6 results on '"agent antiplaquettaire"'
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2. Avulsions dentaires chez les patients sous clopidogrel: étude prospective bi-centrique.
- Author
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Baranes, Marc, Princ, Guy, Spaulding, Christian, Hassin, Michel, Gandolfini, Maria-Pia, Stieltjes, Natalie, Sifi, Yacine, and Alantar, Alp
- Abstract
Dental avulsions in patients receiving clopidogrel: prospective bicentric study. Introduction: Clopidogrel is an antiplatelet drug used in the prevention of atherothrombosis and thrombosis after coronary stent implantation. It increases the risk of bleeding during surgical procedures. In 2015, the French Society of Oral Surgery (SFCO) published a practice guideline which clearly stated that "interruption of clopidogrel before a surgical procedure is not justified". However, there is limited data on tooth avulsions in patients receiving clopidogrel. Subjects and Methods: A prospective bicentric study was performed. The objective was to evaluate the risk of bleeding after tooth avulsion with an hemostatic procedure including surgical glue, in patients treated with clopidogrel alone or associated with aspirin. Patients under switch treatment (heparine, flurbiprofen) or who interrupted their treatment were not included in this study. 99 patients were included, 128 surgical procedures performed and 284 teeth extracted (2 ± 1 per intervention). Results: 12 post-surgical haemorrhages, 11 of which stopped by patient at home by compression with 10% tranexamic acid where noted. 2/3 of these haemorrhage concerned occurred in patients receiving dual antiplatelet therapy. Only one patient required a new local hemostasis procedure at hospital without transfusion or hospitalisation. Discussion: According to these results discontinuation of clopidogrel treatment is not justified for tooth avulsions followed by surgical glue hemostasis. Hemostatic procedures must be reinforced in case of dual antiplatelet therapy. Conclusion: These data confirm the SFCO guidelines. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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3. Management of antiplatelet therapy in patients undergoing elective invasive procedures: Proposals from the French Working Group on perioperative hemostasis (GIHP) and the French Study Group on thrombosis and hemostasis (GFHT). In collaboration with the French Society for Anesthesia and Intensive Care (SFAR).
- Author
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UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Laboratoire de biologie clinique, Godier, Anne, Fontana, Pierre, Motte, Serge, Steib, Annick, Bonhomme, Fanny, Schlumberger, Sylvie, Lecompte, Thomas, Rosencher, Nadia, Susen, Sophie, Vincentelli, André, Gruel, Yves, Albaladejo, Pierre, Collet, Jean-Philippe, French Working Group on perioperative hemostasis (GIHP), Mullier, François, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Laboratoire de biologie clinique, Godier, Anne, Fontana, Pierre, Motte, Serge, Steib, Annick, Bonhomme, Fanny, Schlumberger, Sylvie, Lecompte, Thomas, Rosencher, Nadia, Susen, Sophie, Vincentelli, André, Gruel, Yves, Albaladejo, Pierre, Collet, Jean-Philippe, French Working Group on perioperative hemostasis (GIHP), and Mullier, François
- Published
- 2018
4. Inefficacy of Platelet Transfusion in a Heart Transplant Patient Under Continuous Ticagrelor
- Author
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Huyen T. Tran, Nicolas D'Ostrevy, Kasra Azarnoush, Dat T. Pham, Laura Filaire, Lionel Camilleri, Service chirurgie cardio-vasculaire, CHU Clermont-Ferrand, service de chirurgie thoracique, Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), UNICANCER-UNICANCER, Cardiovascular treatment center, E Hopital Hanoi, Department Cardiology, Saint Paul general Hospital, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Centre Hospitalier Universitaire de Clermont-Ferrand, Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), chirurgie thoracique et cardio-vasculaire, Service de chirurgie cardiaque, Institut Pascal - Clermont Auvergne (IP), and Sigma CLERMONT (Sigma CLERMONT)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS)
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Male ,Ticagrelor ,medicine.medical_specialty ,Adenosine ,agent antiplaquettaire ,medicine.medical_treatment ,Platelet Transfusion ,antiplatelet drugs ,[SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery ,Postoperative Hemorrhage ,030204 cardiovascular system & hematology ,heart transplantation ,hemorrhagic shock ,03 medical and health sciences ,Fatal Outcome ,0302 clinical medicine ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,infarctus du myocarde ,medicine ,Humans ,cardiovascular diseases ,030212 general & internal medicine ,Intensive care medicine ,ComputingMilieux_MISCELLANEOUS ,Heart transplantation ,hémorragie ,business.industry ,Middle Aged ,3. Good health ,Treatment Outcome ,Anesthesiology and Pain Medicine ,Platelet transfusion ,Hemorrhagic shock ,Purinergic P2Y Receptor Antagonists ,Transplant patient ,haemorrhage ,syndrome coronarien ,Cardiology and Cardiovascular Medicine ,business ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,medicine.drug - Abstract
Antiplatelet agents have a predominant role in the therapeutic treatment of acute coronary syndrome (ACS) and myocardial infarction. Recently, ticagrelor has been incorporated in the European Society of Cardiology guidelines for the management of ACS with ST elevation and non-ST elevation.1 The AHA/ACC guidelines further advocate the choice of ticagrelor over clopidogrel in patients with ACS with non-ST elevation treated with an early invasive strategy.2 In fact, major studies have proven the benefits of ticagrelor on cardiovascular death, myocardial infarction, and stroke without an increase in major bleeding risk
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- 2017
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5. Management of antiplatelet therapy in patients undergoing elective invasive procedures: Proposals from the French Working Group on perioperative hemostasis (GIHP) and the French Study Group on thrombosis and hemostasis (GFHT
- Author
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Anne Godier, Pierre Fontana, Serge Motte, Annick Steib, Fanny Bonhomme, Sylvie Schlumberger, Thomas Lecompte, Nadia Rosencher, Sophie Susen, André Vincentelli, Yves Gruel, Pierre Albaladejo, Jean-Philippe Collet, P. Albaladejo, S. Belisle, N. Blais, F. Bonhomme, A. Borel-Derlon, J.Y. Borg, J.-L. Bosson, A. Cohen, J.-P. Collet, E. de Maistre, D. Faraoni, P. Fontana, D. Garrigue Huet, A. Godier, Y. Gruel, J. Guay, J.F. Hardy, Y. Huet, B. Ickx, S. Laporte, D. Lasne, J.H. Levy, J. Llau, G. Le Gal, T. Lecompte, S. Lessire, D. Longrois, S. Madi-Jebara, E. Marret, J.L. Mas, M. Mazighi, P. Mismetti, P.E. Morange, S. Motte, F. Mullier, N. Nathan, P. Nguyen, Y. Ozier, G. Pernod, N. Rosencher, S. Roullet, P.M. Roy, C.M. Samama, S. Schlumberger, J.F. Schved, P. Sié, A. Steib, S. Susen, E. van Belle, P. van Der Linden, A. Vincentelli, P. Zufferey, Fondation Ophtalmologique Adolphe de Rothschild [Paris], Université de Genève (UNIGE), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Techniques pour l'Evaluation et la Modélisation des Actions de la Santé (TIMC-IMAG-ThEMAS), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Centre Hospitalier Universitaire [Grenoble] (CHU), Département d'hématologie biologique[Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-CHU Saint-Eloi, and French Working Group On Perioperative Hemostasis (gihp)
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Local anaesthesia ,medicine.medical_specialty ,Consensus ,[SDV]Life Sciences [q-bio] ,Treatment outcome ,Blood Loss, Surgical ,030204 cardiovascular system & hematology ,Postoperative Hemorrhage ,Drug Administration Schedule ,03 medical and health sciences ,0302 clinical medicine ,Hémorragie ,Risk Factors ,Intensive care ,Surgical ,Medicine ,Humans ,In patient ,Blood Loss ,Chirurgie ,ComputingMilieux_MISCELLANEOUS ,Agent antiplaquettaire ,ddc:616 ,Hemostasis ,ddc:617 ,business.industry ,General surgery ,Antiplatelet therapy ,Thrombosis ,General Medicine ,Perioperative ,medicine.disease ,3. Good health ,Treatment Outcome ,Thrombose ,Anesthésie loco-régionale ,Haemorrhage ,Elective Surgical Procedures ,Platelet aggregation inhibitor ,Surgery ,France ,Cardiology and Cardiovascular Medicine ,business ,Elective Surgical Procedure ,030217 neurology & neurosurgery ,Platelet Aggregation Inhibitors - Abstract
International audience
- Published
- 2018
- Full Text
- View/download PDF
6. Impact des traitements antithrombotiques sur la morbi-mortalité des patients traumatisés
- Author
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Zerr, Bénédicte, Université Grenoble Alpes - UFR Médecine (UGA UFRM), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), and Pierre Albaladejo
- Subjects
Polytraumatisme ,Traitement anticoagulant ,Pronostic ,Mortalité ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,Agent antiplaquettaire - Abstract
Context: Nowadays, occidental population has to face 2 important trends implicated in serious public health issues. First, the use of anticoagulant (AC) and antiplatelet agent (APA) is growing. Secondly, traumas are more frequent and as a result increase death by trauma. Objective: The aim of this study was to compare mortality and outcome in 2 groups of traumatized patients: one group with preinjury AC or APA, and one group without preinjury treatment. Methods: A retrospective study was lead in 3 level I or II trauma centres (Grenoble university hospital and Annecy and Chambéry regional hospitals). Patients with trauma and preinjury use of anticoagulant or antiplatelet agent were included. Demographic, clinical, biological and outcome data were abstracted from an existing traumatic injury data base, the “Trauma REseau Nord Alpin des Urgences”. This data base was completed then with the help of the medical files. Mortality was compared in the 2 groups: with or without preinjury treatment. Results: Between 2012 and 2014, 3784 suffered from a traumatism and 163 patients had preinjury treatment: 46.6% with preinjury VKA use, 39.9% with preinjury aspirin use and 13.5% with preinjury clopidogrel use. Inhospital mortality in the group without preinjury treatment was 6.5% whereas in the group with preinjury treatment it was 13.5%. The hospital length of stay (HLOS) in this treated group was 18.9 ± 22.5 days and 46% of the cohort had good recovery. Among all the patients with preinjury treatment, 30.5% received blood products and 34.4% received medicinal products made from human blood. A surgery was required in 31.3 % of cases and a radio-intervention in 6.1 % of cases. The preinjury use of AC and/or APA was significantly associated with higher mortality (p
- Published
- 2016
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