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Obejective: To explore the effect of fluid resuscitation guided by B-ultrasound measurement of inferior vena cava variability on blood lactic acid levels, pro-inflammatory factors, and immune function in patients with traumatic hemorrhagic shock. Methods: 108 patients with traumatic hemorrhagic shock who were admitted to the Affiliated Hospital of Panzhihua University from April 2020 to February 2023 were selected, according to the different methods of fluid resuscitation, the patients were divided into control group and observation group, with 54 cases each. The control group was treated with traditional restricted fluid resuscitation, and the observation group was treated with B-ultrasonography to guide fluid resuscitation. Clinical indicators, blood lactic acid levels, pro-inflammatory factors, immune function and multiple organ dysfunction syndrome (MODS), acute respiratory distress syndrome (ARDS) and mortality were compared in the two groups. Results: The infusion volume and total blood transfusion volume in the observation group were less than those in the control group, and the hospitalization time in the intensive care unit (ICU) was shorter than that in the control group (P<0.05). After treatment, the blood lactic acid levels of the two groups decreased, and the observation group was lower than the control group during the same period (P<0.05). After treatment, the tumor necrosis factor (TNF)-α, interleukin (IL) -1β and interleukin (IL)-6 levels in the two groups decreased, and the observation group was lower than the control group during the same period (P<0.05). After treatment, CD3+, CD4+, CD4+ /CD8+ in the two groups increased, and CD8+ decreased, and the improvement range in the observation group was greater than that in the control group during the same period (P<0.05). There were no significant differences in MODS, ARDS and mortality between the two groups (P>0.05). Conclusion: Patients with traumatic hemorrhagic shock can receive fluid resuscitation guided by the variability of the vena cava measured by ultrasound, and their pro-inflammatory factors, blood lactic acid levels, and immune function can be significantly improved, which helps to promote patient recovery. [ABSTRACT FROM AUTHOR]

This work aimed to investigate the adoption value of blood lactic acid (BLA) combined with the National Early Warning Score (NEWS) in the early screening of sepsis patients and assessing their severity. The data and materials utilized in this work were obtained from the electronic medical record system of 537 anonymized sepsis patients who received emergency rescue in the emergency rescue area of Liuzhou People's Hospital, Guangxi, from July 1, 2020, to December 26, 2020. Based on the 28-day outcomes of sepsis patients, the medical records were rolled into Group S (407 survival cases) and Group D (130 dead cases). Basic information such as the mode of hospital admission, initial management, use of emergency ventilator within 24 h of admission, NEWS score, arterial oxygen pressure/alveolar oxygen pressure ratio (PaO2/PAO2), alveolar-arterial oxygen difference (A-aDO2), serum creatinine (SCr), blood urea nitrogen (BUN), oxygenation index (OI), Glasgow Coma Scale (GCS), D-dimer, use of vasoactive drugs within 24 h of admission, C-reactive protein (CRP), procalcitonin (PCT), interleukin-6 (IL-6), N-terminal pro-B-type natriuretic peptide (NT-proBNP), quick Sequential Organ Failure Assessment (qSOFA) score, SOFA score, BLA level, NEWS with lactate (NEWS-L) score, SOFA score including lactate level (SOFA-L) score, Intensive Care Unit (ICU) length of stay, total hospital stay, ICU stay/total hospital stay, and septic shock condition were compared between groups. Logistic regression analysis was performed to assess the impact of various predictive factors on prognosis and to plot the receiver operating characteristic (ROC) curve. The results suggested marked differences between Group S and Group D in terms of mean age (t = −5.620; OR = −9.96, 95 % CI: −13.44∼-6.47; P

Abstract Background Retinopathy of prematurity (ROP) is a common disease in premature infants. In recent years, most researchers have used lactic acid as poor prognosis marker in premature infants. This study aims to explore investigate the impact of blood lactic acid levels on ROP. Methods A retrospective case-control study was conducted, and infants with severe ROP born with birth weight (BW) ≤ 1500 g and gestational age (GA) ≤ 32 weeks were enrolled from November 2016 to November 2021. Infants without any stage ROP were included as controls and were matched with ROP infants (1:2) by GA and BW. All selected preterm infants were tested for heel terminal trace blood gas analysis within two weeks of life. Changes in blood lactic acid levels in the two groups were compared and analyzed by using multivariate logistic regression analysis. Sensitivity and specificity were analyzed by receiver operating characteristic (ROC) curve. Results There were 79 infants in ROP group, and 158 infants in control group. The levels of blood lactic acid were significantly higher in the ROP group on days 1, 3, 5, and 7 compared with control group (all p

Objective To investigate the application value of blood lactic acid(Lac) and ROX index in the treatment of elderly patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD) by nasal humidification high-flow oxygen therapy(HFNC). Methods A total of 82 patients with AECOPD who visited the Department of Respiratory and Critical Care Medicine of the Second Medical Center of the PLA General Hospital from March 2020 to March 2023 were selected as the study subjects and treated with HFNC.Patients were divided into effective(n=53) and ineffective(n=29) groups according to the continuous treatment of HFNC for 48 h.The clinical data and serum Lac and ROX indices were compared between the two groups,and the related factors affecting the ineffective treatment of HFNC were analyzed by a mlogistic regression model,the predictive value of blood Lac and ROX indices for the ineffective treatment of HFNC was analyzed by ROC curve. Results The age,acute physiology and chronic health evaluation Ⅱ(APACHEⅡ) score,C-reactive protein(CRP),blood Lac before and 12 h after treatment in the ineffective group were all higher than those in the effective group(P

Copyright of Farmacia is the property of Societatea de Stiinte Farmaceutice Romania and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: Neonatal sepsis is a life-threatening clinical condition. It is associated with high morbidity and mortality if not treated properly. Blood culture remains the gold standard method diagnosis of sepsis, but it takes at least 24 hours for presumptive diagnosis. Owing to the fact that neonates are vulnerable and can deteriorate easily, rapid diagnosis and management is a must. Aim of the work:Determination of the role of mean platelet volume (MPV) and plasma lactate level in the diagnosis and prognosis of neonatal bacteremia. Methods:Study included 108 clinically septic neonates aged 0-28 days. All neonates were subjected to blood culture, complete blood picture (for MPV evaluation), CRP and blood lactic acid level. Results: The current study showed that there was a significant difference between cases and controls as regards MPV, CRP, and lactate with higher mean and median values among cases with P value 0.001, 0.003, and 0.021 respectively. High blood lactic acid level was found to be highly significant in non-survived neonates when compared to the survived ones with P value 0.001. Conclusion: MPV and Blood lactic acid (BLA) tests are simple, rapid, and inexpensive methods to diagnose neonatal bacteremia. The available evidence confirms significantly higher MPV, and BLA in neonates with bacteremia compared to neonates with non-bacteremia causes of sepsis. Therefore, in clinical practice, MPV and BLA could be used as indicators for the early diagnosis of sepsis, while blood lactic acid can be used as well as a predictor of mortality.

To study the efficacy of bedside ultrasound combined with serum lactic acid (LAC) in volume responsiveness of patients with septic shock. A total of 120 patients with septic shock who received diagnosis and treatment in our hospital from October 2015 to October 2017 were selected for the study. Rehydration test was carried out for all patients, and they were divided into response group with 63 cases and non-response group with 57 cases according to the difference of test results. Bedside ultrasound examination and LAC level detection were performed for two groups, and the levels of relevant indicators were compared. Pearson correlation analysis was used to determine the relationship between bedside ultrasound index and LAC level in patients with septic shock. Receiver operating characteristic (ROC) curve analysis was used to determine the efficacy of bedside ultrasound combined with LAC in predicting volume responsiveness of the above patients. The mean arterial pressure (MAP) and central venous pressure (CVP) of the two groups after rehydration were higher than those before rehydration (P＜0.05). The variation rate of respiration of inferior vena cava (△ IVC), peak velocity of aorta (△ VpeakAO) and maximum velocity of brachial artery (△ VpeakBA) in the response group before rehydration were higher than those after rehydration and the non-response group (P＜0.05). The LAC level after rehydration was lower than that before rehydration in two groups, and that in response group was lower than that in non-response group (P＜0.05). Pearson correlation analysis showed that LAC level was positively correlated with △ IVC, △ VpeakAO and △ VpeakBA (P＜0.05). The ROC curve analysis showed that the area under the curve, sensitivity, specificity and Youden index of the volume responsiveness of patients with septic shock predicted by bedside ultrasound combined with LAC were higher than those predicted by bedside ultrasound and LAC alone. The LAC level of patients with septic shock decreased after rehydration. The potency of bedside ultrasound combined with LAC in predicting volume responsiveness of patients with septic shock is high, which has certain clinical application value. [ABSTRACT FROM AUTHOR]

Background: Neonatal sepsis is a life-threatening clinical condition. It is associated with high morbidity and mortality if not treated properly. Blood culture remains the gold standard method for diagnosis of sepsis, but it takes at least 24 hours for presumptive diagnosis. Owing to the fact that neonates are vulnerable and can deteriorate easily, rapid diagnosis and management is a must. Aim of the work: Determination of the role of mean platelet volume (MPV) and plasma lactate level in the diagnosis and prognosis of neonatal bacteremia. Methods: Study included 108 clinically septic neonates aged 0-28 days. All neonates were subjected to blood culture, complete blood picture (for MPV evaluation), C-reactive protein (CRP) and blood lactic acid (BLA) level. Results: The current study showed that there was a significant difference between cases and controls as regards MPV, CRP, and lactate with higher mean and median values among cases with p value 0.001, 0.003, and 0.021 respectively. High blood lactic acid level was found to be highly significant in non-survived neonates when compared to the survived ones with p value 0.001. Conclusion: Mean platelet volume and BLA tests are simple, rapid, and inexpensive methods to diagnose neonatal bacteremia. The available evidence confirms significantly higher MPV, and BLA in neonates with bacteremia compared to neonates with non-bacteremia causes of sepsis. Therefore, in clinical practice, MPV and BLA could be used as indicators for the early diagnosis of sepsis, while BLA can be used as well as a predictor of mortality.. [ABSTRACT FROM AUTHOR]

Copyright of Food Research & Development is the property of Food Research & Development Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Modern Food Science & Technology is the property of Editorial Office of Modern Food Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The production of blood lactic acid in exercise can make the body feel tired and affect the normal movement of the body. Therefore, from the aspects of energy metabolism, mechanical injury, inflammation, free radicals and lipid peroxidation, and growth factors regulating the repair of skeletal muscle injury, the mechanism of Chinese herbal compound on skeletal muscle exercise induced injury is systematically analyzed and discussed. In order to provide theoretical basis for sports training, public health and labor hygiene, one or two of the seven Chinese herbal prescriptions which have good effects on exercise-induced muscle injury are selected. The paper delivers guidelines for avoiding and decreasing exercise caused lactate accumulation and lactic acid. The results show that Chinese herbal fumigation lotion can effectively remove blood lactic acid, accelerate the recovery of muscle strength, and obviously eliminate exercise-induced muscle fatigue. [ABSTRACT FROM AUTHOR]

This work aimed to investigate the adoption value of blood lactic acid (BLA) combined with the National Early Warning Score (NEWS) in the early screening of sepsis patients and assessing their severity. The data and materials utilized in this work were obtained from the electronic medical record system of 537 anonymized sepsis patients who received emergency rescue in the emergency rescue area of Liuzhou People's Hospital, Guangxi, from July 1, 2020, to December 26, 2020. Based on the 28-day outcomes of sepsis patients, the medical records were rolled into Group S (407 survival cases) and Group D (130 dead cases). Basic information such as the mode of hospital admission, initial management, use of emergency ventilator within 24 h of admission, NEWS score, arterial oxygen pressure/alveolar oxygen pressure ratio (PaO 2 /PAO 2 ), alveolar-arterial oxygen difference (A-aDO 2 ), serum creatinine (SCr), blood urea nitrogen (BUN), oxygenation index (OI), Glasgow Coma Scale (GCS), D-dimer, use of vasoactive drugs within 24 h of admission, C-reactive protein (CRP), procalcitonin (PCT), interleukin-6 (IL-6), N-terminal pro-B-type natriuretic peptide (NT-proBNP), quick Sequential Organ Failure Assessment (qSOFA) score, SOFA score, BLA level, NEWS with lactate (NEWS-L) score, SOFA score including lactate level (SOFA-L) score, Intensive Care Unit (ICU) length of stay, total hospital stay, ICU stay/total hospital stay, and septic shock condition were compared between groups. Logistic regression analysis was performed to assess the impact of various predictive factors on prognosis and to plot the receiver operating characteristic (ROC) curve. The results suggested marked differences between Group S and Group D in terms of mean age ( t  = -5.620; OR = -9.96, 95 % CI: -13.44∼-6.47; P  < 0.001). Group S showed drastic differences in terms of mode of hospital admission (χ 2  = 9.618, P  < 0.01), method of initial management (χ 2  = 51.766, P  < 0.001), use of emergency ventilator within 24 h of admission (χ 2  = 98.564, P  < 0.001), incidence of septic shock (χ 2  = 77.545, P  < 0.001), use of vasoactive drugs within 24 h of admission (χ 2  = 102.453, P  < 0.001), heart rate ( t  = -4.063, P  < 0.001), respiratory rate ( t  = -4.758, P  < 0.001), oxygenation status (χ 2  = 20.547, P  < 0.001), NEWS score ( t  = -6.120, P  < 0.001), PaO 2 /PAO 2 ratio ( t  = 2.625, P  < 0.01), A-aDO 2 value ( Z  = -3.581, P  < 0.001), OI value ( Z  = -3.106, P  < 0.01), PLT value ( Z  = -2.305, P  < 0.05), SCr value ( Z  = -3.510, P  < 0.001), BUN value ( Z  = -3.170, P  < 0.01), D-dimer ( Z  = -4.621, P  < 0.001), CRP level ( Z  = -4.057, P  < 0.001), PCT value ( Z  = -2.783, P  < 0.01), IL-6 level ( Z  = -2.904, P  < 0.001), length of hospital stay ( Z  = -4.138, P  < 0.001), total hospital stay ( Z  = -8.488, P  < 0.001), CCU/total hospital stay ( Z  = -9.118, P  < 0.001), NEWS score ( t  = -6.120, P  < 0.001), SOFA score ( t  = -6.961, P  < 0.001), SOFA-L score ( Z  = -4.609, P  < 0.001), NEWS-L score ( Z  = -5.845, P  < 0.001), BLA level ( Z  = -6.557, P  < 0.001), and GCS score ( Z  = 6.909, P  < 0.001) when compared to Group D. The use of ventilators, septic shock, PCT, NEWS score, GCS score, SOFA score, SOFA-L score, NEWS-L score, and BLA level were identified as independent risk factors for predicting the prognosis of sepsis patients ( P  < 0.001). The areas under ROC curve (AUC) of blood lactic acid, PCT, NEWS, NEWS-L, GCS, SOFA, and SOFA-L were 0.695, 0.665, 0.692, 0.698, 0.477, 0.700, and 0.653, respectively. These findings indicate that the combination of BLA with NEWS (NEWS-L) score and SOFA score has certain advantages in assessing the prognosis of sepsis., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors.)

Introduction: Previous studies have revealed that sodium bicarbonate consumption prior to physical activity has a performance-enhancing effect on anaerobic activity. Methods: It was an experimental research using retest and posttest design. 36 healthy professional athletes were randomly assigned to either NaHCO3 group (SBC=18) or placebo group (PLA=18). Respondents in SBC were given sodium bicarbonate solution at a dose of 0.4 gram/kg of bodyweight dissolved in 500 ml of aquades, while PLA group were given mineral water. Sixty minutes after NaHCO3 administration, both groups were assigned to anaerobic activity which was 300 m sprint test. pH level and lactic acid were measured 5 minutes after anaerobic activity, while fatigue index was measured 30 minutes after anaerobic activity. Results: Significant differences between SBC and PLA were found in pH level (p=0,000), blood lactic acid (p=0,000), and fatigue index (p=0,003). Conclusion: The administration of NaHCO3 was able to prevent a decrease in pH and an excessive increase of lactic acid and fatigue index as the result of anaerobic activity. [ABSTRACT FROM AUTHOR]

Introduction: Previous studies have revealed that sodium bicarbonate consumption prior to physical activity has a performance-enhancing effect on anaerobic activity. Methods: It was an experimental research using retest and posttest design. 36 healthy professional athletes were randomly assigned to either NaHCO3 group (SBC=18) or placebo group (PLA=18). Respondents in SBC were given sodium bicarbonate solution at a dose of 0.4 gram/kg of bodyweight dissolved in 500 ml of aquades, while PLA group were given mineral water. Sixty minutes after NaHCO3 administration, both groups were assigned to anaerobic activity which was 300 m sprint test. pH level and lactic acid were measured 5 minutes after anaerobic activity, while fatigue index was measured 30 minutes after anaerobic activity. Results: Significant differences between SBC and PLA were found in pH level (p=0,000), blood lactic acid (p=0,000), and fatigue index (p=0,003). Conclusion: The administration of NaHCO3 was able to prevent a decrease in pH and an excessive increase of lactic acid and fatigue index as the result of anaerobic activity. [ABSTRACT FROM AUTHOR]

We investigated the effects of astaxanthin supplementation and acute high intensity exercise on serum antioxidant capacity of human body, blood lactic acid and serum uric acid metabolism. Sixteen subjects were trained 28 days and were randomly divided into two groups: group A (experimental) and B (control). Four weeks later, all subjects underwent exercise on power bike. Immediately after exercise, the anti-oxidative capacity decreased in 2 groups, the lactic acid values of blood significantly increased, but compared with the group B the antioxidant capacity of the A group was significantly higher and blood lactate value lower. (1) Exercise can temporarily reduce the body's antioxidant capacity, increase blood lactic acid content, and slightly decrease blood uric acid content. (2) Astaxanthin intake can eliminate free radicals produced in the body, significantly reducing the increase in blood lactic acid and reducing blood uric acid value after acute high-intensity exercise. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To study the anti-fatigue effects of aqueous extracts from Xianye Jinquehua (Rooibos, Aspalathus Linears) and Zanghonghua (Saffron, Crocus sativus L.) through classic behavior test (loaded swimming) and detections of blood lactic acid, liver glycogen and muscle glycogen. Methods At first 32 mice were randomly divided into blank control group, Xianye Jinquehua group and Zanghonghua group, and were orally given corresponding medicinals once a day. The test of loaded swimming was conducted in all groups after 14 d. Then 46 mice were randomly divided into blank control group and low-dose Xianye Jinquehua + Zanghonghua group, and were orally given corresponding medicinals once a day. The test of loaded swimming and detection of blood lactic acid were conducted in all groups after 14 d. According to above test results, 100 mice were randomly divided into blank control group, low-dose Xianye Jinquehua + Zanghonghua group, mid-dose Xianye Jinquehua + Zanghonghua group and high-dose Xianye Jinquehua+ Zanghonghua group. After oral medication for 14 d, the content of liver glycogen and muscle glycogen was detected. Results The time of loaded swimming was not improved in Xianye Jinquehua group and Zanghonghua group, and it was prolonged (P<0.05) and content of blood lactic acid was decreased (P<0.05) in low-dose Xianye Jinquehua+ Zanghonghua group. The content of liver glycogen and muscle glycogen was increased in low-dose Xianye Jinquehua + Zanghonghua group, mid-dose Xianye Jinquehua + Zanghonghua group and high-dose Xianye Jinquehua+ Zanghonghua group compared with blank control group (P < 0.05 or P < 0.01). Conclusion The single administration of single Xianye Jinquehua or single Zanghonghua has no anti-fatigue effect, while combination of them has this effect. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the value of early dynamic monitoring of blood lactic acid concentration in evaluating the severity and prognosis of septic shock in children. Methods: 90 children with septic shock were enrolled in this study, starting with diagnostic shock, blood lactate at 0 h and 6 h were dynamically monitored, and 6 h lactate clearances were calculated. According to PCIS scores, they were divided into ≥ 70 points group(n=41), 60~70 points group(n=40) and ＜60 points group(n=9); according to the prognosis, they were divdided into survival group (n=62) and death group (n=28); according to the lactate clearance rate, they were divdided into high lactate clearance rate group (n=57) and low lactate clearance rate group (n=33). The PCIS score, 0 h lactic acid and lactate clearance rate of each group were compared. Results: There were significant in 0 h lactic acid and lactate clearance rate among ≥ 70 points group, 60~70 points group and ＜60 points group (P＜0.05). The 0 h lactic acid and lactate clearance rate in ≥ 70 points group were lower than those in the 60~70 points group, which were lower in ＜60~70 points group than than that in ＜60 points group (P＜ 0.05). There were significant differences in the PCIS scores, 0 h lactic acid and lactate clearance rate between survival group and death group(P＜0.05). There were significant differences in the PCIS scores between high lactate clearance rate group and low lactate clearance rate group(P＜0.05). PCIS score was negative correlated with 0h lactate concentration (r=-0.619), and was positively correlated with the lactate clearance (r=-0.702). Conclusions: In the evaluation of the severity and prognosis of septic shock in children, early lactate clearance rate was more useful than that of single blood lactate acid. [ABSTRACT FROM AUTHOR]

The study was conducted to evaluate the relationship between the blood lactic acid (BLA) level, serum procalcitonin (PCT), C-reactive protein (CRP) and the severity and prognosis of neonatal sepsis. A retrospective analysis was conducted on 90 children with sepsis admitted into the Intensive Care Unit (ICU) of the Hubei Institute for Nationalities Af liated Hospital hospital. Patients were divided into the non-survival group and the survival group. Severity of the 90 patients was evaluated according to Neonatal Critical Illness Score (NCIS). Observations were made on changes of the levels of BLA, PCT and CRP, correlation between BLA, PCT, CRP and NCIS as well as the association of the levels of these proteins with the prognosis of the patients. The 90 sick children were divided into the survival group (61 cases, 67.7%) and the non-survival group (29 cases, 32.2%). They were further stratified into the extremely severe group (n=20), severe group (n=39) and non-severe group (n=31) according to NCIS scoring standard. The BLA and NCIS scores of the non-survival group were significantly greater than those of the survival group. The difference was statistically significant (P<0.05). We found that there was a significant negative correlation between the BLA values and NCIS scores of the two groups. We also demonstrated significant positive correlation between the BLA value, PCT and CR (P<0.05). We observed a significant negative correlation between PCT, CRP and NCIS scores (P<0.05). The PCT level of the non-survival group was significantly higher than that of the survival group (P<0.05), while the NCIS score was significantly lower than that of the survival group (P<0.05). The CRP and PCT protein expression results of the sepsis patients were higher than those of the control group. Therefore, there is a significant correlation between BLA, CRP, PCT and NCIS. The lower the NCIS score is, the more significant the increase of BLA, PCT and CRP. Thus, the combined detection of levels of BLA, PCT and CRP may predict the severity of neonatal sepsis patients and their prognosis. [ABSTRACT FROM AUTHOR]

Background: Asiaticoside is one of the main components of triterpenoid saponins extracted from Centella asiatica . Asiaticoside has shown the effects of wound healing, osteoclastogenesis, anti-inflammatory, anti-cancer, and improving cognition in multiple human disease models. However, studies on the antifatigue effects of asiaticoside have not been explored. Therefore, the aim of this study was to investigate the potential antifatigue effect and underlying mechanism of asiaticoside administration on exhaustive exercise performance., Methods: Male Kunming mice were divided into four groups randomly (n = 20/group). Saline (10 mL/kg) was administered to the model control group and the other three experimental groups were fed with low (10 mg/kg), medium (20 mg/kg) and high (40 mg/kg) asiaticoside once/daily for 14 days. The antifatigue effect of asiaticoside on mice was estimated by analyzing changes in body weight, weight-loaded swimming time, rotating time, lactic acid, urea nitrogen, liver/muscle glycogen, serumal superoxide dismutase, superoxide dismutase and the liver tissues of hematoxylin and eosin (H&E) staining., Results: The results indicated that no significant differences were observed in the body weight of each group ( p > 0.05). Compared with the model control group, supplementation of asiaticoside significantly prolonged the weight-loaded swimming time and rotating time; Decreased the blood lactic acid (LA), blood urea nitrogen (BUN), and serumal malonaldehyde (MDA); And increased the content of liver/muscle glycogen and serumal superoxide dismutase levels (SOD) ( p < 0.05). Furthermore, the pathological results of the liver were improved greatly. The maximal effect was observed in the medium group of 20 mg/kg., Conclusions: Asiaticoside is capable of reducing the fatigue effect by regulating energy consumption, energy metabolism and improving antioxidant activity after exercise. While there are still some shortcomings in this study, our findings provide a scientific basis for developing an asiaticoside-based antifatigue supplement., Competing Interests: The authors declare no conflict of interest., (© 2023 The Author(s). Published by Discovery Medicine.)

Fatigue is a noticeable and highly prevalent symptom in tense, industriously, and economically affluent modern society. Therefore, new antifatigue agents to smooth the fatigue feature are an energetic topic. The total ethanol extract (ESI) of Saussurea involucrata Kar et Kir., known as Tian-Shan snow lotus, was evaluated for antifatigue activity in ICR mice with mice forced swimming test and the determination of the contents of blood lactic acid and serum urea nitrogen. ESI (0.05, 0.15, 0.25 g/kg) was administered orally to mice for 4 weeks. The average swimming times to exhaustion of the ESI-treated ICR mice (0.15, 0.25 g/kg) were prolonged by 132% and 180% (p

As the internal structure of mice is the most similar to that of human body, we used mice instead of humans for the experimental test and observed the anti-fatigue effect of soy isoflavone on the mice during swimming. Then, we further confirmed the remission effect of soy isoflavone on sports fatigue, which provided a solid theoretical basis for its application in sports. We selected the mice as the research objects and divided them into three groups. Through the swimming experiment, we observed the influences of soy isoflavone on hepatic glycogen content, muscle glycogen content, hepatic malondialdehyde and serum urea and the activity of serum lactic acid dehydrogenase in mice. Under the regulation effect of soy isoflavone, protein consumption of the mice reduced in the process of swimming, while fat increased, thus to provide energy for the body, relieve the sports fatigue and improve the exercise tolerance of the body. In addition, supplement of soy isoflavone could also improve the function of skeletal muscle mitochondria of the mice and reduce the generation of oxidative injury products; consequently, soy isoflavone was beneficial to easing the oxidative stress damage during sports. In conclusion, with a favorable regulating effect on the energy metabolism of mice during movement, soy isoflavone can effectively relieve physical fatigue. [ABSTRACT FROM AUTHOR]

Toona sinensis is a perennial deciduous tree commonly found in China that has traditionally been used as a health food and herbal medicine for the treatment of various diseases. Here we explored the anti-fatigue effect of TSL-1 (a bioactive fraction of T. sinensis) in a mouse model. After 1 week of acclimation, 8-week-old ICR mice were fed with either a standard diet or a standard diet containing TSL-1 for 15 days and then subjected to swimming until exhaustion. All mice were immediately sacrificed after exhaustive swimming, and major metabolic substrates were measured in serum and liver. The results showed that feeding TSL-1 to mice significantly increased their maximum swimming times to exhaustion compared with those of the control group (P < 0.05). Furthermore, dietary TSL-1 decreased the levels of blood lactic acid, serum urea nitrogen, and liver malondialdehyde, and increased the activity of superoxide dismutase in serum. Therefore, the present study demonstrated that TSL-1 enhanced the endurance capacity of mice and decreased biochemical markers of fatigue. [ABSTRACT FROM AUTHOR]

The aim of the present study was to analyze the clinical significance of the dynamic monitoring of blood lactic acid levels, the oxygenation index and C-reactive protein (CRP) levels in patients with severe pneumonia. The clinical data of 34 cases with severe pneumonia were collected. According to the clinical outcome, the patients were divided into a survival group (n=26) and a fatality group (n=8). Various factors, including the blood lactic acid level, oxygenation index, CRP level and acute physiology and chronic health evaluation II (APACHE II) score, were retrospectively analyzed in order to investigate whether these values had clinical significance for the prognosis of the patients. No statistically significant differences with regard to age, gender, initial concentrations of blood lactic acid and CRP, and APACHE II scores were observed between the two groups at admission to the Intensive Care Unit. However, the blood lactic acid levels were found to decrease to a normal level within 12-24 h after treatment in the survival group, while the levels were maintained at a higher concentration in the fatality group, even at 72 h after treatment (P<0.05). Furthermore, the oxygenation index in the survival group was significantly higher when compared with that in the fatality group. The oxygenation index was maintained at a normal level in the survival group, while the oxygenation index levels were below normal and continued to decline in the fatality group. A positive correlation was observed between the blood lactic acid level and the APACHE II scores (r=0.656, P<0.05). Therefore, the present study demonstrated that dynamic monitoring of blood lactic acid, oxygenation index and CRP levels in patients with severe pneumonia can be used to evaluate the therapeutic efficiency, in addition to serving as a prognosis indicator, for patients with severe pneumonia. [ABSTRACT FROM AUTHOR]

Hericium erinaceus (HEP) is a notable medicinal fungus grown in China and other oriental countries. Polysaccharides from HEP have recently attracted considerable attention due to their numerous physiological activities. The objective of this study was to evaluate the anti-fatigue activity of HEP in a mouse model. After one week of acclimation, mice were randomly divided into four groups: a control group, a low-dose HEP-treated group, a moderate-dose HEP-treated group, and a high-dose HEP-treated group. The treated groups received HEP (50, 100 and 200 mg/kg, ig), while the control group received saline solution. Following treatment for 28 days, the mice performed a forced swimming test until they were exhausted, then the exhaustive swimming time was recorded along with certain biochemical parameters related to fatigue, including blood lactic acid (BLA), serum urea nitrogen (SUN), tissue glycogen, superoxide dismutase (SOD), glutathione peroxidase (GPx) and malondialdehyde (MDA). These results suggested that HEP has significant anti-fatigue activity by decreasing BLA, SUN and MDA content, as well as increasing tissue glycogen content and antioxidant enzyme activity. Based on these results, this study provided theoretical support for the application of HEP in the field of sports nutrition. [ABSTRACT FROM AUTHOR]

Background: In physical activity or labor, the human body is in a state of high intensity stress, and all parts or physiological functions of the body respond positively to maintain or balance the need for movement. The human body has many physiological changes in the process of movement, and fatigue is the external manifestation of various complex changes inside the human body. Fatigue is also a physiological mechanism of self-protection after the body reaches a certain level of activity, which can prevent the occurrence of life-threatening excessive functional failure. The generation of fatigue is a very complex process, and its mechanism has not been concluded yet. Therefore, it is an important work to search and screen the effective components of natural plants that have anti-fatigue effect and to explore their mechanism., Methods: This was a 8-week, randomized, double-blind, placebo-controlled clinical trial. A total of 110 subjects who passed physical examination were included according to the scheme design, and randomly divided into a test group which was given KRG and a placebo control group. The calculation is carried out according to the standard of sub-high-intensity exercise test., Results: There was no adverse effect on safety index of subjects after taking red ginseng capsule. After KRG treatment, subjective strength grade is significant lower than placebo treatment. Blood lactic acid content is significantly get lower after trial in KRG group, and significant lower than placebo group. Creatine phosphokinase(CK) content is significantly get lower after trial in KRG group, and significant lower than placebo group., Conclusion: According to the criterion in the test scheme, the result shows that KRG is helpful on relieving physical fatigue., Competing Interests: All authors have no conflicts of interest to declare., (© 2021 The Korean Society of Ginseng. Publishing services by Elsevier B.V.)

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Ninety male students were selected as subjects at random from Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore. Their age range from eighteen to twenty one years. They were divided into three equal groups namely control group (Group I), Yogic Practice group (Group II) and Physical Activity group (Group III). The subjects were tested in order to find out the Haemoglobin, Mean Arterial Pressure, Blood Glucose and Blood Lactic Acid in the early morning before the start of the training programme. Group II underwent Yogic practices and group III underwent Physical activity for twelve weeks on five days a week from morning 6.30 am to 7.30 am. The control group did not involve in any training. The pre and posttest scores on selected dependent variables were subjected to ANCOVA to find out significance of the variables. Scheffe's test was used to find out which of the paired means differed significantly. Analysis of data revealed that the level of haemoglobin increased due to twelve weeks training on selected yogic practices and physical activity. Group III showed more haemoglobin level than group II and group I. However, the group II showed much improvement in haemoglobin level than the group I. There was no significant difference in Mean Arterial pressure, blood glucose and blood lactic acid level among all the subjects due to the influence of twelve weeks yogic practices and physical activity. [ABSTRACT FROM AUTHOR]

This study investigated the effects of auricular acupuncture on athletes' recovery abilities after exercise. Subjects were selected from twenty-four male elite university basketball players, randomly divided into two groups: auricular acupuncture group (AAG), and normal control group (NCG), each group containing twelve subjects. Auricular acupuncture was experimented to each AAG athlete while no auricular acupuncture was conducted to each NCG athlete. Each subject in both groups performed a ride on the stationary bike until exhausted. The data of heart rate (HRmax), oxygen consumption (VO2 max), and blood lactic acid were measured at four points of time: during the rest period after warm-ups and at the 5th, 30th and 60th minutes post-exercise, respectively. One-way ANOVA and repeated Scheffé methods were used to test the differences of the data between these two groups. The results showed that both HRmax and blood lactic acid in AAG were significantly lower than those in NCG at the 30th and 60th minutes post-exercise. This suggests that auricular acupuncture can enhance athletes' recovery abilities after aggressive exercise. [ABSTRACT FROM AUTHOR]