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2 results on '"carrageenan-induced paw edema test"'

1. Exploring Therapeutic Potential of Malcolmia Aegyptiaca Spr. and Matthiola Livida DC. Extracts in Rat Models Using Hot-Plate, Writhing and Carrageenan-Induced Paw Edema Tests

Author

Chouikh A., Ben Ali A., and Bousbia Brahim A.

Subjects
malcolmia aegyptiaca spr. (el harra), matthiola livida dc. (chegara), hot-plate test, writhing test, carrageenan-induced paw edema test, Medicine
Abstract

Malcolmia aegyptiaca (locally known as El Harra) and Matthiola livida (locally known as Chegara) are medicinal plants traditionally used to relieve pain and reduce inflammation. Little is known about the flavonoid content or the analgesie and anti-inflammatory properties of these plants.

Published
2024
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2. Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice

Author

Sulaiman, M.R., Perimal, E.K., Akhtar, M.N., Mohamad, A.S., Khalid, M.H., Tasrip, N.A., Mokhtar, F., Zakaria, Z.A., Lajis, N.H., and Israf, D.A.

Subjects
*ANTI-inflammatory agents, *LABORATORY mice, *GRANULOMA, *EDEMA, *ZINGIBER, *INTRAPERITONEAL injections, *ALTERNATIVE medicine, *ANALYSIS of variance, *ANIMAL experimentation, *BIOPHYSICS, *DOSE-effect relationship in pharmacology, *DRUG toxicity, *MATHEMATICS, *RESEARCH methodology, *MEDICINAL plants, *MICE, *RESEARCH funding, *STATISTICS, *PLANT extracts, *DATA analysis, *PHARMACODYNAMICS
Abstract

The anti-inflammatory activity of zerumbone (1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith was investigated using carrageenan-induced paw edema and cotton pellet-induced granuloma tissue formation test in mice. It was demonstrated that intraperitoneal administration of 1 at a dose of 5, 10, 50 and 100mg/kg produced significant dose-dependent inhibition of paw edema induced by carrageenan. It was also demonstrated that 1 at similar doses significantly suppressed granulomatous tissue formation in cotton pellet-induced granuloma test. [Copyright &y& Elsevier]

Published
2010
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