery of viscosity reducer assisted flooding and composite flooding. The results show that viscosity reducer reduces the viscosity of extra heavy oil greatly, and the extra heavy oil is not sensitive to the change of temperature after viscosity reduction. When the concentration of viscosity reducer is 0.4% or more, good viscosity reduction effect can be achieved at different oil-water ratio. In the 1D sand-pack model experiments, compared to steam flooding, foam assisted steam flooding, viscosity reducer assisted steam flooding, and composite flooding, the recovery increased by 4.38%, 17.38%, and 30.46%, respectively. In the 2D sand-pack model experiments, compared to steam flooding, the viscosity reducer assisted steam flooding and composite flooding increase the oil recovery by 12.49% and 16.61%, respectively. The thermochemical composite flooding of extra heavy oil is dominated by erosion, supplemented by displacement. There is a synergistic effect between chemicals in the process of composite flooding. At the same time, the purpose of "enhanced erosion and expanded sweep" is achieved. [ABSTRACT FROM AUTHOR]

Plants are sessile organisms that are often subjected to a multitude of environmental stresses, with the occurrence of these events being further intensified by global climate change. Crop species therefore require specific adaptations to tolerate climatic variability for sustainable food production. Plant stress results in excess accumulation of reactive oxygen species leading to oxidative stress and loss of cellular redox balance in the plant cells. Moreover, enhancement of cellular oxidation as well as oxidative signals has been recently recognized as crucial players in plant growth regulation under stress conditions. Multiple roles of redox regulation in crop production have been well documented, and major emphasis has focused on key redox-regulated proteins and non-protein molecules, such as NAD(P)H, glutathione, peroxiredoxins, glutaredoxins, ascorbate, thioredoxins and reduced ferredoxin. These have been widely implicated in the regulation of (epi)genetic factors modulating growth and health of crop plants, with an agricultural context. In this regard, priming with the employment of chemical and biological agents has emerged as a fascinating approach to improve plant tolerance against various abiotic and biotic stressors. Priming in plants is a physiological process, where prior exposure to specific stressors induces a state of heightened alertness, enabling a more rapid and effective defense response upon subsequent encounters with similar challenges. Priming is reported to play a crucial role in the modulation of cellular redox homeostasis, maximizing crop productivity under stress conditions and thus achieving yield security. By taking this into consideration, the present review is an up-to-date critical evaluation of promising plant priming technologies and their role in the regulation of redox components toward enhanced plant adaptations to extreme unfavorable environmental conditions. The challenges and opportunities of plant priming are discussed, with an aim of encouraging future research in this field toward effective application of priming in stress management in crops including horticultural species. [ABSTRACT FROM AUTHOR]

Nonsyndromic orofacial clefts (nsOFCs) are the most prevalent congenital craniofacial abnormalities, significantly impacting an individual's overall health. They are clinically presented as an incomplete separation of the lips, palate, or both. NsOFC occurs as a separate entity and is not associated with any other syndromic abnormalities. Epigenetics has been regarded as a key factor in increasing the prevalence of orofacial clefts. Studies in the past have aimed to explain the involvement of epigenetics in the formation of nsOFCs. Researchers have also well-investigated and documented certain environmental factors and chemical agents that could influence the occurrence of orofacial clefts. Understanding the role and effect of the etiological factors will directly support postulating preventative measures to minimize the occurrence of clefts. This review article will offer a comprehensive overview of the epigenetics, environmental factors, and chemical agents linked to developing nsOFCs. The article will also focus on the promising epigenetic biomarkers that can potentially detect clefts early. [ABSTRACT FROM AUTHOR]

Implant-related infections (IRIs) represent a significant challenge to modern surgery. The occurrence of these infections is due to the ability of pathogens to aggregate and form biofilms, which presents a challenge to both the diagnosis and subsequent treatment of the infection. Biofilms provide pathogens with protection from the host immune response and antibiotics, making detection difficult and complicating both single-stage and two-stage revision procedures. This narrative review examines advanced chemical antibiofilm techniques with the aim of improving the detection and identification of pathogens in IRIs. The articles included in this review were selected from databases such as PubMed, Scopus, MDPI and SpringerLink, which focus on recent studies evaluating the efficacy and enhanced accuracy of microbiological sampling and culture following the use of chemical antibiofilm. Although promising results have been achieved with the successful application of some antibiofilm chemical pre-treatment methods, mainly in orthopedics and in cardiovascular surgery, further research is required to optimize and expand their routine use in the clinical setting. This is necessary to ensure their safety, efficacy and integration into diagnostic protocols. Future studies should focus on standardizing these techniques and evaluating their effectiveness in large-scale clinical trials. This review emphasizes the importance of interdisciplinary collaboration in developing reliable diagnostic tools and highlights the need for innovative approaches to improve outcomes for patients undergoing both single-stage and two-stage revision surgery for implant-related infections. [ABSTRACT FROM AUTHOR]

Clubroot, caused by Plasmodiophora brassicae, is a destructive soil-borne disease significantly harming global Brassica crop production. This study employed the Williams and European Clubroot Differential (ECD) and Williams systems to identify the pathotypes of P. brassicae collected from Hangzhou City, Yuhang District and Quzhou City, Kaihua County in Zhejiang Province. Greenhouse and field trials were conducted to evaluate the effects of plastic film covering and four chemical agents on the growth parameters and clubroot severity of the Chinese cabbage cultivar 'Granaat'. Potential treatment mechanisms on clubroot were explored through a qPCR analysis of the resting spore density and pH measurement of the soil. Furthermore, treatment with 1-napthaleneacetic acid (NAA), a synthetic auxin, was also evaluated for its potential role in suppressing clubroot. The results indicate that the pathotypes of P. brassicae in the two districts were P1, ECD20/31/12, and P3, ECD20/15/4. While an individual application of plastic film covering could not effectively control clubroot, calcium cyanamid, dazomet and ammonium bicarbonate demonstrated significant efficacy in its management. These three agents significantly reduced the resting spore density in the soil, with calcium cyanamid and ammonium bicarbonate also increasing soil alkalinity. Additionally, ammonium bicarbonate promotes lateral root development in 'Granaat,' helping infected plants access adequate water and nutrients. However, NAA exhibited no efficacy in clubroot control. Therefore, sustained lateral root development is crucial for effectively resisting P. brassicae invasion. Considering application costs and environmental friendliness, we propose the field application of ammonium bicarbonate as the optimal method for clubroot disease management in Zhejiang Province. [ABSTRACT FROM AUTHOR]

In analytical chemistry laboratories, the basic principles of the study of the chemical composition of a material or sample are verified experimentally, through different methods of analysis, for which reason chemical and biological agents are handled daily, to which workers are exposed; hence the need to assess the risk of exposure. The objective of this work was to evaluate the risks in an analytical chemical laboratory using the semi-quantitative method of William Fine, for which a multidisciplinary commission was created made up of specialists and experts with experience in the subject. It was determined that there is a direct relationship between the chemical, fire and explosion risks, the emanation of vapors of volatile substances, due to very high temperatures, or close to sources of ignition that can cause a fire, and generate a chain of events that, when reacting with other substances, can lead to explosions. The chemical and fire risks were evaluated as critical risks, which require immediate stoppage of the activity, and the mechanical, environmental, explosion, and biological risks were evaluated as notable risks, which require an urgent necessary correction. [ABSTRACT FROM AUTHOR]

Copyright of Chemical Engineering (China) / Huaxue Gongcheng is the property of Hualu Engineering Science & Technology Co Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Implant-related infections (IRIs) represent a significant challenge to modern surgery. The occurrence of these infections is due to the ability of pathogens to aggregate and form biofilms, which presents a challenge to both the diagnosis and subsequent treatment of the infection. Biofilms provide pathogens with protection from the host immune response and antibiotics, making detection difficult and complicating both single-stage and two-stage revision procedures. This narrative review examines advanced chemical antibiofilm techniques with the aim of improving the detection and identification of pathogens in IRIs. The articles included in this review were selected from databases such as PubMed, Scopus, MDPI and SpringerLink, which focus on recent studies evaluating the efficacy and enhanced accuracy of microbiological sampling and culture following the use of chemical antibiofilm. Although promising results have been achieved with the successful application of some antibiofilm chemical pre-treatment methods, mainly in orthopedics and in cardiovascular surgery, further research is required to optimize and expand their routine use in the clinical setting. This is necessary to ensure their safety, efficacy and integration into diagnostic protocols. Future studies should focus on standardizing these techniques and evaluating their effectiveness in large-scale clinical trials. This review emphasizes the importance of interdisciplinary collaboration in developing reliable diagnostic tools and highlights the need for innovative approaches to improve outcomes for patients undergoing both single-stage and two-stage revision surgery for implant-related infections.

Alexandru Fofiu,1,2 Robert G Tripon,3 Tiberiu Băţagă,4 Traian V Chirilă2,5– 8 1Department of Orthopedics-Traumatology, Emergency County Hospital Bistriţa, Bistriţa Năsăud, Romania; 2School of Medicine, George Emil Palade University of Medicine, Pharmacy, Science, and Technology, Târgu Mureş, Romania; 3Department of Ophthalmology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology, Târgu Mureş, Romania; 4Department of Orthopedics-Traumatology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology, Târgu Mureş, Romania; 5Department of Research, Queensland Eye Institute, South Brisbane, QLD, Australia; 6School of Chemistry and Physics, Queensland University of Technology, Brisbane, QLD, Australia; 7Australian Institute of Bioengineering and Nanotechnology, University of Queensland, St Lucia, QLD, Australia; 8School of Molecular Science, University of Western Australia, Crawley, WA, AustraliaCorrespondence: Traian V Chirilă, Email traian.chirila@qei.org.auAbstract: Collagens constitute a family of triple-helical proteins with a high level of structural polymorphism and a broad diversity of structural and chemical characteristics. Collagens are designed to form supporting aggregates in the extracellular spaces of our body, but they can be isolated from animal sources and processed to become available as biomaterials with wide applications in biomedicine and bioengineering. Collagens can be conveniently modified chemically, and their propensity for participating in crosslinking reactions is an important feature. While the crosslinking promoted by a variety of agents provides a range of collagen-based products, there has been minor interest for therapies based on the crosslinking of collagen while located within living connective tissues, known as exogenous crosslinking. Currently, there is only one such treatment in ocular therapeutics (for keratoconus), and another two in development, all based on mechanical augmentation of tissues due to ultraviolet (UV)-induced crosslinking. As seen in this review, there was some interest to employ exogenous crosslinking in order to reinforce mechanically the lax tendons with an aim to arrest tear propagation, stabilize the tissue, and facilitate the healing. Here we reviewed in details both the early stages and the actual status of the experimental research dedicated to the topic. Many results have not been encouraging, however there is sufficient evidence that tendons can be mechanically reinforced by chemical or photochemical exogenous crosslinking. We also compare the exogenous crosslinking using chemical agents, which was predominant in the literature reviewed, to that promoted by UV radiation, which was rather neglected but might have some advantages.Keywords: collagen, crosslinking, tendon, chemical agents, ultraviolet radiation, mechanical properties

Chemical agents pose a significant threat to social security, highlighting the crucial role of representative chemical agents adsorption in ensuring the safety our environment. This study explored the application of Magnetic Graphene Oxide Nanoplatelet Composites (MGONCs) in adsorbing the representative chemical agents such as Lewisite (L), O-ethyl S-2-diisopropylaminoethyl methylphosphonothiolate (VX), Sarin (GB), and Soman (GD). MGONCs were synthesized through a physical blending method, with the combination of graphene oxide (GO) and Fe3O4 nanoparticles at a mass ratio of 1:1. Optimization of the adsorption process involved investigating the effects of contact time, temperature, and adsorbent dosage. Remarkably, the adsorption rate of L and VX exceeded 99% when the dosage of MGONCs was 2.5 mg, with a contact time of 30 s at room temperature. Furthermore, GB and GD achieved maximum adsorption rates after a contact time of 20 min, with the dosages of MGONCs at 10 mg and 20 mg, respectively. Characterization of the magnetic composite was accomplished through XRD, TEM, VSM, FTIR, TGA, and BET analyses. Kinetical analysis revealed that the adsorption mechanism of GB and GD on MGONCs followed pseudo-second-order (PSO) kinetics, exhibiting a high regression coefficient. The calculated q e values were 0.103125 mg/g and 0.081349 mg/g, respectively. This research demonstrated the feasibility of utilizing MGONCs as highly efficient adsorbents for representative chemical agents, particularly in on-site sampling scenarios. [ABSTRACT FROM AUTHOR]

Copyright of Izmir Katip Celebi University Faculty of Health Sciences Journal / İzmir Katip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi is the property of Izmir Katip Celebi University, Faculty of Health Sciene Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The aim of this study was to assess the applicability of the bacterial lux biosensors for genotoxicological studies. Biosensors are the strains of E. coli MG1655 carrying a recombinant plasmid with the lux operon of the luminescent bacterium P. luminescens fused with the promoters of inducible genes: recA, colD, alkA, soxS, and katG. The genotoxicity of forty-seven chemical compounds was tested on a set of three biosensors pSoxS-lux, pKatG-lux and pColD-lux, which allowed us to estimate the oxidative and DNA-damaging activity of the analyzed drugs. The comparison of the results with the data on the mutagenic activity of these drugs from the Ames test showed a complete coincidence of the results for the 42 substances. First, using lux biosensors, we have described the enhancing effect of the heavy non-radioactive isotope of hydrogen deuterium (D2O) on the genotoxicity of chemical compounds as possible mechanisms of this effect. The study of the modifying effect of 29 antioxidants and radioprotectors on the genotoxic effects of chemical agents showed the applicability of a pair of biosensors pSoxS-lux and pKatG-lux for the primary assessment of the potential antioxidant and radioprotective activity of chemical compounds. Thus, the results obtained showed that lux biosensors can be successfully used to identify potential genotoxicants, radioprotectors, antioxidants, and comutagens among chemical compounds, as well as to study the probable mechanism of genotoxic action of test substance. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Exact Sciences is the property of Master Editora and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Clubroot, caused by Plasmodiophora brassicae, is a destructive soil-borne disease significantly harming global Brassica crop production. This study employed the Williams and European Clubroot Differential (ECD) and Williams systems to identify the pathotypes of P. brassicae collected from Hangzhou City, Yuhang District and Quzhou City, Kaihua County in Zhejiang Province. Greenhouse and field trials were conducted to evaluate the effects of plastic film covering and four chemical agents on the growth parameters and clubroot severity of the Chinese cabbage cultivar ‘Granaat’. Potential treatment mechanisms on clubroot were explored through a qPCR analysis of the resting spore density and pH measurement of the soil. Furthermore, treatment with 1-napthaleneacetic acid (NAA), a synthetic auxin, was also evaluated for its potential role in suppressing clubroot. The results indicate that the pathotypes of P. brassicae in the two districts were P1, ECD20/31/12, and P3, ECD20/15/4. While an individual application of plastic film covering could not effectively control clubroot, calcium cyanamid, dazomet and ammonium bicarbonate demonstrated significant efficacy in its management. These three agents significantly reduced the resting spore density in the soil, with calcium cyanamid and ammonium bicarbonate also increasing soil alkalinity. Additionally, ammonium bicarbonate promotes lateral root development in ‘Granaat,’ helping infected plants access adequate water and nutrients. However, NAA exhibited no efficacy in clubroot control. Therefore, sustained lateral root development is crucial for effectively resisting P. brassicae invasion. Considering application costs and environmental friendliness, we propose the field application of ammonium bicarbonate as the optimal method for clubroot disease management in Zhejiang Province.

Abstract Sulfur mustard (SM) is an alkylating and forming chemical that was widely used by Iraqi forces during the Iran–Iraq wars. One of the target organs of SM is the skin. Understanding the mechanisms involved in the pathogenesis of SM may help better identify complications and find appropriate treatments. The current study collected ten SM-exposed patients with long-term skin complications and ten healthy individuals. Proteomics experiments were performed using the high-efficiency TMT10X method to evaluate the skin protein profile, and statistical bioinformatics methods were used to identify the differentially expressed proteins. One hundred twenty-nine proteins had different expressions between the two groups. Of these 129 proteins, 94 proteins had increased expression in veterans' skins, while the remaining 35 had decreased expression. The hub genes included RPS15, ACTN1, FLNA, HP, SDHC, and RPL29, and three modules were extracted from the PPI network analysis. Skin SM exposure can lead to oxidative stress, inflammation, apoptosis, and cell proliferation.

One of the priorities in the field of occupational safety and health in the European Union (EU) is research on dissemination and application of scientific results, which results in changes in legislation on exposure assessment to chemical agents and risk estimation. The aim of this paper is to analyze the EU legislation on exposure assessment and risk estimation to chemical agents based on biological monitoring studies, in the context of workers’ health protection, with reference to the occupational hygiene management system and standard. An analysis was made of the current legal regulations as well as recommendations and guidelines for biological monitoring studies in the assessment of workers’ exposure to selected metals. A comparison was made between the regulations in force in Poland and in EU. The rationale for implementing biological monitoring tools in occupational health prevention as an additional tool to protect workers from chemical agents was evaluated. Med Pr. 2022;73(4):349–56

The microbial and physicochemical evaluation of sourced water from the Diobu Neighborhood Water Scheme (DNWS) in Port Harcourt, Nigeria was investigated due to some skepticism by households in apprehension of infection and diseases, so the households disinfect their sourced water using chemical agents to control microbes. Sixty water samples were collected from two household groups; household group 1-4 and 5-8 with each group having 30 samples each. Physiochemical and microbial property of water samples were analyzed using standard laboratory procedure. Heterotrophic bacteria, total coliform, fecal coliform and heterotrophic fungi recorded mean ± standard deviation counts of 219.5 ± 6.0 x 103, 29 ± 1.0 x 101, 21 ± 3.0 x 101 and 105 ± 3.0 x 102CFU/ml, for household group size 1-4 persons respectively. Whereas, household group size 5-8 persons, had mean ± standard deviation counts of 890 ± 1.0 x 103, 55 ± 3.0 x 101, 24 ± 8.0 x 101 and 81 ± 2.0 x 102 cfu/ml, respectively. Temperature of water samples obtained from the household group size 1-4 ranged, from 28°C to 30.5°C whereas, the water samples from homes with household group size 5-8 ranged, from 260C to 300C. The physiochemical results reported hydrogen ion concentrations (pH) of water samples as 5.0 from household group size 1-4 persons while that of the water samples from household group size 5-8 persons recorded between 5.0 and 6.0. Although, drinking water from household size group 5-8 were more laden with microbes of medical importance, there was no significant amount of chlorine, bromine, magnesium and calcium elements observed in the water samples obtained from the homes. Hence, physicochemical examination showed acceptability despite the alleged interference of chemical. Therefore, the alleged use of chemical agents in water had no effect on the microbial quality of the sourced water. [ABSTRACT FROM AUTHOR]

The mining industry, currently undergoing profound changes, is destined to play an increasingly important economic role in the province of Quebec, Canada. Activity in this sector, its real net impact on government tax revenue, the economy, society, and the creation of wealth, is the subject of much discussion. Occupational health and safety is a major preoccupation in the mining sector, in which considerable numbers of workers suffer workplace accidents or occupational diseases due to the use of industrial chemicals, compounding the problem of exposure to noxious substances that exist naturally in mines or are produced inevitably in the course of normal mining operations. Air in mines thus can become laden with a wide variety of chemical agents, in the form of suspended solids, liquid droplets, and vapors and gases. Long-term exposure to most of these agents can seriously harm the health of mineworkers. Prevention remains the key to avoiding the social and economic consequences of these hazards and will make mining a more attractive sector for investment and employment in Canada. The principal focus of this study, presented in two articles, is to set a preliminary theoretical framework for categorizing chemicals in terms of their effects on the health of mineworkers throughout the various phases of mining projects. The objective is to decrease (over the long term) the number of occupational diseases due to the use of chemicals by raising awareness among employers and exposed workers in the mining sector. This research was conducted in four phases. The first article presented a review of the literature [1] on the chemical aspects of health and safety in mining in the province of Quebec. In the present article, the findings on the recurrence of health problems attributable to chemicals encountered in mines and how these effects should therefore be ranked from an occupational health and safety perspective are presented. The results show that various forms of dermatitis are the most recurrent health and safety risk. [ABSTRACT FROM AUTHOR]

Chemical agents pose a significant threat to social security, highlighting the crucial role of representative chemical agents adsorption in ensuring the safety our environment. This study explored the application of Magnetic Graphene Oxide Nanoplatelet Composites (MGONCs) in adsorbing the representative chemical agents such as Lewisite (L), O-ethyl S-2-diisopropylaminoethyl methylphosphonothiolate (VX), Sarin (GB), and Soman (GD). MGONCs were synthesized through a physical blending method, with the combination of graphene oxide (GO) and Fe3O4 nanoparticles at a mass ratio of 1:1. Optimization of the adsorption process involved investigating the effects of contact time, temperature, and adsorbent dosage. Remarkably, the adsorption rate of L and VX exceeded 99% when the dosage of MGONCs was 2.5 mg, with a contact time of 30 s at room temperature. Furthermore, GB and GD achieved maximum adsorption rates after a contact time of 20 min, with the dosages of MGONCs at 10 mg and 20 mg, respectively. Characterization of the magnetic composite was accomplished through XRD, TEM, VSM, FTIR, TGA, and BET analyses. Kinetical analysis revealed that the adsorption mechanism of GB and GD on MGONCs followed pseudo-second-order (PSO) kinetics, exhibiting a high regression coefficient. The calculated qe values were 0.103125 mg/g and 0.081349 mg/g, respectively. This research demonstrated the feasibility of utilizing MGONCs as highly efficient adsorbents for representative chemical agents, particularly in on-site sampling scenarios.

Sand production is considered as one of the significant production issues that significantly reduce wellbore productivity. The process of sand or solids production in production operations is one of the crucial operational inefficiencies that can lead to wells collapsing. Besides, the drilling mud might erupt through the formation. Therefore, it is essential to properly determine what types of solids or sand are produced to correctly predict efficient sand control mechanisms. This paper aimed to compare different sand production control mechanisms and how to control or minimize sand production. Moreover, we consider injection pressure and sand moisture on the sand production rate. According to this study’s findings, pressure injection and moisture increase had caused sand production increase, which should be considered in operational performances. Furthermore, chemical injection such as resin and hydrogel injection usually has efficient sand production control methods. An expandable sand screen is an expandable three-layer component that is driven into the well and expanded.

The study takes into consideration the effect of chemical agents in stabilizing soils considered to be of weak properties. The methodology is based on the procedure of mixing the soil with chemical agents in various proportions, namely, cement as 1%, 3% and 5% of the dry mass of soil, as well as its combination with fly ash in the following proportions: 1.5C-8FA, 3.5C-8FA, 5.5C-8FA, 3.5C-6FA and 3.5C-10FA. The clay material used for this purpose was collected in the area of Currila, Durrës, and the tests determined the effect of these chemical agents in changing the undrained shear strength of the soil.

Exposure to chemical substances at work may result in negative health effects for workers that are classified as occupational diseases after meeting the formal requirements. Objective of the work: to analyse results of inspections by the State Sanitary Inspectorate in the Mazovia Province in years 2012-2019. Materials and methods: Data concerning occupational diseases were obtained within the scope of access to public information from the Provincial Sanitary and Epidemiological Station in Warsaw. The analysis included data on occupational diseases according to disease entities, pathogenic factor, place of work defined according to the Polish Classification of Activity, and occupational exposure to chemical substances. Results: Occupational diseases for which chemical agents constituted an identified aetiological factor during this period of the analysis of the incidence of occupational diseases resulting from occupational exposure to chemical substances among workers employed at employment establishments subject to the official control accounted for 25.9% (445) of all 1717 (100%) diagnosed occupational diseases. The incidence of occupational diseases resulting from exposure to chemical substances has shown an increasing trend since 2017. The main aetiological agent of the diagnosed occupational diseases was asbestos dust, which was responsible for 325 identified cases. Allergenic agents and irritants were the second aetiological causative factor of the diagnosed occupational diseases - 56 cases. Dust containing free crystalline silica was the third aetiological factor causing 47 cases. Conclusions: Understanding the long-term health effects of exposure to chemical substances and application of occupational health and safety regulations requires continuation of official inspections of the working conditions as well as preventive measures aimed at health education of workers, use of protective measures and examination of the work environment. [ABSTRACT FROM AUTHOR]

The objective of the work is to present the current state of knowledge concerning the harmfulness of chemical agents contained in wastewater and sewage sludge to human health and the surrounding environment. Wastewater and sewage sludge are composed of various chemical substances. These include volatile organic compounds (VOCs), persistent organic pollutants (POPs), heavy metals and pharmaceuticals. Inorganic gases, e.g. hydrogen sulphide, ammonia, are also emitted as a result of putrefaction processes occurring during wastewater treatment. Exposure to these diverse chemical agents poses a health risk due to their toxic, mutagenic and carcinogenic effects as well as their negative impact on endocrine functions. Because of the use of wastewater and sewage sludge in agriculture, they can be incorporated into the biological cycle, leading to the accumulation of pollutants in soils, vegetables and fruit as well as their transfer to surface water and groundwater. Not all chemical compounds are biodegradable in the environment, which contributes to their bioaccumulation and even biomagnification. The final recipient is man. While standards set for the content of specific pollutants in sewage sludge used for agricultural purposes are now stricter, they are not always complied with. Furthermore, new chemical compounds (e.g. pharmaceuticals) are identified in wastewater and their elimination with traditional wastewater treatment technologies is more difficult. [ABSTRACT FROM AUTHOR]

Copyright of Medicina y Seguridad del Trabajo is the property of Escuela Nacional de Medicina del Trabajo - Instituto de Salud Carlos III and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background The aim of the study was to analyze data on the exposure of military personnel to carcinogenic chemical substances, ionizing radiation and technological processes. Material and Methods Reports collected from the Military Centers of Preventive Medicine on carcinogens and exposure of workers in military units and institutions were subjected to a detailed analysis. Results The number of workers exposed to carcinogenic factors increased in the period under analysis. In 2019, the total number of people exposed in the workplace to chemical carcinogens or mutagens was 4058, to ionizing radiation – 1015, and to technological processes with carcinogenic or mutagenic effects – 12, compared to 3224, 1289 and 8 people, respectively, in 2018. The most common chemical agents in military units which caused exposure, from the point of view of occupational health and safety, were mixtures of liquid hydrocarbons used as fuel for driving vehicles and devices with internal combustion engines. In military units dedicated to the provision of medical services, exposure to X-ray radiation (diagnostics imaging) and formaldehyde (pathomorphology) was the most common. Conclusions The collected data presents different approaches of individuals in terms of reporting and assessing occupational exposure. Understanding the long-term health effects requires more thorough research. Med Pr. 2021;72(5):501–8

Sulfur mustard (SM) is an alkylating and forming chemical that was widely used by Iraqi forces during the Iran–Iraq wars. One of the target organs of SM is the skin. Understanding the mechanisms involved in the pathogenesis of SM may help better identify complications and find appropriate treatments. The current study collected ten SM-exposed patients with long-term skin complications and ten healthy individuals. Proteomics experiments were performed using the high-efficiency TMT10X method to evaluate the skin protein profile, and statistical bioinformatics methods were used to identify the differentially expressed proteins. One hundred twenty-nine proteins had different expressions between the two groups. Of these 129 proteins, 94 proteins had increased expression in veterans' skins, while the remaining 35 had decreased expression. The hub genes included RPS15, ACTN1, FLNA, HP, SDHC, and RPL29, and three modules were extracted from the PPI network analysis. Skin SM exposure can lead to oxidative stress, inflammation, apoptosis, and cell proliferation. [ABSTRACT FROM AUTHOR]

Objectives: To evaluate the etiological cause distribution in chemical eye injuries during COVID-19 pandemic. Methods: In this retrospective case series, the medical records of patients, who presented with chemical eye injuries between March 30, 2020, and March 1, 2021, were evaluated and compared with the data covering 10 years before the pandemic. Results: Twenty-seven eyes of twenty-three patients (19 adults, 4 children) who presented in pandemic period were included. Alcohol-based hand sanitizer was one of the two most common agents (n = 6 eyes) in the pandemic era. In the last 10 years before the pandemic, 137 eyes of 102 patients were treated for chemical eye injuries. Injuries due to alcohol-based hand sanitizer increased from 3.1 to 21.1% among all patients, and from 0 to 75% among pediatric patients during the pandemic era compared to the pre-pandemic period. The increase was statistically significant both in all patients (p =.003) and in the pediatric patient group (p =.048). Conclusion: Due to COVID-19 pandemic, alcohol-based hand sanitizer use became more common. Consequently, the frequency of hand sanitizer related chemical injuries showed a 13-fold increase and the age group affected by such accidents is altered during the pandemic. Three out of four pediatric patients (75%) were injured with alcohol-based hand sanitizers, which draws attention to the fact that improperly placed hand sanitizer stations, being just at the eye level of children, can cause chemical eye injuries in the pediatric population even more. [ABSTRACT FROM AUTHOR]

[Display omitted] Scheme 1. Schematic illustration of the procedures for activation of WP. • Activating WP with K 2 C 2 O 4 , H 3 PO 4 or ZnCl 2 forms products of distinct nature. • H 3 PO 4 /ZnCl 2 catalyzes formed more bio-oil but less gas, and K 2 C 2 O 4 is opposite. • K 2 C 2 O 4 and ZnCl 2 are more effective than H 3 PO 4 for creating pores from WP. • ZnCl 2 creates abundant macropores via converting fibers in WP to graphitic crystals. • K 2 C 2 O 4 shows lower environmental impact than ZnCl 2 in activating WP. Waste paper (WP) is rich in cellulose, which can be activated to produce porous carbon, bio-oil, and combustible gases. During chemical activation of WP, the use of varied chemical agents not only generates activated carbon of distinct pore structure but also bio-oil/gases of different property. In this study, the activation of WP with varied chemical agents was conducted. The distinct characteristics of activated carbon and also bio-oil/gases were correlated with the different nature of the used chemical agents. The results indicated that H 3 PO 4 and ZnCl 2 catalyzed polymerization reactions for producing more bio-oil while less gases owing to their Brønsted and Lewis acidic sites. K 2 C 2 O 4 showed high activity for cracking/gasification reactions, forming bio-oil with higher abundance of organics with smaller π-conjugated structures. In addition, ZnCl 2 could create a very coarse porous structure with abundant macropores via destroying fiber structure in WP and promoting the growth of graphitic crystals. In comparison, K 2 C 2 O 4 hindered the aromatization and facilitated the formation of amorphous activated carbon. K 2 C 2 O 4 and ZnCl 2 were much more effective than H 3 PO 4 for creating micropores and mesopores from WP, the derived activated carbon showed superior performances as the electrode of supercapacitor and adsorbent for adsorption of oxytetracycline from aqueous solution. In addition, K 2 C 2 O 4 as activating agent showed lower environmental impact than ZnCl 2 in terms of energy consumption, environmental pollution and the greenhouse effect. [ABSTRACT FROM AUTHOR]

The aim of this study was to assess the applicability of the bacterial lux biosensors for genotoxicological studies. Biosensors are the strains of E. coli MG1655 carrying a recombinant plasmid with the lux operon of the luminescent bacterium P. luminescens fused with the promoters of inducible genes: recA, colD, alkA, soxS, and katG. The genotoxicity of forty-seven chemical compounds was tested on a set of three biosensors pSoxS-lux, pKatG-lux and pColD-lux, which allowed us to estimate the oxidative and DNA-damaging activity of the analyzed drugs. The comparison of the results with the data on the mutagenic activity of these drugs from the Ames test showed a complete coincidence of the results for the 42 substances. First, using lux biosensors, we have described the enhancing effect of the heavy non-radioactive isotope of hydrogen deuterium (D2O) on the genotoxicity of chemical compounds as possible mechanisms of this effect. The study of the modifying effect of 29 antioxidants and radioprotectors on the genotoxic effects of chemical agents showed the applicability of a pair of biosensors pSoxS-lux and pKatG-lux for the primary assessment of the potential antioxidant and radioprotective activity of chemical compounds. Thus, the results obtained showed that lux biosensors can be successfully used to identify potential genotoxicants, radioprotectors, antioxidants, and comutagens among chemical compounds, as well as to study the probable mechanism of genotoxic action of test substance.

Lead–zinc tailings are generated during the mining process which is considered as hazardous solid waste due to its high heavy metal content and leachability in the natural state. At present, the most effective technology for disposing heavy metals in solid wastes is the solidification/stabilization (S/S) technique. In terms of S/S technology, chemical stabilization is one of the most potential and practical method. This paper aims to investigate the S/S property of four typical chemical agents (Na2S, NaH2PO4, TMT and Na2EDTA) on the heavy metals in lead–zinc tailings. The results reveal that the heavy metals lead and zinc in tailings are stabilized more effectively by using chelating agents TMT than by using inorganic chemical agents Na2S and NaH2PO4. When the dosage of TMT reaches 4%, the leaching concentration of lead and zinc is 0.18 and 14.60 mg/L according to toxicity characteristic leaching procedure (TCLP), and the stabilization efficiency of lead and zinc is 99.31% and 80.92%, respectively, while the leaching concentration of lead and zinc just drops to 0.41 and 16.00 mg/L with addition of 10% NaH2PO4. Furthermore, the leaching concentration of heavy metal lead in tailings treated by 4% Na2EDTA increases to 53.44 mg/L which far exceeds the standard of pollution control. Therefore, considering stabilization efficiency and dosage, TMT is the preferred agent for solidifying heavy metals in lead–zinc tailings. [ABSTRACT FROM AUTHOR]

Despite culturing the fastest-growing animal in animal husbandry, fish farmers are often adversely economically affected by pathogenic disease outbreaks across the world. Although there are available solutions such as the application of antibiotics to mitigate this phenomenon, the excessive and injudicious use of antibiotics has brought with it major concerns to the community at large, mainly due to the rapid development of resistant bacteria. At present, the use of natural compounds such as phytocompounds that can be an alternative to antibiotics is being explored to address the issue of antimicrobial resistance (AMR). These phytocompounds are bioactive agents that can be found in many species of plants and hold much potential. In this review, we will discuss phytocompounds extracted from plants that have been evidenced to contain antimicrobial, antifungal, antiviral and antiparasitic activities. Further, it has also been found that compounds such as terpenes, phenolics, saponins and alkaloids can be beneficial to the aquaculture industry when applied. This review will focus mainly on compounds that have been identified between 2000 and 2021. It is hoped this review will shed light on promising phytocompounds that can potentially and effectively mitigate AMR. [ABSTRACT FROM AUTHOR]

Membrane fouling is one of the most significant issues to overcome in membrane-based technologies as it causes a decrease in the membrane flux and increases operational costs. This study investigates the effect of common chemical cleaning agents on polymeric nanofibrous membranes (PNM) prepared by polyvinylidene fluoride (PVDF), polyacrylonitrile (PAN), and polyamide 6 (PA6) nanofibers. Common alkaline and acid membrane cleaners were selected as the chemical cleaning agents. Membrane surface morphology was investigated. The PAN PNM were selected and fouled by engine oil and then cleaned by the different chemical cleaning agents at various ratios. The SEM results indicated that the use of chemical agents had some effects on the surface of the nanofibrous membranes. Moreover, alkaline cleaning of the fouled membrane using the Triton X 100 surfactant showed a two to five times higher flux recovery than without using a surfactant. Among the tested chemical agents, the highest flux recovery rate was obtained by a binary solution of 5% sodium hydroxide + Triton for alkaline cleaning, and an individual solution of 1% citric acid for acidic cleaning. The results presented here provide one of the first investigations into the chemical cleaning of nanofiber membranes. [ABSTRACT FROM AUTHOR]

Adam Barsouk,1 Krishna Chaitanya Thandra,2 Kalyan Saginala,3 Prashanth Rawla,4 Alexander Barsouk5 1Sidney Kimmel Cancer Center, Jefferson University, Philadelphia, PA 19107, USA; 2Department of Pulmonary and Critical Care Medicine, Sentara Virginia Beach General Hospital, Virginia Beach, VA, USA; 3Plains Regional Medical Group Internal Medicine, Clovis, NM 88101, USA; 4Department of Medicine, Sovah Health, Martinsville, VA 24112, USA; 5Hematologist-Oncologist, Allegheny Health Network, Pittsburgh, PA 15212, USACorrespondence: Prashanth RawlaDepartment of Internal Medicine/Hospitalist, SOVAH Health, 320 Hospital Dr, Martinsville, VA 24115, USATel +1 336-701-2285Email rawlap@gmail.comAbstract: Primary liver cancer has the sixth highest incidence and fourth highest cancer mortality worldwide. Hepatitis B is the leading cause of liver cancer, though its incidence is decreasing with vaccination. Alcohol is the leading cause of liver transplant, cirrhosis, and cancer in the developed world, and is projected to surpass hepatitis B as the leading hepatic cancer etiology worldwide. Tobacco smoking has shown a positive association with liver cancer in a majority of studies, though not all. Aflatoxin, a mycotoxin produced by Aspergillus, is estimated to account for 3– 20% of global liver cancer cases, 40% of which occur in sub-Saharan Africa. These statistics are confounded by the prevalence of hepatitis B, which may have a synergistic effect on hepatic carcinogenesis. Aflatoxin is ingested and likely inhaled from agricultural products, placing farmers, food processors, and textile workers in developing nations at risk. Vinyl-chloride is used in the production of PVC plastics and causes rare liver angiosarcoma, hepatocellular carcinoma, and other neoplasms. Arsenic and cadmium are naturally-occurring, hepatocarcinogenic metals with high occupational exposure in industries involving coal, metals, plastics, and batteries. Millions of laborers in waste-disposal and manufacturing are exposed to organic solvents and N-nitrosamines, which vary from carcinogenic (group 1) to possibly carcinogenic (group 2B) in their IARC designation. Insecticide DDT is possibly hepatocarcinogenic (group 2B), though continues to be used for malaria control in the developing world. While suggested by case reports, anabolic steroids and oral contraceptives have not been shown to increase liver cancer risk in large studies.Keywords: chemical agents, hepatocellular carcinoma, occupational exposure, aflatoxin, pesticides

Sulfur mustard (SM) is one of the major potent chemical warfare that caused the death of victims in World War I and the Iraq-Iran conflict (1980–1988). The respiratory system is the main target of SM exposure and there are no definitive therapeutic modalities for SM-induced lung injury. The effects of the new pharmaceutical drugs on lung injury induced by SM exposure were summarized in this review. Literature review on PubMed, ScienceDirect, and Google Scholar databases was performed to find papers that reported new treatment approach on SM-exposure-induced injury in the respiratory system until October 2019. The search was restricted to sulfur mustard AND induced injury (in vitro studies, animal experiments, and clinical trials) AND respiratory system OR lung, AND treatment in all fields. Two hundred and eighty-three relevant articles were identified that 97 retrieved articles were eligible and were included in the review. Some new pharmaceutical drugs have shown therapeutic potential in controlling various characteristics of lung injury due to SM exposure. Recent studies showed therapeutic effects of mucolytic drugs, non-steroidal drugs, and antibiotics on reducing lung inflammation, oxidative stress responses, and modulating of the immune system as well as improving of respiratory symptoms and pulmonary function tests. Studies on the therapeutic effects of new agents with amelioration or treatment of SM-induced lung injury were reviewed and discussed.

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Modern personal protective equipment for military personnel against the damaging factors of chemical and biological weapons (CBW) does not always allow to achieve an acceptable combination of body armor, protective helmet, respiratory and skin protective equipment from vapors and aerosols of toxic substances (TS) and biological agents (BA) in one set of equipment. The purpose of the work is to propose a promising form of personal protective equipment for Ground Forces servicemen against the damaging factors of chemical and biological weapons. The main characteristic feature of the existing gas masks is the invariable level of protection against the damaging factors of CBW. However, they do not provide protection for the head of servicemen from bullets and shrapnel. Based on the fact that danger levels for military personnel in case of a CBW attack differ and depend on the type of agent and on the time elapsed after the attack, the authors propose to combine a gas mask and a helmet in one product and to install disk filtering and sorbing elements (PSE) in the temporal region of the protective helmet with an air-duct, connected with an elastic half mask. The first universal PSE (sorbing-filtering) has the characteristics of a gas mask (shortness of breath) for protection from poisonous substances and biological agents in conditions of uncertainty of their use. It is transferred to the firing position simultaneously with the lowering of the visor. The second PSE possesses the parameters of a respirator (sorbing-filtering for easier breathing) for protection against TS. The second PSE should be used after the establishment of the fact of chemical, biological or radioactive contamination within an hour after the use of weapons of mass destruction. Thus, the main part of the soldier's head will be protected against bullets and shrapnel, as well as against TS and BA. To protect the lower part of the soldier's face (the chin, jaws and neck), it is proposed to use a circular elastic strip with a nasolabial device (screen) in the form of a half mask.

The Saudi Arabian Saline Water Conversion Corporation (SWCC) aims to maintain an uninterrupted desalinated water output and has tasked its Desalination Technologies Research Institute (DTRI) with trouble-shooting operational problems and unusual events faced by its desalination plants. Three events were reported and investigated by DTRI. Two were found to involve fungal fouling, and one was found to involve fouling by marine shells. One case of fungal fouling involved a new seawater reverse osmosis membrane and the plant was advised to review the handling and storage practice of membranes. The other case involved product water hoses and manifested itself in the form of black slimy deposits arising from dense fungal growth. The fungus originated from new product hoses and was eliminated by shock-dosing replacement hoses with chlorine. The marine shell fouling involved a feed water line of a combined power/desalination plant. Chlorine, hydrochloric acid, ethylenediaminetetraacetic acid, and fresh water were used to assess their ability to control marine shell fouling in laboratory experiments, with varying results. Since high doses of chlorine were not effective in controlling marine shell fouling, the practice of continuous chlorination should be abandoned in favor of an alternative chlorination regimen, e.g., pulse chlorination.

This study evaluated the application of ultrasound alone or combined with chlorine dioxide (ClO2) for Salmonella Typhimurium and Escherichia coli inactivation in poultry processing chiller tank water. A Full Factorial Design (FFD) 22 was conducted for each microorganism to evaluate the effect of ultrasound exposure time (x1: 1 to 9 min; fixed: 37 kHz; 330 W; 25 °C) using a bath, and ClO2 concentration (x2: 1 to 17 mg L−1) on microorganism count expressed in log CFU mL−1 in distilled water. Variable x2 had a negative effect on Salmonella Typhimurium (-5.09) and Escherichia coli (-2.00) count, improving the inactivation; while a x1 increase present no inactivation improvement, explaining the use of x1 lower level (1 min) and x2 higher level (17 mg L−1). The best condition for microorganism inactivation based on FFD was evaluated in chiller tank water (with organic matter) at 25, 16, and 4 °C; x1 was kept (1 min), however x2 was adjusted to obtain the same residual free chlorine (2.38 mg L−1) considering the ClO2 consumption by organic matter, achieving the value of 30 mg L−1. An inactivation of 49% and 31% were observed for Salmonella Typhimurium and Escherichia coli. When ultrasound was replaced by a simple agitation in the presence of ClO2, there was no inactivation for both microorganisms. Moreover, at poultry carcass pre-chilling (16 °C) and chilling (4 °C) conditions, the synergism of ultrasound combined with ClO2 was more pronounced, with microorganisms’ reductions up to 100%.

Tuberculosis (TB) is a serious public health problem worldwide. The combination of various anti-TB drugs is mainly used to treat TB in clinical practice. Despite the availability of effective antibiotics, effective treatment regimens still require long-term use of multiple drugs, leading to toxicity, low patient compliance, and the development of drug resistance. It has been confirmed that immune recognition, immune response, and immune regulation of Mycobacterium tuberculosis (Mtb) determine the occurrence, development, and outcome of diseases after Mtb infection. The research and development of TB-specific immunotherapy agents can effectively regulate the anti-TB immune response and provide a new approach toward the combined treatment of TB, thereby preventing and intervening in populations at high risk of TB infection. These immunotherapy agents will promote satisfactory progress in anti-TB treatment, achieving the goal of "ultra-short course chemotherapy." This review highlights the research progress in immunotherapy of TB, including immunoreactive substances, tuberculosis therapeutic vaccines, chemical agents, and cellular therapy. [ABSTRACT FROM AUTHOR]

Chemical warfare (CW) agents are toxic synthetic chemicals that affect human's health, and sulfur mustard (SM) is a well-known chemical weapon that caused deaths of victims. The lung is the main target of SM exposure, and there are no definitive therapeutic modalities for lung injury induced by this agent. The possible therapeutic effects of medicinal plants and their active ingredients on lung injury induced by SM were reviewed in this article until the end of June 2021. Medicinal plants including Crocus sativus, Curcuma longa, Thymus vulgaris, Nigella sativa, and Zataria multiflora and also natural compounds showed therapeutic potential in improving of various features of lung injury induced by SM and other related chemical agents. Several studies showed therapeutic effects of some medicinal plants and natural products on lung inflammation, oxidative stress, and immune responses in experimental studies in SM-induced lung injury. In addition, clinical studies also showed the effect of medicinal plants and natural compounds on respiratory symptoms, pulmonary function tests (PFTs), and inflammatory markers. The therapeutic effects of medicinal plants and natural products on lung disorder induced by SM and related chemical agents were shown through amelioration of various features of lung injury. [ABSTRACT FROM AUTHOR]

In chemical laboratories, research, teaching or analysis tasks are carried out daily in which a wide variety of dangerous substances and mixtures are handled that affect the health and safety of the people exposed to them and that can contaminate the environment. This work was carried out with the objective of evaluating chemical risks in a physical chemistry laboratory using the method of Dangerousness Index in the handling of Chemical Agents (IPMAQ) and based on said evaluation, a classification of the dangerousness of the indispensable laboratory for carry out preventive planning following technical criteria. The aspects of: handling and use of chemical substances, laboratory materials and equipment and activities at work were analyzed, by identifying the processes, danger factors and evaluation of the risk levels to which teachers, workers are exposed, students, administrative staff and visitors using the NTP 937 methodology of the Spanish Institute for Safety and Hygiene at Work and the IPMAQ methodology. The dangerousness index in the laboratory showed that the level of chemical containment is minimal and according to the value obtained from the Dangerous Index in the handling of Chemical Agents, it was considered that the chemical risk in the laboratory is high and that the conditions of the laboratory are not adequate, so it is necessary to immediately take a series of measures to eradicate this situation. [ABSTRACT FROM AUTHOR]

Tuberculosis (TB) is a serious public health problem worldwide. The combination of various anti-TB drugs is mainly used to treat TB in clinical practice. Despite the availability of effective antibiotics, effective treatment regimens still require long-term use of multiple drugs, leading to toxicity, low patient compliance, and the development of drug resistance. It has been confirmed that immune recognition, immune response, and immune regulation of Mycobacterium tuberculosis (Mtb) determine the occurrence, development, and outcome of diseases after Mtb infection. The research and development of TB-specific immunotherapy agents can effectively regulate the anti-TB immune response and provide a new approach toward the combined treatment of TB, thereby preventing and intervening in populations at high risk of TB infection. These immunotherapy agents will promote satisfactory progress in anti-TB treatment, achieving the goal of “ultra-short course chemotherapy.” This review highlights the research progress in immunotherapy of TB, including immunoreactive substances, tuberculosis therapeutic vaccines, chemical agents, and cellular therapy.