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Cardiac conduction regulatory RNA (CCRR) has been documented as an antiarrhythmic lncRNA in our earlier investigation. This study aimed to evaluate the effects of CCRR on SERCA2a and the associated Ca2+ homeostasis in myocardial infarction (MI). Overexpression of CCRR via AAV9-mediated delivery not only partially reversed ischemia-induced contractile dysfunction but also alleviated abnormal Ca2+ homeostasis and reduced the heightened methylation level of SERCA2a following MI. These effects were also observed in CCRR over-expressing transgenic mice. A conserved sequence domain of CCRR mimicked the protective function observed with the full length. Furthermore, silencing CCRR in healthy mice led to intracellular Ca2+ overloading of cardiomyocytes. CCRR increased SERCA2a protein stability by upregulating FTO expression. The direct interaction between CCRR and FTO protein was characterized by RNA-binding protein immunoprecipitation (RIP) analysis and RNA pulldown experiments. Activation of NFATc3 was identified as an upstream mechanism responsible for CCRR downregulation in MI. This study demonstrates that CCRR is a protective lncRNA that acts by maintaining the function of FTO, thereby reducing the m6A RNA methylation level of SERCA2a, ultimately preserving calcium homeostasis for myocardial contractile function in MI. Therefore, CCRR may be considered a promising therapeutic strategy with a beneficial role in cardiac pathology. [ABSTRACT FROM AUTHOR]

A band-pass filter (BPF) is an essential part of a wireless communication system as it functions to reduce interference and noise. Many structures have been proposed to achieve a high-quality BPF. Typically, these structures utilize vias. However, vias has several drawbacks, including impedance discontinuities, increased resistance values, and complex structures. In this study, we propose a dual-band BPF based on a cascaded closed ring resonator (CCRR) without using vias. Specifically, the proposed structure consists of multiple CCRRs connected at the corner pattern and incorporates capacitive coupling to the input impedance. Additionally, the CCRR configuration has dual sizing to achieve dual-band performance. Subsequently, the proposed BPF is simulated and fabricated using Duroid Rogers RT 5880 with dielectric constant εr = 2.2, dissipation factor tan δ = 0.0009, and thickness h = 1.575 mm. The measurement results demonstrated that the dual-band BPF operated at a resonant frequency of 2.50 GHz with a transmission coefficient (S21) value of -2.18 dB in the first band. In the second band, a resonant frequency of 3.70 GHz was obtained with an S21 value of -1.43 dB. The bandwidth in the first band was 160 MHz, and in the second band, it was 110 MHz. Moreover, based on the measurement results, the reflection coefficient (S11) in the first band was -11.05 dB, while in the second band, it was -23.3 dB. The excellent agreement between the simulation and measurement validates the proposed method.

In this paper, we propose a novel low complexity Partial Transmit Sequence (PTS) technique employing Random phase sequence matrix (RPSM) for peak to average power ratio (PAPR) reduction in orthogonal frequency division multiplexing (OFDM) systems. The main goal of our suggested scheme is to achieve the optimum phase sequence matrix to minimize PAPR and simultaneously reduce the computational complexity by decreasing the number of Inverse Fast Fourier Transform (IFFT) operations required. Lower PAPR reduces the complexity of Digital to Analog converters (DAC) and increases the efficiency of power amplifiers. Analytical expressions for Complementary Cumulative Distribution Function (CCDF), Number of subcarriers, subblocks and Total computational complexity are derived. Simulation results match closely with the analytical results. It is demonstrated that a favorable tradeoff can be achieved between the reduction of PAPR and computational complexity. It is observed that the suggested modified PTS technique outperforms the traditional PTS (T-PTS) technique.

Abstract Selected mapping (SLM) algorithm has been widely used for reducing high peak-to-average power ratio (PAPR) of orthogonal frequency division multiplexing (OFDM) signal. One of the factors affecting SLM performance is high computational complexity. To overcome this effect, in this paper, the time domain signals available at the output of IFFT blocks are separated into real odd, real even, imaginary odd and imaginary even subsequences using Fourier transform properties. To generate more candidates, the subsequences corresponding to each time-domain signals are swapped to get M4 candidates from M IFFT operation as swapped SLM. Then the real subsequences are retained and the imaginary subsequences are transformed into time reversed, circularly shifted and time-reversal of circularly shifted subsequences. Therefore, the proposed scheme generates 4M4 candidates by combining different real subsequences and imaginary subsequences using only M IFFT operations. The simulation results illustrate that the proposed SLM scheme offers an improved PAPR reduction performance than other existing algorithms. Also, the proposed algorithm achieves 97% computational complexity reduction in terms of multiplications and 67% in terms of additions when compared to CSLM. Similarly, it provides 75% complexity reduction in terms of multiplications and 20% in terms additions when compared to swapped SLM. [ABSTRACT FROM AUTHOR]

This paper accurately extracted the information of arable land, grassland (wetland), forest land, water area and construction land, based on 1: 250000 basic geographic information data. It made model modification of comprehensive CCRR to achieve carrying capacity calculation taking resource quality into consideration. Ultimately it achieved a comprehensive assessment of CCRR status in China. The top ten cities where the status of carrying capacity of resources was overloaded were Wenzhou, Shanghai, Chengdu, Baoding, Shantou, Jieyang, Dongguan, Fuyang, Zhoukou and Handan. The cities were basically distributed in the central and southern areas with convenient transportation and more economically developed areas. Among the cities in surplus status, resources carrying capacity in Hulun Buir was the most abundant, followed by Heihe, Bayingolin Mongol Autonomous Prefecture, Qiqihar, Chifeng and Jiamusi, all of which were located in northeastern China with a small population and plentiful cultivated land. [ABSTRACT FROM AUTHOR]

In this paper, we propose a novel low complexity Partial Transmit Sequence (PTS) technique employing Random phase sequence matrix (RPSM) for peak to average power ratio (PAPR) reduction in orthogonal frequency division multiplexing (OFDM) systems. The main goal of our suggested scheme is to achieve the optimum phase sequence matrix to minimize PAPR and simultaneously reduce the computational complexity by decreasing the number of Inverse Fast Fourier Transform (IFFT) operations required. Lower PAPR reduces the complexity of Digital to Analog converters (DAC) and increases the efficiency of power amplifiers. Analytical expressions for Complementary Cumulative Distribution Function (CCDF), Number of subcarriers, subblocks and Total computational complexity are derived. Simulation results match closely with the analytical results. It is demonstrated that a favorable tradeoff can be achieved between the reduction of PAPR and computational complexity. It is observed that the suggested modified PTS technique outperforms the traditional PTS (T-PTS) technique. [ABSTRACT FROM AUTHOR]

Selected mapping (SLM) technique is commonly employed for reducing peak to average power ratio (PAPR) in orthogonal frequency division multiplexing (OFDM) systems. Conventional SLM scheme has better spectral efficiency, but requires a bank of inverse fast Fourier transforms (IFFTs) to produce candidate signals, resulting in a dramatic increase in computational complexity. To reduce the computational complexity of the SLM technique, this paper proposes a new PAPR reduction scheme of OFDM system, called a modified fast T-transform based SLM OFDM scheme, which considerably reduces the computational complexity with better PAPR reduction performance compared to the conventional T-SLM OFDM scheme. The proposed scheme is analytically and numerically evaluated for the OFDM system specified in the IEEE 802.16d standard. For the OFDM system with 256 subcarriers, the proposed scheme can reduce the complex multiplications by 68.7 % with the lower PAPR by range of 7 dB which is about 1 dB less than the conventional SLM based OFDM. [ABSTRACT FROM AUTHOR]

El objetivo del estudio es analizar la incidencia de los Convenios de Coordinación en materia de Reasignación de Recursos –CCRR– sobre el desempeño turístico de los destinos seleccionados: Pueblos Mágicos, Ciudades Patrimonio y playas. El desempeño turístico se definió como el éxito que tiene un lugar turístico cuando los ciudadanos y las empresas están satisfechos con su comunidad y cuando la localidad en cuestión está a la altura de las expectativas de los visitantes y los inversores. A fin de calcular el impacto de los CCRR sobre el desempeño turístico, se construyó la variable dependiente, en este caso el Índice de Desempeño Turístico –IDT–, y como variable independiente se consideraron tanto los proyectos realizados como los apoyos gubernamentales. Mediante e la técnica de análisis de componentes principales se calculó después el Índice de Desempeño Turístico, el cual incluye siete dimensiones para su conformación: 1) condiciones para el turismo en el destino, 2) planeación estratégica y sustentabilidad, 3) operación, 4) resultados, 5) satisfacción, 6) gobernanza y 7) seguridad. Una vez calculado el IDT, se realizó el análisis de impacto de los CCRR sobre el IDT a través de una serie de regresiones econométricas, cuyos resultados concluyen que los CCRR sí han tenido un impacto positivo en el mejoramiento del IDT en los últimos diez años, principalmente en la vocación turística de los destinos y en la disminución del rezago social.

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