Large-scale application of new energies is a major approach to achieving carbon peaking and carbon neutralization. Conducting research on the safety risk prevention and control strategy of new energy application helps in the establishment of a monitoring, risk prevention, and guarantee system for new energy application and promotes the high-quality development of related industries. Currently, new energy application in China involves various types of emerging infrastructures and faces challenges such as complex causes of safety accidents, incomplete understanding of safety risks, inadequate safety prevention and control technology systems, and lagging construction of a safety regulatory system. This study analyzes the current status and safety situation of new energy application in China and delves into the safety risk prevention and control issues faced by new energy application infrastructures such as charging/swapping stations, energy storage stations, hydrogen fuelling stations, and integrated energy stations. It also summarizes the current situation and experiences abroad regarding safety risk prevention and control. To establish a comprehensive system for preventing and controlling safety accidents before, during, and after they occur, and to enhance the safety risk management and regulatory capabilities of all stakeholders, this study constructs a strategic framework for safety risk prevention and control for new energy application. It clarifies the key tasks in terms of management and technology development and proposes medium- to long-term engineering and technological support projects. Furthermore, we propose development suggestions in terms of top-level design, governance standards, regulatory platforms, technological research and development, talent cultivation, and ecological co-construction, thus to promote the safety research and application of new energies.