1. Research progress of the transcription factor Brn4 (Review)
- Author
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Jue Wang, Guohua Jin, Yuying Wu, Xinhua Zhang, and Xunrui Zhang
- Subjects
inner ear ,Neural Tube ,Cancer Research ,Embryonic Development ,Review ,Computational biology ,Biology ,Biochemistry ,Homology (biology) ,Genetics ,medicine ,Animals ,Humans ,pancreas ,Molecular Biology ,Gene ,Transcription factor ,neural stem cells ,brain 4 ,Embryogenesis ,Neural tube ,reprogramming ,differentiation ,Cell cycle ,Neural stem cell ,medicine.anatomical_structure ,Oncology ,Ear, Inner ,POU Domain Factors ,Molecular Medicine ,Reprogramming - Abstract
Brain 4 (Brn4) is a transcription factor belonging to the POU3 family, and it is important for the embryonic development of the neural tube, inner ear and pancreas. In addition, it serves a crucial role in neural stem cell differentiation and reprogramming. The present review aimed to summarize the chromosomal location, species homology, protein molecular structure and tissue distribution of Brn4, in addition to its biological processes, with the aim of providing a reference of its structure and function for further studies, and its potential use as a gene therapy target.
- Published
- 2020
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