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Primary cutaneous adenoid cystic carcinoma (PCACC) is a rare tumor with an estimated incidence rate of 0.23 cases/1,000,000 people per year. A 60-year-old man presented a scalp lesion in 2017. Initially, it was not possible to perform a histopathologic diagnosis. In 2018, surgical biopsy and immunohistochemistry of the local skin recurrence indicated a diagnosis of PCACC (treatment was surgery and radiotherapy). In 2020, a new local tumor recurred and was surgically resected. The patient had systemic metastases (pulmonary metastases) and underwent chemotherapy. Currently, the pulmonary metastases are stable. The PCACC has progressed to pachymeninges. more...

Objectives The aim of this study is find a practical and easy way to histologically differentiate between two malignant tumors namely Adenoid Cystic Carcinoma (ACC) and Polymorphous Low-grade Adeno Carcinoma (PLGA) silver nitrate staining. Methods In this cross-sectional study, 30 parrafin-embedded blocks of ACC and nine paraffin-embedded blocks of PLGA with the most acceptable standards were selected and stained with silver nitrate. Then the number and quality (size and pattern) of the stained spots in five random microscopic fields at 100× magnification (at least 100 cells) were evaluated. T-test was used to compare the number of dots between the two tumors while the quality of dots was compared with the Mann-Whitney U test. Results The mean silver stainable nucleolus organizer region (AgNOR) count was 3/45 for ACC and 2/45 for PLGA. Significant differences were observed in the number of dots between ACC and PLGA (p=0.004), but there was no statistically significant difference between the two tumors in terms of quality of dots. Conclusion AgNOR count can be useful as an available method in confirm the diagnosis of ACC and differentiate it from PLGA. [ABSTRACT FROM AUTHOR] more...

O carcinoma adenóide cístico (CAC) é neoplasia maligna de glândula salivar que acomete principalmente as glândulas parótidas, as submandibulares e as salivares acessórias, sendo raro nas glândulas sublinguais. Com crescimento lento e natureza infiltrativa, clinicamente apresenta-se como nódulo de consistência endurecida. O presente trabalho teve como objetivo revisar a literatura atual sobre o tema em relação aos aspectos clínicos e histopatológicos, bem como relatar um caso de CAC na região submandibular.The adenoid cystic carcinoma (ACC) is a malignant neoplasm of salivary gland that arises preferencially in parotid glands, submandibular and minor salivary glands, but is uncommon in sublingual glands. The ACC is a slow growth and infiltrative tumour that clinically is characterized by a firm mass. The present study aims to rewiew the atually literature of the ACC in relation of clinical and histopathological features and describes a case of ACC in submandibular gland. more...

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