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3 results on '"beta-tromboglobulina"'

1. Effect of sublingual immunotherapy on platelet activity in children with allergic rhinitis

Author

Yanqiu Chen, Lifeng Zhou, and Yan Yang

Subjects
Rinite alérgica, Ativação plaquetária, Imunoterapia sublingual, Fator 4 plaquetário, Beta-tromboglobulina, Otorhinolaryngology, RF1-547
Abstract

Abstract Introduction: The role of platelet activation in allergic inflammation is receiving increasing attention. Sublingual immunotherapy for allergic rhinitis can modify the immunological process to an allergen, rather than simply treating symptoms. Objective: The aim of this study was to explore the role of platelet activation during sublingual immunotherapy in children with allergic rhinitis. Methods: Forty-two House Dust Mite - sensitized children with allergic rhinitis were enrolled and received House Dust Mite allergen extract for sublingual immunotherapy or placebo. Serum of different time points during treatment was collected and used for detection of Platelet Factor-4 and Beta-Thromboglobulin concentration by Enzyme-Linked Immuno Sorbent Assay. Results: Our data showed decreased expression of Platelet Factor-4 and Beta-Thromboglobulin protein after one year's sublingual immunotherapy. In addition, the decrease of symptom scores and serum Platelet Factor-4 and Beta-Thromboglobulin protein concentrations was positively related. Conclusion: During sublingual immunotherapy, platelet activation was inhibited significantly. Our results might indicate that inhibition of platelet activation within the systemic circulation is an important mechanism during sublingual immunotherapy.

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2. Platelet activation and endothelial factors in standard exercise test before and after menopause

Author

Krzysiek, Józef, Milewicz, Tomasz, Dybkowski, Robert, Janczak-Saif, Agnieszka, Dembińska-Kieć, Aldona, Zdzienicka, Anna, Guevara, Ibeth F., Sztefko, Krystyna, Radowicki, S., Dubiel, Jacek, and Klimek, Rudolf

Subjects
vascular endothelial growth factor, śródbłonkowo-naczyniowy czynnik wzrostu, czynniki śródbłonkowe, czynnik von Willebranda, menopause, von Willebrand factor, endotelina-1, tlenek azotu, standardowy test wysiłkowy, standard exercise test, nitric oxide, beta-tromboglobulina, menopauza, endothelin-1, platelet activation, beta-thromboglobulin, aktywacja płytek, endothelial factors
Published
2001

3. Effect of sublingual immunotherapy on platelet activity in children with allergic rhinitis

Author

Yanqiu Chen, Yan Yang, and Lifeng Zhou

Subjects
0301 basic medicine, Male, Beta-Thromboglobulin, Ativação plaquetária, Enzyme-Linked Immunosorbent Assay, medicine.disease_cause, Placebo, Platelet Factor 4, Allergic rhinitis, Allergic inflammation, 03 medical and health sciences, 0302 clinical medicine, Allergen, Medicine, Humans, Platelet, Fator 4 plaquetário, Platelet activation, Beta-tromboglobulina, Child, Imunoterapia sublingual, House dust mite, Sublingual immunotherapy, biology, business.industry, biology.organism_classification, lcsh:Otorhinolaryngology, Rhinitis, Allergic, Rinite alérgica, lcsh:RF1-547, Platelet Factor-4, 030104 developmental biology, Treatment Outcome, 030228 respiratory system, Otorhinolaryngology, Beta-thromboglobulin, Immunology, Female, business, Platelet factor 4
Abstract

Introduction: The role of platelet activation in allergic inflammation is receiving increasing attention. Sublingual immunotherapy for allergic rhinitis can modify the immunological process to an allergen, rather than simply treating symptoms. Objective: The aim of this study was to explore the role of platelet activation during sublingual immunotherapy in children with allergic rhinitis. Methods: Forty-two House Dust Mite - sensitized children with allergic rhinitis were enrolled and received House Dust Mite allergen extract for sublingual immunotherapy or placebo. Serum of different time points during treatment was collected and used for detection of Platelet Factor-4 and Beta-Thromboglobulin concentration by Enzyme-Linked Immuno Sorbent Assay. Results: Our data showed decreased expression of Platelet Factor-4 and Beta-Thromboglobulin protein after one year's sublingual immunotherapy. In addition, the decrease of symptom scores and serum Platelet Factor-4 and Beta-Thromboglobulin protein concentrations was positively related. Conclusion: During sublingual immunotherapy, platelet activation was inhibited significantly. Our results might indicate that inhibition of platelet activation within the systemic circulation is an important mechanism during sublingual immunotherapy. Resumo Introdução: O papel da ativação de plaquetas na inflamação alérgica recebeu atenção crescente. A imunoterapia sublingual para rinite alérgica pode modificar o processo imunológico a um alérgeno, em vez de tratar os sintomas simplesmente. Objetivo: Explorar o papel da ativação plaquetária durante a imunoterapia sublingual em crianças com rinite alérgica. Método: Quarenta e duas crianças com rinite alérgica sensibilizadas por ácaros de poeira domiciliar (APD) foram inscritas e receberam extrato de alérgeno de APD para imunoterapia sublingual ou placebo. O soro de diferentes pontos no tempo durante o tratamento foi recolhido e usado para a detecção de fator 4 plaquetário e concentração de beta-tromboglobulina por ensaio imunoenzimático. Resultados: Nossos dados mostraram diminuição da expressão de fator 4 plaquetário e proteína beta-tromboglobulina após imunoterapia sublingual de um ano. Além disso, a diminuição dos escores de sintomas e o fator 4 plaquetário sérico e concentrações de proteína beta-tromboglobulina foram relacionados de maneira positiva. Conclusão: Durante imunoterapia sublingual, a ativação plaquetária foi inibida significativamente. Os nossos resultados podem indicar que a inibição da ativação de plaquetas dentro da circulação sistêmica é um mecanismo importante durante imunoterapia sublingual.

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