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Improvement of methods of complex treatment of periodontium diseases continues to be an urgent problem of dentistry and requires an interdisciplinary approach. The severity of thecourse of periodontitis and the severity of destructive phenomena dictates the need to use osteoplastic agents to restore damaged periodontium tissues. It has been proven that the efficiency of membrane technology is significantly increased when membranes and substitute materials are used together. The positive effect of the combined use of Platelet Rich Plasma (PRP — autogenous growth factors), osteoplastic materials, and the method of Guided Tissue Regeneration (GTR) has been confirmed. To increase the efficiency of reconstructive treatment of patients with generalized periodontitis through the combined use of alloplastic, Platelet Rich Plasma, and the method of Guided Tissue Regeneration. Method of testing: clinical, X-ray. For the period 2018–2019, 34patients with chronic generalized periodontal atrophy of moderate severity were under observation. All patients underwent professional oral hygiene, laser therapy, and antibacterial therapy with rovamycin. 6patients in complex therapy underwent surgical interventions: osteogingivoplasty with biocomposite materials using GTR auto-allogenic membranes. Bone defects were filled with biocomposite material: hydroxylappatite granules (Polistom, RF) in combination with PRP, on top of an alto plasma membrane isolated from PRP and collagen membrane (Polistom, RF). The immediate and long-term periods of treatment were quite favorable. Control X-ray examination after 12 months showed restoration of a bone defect with an organotypic structure.

Improvement of methods of treatment of odontogenic cysts of the jaws continues to be an urgent problem in surgical dentistry and maxillofacial surgery. Currently, the most promising is the use of multicomponent osteoplastic materials in order to optimize reparative osteogenesis after cystectomy for extensive jaw cysts. The aim of the study is to improve the method of cystectomy in the surgical treatment of large cysts of the upper jaw with osteoplasty of the bone defect with biocomposite materials in combination with the method of directed tissue regeneration. Clinical, radiological, histological. During the period 2015-2019, 54 patients with odontogenic cysts of the jaws were under observation, of which 12 were diagnosed as extensive. After cystectomy, the bone cavity was filled with biocomposite material: hydroxylappatite granules (Polistom, RF) in combination with PRP, on top of an autoplasma membrane isolated from PRP and collagen membrane. The immediate and long-term periods of treatment were quite favorable. Control X-ray examination after 12 months showed complete recovery of the bone defect with an organotypic structure in all patients.

В статье говорится о сравнении эффективности применения «гиалуронатов» и аутоплазмы при остеоартрите коленных суставов у пациентов молодого возраста. В исследовании принимали участие пациенты возраста 16-28 лет с остеоартритом коленных суставов различных стадий, которым внутрисуставно вводились гиалуронаты или\и аутоплазма, обогащенная тромбоцитами. Далее проводилась клинико-инструментальная оценка (по шкале боли ВАШ и ультразвуковая диагностика). В ходе исследования нами не было выявлено значимого различия эффективности курсового лечения между «гиалуронатами» и аутоплазмой, обогащенной тромбоцитами. Однако, в случае раннего остеоартрита у молодых пациентов, обезболивающее действие наблюдалось в первые сутки после инъекции аутоплазмы. Также применение аутоплазмы оказалось экономически более выгодным для пациентов, The article deals with the comparison of the effectiveness of the use of "hyaluronic acid" and autoplasma in osteoarthritis of the knee joints in young patients.The study involved patients aged 16-28 years with osteoarthritis of the knee joints of various stages, who were intra-articularly injected with hyaluronates or\and autoplasm enriched with platelets. Next, a clinical and instrumental assessment was performed (according to the VAS pain scale and ultrasound diagnostics). During the study, we did not find a significant difference in the effectiveness of the course of treatment between "hyaluronates" and platelet-rich autolasma. However, in the case of early osteoarthritis in young patients, the analgesic effect was observed in the first day after the injection of autoplasma. The use of autoplasma also proved to be more cost-effective for patients.

Внутриматочные синехии (ВМС) по-прежнему представляют собой большую медико-социальную проблему. Прогноз в отношении репродуктивной функции и качества дальнейшей жизни при гинекологических операциях во многом определяется возможным спаечным процессом. Пусковым механизмом формирования ВМС является травма базального слоя эндометрия, которая может быть вызвана различными факторами, включая внутриматочные вмешательства. В настоящее время «золотым стандартом» диагностики и лечения ВМС является гистероскопия (ГС) и их разделение. Для профилактики образования спаек традиционно используются заместительная гормонотерапия с целью ускоренной пролиферации нормального эндометрия, специальные внутриматочные устройства или введение баллонных катетеров, противоспаечные барьеры. Однако остаётся высокий риск рецидива, а при наступении беременности развитие её осложнений. Применение аутоплазмы, содержащей тромбоциты, в лечении синехий полости матки способствует снижению риска рецидива ВМС после их разделения, восстановлению менструальной и репродуктивной функций.The problem of intrauterine synechia (IUS) is still a major medical and social problem. The prognosis for reproductive function and the quality of later life during gynecological operations is largely determined by the possible adhesive process. The trigger for the formation of IUS is trauma to the basal layer of the endometrium, which can be caused by various factors, including intrauterine interventions. Currently, the «gold standard» for the diagnosis and treatment of IUS is hysteroscopy and their separation. To prevent the formation of adhesions, hormone replacement therapy is traditionally used to accelerate the proliferation of the normal endometrium, special intrauterine devices or the introduction of balloon catheters, anti-adhesion barriers. However, there remains a high risk of relapse, and when pregnancy occurs, the development of its complications. The use of autoplasma containing platelets in the treatment of synechia of the uterine cavity helps reduce the risk of relapse of the IUD after separation, restoration of menstrual and reproductive functions., The problem of intrauterine synechia (IUS) is still a major medical and social problem. The prognosis for reproductive function and the quality of later life during gynecological operations is largely determined by the possible adhesive process. The trigger for the formation of IUS is trauma to the basal layer of the endometrium, which can be caused by various factors, including intrauterine interventions. Currently, the «gold standard» for the diagnosis and treatment of IUS is hysteroscopy and their separation. To prevent the formation of adhesions, hormone replacement therapy is traditionally used to accelerate the proliferation of the normal endometrium, special intrauterine devices or the introduction of balloon catheters, anti-adhesion barriers. However, there remains a high risk of relapse, and when pregnancy occurs, the development of its complications. The use of autoplasma containing platelets in the treatment of synechia of the uterine cavity helps reduce the risk of relapse of the IUD after separation, restoration of menstrual and reproductive functions.

Заболевания пародонта являются распространенной проблемой современной стоматологии. Очень часто данная патология сопровождается убылью мягких тканей пародонта. Прогноз течения рецессии не всегда является благоприятным, так как посредством имеющихся методов не удается достичь полной регенерации тканей. Поэтому возникает интерес к использованию аутоплазмы, для коррекции утраченных тканей. Действуя на все звенья регенерации тканей, она обеспечивает усиление трофики и тканевого анаболизма. Цель исследования: изучить эффективность лечения посредством аутотрансплантации плазмы, богатой тромбоцитами. Для исследования было отобрано 47 пациентов без соматической патологии, которые тщательно обследовались. Исследуемые получали по 3 инъекции плазмы богатой тромбоцитами с промежутками 7-10 дней, обследование пациентов проводили через 1, 3, 6 и 9 месяцев. Оценивали ширину прикрепления, биотип и состояние микрогемоциркуляции. Посредством инъекций удалось получить значительный прирост тканей, существенно улучшились показатели сосудистого русла тканей пародонта, достигнуты изменения биотипа десны. Полученные результаты клинических и функциональных исследований позволяют утверждать об эффективности использования инъекций аутоплазмы с целью лечения рецессии десны различной этиологии. Однако стоит отметить, что эффект является непостоянным и возникает необходимость проведения повторных курсов., Periodontal diseases are wide spread problem in modern stomatology. Very often this pathology is following by waste of soft periodontal tissues. The forecast of the recession is not always favorable, since the available methods do not allow the complete regeneration of tissues. Therefore, there is interest in the use of autoplasma for the correction of lost tissues. Influencing on all elements of regeneration the use of autoplasma provides improving of trophic and tissue anabolism. The research purpose is to study the effectiveness of treatment by autotransplantation of plasma rich in platelets. For this research 47 patients without somatic pathology were selected and scrupulously examined. The patients got by 3 injections of platelet-rich plasma with the interval 7-10 days. The patients were examined after 1, 3, 6 and 9 months. An attachment width, a biotype and a microhemocirculation status were evaluated. It was possible to obtain a significant increase in tissue by injection. The parameters of the vascular bed of the periodontal tissues have significantly improved, the changes in the gingival biotype of the gum have been achieved. The obtained results of clinical and functional studies allow to confirming about using autoplasma injections for the treatment gingival recession different etiology. However, it should be noted that the effect is not permanent and there is a need for repeated courses.